619-12-5

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Characterization of three new deletions in the β-globin gene cluster during a screening survey in two French urban areas.

Serge Pissard et al.

Clinica chimica acta; international journal of clinical chemistry, 415, 35-40 (2012-09-18)

Deletions represent about 5% of the mutations in the β-globin gene cluster. We report here the screening for such deletions in the two French urban areas of Paris and Lyon between 2003 and 2010. Semi-quantitative PCR methods were used for

Genetic diversity of beta-thalassemia mutations in Pakistani population.

B Khateeb et al.

JPMA. The Journal of the Pakistan Medical Association, 50(9), 293-296 (2000-10-24)

beta-thalassemia is one of the most common inherited single gene disorder in Pakistan. It is characterized by reduced or absent beta-globin gene expression resulting in abnormal maturation and survival of red blood cells. Due to high prevalence of this disease

Prevalence, clinico-pathological value, and co-occurrence of PDGFRA abnormalities in diffuse gliomas.

Agustí Alentorn et al.

Neuro-oncology, 14(11), 1393-1403 (2012-10-18)

PDGFRA is a critical gene in glioma biology. Similar to EGFR, PDGFRA has been shown to be overexpressed, amplified, mutated, or truncated in gliomas, particularly glioblastomas. In addition, PDGFRA has been recently shown to be rearranged in glioblastoma. However, the

The anti-inflammatory effects of inhaled corticosteroids versus anti-leukotrienes on the lymphocyte P-glycoprotein (PGP) expression in asthmatic children.

Frantisek Kopriva et al.

The Journal of asthma : official journal of the Association for the Care of Asthma, 46(4), 366-370 (2009-06-02)

Inhaled corticosteroids (ICS) are used in asthma therapy for their anti-inflammatory effects. P-glycoprotein (PGP) is a transmembrane efflux pump for many drugs, including corticosteroids. Expression of PGP is associated with therapy resistant disease. The purpose of this study was to

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