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Sarah L Noton et al.
Journal of virology, 89(15), 7786-7798 (2015-05-23)
Respiratory syncytial virus (RSV) is the leading cause of pediatric respiratory disease. RSV has an RNA-dependent RNA polymerase that transcribes and replicates the viral negative-sense RNA genome. The large polymerase subunit (L) has multiple enzymatic activities, having the capability to
Xuebin Tian et al.
Infection and drug resistance, 13, 501-512 (2020-02-29)
The emergence and spread of carbapenem-resistant Escherichia coli (E. coli) pose a serious threat to human health worldwide. This study aimed to investigate the molecular mechanisms underlying carbapenem resistance and their prevalence among E. coli in China. A collection of
G C Tian et al.
Biochemistry, 29(18), 4296-4304 (1990-05-08)
Using site-specific mutagenesis, we have probed the structural and functional roles of lysine-21 and lysine-27 of adenylate kinase (AK) from chicken muscle expressed in Escherichia coli. The two residues were chosen since according to the nuclear magnetic resonance (NMR) model
J G van Andel
Radiologia clinica, 46(1), 50-69 (1977-01-01)
80 patients with carcinoma of the nasopharynx classified according to TNM categories who have been treated in the RRTI between January 1947 and January 1966 are discussed. During 1947-1957 patients were treated by orthovoltage, and after this period by cobalt
V P Avdoshin et al.
Urologiia (Moscow, Russia : 1999), (5)(5), 18-20 (2013-01-25)
The evaluation of clinical efficacy of combined treatment and metaphylaxis in 58 patients with gout complicated by nephropathy and urolithiasis was performed. The study included 41 (71%) men and 27 (29%) women aged 44 to 88 years (mean age -
Mitsuhiko Ohta et al.
Oncology reports, 15(6), 1529-1532 (2006-05-11)
We previously reported some cancer testis antigens, especially for MAGE genes, to be expressed in a relatively high population of gastro-intestinal and breast cancers. TRAG-3 (Taxol resistant associated gene-3) may be another cancer testis antigen; however, its expression has still
T Takada et al.
Biochemical and biophysical research communications, 270(3), 728-732 (2000-04-25)
We previously cloned MRP3, which is responsible for the cellular extrusion of organic anions, as an inducible transporter in the liver under cholestatic conditions. In the present study, we investigated the mechanism for the expression of human MRP3. The cap
Nicole M Merritt et al.
Oncotarget, 9(60), 31620-31636 (2018-09-01)
TAZ and YAP are transcriptional coactivators negatively regulated by the Hippo pathway that have emerged as key oncoproteins in several cancers including sarcomas. We hypothesized that loss of expression of the Hippo kinases might be a mechanism of activating TAZ
D S Mikhaĭlenko et al.
Genetika, 41(9), 1289-1293 (2005-10-26)
The GIPC1 gene product promotes clustering of some transmembrane receptors, including those involved in carcinogenesis, and protects them against ubiquitin-dependent degradation. The 5' untranslated region of GIPC1 contains a polymorphic trinucleotide CGG repeat, which has not been characterized earlier. In
Ashlyn Tom et al.
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 27(1), 97-103 (2017-09-09)
Gastrointestinal (GI) symptoms pose a significant burden to patients receiving chemoradiation therapy (CRT) for anal cancer; however, the impact of symptoms from the patient perspective has not been quantified. This retrospective study examined and compared patient and clinician reports of
Aleem Gangjee et al.
Journal of medicinal chemistry, 51(15), 4589-4600 (2008-07-09)
Novel classical antifolates (3 and 4) and 17 nonclassical antifolates (11-27) were synthesized as antitumor and/or antiopportunistic infection agents. Intermediates for the synthesis of 3, 4, and 11-27 were 2,4-diamino-5-alkylsubstituted-7H-pyrrolo[2,3-d]pyrimidines, 31 and 38, prepared by a ring transformation/ring annulation sequence
S-W Chen et al.
International journal of laboratory hematology, 30(2), 133-138 (2008-03-13)
Aberrant antigen expression in acute myeloid leukemia (AML) has been extensively studied in the West with limited reports from Taiwan. We carried out this retrospective study to characterize the frequency and significance of aberrant antigen expression of AML in Taiwan.
Renly Lim et al.
International urogynecology journal, 29(7), 997-1004 (2017-07-27)
We evaluated patients' perception and satisfaction with nonsurgical pulsed magnetic stimulation (PMS) for treatment of female stress urinary incontinence (SUI) in a randomized, double-blind, sham-controlled trial. Women with SUI (n = 120) were randomized to either active or sham PMS for 8 weeks
Melinda A B Petrina et al.
Anaerobe, 47, 115-119 (2017-05-20)
Secnidazole, a 5-nitroimidazole with a longer half-life, is structurally related to metronidazole and tinidazole. For treatment of bacterial vaginosis (BV), secnidazole is a suitable single-dose oral drug having a longer serum half-life than metronidazole. The objective of this study was
Kazuo Mihara et al.
Therapeutic drug monitoring, 25(3), 287-293 (2003-05-27)
The effects of various CYP2D6 genotypes on the steady-state plasma concentrations (Css) of risperidone and its active metabolite, 9-hydroxyrisperidone, were studied in 85 Japanese schizophrenic patients (27 men and 58 women) treated with 6 mg/d risperidone for at least 2
Eric Druyts et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 56(7), 961-967 (2012-12-18)
A systematic review and meta-analysis were conducted to examine the efficacy and safety of pegylated interferon (peg-IFN) alfa-2a and peg-IFN alfa-2b plus ribavirin (RBV) in children and adolescents with chronic hepatitis C virus (HCV). Medline, Embase, and Cochrane Central Register
Gisèle Nkontchou et al.
Journal of hepatology, 53(5), 827-833 (2010-08-24)
Mechanisms linking obesity and unfavourable outcomes in patients with viral hepatitis C (HCV) cirrhosis are not well understood. Obesity is associated with insulin resistance, increased leptin, and decreased adiponectin serum levels. We assessed the predictive value of those factors for
Gokhan Kus et al.
In vitro cellular & developmental biology. Animal, 51(10), 1056-1063 (2015-07-15)
Ceramidases are key enzymes that decrease ceramide levels in cells. A reduction in ceramide concentration impairs ceramide signalling, and results in apoptosis resistance in cancer cells. This study investigates the potential for ceranib-2, a novel ceramidase inhibitor, to affect the
R Hájková et al.
Journal of pharmaceutical and biomedical analysis, 32(4-5), 921-927 (2003-08-06)
A novel reversed-phase high-performance liquid chromatographic method with UV spectrophotometric detection was developed and validated for the determination of compounds in topical cream. The method describes determination of active component hydrocortisone acetate (HCA), its degradation products hydrocortisone (HC) and cortisone
Nathan J Robison et al.
Pediatric blood & cancer, 61(4), 636-642 (2013-10-15)
Preclinical models show that an antiangiogenic regimen at low-dose daily (metronomic) dosing may be effective against chemotherapy-resistant tumors. We undertook a prospective, open-label, single-arm, multi-institutional phase II study to evaluate the efficacy of a "5-drug" oral regimen in children with
The EGFR tyrosine kinase inhibitor tyrphostin AG-1478 causes hypomagnesemia and cardiac dysfunction.
William B Weglicki et al.
Canadian journal of physiology and pharmacology, 90(8), 1145-1149 (2012-06-01)
We determined whether the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) N-(3-chlorophenyl)-6,7-dimethoxy-4-quinazolinamine (tyrphostin AG-1478) causes hypomagnesemia and cardiac dysfunction in rats. Tyrphostin was administered (3 times per week, intraperitoneal injection, to achieve 21.4 mg·(kg body mass)(-1)·day(-1)) to normomagnesemic
Ting Zhou et al.
Bioorganic & medicinal chemistry, 18(18), 6678-6689 (2010-08-24)
In a continued study, 23 3'R,4'R-di-O-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP) derivatives (5-27) were synthesized, and screened for anti-HIV activity against both a non-drug-resistant NL4-3 strain and multiple reverse transcriptase (RT) inhibitor-resistant (RTMDR-1) strain, using 2-EDCP (4) and 2-MDCP (35) as controls. New DCP
Ming-Tsang Wu et al.
Journal of the Formosan Medical Association = Taiwan yi zhi, 103(5), 337-343 (2004-06-25)
Many epidemiological studies have investigated the relationship between p53 codon 72 polymorphism and cervical cancer risk, but the findings are still conflicting. In contrast, data are lacking on the relationship between XRCC1 polymorphism and cervical neoplasm risk. This community-based nested
Sigríthur K Bodvarsdóttir et al.
Cancer genetics and cytogenetics, 176(2), 93-99 (2007-07-28)
The complex roles of genomic instability, MYC oncogene amplification, activation of telomerase, and p53 function still remain to be fully described in breast tumors. MYC stimulates the telomerase catalytic subunit, TERT, which interacts with p53. Oncogene MYC amplification analysis was
M Tsuneizumi et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 7(11), 3526-3532 (2001-11-14)
EBAG9, an estrogen-responsive gene located at 8q23 was identified in an effort to clone CpG-binding sites. Its product was later found to be identical to RCAS1, a cancer cell-surface antigen implicated in immune escape. We determined the sequence of the
Wissame El Bakkouri et al.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 33(4), 539-544 (2012-05-10)
To evaluate the perceptive and linguistic results in 2 predefined genetic population of children with implants. Retrospective cohort study. Otolaryngology department of a tertiary referral hospital. Among 336 children with prelingual deafness who underwent implantation in our department between 1997
Anupama Vijaya Nadaraja et al.
Journal of environmental health science & engineering, 13, 56-56 (2015-07-30)
Perchlorate is an emerging water contaminant that disrupts normal functioning of human thyroid gland and poses serious threat to health, especially for pregnant women, fetus and children. High level of perchlorate contamination in fresh water sources at places nearby ammonium
J K Rybakowski et al.
Pharmacopsychiatry, 42(1), 20-22 (2009-01-21)
Previously, we have found an association between the -48 A/G polymorphism of the dopamine receptor D1 (DRD1) gene and bipolar disorder. The aim of the present study was to investigate a possible association of this polymorphism with the quality of
Agnieszka K Witkiewicz et al.
Journal of the American College of Surgeons, 208(5), 781-787 (2009-05-30)
The recently discovered indoleamine 2,3-dioxygenase-2 (IDO2) gene has 2 functional polymorphisms that abolish its enzymatic activity. We hypothesize that expression of the IDO2 enzyme in primary pancreatic ductal adenocarcinomas (PDA) can help cancer cells evade immune detection. Because the IDO2
Geoffrey Y Sasaki et al.
Antioxidants (Basel, Switzerland), 11(12) (2022-12-24)
Obesity-related cardiometabolic disorders are driven by inflammation, oxidative stress, and gut dysbiosis. Green tea catechins protect against cardiometabolic disorders by anti-inflammatory, antioxidant, and prebiotic activities. However, whether obesity alters catechin bioavailability remains unknown. We hypothesized that obesity would decrease catechin
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