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Jin Qu et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(4), 468-474 (2015-01-23)
The purpose of the current study was to develop a novel technology to enhance tendon-to-bone interface healing by trypsinizing and mineralizing (TM) an intrasynovial tendon allograft in a rabbit bone tunnel model. Eight rabbit flexor digitorum profundus (FDP) tendons were
Yu Zhou et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(16), 5237-5242 (2015-04-08)
To probe structure and gating-associated conformational changes in BK-type potassium (BK) channels, we examined consequences of Cd(2+) coordination with cysteines introduced at two positions in the BK inner pore. At V319C, the equivalent of valine in the conserved Kv proline-valine-proline
Yuying Suo et al.
Journal of molecular biology, 427(4), 887-900 (2014-12-24)
During export in Escherichia coli, SecB, a homotetramer structurally organized as a dimer of dimers, forms a complex with two protomers of SecA, which is the ATPase that provides energy to transfer a precursor polypeptide through the membrane via the
Evanthia Tambosis et al.
International journal of dermatology, 51(8), 935-938 (2012-07-14)
The cheapest, most rapid method for the diagnosis of mycotic skin and nail infections is direct examination of samples using a KOH preparation. The standard KOH wet mount lacks a color contrast. Various contrast dyes are available. Parker ink is
Mohamed Montassar Lasram et al.
Environmental toxicology and pharmacology, 38(2), 542-553 (2014-09-03)
Insulin resistance and risk of type 2 diabetes are the most important complications following exposure to organophosphorous (OPs) pesticides. Regarding the importance of liver on metabolic pathways regulation, in particular blood glucose homeostasis, we focused on liver inflammation and oxidative
Hideki Shirakawa et al.
Journal of biomechanics, 46(4), 696-701 (2012-12-25)
We have studied stress relaxation of bovine femoral cortical bone specimens treated with KOH aqueous solution which had been known to degrade selectively protein molecules in bone. With the KOH treatment, we found an increase in specimens' volume. This increase
Ratchanee Kongkachuichai et al.
Food chemistry, 173, 838-846 (2014-12-04)
Evidence from epidemiological studies has strongly suggested that diets rich in fruits and vegetables play a vital role in disease prevention. The aim of this study was to determine nutrient and antioxidant content for 15 varieties of indigenous vegetables and
Javed Iqbal et al.
Toxicology mechanisms and methods, 24(8), 544-551 (2014-07-26)
Advancement in the field of analytical food-chemistry has explored various experimental techniques for aflatoxins (AFs) quantification. The present study was aimed to compare four different techniques; thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), liquid chromatography-tandem mass spectrometry (LC-MS/MS) and enzyme-linked
Mélanie Bonizec et al.
Nucleic acids research, 42(17), 10975-10986 (2014-09-04)
Cdc48/p97 is an evolutionary conserved ubiquitin-dependent chaperone involved in a broad array of cellular functions due to its ability to associate with multiple cofactors. Aside from its role in removing RNA polymerase II from chromatin after DNA damage, little is
Katanchalee Mai-Ngam et al.
Carbohydrate polymers, 112, 440-447 (2014-08-19)
The synthesis of two comb-like dextran surfactant polymers, that are different in their dextran molecular weight (MW) distribution and the presence of carboxylic groups, and their characterization are reported. A bimodal carboxylic dextran surfactant polymer consists of poly(vinyl amine) (PVAm)
Casandra R Cox et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(39), 14057-14061 (2014-09-17)
Direct solar-to-fuels conversion can be achieved by coupling a photovoltaic device with water-splitting catalysts. We demonstrate that a solar-to-fuels efficiency (SFE) > 10% can be achieved with nonprecious, low-cost, and commercially ready materials. We present a systems design of a
Jinhui Xu et al.
European journal of drug metabolism and pharmacokinetics, 39(4), 301-310 (2013-12-24)
The extended use of doxorubicin (DOX) could be limited due to the emergence of drug resistance and cardiotoxicity associated with its treatment. Conjugates of DOX with transferrin (DOX-TRF) can effectively alleviate these side effects, thereby leading to a better treatment.
Fumiyuki Takasaki et al.
Dalton transactions (Cambridge, England : 2003), 44(2), 645-652 (2014-11-12)
The speciation of zirconium complexes in ammonium zirconium carbonate (AZC) solutions should be further studied in order to develop high-performance AZC complexes for use in elaborate industrial materials. Thus, the speciation and the structure of various zirconium species in ammonium
Nungruthai Suphrom et al.
The Journal of pharmacy and pharmacology, 66(9), 1282-1293 (2014-06-07)
Curcuma aeruginosa Roxb. extract is a 5α-reductase antagonist that can be used to treat hair loss. We aimed to study the stability of antiandrogenic constituents, germacrone and other sesquiterpene components in the extract. Germacrone and the extract were analyzed as solid
Madhur D Shastri et al.
PloS one, 10(3), e0118798-e0118798 (2015-03-05)
T-cell-mediated inflammatory cytokines, such as interleukin (IL)-4, IL-5, IL-13 and tumor necrosis factor-alpha (TNF-α), play an important role in the initiation and progression of inflammatory airways diseases. Low-molecular-weight heparins (LMWHs), widely used anticoagulants, possess anti-inflammatory properties making them potential treatment
Lesley C Homer et al.
Lab animal, 41(11), 327-335 (2012-10-20)
Alkaline hydrolysis-based tissue dissolvers (TDs) are commercially available tools for the digestion and decontamination of infectious animal waste. The authors carried out a series of experiments to verify whether the TD in their facility completely digested animal carcasses and inactivated
Veronika F S Pape et al.
Journal of inorganic biochemistry, 144, 18-30 (2015-01-16)
Three novel pyrimidinylhydrazones substituted at either the aromatic moiety or at the imine carbon atom were synthesized and characterized by standard analytical methods. All compounds were found to be toxic in the micro- to submicromolar range against a diverse panel
D J Smith et al.
Journal of agricultural and food chemistry, 62(48), 11756-11766 (2014-11-20)
The distribution and chemical fate of (36)Cl-ClO2 gas subsequent to fumigation of tomatoes or cantaloupe was investigated as were major factors that affect the formation of chloroxyanion byproducts. Approximately 22% of the generated (36)Cl-ClO2 was present on fumigated tomatoes after
Marta Calatayud et al.
Archives of toxicology, 89(4), 555-564 (2014-05-28)
Chronic exposure to inorganic arsenic (As) is associated with type 2 diabetes, cardiovascular diseases and cancer. Ingested inorganic As is transformed within the gastrointestinal tract and can give rise to more toxic species such as monomethylarsonous acid [MMA(III)] and dimethylarsinous
In-Seek Jeong et al.
Journal of food science, 77(10), C1042-C1046 (2012-09-18)
In this study, nonheated saponification was employed as a novel, rapid, and easy sample preparation method for the determination of cholesterol in emulsified foods. Cholesterol content was analyzed using gas chromatography with a flame ionization detector (GC-FID). The cholesterol extraction
Rajat Sharma et al.
Applied biochemistry and biotechnology, 169(3), 761-772 (2013-01-01)
Chemical pretreatment of lignocellulosic biomass has been extensively investigated for sugar generation and subsequent fuel production. Alkaline pretreatment has emerged as one of the popular chemical pretreatment methods, but most attempts thus far have utilized NaOH for the pretreatment process.
Izaskun Valdivielso et al.
Food chemistry, 173, 709-717 (2014-12-04)
Carotenoids and tocopherols from botanical species abundant in Atlantic mountain grasslands were simultaneously extracted using one-step solid-liquid phase. A single n-hexane/2-propanol extract containing both types of compounds was injected twice under two different sets of HPLC conditions to separate the
Avner Shemer et al.
The Journal of family practice, 61(9), 552-554 (2012-09-25)
In onychomycosis, proper specimen collection is essential for an accurate diagnosis and initiation of appropriate therapy. Several techniques and locations have been suggested for specimen collection. To investigate the optimal technique of fungal sampling in onychomycosis. We reexamined 106 patients
Marcia Vizzotto et al.
Food chemistry, 164, 363-370 (2014-07-06)
Polyphenolic extracts and fractions of selected peach and plum genotypes were evaluated for cell viability and antiproliferation activity in vitro against an estrogen independent MDA-MB-435 and estrogen dependent MCF-7 breast cancer cell lines and one non-cancerous breast line MCF-10A. All
Frank J Symons et al.
Pain medicine (Malden, Mass.), 16(2), 249-256 (2014-09-23)
Assessing and treating pain in nonverbal children with developmental disabilities are a clinical challenge. Current assessment approaches rely on clinical impression and behavioral rating scales completed by proxy report. Given the growing health relevance of the salivary metabolome, we undertook
Michel Boutin et al.
Journal of the American Society for Mass Spectrometry, 26(3), 499-510 (2015-01-15)
Fabry disease is an X-linked, complex, multisystemic lysosomal storage disorder presenting marked phenotypic and genotypic variability among affected male and female patients. Glycosphingolipids, mainly globotriaosylceramide (Gb(3)) isoforms/analogs, globotriaosylsphingosine (lyso-Gb(3)) and analogs, as well as galabiosylceramide (Ga(2)) isoforms/analogs accumulate in the
Suzan Semaan et al.
CNS neuroscience & therapeutics, 21(2), 164-172 (2014-10-14)
Although compelling evidence suggests that human hypothalamic hamartoma (HH) is intrinsically epileptogenic for gelastic seizures, the molecular mechanisms responsible for epileptogenesis within HH remain to be elucidated. The aim of this study was to test the hypothesis that hyperactivation of
Mohammad I K Hamad et al.
Journal of neuroscience methods, 240, 48-60 (2014-12-03)
Calcium imaging has unraveled the calcium-dependent mechanisms underlying neuronal function. Acetoxymethyl ester (AM) dyes are widely employed for calcium imaging. Pluronic F127 (PF127) as a surfactant and dimethyl sulfoxide (DMSO) as a solvent are used to dissolve the dyes, but
Marzieh Kamankesh et al.
Meat science, 103, 61-67 (2015-01-27)
A simple and rapid analytical tech nique for the simultaneous determination of 16 polycyclic aromatic hydrocarbons (PAHs) in grilled meat was developed using microwave-assisted extraction and dispersive liquid-liquid microextraction (MAE-DLLME) followed by gas chromatography-mass spectrometry (GC-MS). The effective parameters in
Fen Li et al.
Environmental technology, 35(17-20), 2575-2581 (2014-08-26)
Sludge-activated carbons (SACs) prepared with excess of activated sludge are used to solve the problems of sludge disposal and odour pollution in a sewage treatment plant. For the preparation, ZnCl2, KOH and H2SO4 are used as activators, respectively. The structure
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