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S M Abdel-Rahman et al.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 56(3), 243-245 (1999-02-25)
The stability of terbinafine 25 mg/mL (as the hydrochloride salt) in an extemporaneously prepared oral suspension at 25 and 4 degrees C was studied. Twenty 250-mg terbinafine tablets were crushed to a fine powder and diluted to a concentration of
D Fischer et al.
Anticancer research, 29(9), 3641-3645 (2009-08-12)
Tissue-specific expression of 25-hydroxyvitamin D-1alpha-hydroxylase (1alpha-OHase) and vitamin D-hydroxylase (24-OHase) may act as the pivotal link between 25-hydroxyvitamin D3 (25(OH)D3) serum levels and the anticancer effects of 1,25-dihydoxyvitamin D3 (1,25(OH)2D3) and alternative splicing of the enzymes may regulate their biological
D Fischer et al.
Cancer genomics & proteomics, 4(4), 295-300 (2007-09-20)
It is known that 25(OH)D3 can be metabolized to 1,25(OH)2 D3 by 1alpha-OHase in breast tissue. This tissue-specific expression of 1alpha-OHase may act as the pivotal link between vitamin D status (25(OH)D3 levels) and the anticancer effects of 1,25(OH)2 D3.
Robson Ramos de Souza et al.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 22(6), 245-249 (2012-10-20)
The purpose of our study was to investigate the prevalence of the PAX3/7-FKHR fusion genes and quantify the IGF2 gene expression in rhabdomyosarcoma (RMS) samples. Soft tissue sarcomas account 5% of childhood cancers and 50% of them are RMS. Morphological
Tayfun Güngör et al.
Lancet (London, England), 383(9915), 436-448 (2013-10-29)
In chronic granulomatous disease allogeneic haemopoietic stem-cell transplantation (HSCT) in adolescents and young adults and patients with high-risk disease is complicated by graft-failure, graft-versus-host disease (GVHD), and transplant-related mortality. We examined the effect of a reduced-intensity conditioning regimen designed to
Li Li et al.
Drug metabolism and disposition: the biological fate of chemicals, 34(8), 1411-1416 (2006-05-09)
Genotype/phenotype analysis with human hepatocytes has identified a new inactive CYP2D6 allele, CYP2D6*56. Cryopreserved human hepatocytes from 51 livers were evaluated for CYP2D6 activity with dextromethorphan as the probe substrate. Hepatocyte lots that lacked CYP2D6 activity were further evaluated for
Shuhui Wang et al.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 34(6), 498-503 (2009-07-10)
To identify the genetic characteristics in patients with nonsydromic hearing loss (NSHL) in Hunan province, to determine the prevalence and spectrum of mutations in GJB2 gene, and to explore the pathogenic mechanism. A total of 140 sporadic patients with NSHL
Varinderpal S Dhillon et al.
Molecular cancer, 3, 33-33 (2004-12-03)
Granulosa cell tumors (GCTs) are relatively rare and are subtypes of the sex-cord stromal neoplasms. Methylation induced silencing in the promoters of genes such as tumor suppressor genes, DNA repair genes and pro-apoptotic genes is recognised as a critical factor
Bernard Belhassen et al.
Circulation, 110(13), 1731-1737 (2004-09-24)
Automatic implantable cardioverter-defibrillator therapy is considered the only effective treatment for high-risk patients with Brugada syndrome. Quinidine depresses I(to) current, which may play an important role in the arrhythmogenesis of this disease. The effects of quinidine bisulfate (mean dose, 1483+/-240
Jian-Hua Li et al.
World journal of gastroenterology, 11(20), 3144-3146 (2005-05-27)
To study the status of hMLH1 gene point mutations of gastric cancer kindreds and gastric cancer patients from northern China, and to find out gene mutation status in the population susceptible to gastric cancer. Blood samples of 120 members from
K J Park et al.
Clinical radiology, 69(9), 939-944 (2014-05-29)
To investigate the correlation between implant appearance on ultrasound (US) and voiding cystourethrography (VCUG) results after dextranomer-hyaluronic acid copolymer (DxHA) injection in children with vesicoureteral reflux (VUR). Consecutive cases of primary VUR treated by endoscopic subureteral injection of DxHA were
Ayhan Ozcan et al.
Archives of pathology & laboratory medicine, 136(12), 1541-1551 (2012-12-01)
The diagnosis of renal cell carcinoma (RCC) remains problematic, especially in the context of metastasis or small-needle biopsies. PAX2 and PAX8 transcription factors are known to be expressed by several histologic types of renal neoplasms. To evaluate the diagnostic utility
Min-Cheng Su et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 21(11), 1379-1386 (2008-06-17)
Cadherin-17, also called liver-intestine cadherin, is a calcium-dependent transmembrane glycoprotein that mediates cell-cell adhesion in intestinal epithelium. Expression of cadherin-17 was reported in gastric, pancreatic, and colorectal adenocarcinomas but not in other tumors. Whether cadherin-17 can be used as a
Ashlee E Watts et al.
Veterinary surgery : VS, 40(5), 563-570 (2011-05-07)
To determine in vitro elution characteristics of amikacin and ticarcillin from fiber reinforced calcium phosphate beads (FRCP). Experimental. FRCP beads with water (A), amikacin (B), ticarcillin/clavulanate (C), or both amikacin and ticarcillin/clavulanate (D) were bathed in mL phosphate-buffered saline (PBS)
S L Pulley et al.
Journal of dairy science, 98(9), 6188-6201 (2015-07-06)
The objective was to determine the incidence of LH surges and ovulatory responses in lactating dairy cows enrolled in a timed artificial insemination (TAI) program. Cows were assigned randomly to 2 presynchronization treatments: (1) Pre10 (n=37): 2 injections of PGF2α
Pietro Di Pasquale et al.
Scandinavian cardiovascular journal : SCJ, 38(2), 93-97 (2004-06-19)
The ACE-D allele has been associated with cardiovascular disease. The study evaluates the relationship between the ACE-ID genotypes and diastolic function in healthy subjects after 6 years of follow-up. Two hundred and seventy-five healthy volunteers aged 25-55 years had normal
M C Pereira et al.
Veterinary parasitology, 38(2-3), 121-129 (1991-03-01)
The anthelmintic efficacy of ivermectin (IVM), piperazine citrate (PPZ) and fenbendazole (FBZ) alone, and combinations of FBZ with varying dosages of PPZ, was evaluated for the control of strongyles of Mangalarga equids. In all cases of positive strongly egg counts
I I Akhmetov et al.
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 92(7), 883-888 (2007-02-16)
Muscle fiber composition of m. vastus lateralis has significant individual variability mainly depending on genetic factors. Present study shows analysis of association between polymorphisms of three muscle performance-related genes and muscle fiber type composition in 48 young healthy men. DNA
A Digaitiene et al.
Journal of applied microbiology, 112(4), 732-742 (2012-02-09)
To screen five strains of lactic acid bacteria (LAB) isolated from rye sourdoughs for the potential production of antimicrobial substances. Lactobacillus sakei KTU05-06, Pediococcus acidilactici KTU05-7, Pediococcus pentosaceus KTU05-8, KTU05-9 and KTU05-10 isolated from rye sourdoughs were investigated for the
Yoshihisa Shimizu et al.
Clinical chemistry and laboratory medicine, 57(9), 1388-1396 (2019-03-13)
Background Many reports address the stability of biochemical analytes in serum. However, studies covering a wide range of storage temperatures are unavailable. Using equipment enabling precise temperature control, we investigated the effect of six different storage temperatures on serum analytes.
M M Khalil et al.
Scientific reports, 10(1), 8607-8607 (2020-05-27)
Novel multiwalled carbon nanotubes/ Fe-Co doped titanate nanotubes nanocomposite (MWCNTs/Fe-Co doped TNTs) facilitated the charge transfer and enhanced sensitivity and selectivity. Herein, three novel modified carbon paste sensors (CPSs) based on MWCNTs (sensor I), Fe-Co doped TNTs (sensor II) and
Jason M Foster et al.
World journal of surgical oncology, 8, 88-88 (2010-10-15)
There is a paucity of information about the molecular perturbations involved in MPM tumor formation. We previously reported that EGFR-TK mutations in MPM were predictive of achieving optimal surgical cytoreduction, but the status of EGFR pathway activation potential of these
K Suzuki et al.
International journal of immunopathology and pharmacology, 24(1), 7-14 (2011-04-19)
Both the number and functional capacity of T-regulatory (Treg) cells are known to be decreased in various autoimmune diseases. FOXP3, an essential transcription factor for Treg cells, has three isoforms in humans, wild, and exon 2- and exon 2-exon 7-lacking
Anna Vasků et al.
Clinical chemistry and laboratory medicine, 41(10), 1299-1303 (2003-10-29)
Remodelling of extracellular matrix by activated matrix metalloproteinases is considered to contribute to progression of ventricle remodelling during chronic heart failure. The aim of this study was to associate two promoter polymorphisms, -790T/G and -735C/T, in the gene for matrix
Marit Poffers et al.
Anesthesiology, 128(6), 1151-1166 (2018-03-07)
Voltage-gated sodium channels generate action potentials in excitable cells, but they have also been attributed noncanonical roles in nonexcitable cells. We hypothesize that voltage-gated sodium channels play a functional role during extravasation of neutrophils. Expression of voltage-gated sodium channels was
Alexandra Miller et al.
Journal of psychiatric research, 44(12), 788-794 (2010-02-23)
Premenstrual Dysphoric Disorder (PMDD) is a mood disorder affecting about 5% of women and is associated with substantial morbidity. Albeit inconsistently, PMDD is described as being characterized by heritable personality traits. Although PMDD is a heritable disorder, it is unclear
Michele Tonelli et al.
Bioorganic & medicinal chemistry, 17(13), 4425-4440 (2009-06-02)
Twelve aminoarylazocompounds (A-C) and 46 aryltriazene 7 derivatives (D-G) have been synthesized and evaluated in cell-based assays for cytotoxicity and antiviral activity against a panel of 10 RNA and DNA viruses. Eight aminoazocompounds and 27 aryltriazene derivatives exhibited antiviral activity
Shuichi Miyamoto et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 35(7), 1424-1430 (2016-08-21)
The principal aim of this study was to clarify the time course of pain-related behavior and pain-related sensory innervation in a rat model of hip osteoarthritis (OA) induced by intra-articular injection of mono-iodoacetate (MIA). Using 6-week-old male Sprague Dawley rats
Luca Arcaini et al.
Blood cells, molecules & diseases, 42(3), 286-291 (2009-03-03)
Immunoglobulin gene usage and somatic mutation patterns were studied in 59 patients with splenic marginal zone lymphoma and were correlated with clinical characteristics. Fifty-nine IGHV rearrangements were amplified. IGHV1, IGHV3, and IGHV4 subgroups accounted for 30%, 56%, and 14% of
Mélanie Bousquenaud et al.
The international journal of cardiovascular imaging, 28(6), 1407-1415 (2011-11-26)
The rat myocardial infarction (MI) model is widely used to study left ventricular (LV) remodeling. In this study, acipimox-enhanced (18)F-Fluorodeoxyglucose (FDG) gated-positron emission tomography (PET) was assessed for characterizing and predicting early remodeling in the rat infarct model. Nineteen Wistar
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