59304

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Analysis of glucuronide and sulfate steroids in urine by ultra-high-performance supercritical-fluid chromatography hyphenated tandem mass spectrometry.

Mickael Doué et al.

Analytical and bioanalytical chemistry, 407(15), 4473-4484 (2015-03-05)

Profiling conjugated urinary steroids to detect anabolic-steroid misuse is recognized as an efficient analytical strategy in both chemical-food-safety and anti-doping fields. The relevance and robustness of such profiling rely on the analysis of glucuronide and sulfate steroids, which is expected

ARHGEF12 influences the risk of glaucoma by increasing intraocular pressure.

Henriët Springelkamp et al.

Human molecular genetics, 24(9), 2689-2699 (2015-02-01)

Primary open-angle glaucoma (POAG) is a blinding disease. Two important risk factors for this disease are a positive family history and elevated intraocular pressure (IOP), which is also highly heritable. Genes found to date associated with IOP and POAG are

Cyclosporine A enhances gluconeogenesis while sirolimus impairs insulin signaling in peripheral tissues after 3 weeks of treatment.

P C Lopes et al.

Biochemical pharmacology, 91(1), 61-73 (2014-06-25)

Cyclosporine A (CsA) and sirolimus (SRL) are immunosuppressive agents (IA) associated with new-onset diabetes after transplantation (NODAT). This study aims to evaluate the effects of 3-weeks of treatment with either CsA (5 mg/kg BW/day) or SRL (1 mg/kg BW/day) on

miR-126-3p Inhibits Thyroid Cancer Cell Growth and Metastasis, and Is Associated with Aggressive Thyroid Cancer.

Yin Xiong et al.

PloS one, 10(8), e0130496-e0130496 (2015-08-06)

Previous studies have shown that microRNAs are dysregulated in thyroid cancer and play important roles in the post-transcriptional regulation of target oncogenes and/or tumor suppressor genes. We studied the function of miR-126-3p in thyroid cancer cells, and as a marker

Characterization of dedifferentiating human mature adipocytes from the visceral and subcutaneous fat compartments: fibroblast-activation protein alpha and dipeptidyl peptidase 4 as major components of matrix remodeling.

Julie Lessard et al.

PloS one, 10(3), e0122065-e0122065 (2015-03-31)

Mature adipocytes can reverse their phenotype to become fibroblast-like cells. This is achieved by ceiling culture and the resulting cells, called dedifferentiated fat (DFAT) cells, are multipotent. Beyond the potential value of these cells for regenerative medicine, the dedifferentiation process

Genome-wide analysis of miRNA and mRNA transcriptomes during amelogenesis.

Kaifeng Yin et al.

BMC genomics, 15, 998-998 (2014-11-20)

In the rodent incisor during amelogenesis, as ameloblast cells transition from secretory stage to maturation stage, their morphology and transcriptome profiles change dramatically. Prior whole genome transcriptome analysis has given a broad picture of the molecular activities dominating both stages

Multi-omic signature of body weight change: results from a population-based cohort study.

Simone Wahl et al.

BMC medicine, 13, 48-48 (2015-04-11)

Excess body weight is a major risk factor for cardiometabolic diseases. The complex molecular mechanisms of body weight change-induced metabolic perturbations are not fully understood. Specifically, in-depth molecular characterization of long-term body weight change in the general population is lacking.

Development of a new sorptive extraction method based on simultaneous direct and headspace sampling modes for the screening of polycyclic aromatic hydrocarbons in water samples.

Sara Triñanes et al.

Talanta, 132, 433-442 (2014-12-06)

A new straightforward and inexpensive sample screening method for both EPA and EU priority polycyclic aromatic hydrocarbons (PAHs) in water has been developed. The method is based on combined direct immersion and headspace (DIHS) sorptive extraction, using low-cost disposable material

Rapid, culture-independent, optical diagnostics of centrifugally captured bacteria from urine samples.

Ulrich-Christian Schröder et al.

Biomicrofluidics, 9(4), 044118-044118 (2015-09-05)

This work presents a polymeric centrifugal microfluidic platform for the rapid and sensitive identification of bacteria directly from urine, thus eliminating time-consuming cultivation steps. This "Lab-on-a-Disc" platform utilizes the rotationally induced centrifugal field to efficiently capture bacteria directly from suspension

Ethanol as an alternative to formaldehyde for the enhancement of manganese(IV) chemiluminescence detection.

Zoe M Smith et al.

Talanta, 130, 221-225 (2014-08-28)

Previous applications of manganese(IV) as a chemiluminescence reagent have required the use of formaldehyde to enhance the emission intensity to analytically useful levels. However, this known human carcinogen (by inhalation) is not ideal for routine application. A wide range of

Strategies for Coordination of a Serosurvey in Parallel with an Immunization Coverage Survey.

Mark A Travassos et al.

The American journal of tropical medicine and hygiene, 93(2), 416-424 (2015-06-10)

A community-based immunization coverage survey is the standard way to estimate effective vaccination delivery to a target population in a region. Accompanying serosurveys can provide objective measures of protective immunity against vaccine-preventable diseases but pose considerable challenges with respect to

miRNAs regulated overexpression of ryanodine receptor is involved in chlorantraniliprole resistance in Plutella xylostella (L.).

Xiuxia Li et al.

Scientific reports, 5, 14095-14095 (2015-09-16)

The amino acid mutations in ryanodine receptor (RyR) and elevated activity of detoxification enzymes have been associated with the diamide insecticide resistance in the diamondback moth, Plutella xylostella (L.). The up-regulation of P. xylostella RyR mRNA (PxRyR) expression has also

Quantitative lipidomic analysis of plasma and plasma lipoproteins using MALDI-TOF mass spectrometry.

Jorge Serna et al.

Chemistry and physics of lipids, 189, 7-18 (2015-05-26)

Knowledge of the plasma lipid composition is essential to clarify the specific roles of different lipid species in various pathophysiological processes. In this study, we developed an analytical strategy combining high-performance liquid chromatography with evaporative light scattering detection (HPLC-ELSD) and

Olanzapine inhibits proliferation, migration and anchorage-independent growth in human glioblastoma cell lines and enhances temozolomide's antiproliferative effect.

Georg Karpel-Massler et al.

Journal of neuro-oncology, 122(1), 21-33 (2014-12-20)

The poor prognosis of patients with glioblastoma fuels the search for more effective therapeutic compounds. We previously hypothesised that the neuroleptic olanzapine may enhance antineoplastic effects of temozolomide the standard chemotherapeutic agent used in this disease. This study tested this

Targeted proteomic analyses of nasal lavage fluid in persulfate-challenged hairdressers with bleaching powder-associated rhinitis.

Harriet Mörtstedt et al.

Journal of proteome research, 14(2), 860-873 (2014-12-30)

Hairdressers have an increased risk for developing airway symptoms, for example, asthma and rhinitis. Persulfates, which are oxidizing agents in bleaching powder, are considered important causal agents for these symptoms. However, the underlying mechanisms are unclear. The aim was therefore

Investigation on performance of zirconia and magnesia-zirconia stationary phases in hydrophilic interaction chromatography.

Qing Wang et al.

Talanta, 129, 438-447 (2014-08-17)

In the current study, zirconia (ZrO2) and its composite, magnesia-zirconia (MgO-ZrO2), were prepared as the hydrophilic interaction chromatographic (HILIC) stationary phases (SPs). Different experimental variables including water content, pH and buffer concentration in the mobile phase (MP) as well as

In vivo isotopically labeled atherosclerotic aorta plaques in ApoE KO mice and molecular profiling by matrix-assisted laser desorption/ionization mass spectrometric imaging.

Jose Castro-Perez et al.

Rapid communications in mass spectrometry : RCM, 28(22), 2471-2479 (2014-10-11)

The ability to quantify rates of formation, regression and/or remodeling of atherosclerotic plaque should facilitate a better understanding of the pathogenesis and management of cardiovascular disease. In the current study, we coupled a stable isotope labeled tracer protocol with matrix-assisted

Exogenous application of methyl jasmonate lowers the effect of cadmium-induced oxidative injury in rice seedlings.

Indra Singh et al.

Phytochemistry, 108, 57-66 (2014-10-11)

Rice seedlings grown under 50 μM cadmium alone or in combination with 5 μM methyl jasmonate were investigated for Cd-induced oxidative injury at 3, 7 and 10 days of treatment. MeJA treatments alone did not have any significant change in

Electrospun superhydrophobic membranes with unique structures for membrane distillation.

Yuan Liao et al.

ACS applied materials & interfaces, 6(18), 16035-16048 (2014-08-26)

With modest temperature demand, low operating pressure, and high solute rejection, membrane distillation (MD) is an attractive option for desalination, waste treatment, and food and pharmaceutical processing. However, large-scale practical applications of MD are still hindered by the absence of

Development of an in vitro liquid chromatography-mass spectrometry method to evaluate stereo and chemical stability of new drug candidates employing immobilized artificial membrane column.

Giuseppe Cannazza et al.

Journal of chromatography. A, 1363, 216-225 (2014-06-18)

A stopped-flow HPLC method was developed to evaluate configurational and chemical stability of pharmaceutical compounds employing immobilized artificial membranes (IAM) column to simulate conditions that pharmaceutical compounds will meet in vivo. The method was applied to recent developed chiral 5-arylbenzothiadiazine

Development and characterization of mixed niosomes for oral delivery using candesartan cilexetil as a model poorly water-soluble drug.

Zerrin Sezgin-Bayindir et al.

AAPS PharmSciTech, 16(1), 108-117 (2014-09-11)

The aim of this study was to prepare candesartan cilexetil-loaded niosomes and mixed niosomes to enhance the aqueous solubility of the drug, thus improving its oral bioavailability. The formulations were prepared using various types and combinations of surfactants, copolymers, and

Stereoselective determination of 2-benzamidomethyl-3-oxobutanoate and methyl-2-benzoylamide-3-hydroxybutanoate by chiral high-performance liquid chromatography in biotransformation.

Xiang Chen et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 974, 57-64 (2014-12-03)

(2S, 3R)-methyl-2-benzamidomethyl-3-hydroxybutyrate (MBHB) is a key intermediate in the synthesis of 4-aceoxyazetidinone, a building block for the production of penems and carbapenems. More attentions have been paid to screen biocatalysts achieving asymmetric preparation of (2S, 3R)-MBHB. In this study, an

A novel embryonic plasticity gene signature that predicts metastatic competence and clinical outcome.

Rama Soundararajan et al.

Scientific reports, 5, 11766-11766 (2015-07-01)

Currently, very few prognosticators accurately predict metastasis in cancer patients. In order to complete the metastatic cascade and successfully colonize distant sites, carcinoma cells undergo dynamic epithelial-mesenchymal-transition (EMT) and its reversal, mesenchymal-epithelial-transition (MET). While EMT-centric signatures correlate with response to

Collapse of Particle-Laden Interfaces under Compression: Buckling vs Particle Expulsion.

Sepideh Razavi et al.

Langmuir : the ACS journal of surfaces and colloids, 31(28), 7764-7775 (2015-06-23)

Colloidal particles can bind to fluid interfaces with a capillary energy that is thousands of times the thermal energy. This phenomenon offers an effective route to emulsion and foam stabilization where the stability is influenced by the phase behavior of

Novel molecularly imprinted stir bar sorptive extraction based on an 8-electrode array for preconcentration of trace exogenous estrogens in meat.

Li Qiao et al.

Analytica chimica acta, 853, 342-350 (2014-12-04)

A novel 8-electrode array as stir bar was designed for selective extraction of trace level exogenous estrogens from food samples, followed by liquid desorption and HPLC-photodiode array detection. The array consisted of 8 screen-printed electrodes and each electrode was modified

Reduced parasite motility and micronemal protein secretion by a p38 MAPK inhibitor leads to a severe impairment of cell invasion by the apicomplexan parasite Eimeria tenella.

Françoise I Bussière et al.

PloS one, 10(2), e0116509-e0116509 (2015-02-18)

E. tenella infection is associated with a severe intestinal disease leading to high economic losses in poultry industry. Mitogen activated protein kinases (MAPKs) are implicated in early response to infection and are divided in three pathways: p38, extracellular signal-regulated protein

A multi-site array for combined local electrochemistry and electrophysiology in the non-human primate brain.

Anita A Disney et al.

Journal of neuroscience methods, 255, 29-37 (2015-08-01)

Currently, the primary technique employed in circuit-level study of the brain is electrophysiology, recording local field or action potentials (LFPs or APs). However most communication between neurons is chemical and the relationship between electrical activity within neurons and chemical signaling

Lectin coated MgO nanoparticle: its toxicity, antileishmanial activity, and macrophage activation.

Ali Jebali et al.

Drug and chemical toxicology, 37(4), 400-409 (2014-01-08)

The purpose of this research was to evaluate toxicity of uncoated magnesium oxide nanoparticles (MgO NPs), MgO NPs coated with Peanut agglutinin (PNA) lectin, and PNA alone on the promastigotes of Leishmania major (L. major) and macrophages of BALB/c mice.

On the Role of Interfaces in Planar-Structured HC(NH2 )2 PbI3 Perovskite Solar Cells.

Dong-Jin Seol et al.

ChemSusChem, 8(14), 2414-2419 (2015-04-18)

Planar-structured HC(NH2 )2 PbI3 (FAPbI3 ) perovskite solar cells were prepared via a two-step deposition process. To investigate the role of interface, the perovskite morphology was intentionally modified by varying HC(NH2 )2 I concentration. Surface and grain sizes of the

[On interactions of drugs on and in the skin/comparative studies on the mutual influences of ethyleneglycol-monosalicylate and benzylnicotinate (author's transl)].

A Zesch et al.

Dermatosen in Beruf und Umwelt. Occupation and environment, 29(6), 161-167 (1981-01-01)

Three radioactively marked substances (on the basis of a carbopol gel, 80% water - isopropanol) were analyzed comparatively in regard to the penetration of ethyleneglycolmonosalicylate and benzylnicotinate to intact and impaired human skin. The objective of the in-vitro study was

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