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显示 1-30 共 765 条结果 关于 "563110" 范围 论文
Reihane Seifi Moroudi et al.
Molecular biology reports, 41(12), 8019-8030 (2014-09-07)
One of the important behaviors of dogs is trainability which is affected by learning and memory genes. These kinds of the genes have not yet been identified in dogs. In the current research, these genes were found in animal models
Michael Murphy et al.
The Journal of biological chemistry, 290(31), 19218-19232 (2015-06-18)
Endotoxin tolerance reprograms Toll-like receptor (TLR) 4-mediated macrophage responses by attenuating induction of proinflammatory cytokines while retaining expression of anti-inflammatory and antimicrobial mediators. We previously demonstrated deficient TLR4-induced activation of IL-1 receptor-associated kinase (IRAK) 4, IRAK1, and TANK-binding kinase (TBK)
Xiao Wang et al.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 272(9), 2363-2369 (2014-11-02)
The presence of bacterial biofilms (BBF) and fungal biofilms (FBF) is associated with greater disease severity in chronic rhinosinusitis. However, researches on biofilms in fungal rhinosinusitis are rare. This study investigated the relationship between biofilms and clinical features in patients
Jetze Visser et al.
Tissue engineering. Part A, 21(7-8), 1195-1206 (2015-01-06)
Decellularized tissues have proven to be versatile matrices for the engineering of tissues and organs. These matrices usually consist of collagens, matrix-specific proteins, and a set of largely undefined growth factors and signaling molecules. Although several decellularized tissues have found
Ting Liu et al.
Biotechnology and bioengineering, 112(10), 2051-2059 (2015-04-23)
Electroactive biofilms play essential roles in determining the power output of microbial fuel cells (MFCs). To engineer the electroactive biofilm formation of Shewanella oneidensis MR-1, a model exoelectrogen, we herein heterologously overexpressed a c-di-GMP biosynthesis gene ydeH in S. oneidensis
Yeon Jeong Kim et al.
Biomaterials, 35(26), 7501-7510 (2014-06-12)
Circulating tumor cells (CTCs) are rare cells and the presence of these cells may indicate a poor prognosis and a high potential for metastasis. Despite highly promising clinical applications, CTCs have not been investigated thoroughly, due to many technical limitations
Hussein Shehade et al.
Journal of immunology (Baltimore, Md. : 1950), 195(4), 1372-1376 (2015-07-17)
Tissue hypoxia can occur in physiological and pathological conditions. When O2 availability decreases, the transcription factor hypoxia-inducible factor (HIF)-1α is stabilized and regulates cellular adaptation to hypoxia. The objective of this study was to test whether HIF-1α regulates T cell
Isaak Quast et al.
The Journal of clinical investigation, 125(11), 4160-4170 (2015-10-06)
IgG molecules exert both pro- and antiinflammatory effector functions based on the composition of the fragment crystallizable (Fc) domain glycan. Sialylated IgG Fc domains have antiinflammatory properties that are attributed to their ability to increase the activation threshold of innate
Jaeyop Lee et al.
The Journal of experimental medicine, 212(3), 385-399 (2015-02-18)
In mice, two restricted dendritic cell (DC) progenitors, macrophage/dendritic progenitors (MDPs) and common dendritic progenitors (CDPs), demonstrate increasing commitment to the DC lineage, as they sequentially lose granulocyte and monocyte potential, respectively. Identifying these progenitors has enabled us to understand
Junko Okano et al.
Biochemical and biophysical research communications, 461(4), 695-701 (2015-04-30)
Bone marrow-derived cells (BMDCs) can migrate into the various organs in the mice irradiated by ionizing radiation (IR). However, it may not be the case in the skin. While IR is used for bone marrow (BM) transplantation, studying with the
Gaëlle Breton et al.
The Journal of experimental medicine, 212(3), 401-413 (2015-02-18)
Two subsets of conventional dendritic cells (cDCs) with distinct cell surface markers and functions exist in mouse and human. The two subsets of cDCs are specialized antigen-presenting cells that initiate T cell immunity and tolerance. In the mouse, a migratory
Emile B Gordon et al.
mBio, 6(3), e00725-e00725 (2015-06-04)
Malaria is an infectious disease caused by parasites of several Plasmodium spp. Cerebral malaria (CM) is a common form of severe malaria resulting in nearly 700,000 deaths each year in Africa alone. At present, there is no adjunctive therapy for
Melanie A Ngo et al.
Molecular and cellular biochemistry, 392(1-2), 187-204 (2014-04-03)
Cardiac fibrosis accompanies a variety of myocardial disorders, and is induced by myofibroblasts. These cells may be composed of a heterogeneous population of parent cells, including interstitial fibroblasts and circulating progenitor cells. Direct comparison of human bone marrow-derived mesenchymal stem
Sarah A Ingersoll et al.
Journal of immunology (Baltimore, Md. : 1950), 194(11), 5520-5528 (2015-05-01)
Bacteria colonize cystic fibrosis (CF) airways, and although T cells with appropriate Ag specificity are present in draining lymph nodes, they are conspicuously absent from the lumen. To account for this absence, we hypothesized that polymorphonuclear neutrophils (PMNs), recruited massively
Eugenio Redolfi Riva et al.
ACS nano, 8(6), 5552-5563 (2014-05-07)
We report on the fabrication and characterization of a freestanding ultrathin, mucoadhesive gold nanoshell/polysaccharide multilayer nanocomposite (thermonanofilm, TNF), that can be used for controlled photothermal ablation of tissues through irradiation with near-infrared radiation (NIR) laser. The aim of this work
Debargh K Dutta et al.
PloS one, 10(4), e0124389-e0124389 (2015-04-22)
Multinucleate giant cells (MGCs) are formed by the fusion of 5 to 15 monocytes or macrophages. MGCs can be generated by hip implants at the site where the metal surface of the device is in close contact with tissue. MGCs
Han-Ning Huang et al.
Marine drugs, 13(5), 3241-3258 (2015-05-27)
Shrimp anti-lipopolysaccharide factor (SALF) is an antimicrobial peptide with reported anticancer activities, such as suppression of tumor progression. In this study, we prepared a potential cancer vaccine comprised of SALF in conjunction with the cell lysate of inactivated murine bladder
Tina O Bose et al.
Journal of immunology (Baltimore, Md. : 1950), 193(6), 2863-2872 (2014-08-12)
The process of lymphopoiesis begins in the bone marrow (BM) and requires multiple cellular intermediates. For T cell production, lymphoid progenitors exit the BM and home to the thymus where maturation and selection ensue. These processes are dependent on a
Simon Junankar et al.
Nature communications, 6, 6548-6548 (2015-03-31)
Basal-like breast cancer (BLBC) is a heterogeneous disease with poor prognosis; however, its cellular origins and aetiology are poorly understood. In this study, we show that inhibitor of differentiation 4 (ID4) is a key regulator of mammary stem cell self-renewal
Deep Mandal et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(34), 12042-12052 (2015-07-18)
A pyrene-containing phenylboronic acid (PBA) functionalized low-molecular-weight hydrogelator was synthesized with the aim to develop glucose-sensitive insulin release. The gelator showed the solvent imbibing ability in aqueous buffer solutions of pH values, ranging from 8-12, whereas the sodium salt of
Jason K F Wong et al.
PloS one, 9(11), e112672-e112672 (2014-11-11)
Repaired tendons may be complicated by progressive fibrosis, causing adhesion formation or tendon softening leading to tendon rupture and subsequent reduced range of motion. There are few therapies available which improve the gliding of damaged tendons in the hand. We
Lise Søndergaard et al.
International journal of food microbiology, 213, 59-70 (2015-07-29)
Reduction of sodium chloride (NaCl) in cheese manufacturing is a challenge for the dairy industry. NaCl has a profound role on microbial development influencing cheese sensory and technological properties. The purpose of this work was to investigate how proliferation, distribution
Deepa Talreja et al.
Current eye research, 39(7), 695-704 (2014-02-08)
Acinetobacter (A.) baumannii is an opportunistic pathogen and has been reported as a causative agent of ocular infections. The aim of this study is to identify virulence properties (biofilm formation, adhesion, invasion and cytotoxicity) and antibiotic resistance among A. baumannii
W Carrillo et al.
Journal of food protection, 77(10), 1732-1739 (2014-10-07)
The antimicrobial activity of heat-denatured and hydrolyzed hen egg white lysozyme against oenological lactic acid and acetic acid bacteria was investigated. The lysozyme was denatured by heating, and native and heat-denatured lysozymes were hydrolyzed by pepsin. The lytic activity against
Giuseppe Pettinato et al.
PloS one, 9(11), e100742-e100742 (2014-11-05)
We report a technology to form human embryoid bodies (hEBs) from singularized human embryonic stem cells (hESCs) without the use of the p160 rho-associated coiled-coil kinase inhibitor (ROCKi) or centrifugation (spin). hEB formation was tested under four conditions: +ROCKi/+spin, +ROCKi/-spin
René H M Raeven et al.
PloS one, 9(8), e104548-e104548 (2014-08-20)
Worldwide resurgence of pertussis necessitates the need for improvement of pertussis vaccines and vaccination strategies. Since natural infections induce a longer-lasting immunity than vaccinations, detailed knowledge of the immune responses following natural infection can provide important clues for such improvement.
Jared M Odegard et al.
Journal of immunotherapy (Hagerstown, Md. : 1997), 38(2), 41-53 (2015-02-07)
Dendritic cells (DCs) are essential antigen-presenting cells for the initiation of cytotoxic T-cell responses and therefore attractive targets for cancer immunotherapy. We have developed an integration-deficient lentiviral vector termed ID-VP02 that is designed to deliver antigen-encoding nucleic acids selectively to
Jennifer Downey et al.
Bone, 71, 164-170 (2014-12-03)
Skeletal muscle has strong regenerative capabilities. However, failed regeneration can lead to complications where aberrant tissue forms as is the case with heterotopic ossification (HO), in which chondrocytes, osteoblasts and white and brown adipocytes can arise following severe trauma. In
Krister Blodörn et al.
PloS one, 9(6), e100392-e100392 (2014-06-20)
The development of safe and effective vaccines against both bovine and human respiratory syncytial viruses (BRSV, HRSV) to be used in the presence of RSV-specific maternally-derived antibodies (MDA) remains a high priority in human and veterinary medicine. Herein, we present
M Purschke et al.
The British journal of dermatology, 172(4), 1021-1028 (2014-10-14)
Epidermal suction blister grafts are an effective treatment for chronic wounds or vitiligo, but this treatment is time consuming and limited to small areas. To compare two novel strategies to create fractional epidermal grafts. Epidermal blisters were raised from fresh
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