58-36-6

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A Retrospective Analysis of the Cartilage Kunitz Protease Inhibitory Proteins Identifies These as Members of the Inter-α-Trypsin Inhibitor Superfamily with Potential Roles in the Protection of the Articulatory Surface.

Susan M Smith et al.

International journal of molecular sciences, 20(3) (2019-01-27)

The aim of this study was to assess if the ovine articular cartilage serine proteinase inhibitors (SPIs) were related to the Kunitz inter-α-trypsin inhibitor (ITI) family. Ovine articular cartilage was finely diced and extracted in 6 M urea and SPIs

A randomized clinical trial of the efficacy and safety of terconazole vaginal suppository versus oral fluconazole for treating severe vulvovaginal candidiasis.

Ting Li et al.

Medical mycology, 53(5), 455-461 (2015-04-17)

Terconazole is a new, broad-spectrum, triazole antifungal agent. The aim of this study was to compare the efficacy and safety of a 6-day course of a terconazole vaginal suppository (80 mg) with two doses of oral fluconazole (150 mg) for

Correlation of a single nucleotide polymorphism in the E-cadherin gene promoter with tumorigenesis and progression of gastric carcinoma in Japan.

Kazuya Kuraoka et al.

International journal of oncology, 23(2), 421-427 (2003-07-10)

A C/A single nucleotide polymorphism (SNP) in the E-cadherin gene promoter has been shown to affect transcriptional efficiency in vitro. In this study, we analyzed the C/A SNP in 106 gastric carcinoma cases and 90 cancer-free controls compared with clinicopathological

A vaccine of L2 epitope repeats fused with a modified IgG1 Fc induced cross-neutralizing antibodies and protective immunity against divergent human papillomavirus types.

Xue Chen et al.

PloS one, 9(5), e95448-e95448 (2014-05-08)

Current human papillomavirus (HPV) major capsid protein L1 virus-like particles (VLPs)-based vaccines in clinic induce strong HPV type-specific neutralizing antibody responses. To develop pan-HPV vaccines, here, we show that the fusion protein E3R4 consisting of three repeats of HPV16 L2

Expression of betacellulin, heparin-binding epidermal growth factor and epiregulin in human malignant fibrous histiocytoma.

Tetsuji Yamamoto et al.

Anticancer research, 24(3b), 2007-2010 (2004-07-28)

Heparin-binding epidermal growth factor (HB-EGF), betacellulin (BTC) and epiregulin (EPR) are members of the EGF system and involved in the cell growth of various epithelial malignancies. There have been no reports on the HB-EGF, BTC and EPR expression in mesenchymal

Prevalence and clinical significance of the MYD88 (L265P) somatic mutation in Waldenstrom's macroglobulinemia and related lymphoid neoplasms.

Marzia Varettoni et al.

Blood, 121(13), 2522-2528 (2013-01-29)

A study has shown that MYD88 (L265P) is a recurring somatic mutation in Waldenström's macroglobulinemia (WM). We developed an allele-specific polymerase chain reaction (PCR) for this mutation, and analyzed bone marrow or peripheral blood samples from 58 patients with WM

Short mucin 6 alleles are associated with H pylori infection.

Thai V Nguyen et al.

World journal of gastroenterology, 12(37), 6021-6025 (2006-09-30)

To investigate the relationship between mucin 6 (MUC6) VNTR length and H pylori infection. Blood samples were collected from patients visiting the Can Tho General Hospital for upper gastrointestinal endoscopy. DNA was isolated from whole blood, the repeated section was

[Frequencies of allelic polymorphism of endothelial NO-synthase gene in patients with acute coronary syndrome in Ukrainian population].

V E Dosenko et al.

TSitologiia i genetika, 39(2), 49-54 (2005-09-16)

Endothelial NO-synthase (eNOS) gene allelic polymorphism in 221 patients with acute coronary syndrome and in 83 practically healthy people was determined. It was shown that interrelations of normal homozygotes, heterozygotes and pathologic homozygotes in T/C promoter polymorphism analysis accout 48%

Comparison of pyritinol and auranofin in the treatment of rheumatoid arthritis. The European Multicentre Study Group.

E M Lemmel

British journal of rheumatology, 32(5), 375-382 (1993-05-01)

The efficacy and tolerability of pyritinol (PY) and auranofin (AU) were compared in a multicentre double-blind study. Patients with RA received 600 mg/day PY or 6 mg/day AU for 1 year. Response was rated by a defined improvement in at

Priming effect of bivalent and quadrivalent vaccine for HPV 31/33/45/52: an exploratory analysis from two clinical trials.

Chantal Sauvageau et al.

Human vaccines & immunotherapeutics, 16(3), 590-594 (2019-09-24)

The main objective of this post hoc analysis is to compare the magnitude of the immune response to HPV31/33/45/52 and 58 after a dose of 9vHPV vaccine given to naïve (previously unvaccinated) subjects and subjects previously vaccinated with a dose

The interleukin-6 promoter polymorphism in Gaucher disease: a new modifier gene?

G Altarescu et al.

QJM : monthly journal of the Association of Physicians, 96(8), 575-578 (2003-08-05)

Individuals with Gaucher disease vary significantly with regard to degree of bone disease, but there are no predictive markers for severity of skeletal involvement. To determine the frequency of polymorphisms of interleukin-6 (IL-6) among patients with Gaucher disease, and the

Prospective observational single-centre cohort study to evaluate the effectiveness of treating lupus nephritis with rituximab and mycophenolate mofetil but no oral steroids.

Marie B Condon et al.

Annals of the rheumatic diseases, 72(8), 1280-1286 (2013-06-07)

Lupus nephritis (LN) is a serious complication of systemic lupus erythematosus (SLE). All current treatment regimens include oral steroids, which are associated with severe adverse events and long-term damage. We have piloted a steroid-avoiding protocol (rituxilup) for the treatment of

Epigenetics and rheumatoid arthritis: the role of SENP1 in the regulation of MMP-1 expression.

Hanna Maciejewska-Rodrigues et al.

Journal of autoimmunity, 35(1), 15-22 (2010-01-19)

The aggressive phenotype of RA synovial fibroblasts (RASF) is characterised by the increased expression of matrix metalloproteinase (MMP)-1 as well as the small ubiquitin like modifier (SUMO)-1 and decreased expression of SUMO-specific protease SENP1. Since we showed an increased activity

Lack of association between tumour necrosis factor receptor types 1 and 2 gene polymorphism and severe acute alcoholic hepatitis.

Eric Nguyen-Khac et al.

European journal of gastroenterology & hepatology, 22(7), 794-800 (2009-07-31)

Tumour necrosis factor-alpha (TNF-alpha) is involved in the physiopathology of severe acute alcoholic hepatitis (AAH) binding with TNF receptor types TNFR1 and TNFR2, whose serum concentrations are elevated. We studied the role of TNFR1 and TNFR2 gene polymorphism in AAH

Aberrant co-expression of CD19 and CD56 as surrogate markers of acute myeloid leukemias with t(8;21) in Taiwan.

S-W Chen et al.

International journal of laboratory hematology, 30(2), 133-138 (2008-03-13)

Aberrant antigen expression in acute myeloid leukemia (AML) has been extensively studied in the West with limited reports from Taiwan. We carried out this retrospective study to characterize the frequency and significance of aberrant antigen expression of AML in Taiwan.

Mechanical and physical properties of carbon-graphite fiber-reinforced polymers intended for implant suprastructures.

Susanna Segerström et al.

Dental materials : official publication of the Academy of Dental Materials, 23(9), 1150-1156 (2006-11-23)

Mechanical properties and quality of fiber/matrix adhesion of poly(methyl methacrylate) (PMMA)-based materials, reinforced with carbon-graphite (CG) fibers that are able to remain in a plastic state until polymerization, were examined. Tubes of cleaned braided CG fibers were treated with a

Durable immunity to oncogenic human papillomaviruses elicited by adjuvanted recombinant Adeno-associated virus-like particle immunogen displaying L2 17-36 epitopes.

Subhashini Jagu et al.

Vaccine, 33(42), 5553-5563 (2015-09-19)

Vaccination with the minor capsid protein L2, notably the 17-36 neutralizing epitope, induces broadly protective antibodies, although the neutralizing titers attained in serum are substantially lower than for the licensed L1 VLP vaccines. Here we examine the impact of other

Site-specific glycation of lens crystallins by ascorbic acid.

B J Ortwerth et al.

Biochimica et biophysica acta, 1117(2), 207-215 (1992-09-15)

The oxidation of ascorbic acid leads to the formation of several compounds which are capable of reacting with protein amino groups via a Maillard reaction. Radioactivity from [1-14C]ascorbic acid was linearly incorporated into lens crystallins over a 10 day period

Long-term remission and recurrence rates after first and second transsphenoidal surgery for Cushing's disease: care reality in the Munich Metropolitan Region.

C Dimopoulou et al.

European journal of endocrinology, 170(2), 283-292 (2013-11-13)

Transsphenoidal surgery (TSS) presents the treatment of choice for Cushing's disease (CD). Remission and recurrence rates vary dependent on tumor size, extension, adenoma visibility on magnetic resonance imaging, and neurosurgical expertise. Other than published from single-surgeon neurosurgical series so far

The differences in CXCR4 protein expression are significant for the five molecular subtypes of breast cancer.

Ming Zhang et al.

Ultrastructural pathology, 36(6), 381-386 (2012-12-12)

The aim was to investigate the expression of the CXCR4 protein in five molecular subtypes of breast cancer. The authors randomly selected the breast cancer paraffin-embedded specimens of the Affiliated Third Hospital of Harbin Medical University between 2007 and 2009.

Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma.

Hideyasu Takagi et al.

Journal of gastroenterology, 43(5), 378-389 (2008-07-02)

Activation of the Wnt signaling pathway is frequently observed in hepatocellular carcinoma (HCC), though mutation of three of its components, CTNNB1, AXIN1, and AXIN2, is observed substantially less often. We examined the relationship between Wnt signaling and epigenetic alteration of

Distribution of bromophenols in species of marine polychaetes and bryozoans from eastern Australia and the role of such animals in the flavor of edible ocean fish and prawns (shrimp).

F B Whitfield et al.

Journal of agricultural and food chemistry, 47(11), 4756-4762 (1999-12-20)

Sixteen species (44 samples) of marine polychaetes and 10 species (14 samples) of bryozoans from eastern Australia were analyzed by GC/MS for the key seafood flavor components 2- and 4-bromophenol, 2, 4- and 2,6-dibromophenol, and 2,4,6-tribromophenol. All five bromophenols were

CD9-regulated adhesion. Anti-CD9 monoclonal antibody induce pre-B cell adhesion to bone marrow fibroblasts through de novo recognition of fibronectin.

A Masellis-Smith et al.

Journal of immunology (Baltimore, Md. : 1950), 152(6), 2768-2777 (1994-03-15)

The modulation of adhesive interaction between lymphocyte progenitors and bone marrow stroma may critically determine the maturation and migration of B cell progenitors. mAb against CD9 and beta 1 integrins are reported to induce the homotypic adhesion of pre-B cells.

Mycophenolate mofetil therapy in the management of inflammatory bowel disease--a retrospective case series and review.

Matthew R Smith et al.

Journal of Crohn's & colitis, 8(8), 890-897 (2014-02-11)

The role of mycophenolate mofetil (MMF) as an immunomodulatory drug in managing inflammatory bowel disease (IBD) is yet to be fully defined. We reviewed our experience of MMF in treating patients with IBD. Retrospective analysis was performed on all patients

Sensitivity and specificity of a urinary screening test used in an emergency setting to detect abnormal first trimester pregnancies.

João L G Teixeira et al.

American journal of obstetrics and gynecology, 212(1), 58-58 (2014-07-02)

To evaluate the performance of a commercial urinary test to screen for abnormal first trimester pregnancies in women presenting to an emergency room. In this prospective observational cohort, women with a confirmed first trimester pregnancy (gestational age <12 weeks) provided

Aggregatibacter actinomycetemcomitans and its relationship to initiation of localized aggressive periodontitis: longitudinal cohort study of initially healthy adolescents.

Daniel H Fine et al.

Journal of clinical microbiology, 45(12), 3859-3869 (2007-10-19)

Aggregatibacter actinomycetemcomitans is frequently associated with localized aggressive periodontitis (LAP); however, longitudinal cohort studies relating A. actinomycetemcomitans to initiation of LAP have not been reported. A periodontal assessment was performed on 1,075 primarily African-American and Hispanic schoolchildren, ages 11 to

Nutritional Therapy Modulates Intestinal Microbiota and Reduces Serum Levels of Total and Free Indoxyl Sulfate and P-Cresyl Sulfate in Chronic Kidney Disease (Medika Study).

Biagio Raffaele Di Iorio et al.

Journal of clinical medicine, 8(9) (2019-09-13)

In chronic kidney disease (CKD), the gut-microbiota metabolites indoxyl sulfate (IS) and p-cresyl sulfate (PCS) progressively accumulate due to their high albumin-binding capacity, leading to clinical complications. In a prospective crossover controlled trial, 60 patients with CKD grades 3B-4 (GFR

Immune reconstitution inflammatory syndrome in neutropenic patients with invasive pulmonary aspergillosis.

Jiwon Jung et al.

The Journal of infection, 70(6), 659-667 (2015-01-20)

Clinical and radiologic deterioration is sometimes observed during neutrophil recovery in patients with invasive pulmonary aspergillosis (IPA). This deterioration can be caused by immune reconstitution inflammatory syndrome (IRIS) as well as by progression of the IPA. However, there is limited

Results of a randomized trial of chlorambucil versus fludarabine for patients with untreated Waldenström macroglobulinemia, marginal zone lymphoma, or lymphoplasmacytic lymphoma.

Véronique Leblond et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(3), 301-307 (2012-12-13)

Treatment options for patients with Waldenström macroglobulinemia (WM) and closely related disorders include alkylating agents, purine analogs, and monoclonal antibodies. No large randomized studies have yet been reported comparing any of these approaches. The randomized WM1 study (Trial Comparing Chlorambucil

Preliminary findings on the role of PLIN1 polymorphisms on body composition and energy metabolism response to energy restriction in obese women.

J R Ruiz et al.

The British journal of nutrition, 106(4), 486-490 (2011-03-12)

The aim of the present study was to investigate the association of PLIN1 11482G>A (rs894160) and PLIN1 13041A>G (rs2304795) polymorphisms with body composition, energy and substrate metabolism, and the metabolic response to a 12-week energy-restricted diet in obese women. The

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