59-50-7

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Low-affinity signature of the rat beta-parvalbumin CD site. Evidence for remote determinants.

Michael T Henzl et al.

Biochemistry, 46(1), 23-35 (2007-01-03)

Although rat beta-parvalbumin and chicken parvalbumin 3 (CPV3) are identical at 74 of 108 residues, rat beta exhibits perceptibly lower Ca2+ and Mg2+ affinities. At 25 degrees C, in Hepes-buffered saline, at pH 7.4, the overall deltadeltaG degrees ' values

CTNNB1 mutations and beta-catenin expression in endometrial carcinomas.

Pilar Machin et al.

Human pathology, 33(2), 206-212 (2002-04-17)

Mutations in the beta-catenin gene (CTNNB 1) with abnormal nuclear accumulation of beta-catenin have recently been identified in endometrial carcinoma (EC). Their relationship with microsatellite instability (MI) is unclear. It has been suggested that matrix metalloproteinase-7 (MMP-7) and cyclin D1

Increased risk for atherosclerosis of various macrophage scavenger receptor 1 alleles.

Ronen Durst et al.

Genetic testing and molecular biomarkers, 13(5), 583-587 (2009-09-01)

Macrophage scavenger receptor 1 (MSR1) mediates the uptake of modified low density lipoprotein (LDL)-cholesterol. The significance of MSR1 in atherosclerosis development in animal models is uncertain. In this study we sought to determine the significance of MSR1 polymorphisms in its

Characterization of Shiga toxin-producing Escherichia coli O26 strains and establishment of selective isolation media for these strains.

Reiji Hiramatsu et al.

Journal of clinical microbiology, 40(3), 922-925 (2002-03-07)

We characterized the carbohydrate-fermenting ability of 31 strains of Shiga toxin-producing Escherichia coli (STEC) O26 isolated from diarrhea patients in Aichi Prefecture, Japan, in order to establish selective isolation media for these strains. None of the 31 STEC O26 strains

Synthesis and evaluation of the anti parasitic activity of aromatic nitro compounds.

Marcela S Lopes et al.

European journal of medicinal chemistry, 46(11), 5443-5447 (2011-09-24)

A series of nitroaromatic compounds was synthesized and evaluated as potential antileishmanial and trypanocidal agents. Five compounds exerted significant anti-leishmanial activity in vitro against promastigotes forms of Leishmania (L.) amazonensis, with IC(50) in the range of 23-59 μmol L(-1), but

The value of CDX2 and cytokeratins 7 and 20 expression in differentiating colorectal adenocarcinomas from extraintestinal gastrointestinal adenocarcinomas: cytokeratin 7-/20+ phenotype is more specific than CDX2 antibody.

Reyhan Bayrak et al.

Diagnostic pathology, 7, 9-9 (2012-01-25)

Metastatic adenocarcinoma from an unknown primary site is a common clinical problem. Determining the cytokeratin (CK) 7/CK20 pattern of tumors is one of the most helpful procedures for this purpose since the CK7-/CK20+ pattern is typical of colorectal adenocarcinomas. CDX2

Endothelin ETA receptors and endothelium partially mediate the positive inotropic and lusitropic effects of angiotensin II.

Paulo Castro-Chaves et al.

European journal of pharmacology, 544(1-3), 91-96 (2006-07-18)

We analyzed the influence of endothelin-1 and endocardial endothelium on the myocardial effects of angiotensin-II. Angiotensin-II (10(-9)-10(-5) M) was tested in rabbit right papillary muscles in absence (Protocol-A) or presence of PD-145065 (10(-7) M; Protocol-B), BQ-123 (10(-7) M; Protocol-C) or

Splenic marginal zone lymphoma: Clinical clustering of immunoglobulin heavy chain repertoires.

Luca Arcaini et al.

Blood cells, molecules & diseases, 42(3), 286-291 (2009-03-03)

Immunoglobulin gene usage and somatic mutation patterns were studied in 59 patients with splenic marginal zone lymphoma and were correlated with clinical characteristics. Fifty-nine IGHV rearrangements were amplified. IGHV1, IGHV3, and IGHV4 subgroups accounted for 30%, 56%, and 14% of

Erythrocyte metallothionein as an index of zinc status in humans.

A Grider et al.

Proceedings of the National Academy of Sciences of the United States of America, 87(4), 1259-1262 (1990-02-01)

Metallothionein concentrations in erythrocyte lysates derived from human subjects were measured by an ELISA procedure. IgG obtained from serum of sheep injected with human metallothionein 1 was used in this competitive assay. Subjects were fed a semipurified zinc-deficient diet (0.7

Seco-limonoid derived from Raputia heptaphylla promotes the control of cutaneous leishmaniasis in hamsters (Mesocricetus auratus).

Diana Granados-Falla et al.

Parasitology, 143(3), 289-299 (2015-12-24)

The rational search of novel bioactive molecules against pathogens with immunomodulatory activity is presently one of the most significant approaches to discover and design new therapeutic agents for effective control of infectious diseases, such as the infection caused by Leishmania

Limited influence of UGT1A1*28 and no effect of UGT2B7*2 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes.

Vincent C Peterkin et al.

British journal of clinical pharmacology, 64(4), 458-468 (2007-06-09)

UGT1A1 and UGT2B7 are enzymes that commonly contribute to drug glucuronidation. Since genetic factors have been suggested to contribute to variability in activities and expression levels of these enzymes, a quantitative assessment of the influence of the major genotypes (UGT1A1*28

Interleukin 2 (IL 2) inhibitor in rheumatoid synovial fluid: correlation with prognosis and soluble IL 2 receptor levels.

P Miossec et al.

Journal of clinical immunology, 10(2), 115-120 (1990-03-01)

A soluble activity inhibiting over 50% of the CTLL-2 cell line response to recombinant human interleukin 2 (IL 2) was found in 17 of 29 (59%) rheumatoid synovial fluids. To study the prognosis value of this activity, 16 rheumatoid synovial

Vesicular transport and apotransferrin in intestinal iron absorption, as shown in the Caco-2 cell model.

Mizue Moriya et al.

American journal of physiology. Gastrointestinal and liver physiology, 290(2), G301-G309 (2005-09-24)

The potential roles of vesicular transport and apotransferrin (entering from the blood) in intestinal Fe absorption were investigated using Caco-2 cell monolayers with tight junctions in bicameral chambers as a model. As shown previously, addition of 39 microM apotransferrin (apoTf)

EGFR Mutational Profiling in Non-Small Cell Lung Cancer: The Clinical Performance of a Sensitive Reverse-Hybridization Assay.

Gernot Kriegshäuser et al.

Applied immunohistochemistry & molecular morphology : AIMM, 26(6), 388-392 (2016-11-02)

In patients with non-small cell lung cancer (NSCLC), epidermal growth factor receptor (EGFR) mutations have been associated with the tumor response to targeted therapy with EGFR tyrosine kinase inhibitors. Although labor intensive and not very sensitive (ie, an analytical sensitivity

Low frequency of factor V Leiden and prothrombin G20210A mutations in patients with hepatic venous outflow tract obstruction in northern India: a case-control study.

Sirish I Kumar et al.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 24(5), 211-215 (2005-12-20)

Factor V Leiden (FVL) and prothrombin gene (G20210A) mutations are known to be associated with venous thromboembolism. Several studies have shown an association of these mutations with hepatic venous outflow tract obstruction (HVOTO). We studied the prevalence of these mutations

Enhanced disappearance of dicofol by water hyacinth in water.

H Xia

Environmental technology, 29(3), 297-302 (2008-07-10)

The efficiency and primary mechanism of phytoremediation of water contaminated with dicofol, an organochlorine pesticide, by water hyacinth (Eichhornia crassipes) was investigated. After 10 days of incubation in nutrient solution at 25 +/- 1 degree C, the remaining dicofol which

Individual and combined effects of dosages of azoxystrobin and epoxiconazole in wheat.

M Moreau et al.

Communications in agricultural and applied biological sciences, 70(3), 91-99 (2006-04-28)

The effects of single fungicide applications on Mycosphaerella graminicola (septoria leaf blotch) control and winter wheat yield were evaluated in field trials conducted in central Belgium between 2000 and 2004. Individual applications of 25, 50, 75 and 100% of the

Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28).

Francesco Berardi et al.

Journal of medicinal chemistry, 52(23), 7817-7828 (2009-10-22)

sigma(2)-Agonist 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (7, PB 28), which proved to revert doxorubicin resistance in breast cancer cells, was taken as a template to prepare new analogs. One of the two basic N-atoms was alternatively replaced by a methine or converted into an

Effect of timing of insemination after CIDR removal with or without GnRH on pregnancy rates in Nili-Ravi buffalo.

M S Haider et al.

Animal reproduction science, 163, 24-29 (2015-11-01)

There are limited studies available on when to inseminate, if using CIDR or CIDR-GnRH protocols for optimal fertility in buffalo. Therefore, the objective of the present study was to determine the optimum time of AI in relation to CIDR removal

The use of the fungus Dichomitus squalens for degradation in rotating biological contactor conditions.

Ceněk Novotný et al.

Bioresource technology, 114, 241-246 (2012-04-20)

Biodegradation potential of Dichomitus squalens in biofilm cultures and rotating biological contactor (RBC) was investigated. The fungus formed thick biofilms on inert and lignocellulosic supports and exhibited stable activities of laccase and manganese peroxidase to reach 40-62 and 25-32% decolorization

Glutamate uptake shapes low-[Mg2+] induced epileptiform activity in juvenile rat hippocampal slices.

Gabriella Nyitrai et al.

Brain research, 1309, 172-178 (2009-11-17)

A wide range of data support a role for ambient glutamate (Glu) in epilepsy, although temporal patterns associated with the cellular uptake of Glu have not been addressed in detail. We report on the effects of Glu uptake inhibitors on

Assessment of the rate of long-term complete remission off therapy in patients with pemphigus treated with different regimens including medium- and high-dose corticosteroids.

Naif Almugairen et al.

Journal of the American Academy of Dermatology, 69(4), 583-588 (2013-07-16)

Few studies have evaluated pemphigus treatments according to the definitions of the consensus statement. Prognostic factors for complete remission off therapy (CRoffT) remain unknown. We sought to assess the rate of CRoffT in patients with pemphigus treated with different regimens.

Comparative molecular field analysis and synthetic validation of a hydroxyamide-propofol binding and functional block of neuronal voltage-dependent sodium channels.

Milton L Brown et al.

Bioorganic & medicinal chemistry, 17(19), 7056-7063 (2009-09-15)

Voltage gated sodium channels represent an important therapeutic target for a number of neurological disorders including epilepsy. Unfortunately, medicinal chemistry strategies for discovering new classes of antagonist for trans-membrane ion channels have been limited to mostly broad screening compound arrays.

Combined Treatment of Sulfonyl Chromen-4-Ones (CHW09) and Ultraviolet-C (UVC) Enhances Proliferation Inhibition, Apoptosis, Oxidative Stress, and DNA Damage against Oral Cancer Cells.

Sheng-Chieh Wang et al.

International journal of molecular sciences, 21(17) (2020-09-10)

The sensitizing effect of chromone-derived compounds on UVC-induced proliferation inhibition has not been comprehensively investigated so far. The subject of this study was to examine the proliferation change of oral cancer cells while using the combined treatment of UVC (254

Identification of D3 and sigma receptors in the rat striatum and nucleus accumbens using (+/-)-7-hydroxy-N,N-di-n-[3H]propyl-2-aminotetralin and carbetapentane.

D R Wallace et al.

Journal of neurochemistry, 64(2), 700-710 (1995-02-01)

Cross-reactions between dopamine D3 and sigma receptor ligands were investigated using (+/-)-7-hydroxy-N,N-di-n-[3H]propyl-2-aminotetralin [(+/-)-7-OH-[3H]-DPAT], a putative D3-selective radioligand, in conjunction with the unlabeled sigma ligands 1,3-di(2-tolyl)guanidine (DTG), carbetapentane, and R(-)-N-(3-phenyl-1-propyl)-1-phenyl-2-aminopropane [R(-)-PPAP]. In transfected CCL1.3 mouse fibroblasts expressing the human D3 receptor

Chronic exposure to Delta9-tetrahydrocannabinol downregulates oxytocin and oxytocin-associated neurophysin in specific brain areas.

Elena Butovsky et al.

Molecular and cellular neurosciences, 31(4), 795-804 (2006-03-04)

Cannabinoids are widely abused drugs. Our goal was to identify genes modulated by Delta9-tetrahydrocannabinol (Delta9-THC) treatment. We found that chronic administration of Delta9-THC (1.5 mg/kg/day, i.p.; 7 days) to rats, downregulates the expression of oxytocin-neurophysin (OT-NP) mRNA and of OT

Characteristics and Outcomes in Patients Presenting With COVID-19 and ST-Segment Elevation Myocardial Infarction.

Anas Hamadeh et al.

The American journal of cardiology, 131, 1-6 (2020-08-01)

There is limited information regarding clinical characteristics and outcomes of patients with SARS-CoV-2 (COVID-19) disease presenting with ST-segment elevation myocardial infarction (STEMI). In this multicenter retrospective study, we reviewed charts of patients admitted with symptomatic COVID-19 infection and STEMI to

Endocrine effects of tobacco smoke exposure during lactation in weaned and adult male offspring.

A P Santos-Silva et al.

The Journal of endocrinology, 218(1), 13-24 (2013-04-23)

Children from pregnant smokers show more susceptibility to develop obesity in adult life. Previously, we failed to demonstrate a program for obesity in rat offspring only when the mothers were exposed to tobacco smoke during lactation. Here, we studied the

Classification of Intracranial Stenoses: Discrepancies between Transcranial Duplex Sonography and Computed Tomography Angiography.

Leon Alexander Danyel et al.

Ultrasound in medicine & biology, 46(8), 1889-1895 (2020-05-23)

Transcranial color-coded duplex sonography (TCCS) and computed tomography angiography (CTA) are widely used to identify intracranial stenoses (ISs). We assessed concordance of IS grading between TCCS and CTA and proposed new TCCS criteria for severe IS ≥70%. One hundred two

Clinical significance of MYCN amplification and ploidy in favorable-stage neuroblastoma: a report from the Children's Oncology Group.

Jennifer Schneiderman et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 26(6), 913-918 (2008-02-19)

MYCN amplification is rarely detected in patients with favorable-stage neuroblastoma (NB). To determine the clinical significance of MYCN amplification in children with favorable-stage NB, we performed a retrospective review of data from the Pediatric Oncology Group (POG) biology study 9047.

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