579-10-2

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关键词:'579-10-2'

显示 1-21 共 21 条结果关于 "579-10-2" 范围论文

Acute adenosine preconditioning is mediated by p38 MAPK activation in discrete subcellular compartments.

Cherry Ballard-Croft et al.

American journal of physiology. Heart and circulatory physiology, 288(3), H1359-H1366 (2004-11-13)

Although acute adenosine preconditioning (PC) is well established, the signaling pathways mediating this cardioprotection remain unclear. Because adenosine receptor agonists activate p38 MAPK and this kinase has been implicated in ischemic and pharmacological PC, the purpose of this study was

Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors.

Gilda Neves et al.

Bioorganic & medicinal chemistry, 18(5), 1925-1935 (2010-02-16)

We described herein the design, synthesis, and pharmacological evaluation of N-phenylpiperazine heterocyclic derivatives as multi-target compounds potentially useful for the treatment of schizophrenia. The isosteric replacement of the heterocyclic ring at the biaryl motif generating pyrazole, 1,2,3-triazole, and 2-methylimidazole[1,2-a]pyridine derivatives

H-point standard addition method for the selective simultaneous determination of nickel and copper using 1-(2-pyridylazo)-2-naphthol in Tween 80 micellar media.

Habibollah Eskandari et al.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 20(7), 1095-1098 (2004-08-06)

The H-point standard addition method (HPSAM) has been applied for the simultaneous determination of nickel and copper in trace levels, using 1-(2-pyridylazo)-2-naphthol (PAN) as a chromogenic reagent in aqueous Tween 80 micellar media. Under the optimum condition, the simultaneous determinations

Amino acid regions 572-579 and 657-666 of the spacer domain of ADAMTS13 provide a common antigenic core required for binding of antibodies in patients with acquired TTP.

Brenda M Luken et al.

Thrombosis and haemostasis, 96(3), 295-301 (2006-09-06)

Antibodies directed against ADAMTS13 have been detected in the majority of patients with acquired thrombotic thrombocytopenic purpura (TTP). We have previously localized a major antigenic determinant within the spacer domain of ADAMTS13. To identify the amino acid residues of the

Autologous red cell agglutination assay for HIV-1 antibodies: simplified test with whole blood.

B E Kemp et al.

Science (New York, N.Y.), 241(4871), 1352-1354 (1988-09-09)

An antibody detection procedure based on agglutination of autologous red cells has been developed for samples of whole blood. A nonagglutinating monoclonal antibody to human red blood cells conjugated to a synthetic peptide antigen (in this case residues 579 to

A genetic linkage map of 27 markers on human chromosome 21.

M B Petersen et al.

Genomics, 9(3), 407-419 (1991-03-01)

We have constructed a genetic linkage map of the long arm of human chromosome 21 comprising 27 DNA markers. This map is an updated version of that reported earlier by group (1989, Genomics 4: 579-591), which contained 17 DNA markers.

Arginase-2 is cooperatively up-regulated by nitric oxide and histone deacetylase inhibition in human umbilical artery endothelial cells.

Bernardo J Krause et al.

Biochemical pharmacology, 99, 53-59 (2015-11-10)

Arginase-2 counteracts endothelial nitric oxide synthase (eNOS) activity in human endothelium, and its expression is negatively controlled by histone deacetylase (HDAC2). Conversely NO inhibits HDAC and previous studies suggest that arginase-2 is up-regulated by NO. We studied whether NO regulates

Alpha-2-HS-glycoprotein plasma level decrease correlates with age in patients with myelodysplastic syndromes.

Pavel Majek et al.

Cancer biomarkers : section A of Disease markers, 20(4), 637-639 (2017-09-05)

It has been indicated in plasma proteomic studies on different myelodysplastic syndrome (MDS) cohorts that alpha-2-HS-glycoprotein could be a promising MDS biomarker candidate. The goal of this work was to estimate alpha-2-HS-glycoprotein (AHSG) plasma levels and its biomarker value in

The establishment and evaluation of a new model for the prediction of prostate cancer.

Qi Wang et al.

Medicine, 96(11), e6138-e6138 (2017-03-16)

To develop a new prostate cancer predictor (PCP) model using the combination of total prostate-specific antigen (tPSA), free PSA (fPSA), and complexed PSA (cPSA).The diagnoses of all the included patients were confirmed pathologically in Daping Hospital between December 1, 2011

The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner.

G Rammes et al.

Neuroscience letters, 306(1-2), 81-84 (2001-06-19)

The type 3 serotonin (5-HT(3)) receptor is a ligand-gated ion channel. In concentration-clamp experiments, we investigated the effects of the uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonists memantine, amantadine and MRZ 2/579 on 5-HT receptors stabley expressed in HEK-293 cells and on

Increased immunodetection of acidic fibroblast growth factor in bladder cancer, detectable in urine.

D K Chopin et al.

The Journal of urology, 150(4), 1126-1130 (1993-10-01)

Acidic fibroblast growth factor is a regulatory peptide involved in cell proliferation, differentiation and motility. We used a polyclonal antiserum raised against purified native bovine acidic fibroblast growth factor, with no cross-reactivity for basic fibroblast growth factor to detect acidic

cMET and refractive error progression in children.

Chiea C Khor et al.

Ophthalmology, 116(8), 1469-1474 (2009-06-09)

To assess whether genetic variation in cMET is associated with refractive error or change in refractive error over time. Cohort study. Discovery set (Set 1: N = 579 children; 403 cases, 176 controls). Confirmatory set (Set 2: N = 547

Identification of a region of beta-amyloid precursor protein essential for its gelatinase A inhibitory activity.

Shouichi Higashi et al.

The Journal of biological chemistry, 278(16), 14020-14028 (2003-02-15)

Because beta-amyloid precursor protein (APP) has the abilities both to interact with extracellular matrix and to inhibit gelatinase A activity, this molecule is assumed to play a regulatory role in the gelatinase A-catalyzed degradation of extracellular matrix. To determine a

Demonstration of a functional requirement for the carbamate nitrogen of ribulosebisphosphate carboxylase/oxygenase by chemical rescue.

H B Smith et al.

Biochemistry, 30(21), 5172-5177 (1991-05-28)

Ribulosebisphosphate carboxylase/oxygenase is reversibly activated by the reaction of CO2 with a specific lysyl residue (Lys191 of the Rhodospirillum rubrum enzyme) to form a carbamate that coordinates an essential Mg2+ cation. Surprisingly, the Lys191----Cys mutant protein, in the presence of

Induction of endothelial cell proliferation by recombinant and microparticle-tissue factor involves beta1-integrin and extracellular signal regulated kinase activation.

Mary E W Collier et al.

Arteriosclerosis, thrombosis, and vascular biology, 30(9), 1810-1817 (2010-07-10)

Increased levels of circulating tissue factor (TF) in the form of microparticles increase the risk of thrombosis. However, any direct influence of microparticle-associated TF on vascular endothelial cell proliferation is not known. In this study, the influence of recombinant and

Increased vesicle recycling in response to osmotic cell swelling. Cause and consequence of hypotonicity-provoked ATP release.

Thea van der Wijk et al.

The Journal of biological chemistry, 278(41), 40020-40025 (2003-07-23)

Osmotic swelling of Intestine 407 cells leads to an immediate increase in cell surface membrane area as determined using the fluorescent membrane dye FM 1-43. In addition, as measured by tetramethylrhodamine isothiocyanate (TRITC)-dextran uptake, a robust (>100-fold) increase in the

Determination of the disulfide bridges in factor Va heavy chain.

J Xue et al.

Biochemistry, 33(44), 13109-13116 (1994-11-08)

The M(r) = 94,000 heavy chain of bovine factor Va contains 10 cysteine residues which are distributed in the 2 A domains which make up this portion of the factor V molecule. The A1 domain contains four cysteines while the

Simultaneous quantification of IMPDH activity and purine bases in lymphocytes using LC-MS/MS: assessment of biomarker responses to mycophenolic acid.

Nils Tore Vethe et al.

Therapeutic drug monitoring, 36(1), 108-118 (2013-09-26)

The development of biomarkers describing the individual responses to the immunosuppressant mycophenolic acid (MPA) has focused on the target enzyme activity [inosine 5'-monophosphate dehydrogenase (IMPDH)]. An extended strategy is to quantify the metabolic consequences of IMPDH inhibition. The aim of

Human cancers converge at the HIF-2alpha oncogenic axis.

Aleksandra Franovic et al.

Proceedings of the National Academy of Sciences of the United States of America, 106(50), 21306-21311 (2009-12-04)

Cancer development is a multistep process, driven by a series of genetic and environmental alterations, that endows cells with a set of hallmark traits required for tumorigenesis. It is broadly accepted that growth signal autonomy, the first hallmark of malignancies

Role of angiotensin II in L-NAME-induced systemic and renal hemodynamic effects in hydrochlorothiazide-pretreated hypertensive subjects.

Nicole A van der Linde et al.

Journal of hypertension, 21(2), 345-351 (2003-02-06)

Experimental evidence suggests that in conditions associated with an activated renin-angiotensin system, unopposed activity of angiotensin II underlies the marked renal vasoconstrictor response to nitric oxide synthase inhibition. In the present study, we investigated whether this holds true in hypertensive

Relative oral bioavailability of morphine and naltrexone derived from crushed morphine sulfate and naltrexone hydrochloride extended-release capsules versus intact product and versus naltrexone solution: a single-dose, randomized-sequence, open-label, three-way crossover trial in healthy volunteers.

Franklin K Johnson et al.

Clinical therapeutics, 32(6), 1149-1164 (2010-07-20)

Morphine sulfate/sequestered naltrexone hydrochloride (HCl) (MS-sNT) extended-release fixed-dose combination capsules, approved by the US Food and Drug Administration (FDA) in August 2009 for chronic moderate to severe pain, contain extended-release morphine pellets with a sequestered core of the opioid antagonist

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