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Adam K Wheatley et al.
Journal of immunology (Baltimore, Md. : 1950), 195(2), 602-610 (2015-06-17)
Because of significant viral diversity, vaccines that elicit durable and broad protection against influenza have been elusive. Recent research has focused on the potential of highly conserved regions of the viral hemagglutinin (HA) as targets for broadly neutralizing Ab responses.
Ali Adem Bahar et al.
Applied microbiology and biotechnology, 99(19), 8125-8135 (2015-05-28)
Antimicrobial dendrimeric peptides (AMDP) are a relatively new class of agents displaying repetitive functional groups on a branched core. Previously, we have investigated the length requirement for antimicrobial activity of peptides consisting of repeated arginine (R) and tryptophan (W) side
Laurent Gorvel et al.
PloS one, 9(6), e99420-e99420 (2014-06-11)
Dendritic cells (DCs) orchestrate host defenses against microorganisms. In infectious diseases due to intracellular bacteria, the inefficiency of the immune system to eradicate microorganisms has been attributed to the hijacking of DC functions. In this study, we selected intracellular bacterial
Maria Fernanda Pascutti et al.
PLoS pathogens, 11(3), e1004675-e1004675 (2015-03-05)
Chronic infections are characterized by the inability to eliminate the persisting pathogen and often associated with functional impairment of virus-specific T-cell responses. Costimulation through Glucocorticoid-induced TNFR-related protein (GITR) can increase survival and function of effector T cells. Here, we report
Raymond N Allan et al.
PloS one, 9(9), e107015-e107015 (2014-09-05)
Streptococcus pneumoniae accounts for a significant global burden of morbidity and mortality and biofilm development is increasingly recognised as important for colonization and infection. Analysis of protein expression patterns during biofilm development may therefore provide valuable insights to the understanding
Peter R Atsatt et al.
PloS one, 9(4), e95266-e95266 (2014-04-30)
Diverse fungi live all or part of their life cycle inside plants as asymptomatic endophytes. While endophytic fungi are increasingly recognized as significant components of plant fitness, it is unclear how they interact with plant cells; why they occur throughout
Guo-Jyun Lai et al.
Carbohydrate polymers, 111, 288-297 (2014-07-20)
Nanofibrous membrane scaffolds of chitosan (CS), silk fibroin (SF) and CS/SF blend were prepared by electrospinning and studied for growth and osteogenic differentiation of human bone marrow mesenchymal stem cells (hMSCs). The morphology and physico-chemical properties of all membrane scaffolds
Xiaodong Ma et al.
Nature communications, 6, 7151-7151 (2015-05-21)
MicroRNAs (miRNAs) regulate apoptosis, yet their role in regulated necrosis remains unknown. miR-21 is overexpressed in nearly all human cancer types and its role as an oncogene is suggested to largely depend on its anti-apoptotic action. Here we show that
Cornelia Frese et al.
Acta odontologica Scandinavica, 72(5), 321-330 (2014-01-23)
Currently, there are many fibre-reinforced composites (FRCs) available which differ in the type and volume fraction of fibres, pre-treatment of fibres and matrix composition. The aims of this in vitro investigation were to determine whether there is a difference in
Tomokazu Sumida et al.
Nature communications, 6, 6241-6241 (2015-02-27)
Hypertension induces structural remodelling of arteries, which leads to arteriosclerosis and end-organ damage. Hyperplasia of vascular smooth muscle cells (VSMCs) and infiltration of immune cells are the hallmark of hypertensive arterial remodelling. However, the precise molecular mechanisms of arterial remodelling
Sampa Santra et al.
PLoS pathogens, 11(8), e1005042-e1005042 (2015-08-04)
HIV-1 mucosal transmission begins with virus or virus-infected cells moving through mucus across mucosal epithelium to infect CD4+ T cells. Although broadly neutralizing antibodies (bnAbs) are the type of HIV-1 antibodies that are most likely protective, they are not induced
Magali M Moretto et al.
Infection and immunity, 83(12), 4719-4730 (2015-09-30)
Microsporidia, which belong to the kingdom Fungi, are important opportunistic pathogens in HIV-infected populations and organ transplant recipients that are often associated with a broad range of symptoms, such as diarrhea, nephritis, and encephalitis. Natural infection occurs via the oral
Robert Tacke et al.
Scientific reports, 5, 10055-10055 (2015-06-20)
Tissue macrophages function to maintain homeostasis and regulate immune responses. While tissue macrophages derive from one of a small number of progenitor programs, the transcriptional requirements for site-specific macrophage subset development are more complex. We have identified a new tissue
Todd M Kolb et al.
Microcirculation (New York, N.Y. : 1994), 22(8), 724-736 (2015-09-10)
Myocardial angiogenesis is presumed to play a role in RV adaptation to PH, though definitive evidence and functional correlations are lacking. We aimed to use definitive methods to correlate RV angiogenesis, hypertrophy, and function in a murine PH model. Mice
Hidehiro Nakamura et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(10), 1523-1530 (2015-07-16)
Corticosteroids (CS) or hyaluronic acid (HA) is used in subacromial injection for the conservative treatment of rotator cuff tears (RCT); this study addresses the question of how CS and HA affect the tendon tissue and fibroblasts in vitro and in
Amina Dawoodji et al.
Journal of immunology (Baltimore, Md. : 1950), 193(5), 2118-2126 (2014-07-27)
The mechanisms behind destruction of the adrenal glands in autoimmune Addison's disease remain unclear. Autoantibodies against steroid 21-hydroxylase, an intracellular key enzyme of the adrenal cortex, are found in >90% of patients, but these autoantibodies are not thought to mediate
Majid Kazemian et al.
Molecular systems biology, 11(8), 826-826 (2015-08-09)
Crucial parts of the genome including genes encoding microRNAs and noncoding RNAs went unnoticed for years, and even now, despite extensive annotation and assembly of the human genome, RNA-sequencing continues to yield millions of unmappable and thus uncharacterized reads. Here
Ngo Vy Thao et al.
Marine environmental research, 109, 95-102 (2015-06-27)
The biodegradation of proteins in seawater requires various proteases which are commonly thought to be mainly derived from heterotrophic bacteria. We, however, found that protists showed a high protease activity and continuously produced trypsin-type enzymes. The free-living marine heterotrophic ciliate
Laura M Breshears et al.
BMC microbiology, 15, 276-276 (2015-12-15)
The vaginal microbiota can impact the susceptibility of women to bacterial vaginosis (BV) and sexually transmitted infections (STIs). BV is characterized by depletion of Lactobacillus spp., an overgrowth of anaerobes (often dominated by Gardnerella vaginalis) and a pH > 4.5. BV is
Alice Cheng et al.
Biofabrication, 6(4), 045007-045007 (2014-10-08)
Additive manufacturing by laser sintering is able to produce high resolution metal constructs for orthopedic and dental implants. In this study, we used a human trabecular bone template to design and manufacture Ti-6Al-4V constructs with varying porosity via laser sintering.
Ton Yoisungnern et al.
Scientific reports, 5, 11170-11170 (2015-06-09)
Silver nanoparticles (AgNPs) have many features that make them attractive as medical devices, especially in therapeutic agents and drug delivery systems. Here we have introduced AgNPs into mouse spermatozoa and then determined the cytotoxic effects of AgNPs on sperm function
Na-Young Choi et al.
BioMed research international, 2015, 239519-239519 (2015-08-08)
In this study, we used ethanol extract of A. princeps and investigated its antibacterial effects against MRSA. Ethanol extract of A. princeps significantly inhibited MRSA growth and organic acid production during glucose metabolism at concentrations greater than 1 mg/mL (P < 0.05). MRSA
Gloria Omosa-Manyonyi et al.
PloS one, 10(5), e0125954-e0125954 (2015-05-12)
Sequential prime-boost or co-administration of HIV vaccine candidates based on an adjuvanted clade B p24, RT, Nef, p17 fusion protein (F4/AS01) plus a non-replicating adenovirus 35 expressing clade A Gag, RT, Int and Nef (Ad35-GRIN) may lead to a unique
Guobao Chen et al.
ACS applied materials & interfaces, 7(29), 15790-15802 (2015-07-08)
A growing body of evidence has shown that extracellular matrix (ECM) stiffness can modulate stem cell adhesion, proliferation, migration, differentiation, and signaling. Stem cells can feel and respond sensitively to the mechanical microenvironment of the ECM. However, most studies have
Manuela Carvalheiro et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 93, 346-352 (2015-05-06)
Leishmaniasis, a vector-borne parasitic disease caused by Leishmania protozoa, is one of the most neglected tropical diseases in terms of drug discovery and development. Current treatment is based on a limited number of chemotherapeutic agents all of which present either/or
Jung-Min Lee et al.
Journal of translational medicine, 13, 239-239 (2015-07-23)
PARP inhibitors (PARPi) are a novel class of drugs with activity in patients with acquired or germline homologous recombination (HR) deficiency-associated high-grade serous ovarian cancer (HGSOC). We hypothesized that measuring γH2AX as an indicator of DNA double-strand breaks (DSB), and
Martina Seifert et al.
The Journal of surgical research, 193(2), 933-941 (2014-12-03)
Undesirable processes of inflammation, calcification, or immune-mediated reactions are limiting factors in long-term survival of heart valves in patients. In this study, we target the modulatory effects of ice-free cryopreservation (IFC) of xenogeneic heart valve leaflet matrices, without decellularization, on
Kyle J Berean et al.
Scientific reports, 5, 11515-11515 (2015-06-23)
Unique in vivo tests were conducted through the use of a fistulated ruminant, providing an ideal environment with a diverse and vibrant microbial community. Utilizing such a procedure can be especially invaluable for investigating the performance of antimicrobial materials related
Andrew Freeman et al.
PloS one, 9(10), e110928-e110928 (2014-10-24)
Squamous Cell Carcinoma (SCC) is a type of non-melanoma skin cancer prevalent in immune-suppressed transplant recipients and older individuals with a history of chronic sun-exposure. SCC itself is believed to be a late-stage manifestation that can develop from premalignant lesions
L A Ramirez et al.
Journal of leukocyte biology, 96(6), 1055-1063 (2014-08-27)
HIV-1-infected subjects, despite control of viral replication with ART, have an altered immune cytokine/chemokine milieu. Changes in systemic cytokines and chemokines can alter immune responses. IP-10, in particular, has been associated with pathogenesis in a number of conditions, and we
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