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显示 1-30 #N/A 145 条结果 关于 "62288" 范围 论文
G A Martin et al.
The Journal of biological chemistry, 263(22), 10907-10914 (1988-08-05)
Hepatic triglyceride lipase (H-TGL) was isolated from human postheparin plasma by column chromatography on heparin-Sepharose and phenyl-Sepharose and immunoaffinity chromatography with monoclonal antibodies. The purified enzyme had an apparent molecular weight of 65,000 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis and
A Kotronen et al.
Diabetologia, 52(6), 1056-1060 (2009-02-19)
It has recently been suggested that the rs738409 G allele in PNPLA3, which encodes adiponutrin, is strongly associated with increased liver fat content in three different ethnic groups. The aims of the present study were as follows: (1) to try
Wei Liu et al.
Journal of nanoscience and nanotechnology, 14(4), 3068-3072 (2014-04-17)
Magnetic Fe3O4 nanoparticles were prepared with coprecipitatation method and covered with SiO2 to form the core-shell Fe3O4@SiO2 nanoparticles. Then the nanoparticles were modified with glutaradehyde for functionalization of the surface to aldehyde groups. The transmission electron microscopy confirmed the core-shell
K Hirata et al.
The Journal of biological chemistry, 274(20), 14170-14175 (1999-05-13)
A new lipoprotein lipase-like gene has been cloned from endothelial cells through a subtraction methodology aimed at characterizing genes that are expressed with in vitro differentiation of this cell type. The conceptual endothelial cell-derived lipase protein contains 500 amino acids
Hideto Nakajima et al.
Hypertension (Dallas, Tex. : 1979), 61(5), 1002-1007 (2013-03-06)
Lipoprotein lipase has been considered as the only enzyme capable of generating lipid-derived fatty acids for cardiac energy. Endothelial lipase is another member of the triglyceride lipase family and hydrolyzes high-density lipoproteins. Although endothelial lipase is expressed in the heart
Daniela S Gerhard et al.
Genome research, 14(10B), 2121-2127 (2004-10-19)
The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random
M W Bodmer et al.
Biochimica et biophysica acta, 909(3), 237-244 (1987-08-25)
The molecular cloning of a cDNA coding for human gastric lipase and its expression in yeast is described. A lipase present in human gastric aspirates was purified and its N-terminal amino-acid sequence was determined. This was found to be homologous
Andrew C Lake et al.
Journal of lipid research, 46(11), 2477-2487 (2005-09-10)
Adiponutrin and a related protein, adipocyte triglyceride lipase (ATGL; also known as Desnutrin), were recently described as adipocyte-specific proteins with lipid hydrolase activity. Using bioinformatics, we identified three additional Adiponutrin family members (GS2, GS2-Like, and PNPLA1). Here, we report on
Yanzhi Jiang et al.
Gene, 539(1), 173-179 (2014-02-04)
Adipose triglyceride lipase (ATGL), catalyzing the initial step of hydrolysis of triacylglycerol (TAG) in adipocytes, has been known to be inhibited by G0/G1 switch protein 2 (G0S2). In this study, we determined tissue expression pattern and polymorphism of G0S2 gene
Noah Dephoure et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(31), 10762-10767 (2008-08-02)
The eukaryotic cell division cycle is characterized by a sequence of orderly and highly regulated events resulting in the duplication and separation of all cellular material into two newly formed daughter cells. Protein phosphorylation by cyclin-dependent kinases (CDKs) drives this
Mark T Ross et al.
Nature, 434(7031), 325-337 (2005-03-18)
The human X chromosome has a unique biology that was shaped by its evolution as the sex chromosome shared by males and females. We have determined 99.3% of the euchromatic sequence of the X chromosome. Our analysis illustrates the autosomal
Pierre-Marie Badin et al.
Endocrinology, 154(4), 1444-1453 (2013-03-09)
Elevated expression/activity of adipose triglyceride lipase (ATGL) and/or reduced activity of hormone-sensitive lipase (HSL) in skeletal muscle are causally linked to insulin resistance in vitro. We investigated here the effect of high-fat feeding on skeletal muscle lipolytic proteins, lipotoxicity, and
Preparation of passion fruit-typical 2-alkyl ester enantiomers via lipase-catalyzed kinetic resolution
Strohalm H, et al.
Journal of Agricultural and Food Chemistry, 58(10), 6328-6333 (2010)
Sol Cuenca et al.
Frontiers in plant science, 7, 464-464 (2016-05-06)
Elongated flexuous plant viral nanoparticles (VNPs) represent an interesting platform for developing different applications in nanobiotechnology. In the case of potyviruses, the virion external surface is made up of helically arrayed domains of the viral structural coat protein (CP), repeated
Mary G McCoy et al.
Journal of lipid research, 43(6), 921-929 (2002-05-29)
Endothelial lipase (EL) is a new member of the triglyceride lipase gene family previously reported to have phospholipase activity. Using radiolabeled lipid substrates, we characterized the lipolytic activity of this enzyme in comparison to lipoprotein lipase (LPL) and hepatic lipase
Daniela Tavian et al.
Human molecular genetics, 21(24), 5318-5328 (2012-09-20)
The lack of adipose triglyceride lipase (ATGL), a patatin-like phospholipase domain-containing enzyme that hydrolyzes fatty acids from triacylglycerol (TAG) stored in multiple tissues, causes the autosomal recessive disorder neutral lipid storage disease with myopathy (NLSD-M). In two families of Lebanese
M B Mazzucco et al.
The Journal of endocrinology, 217(3), 303-315 (2013-03-14)
Metabolic alterations in obese and overweight mothers impact the placenta and the fetus, leading to anomalies in fetal growth and lipid accretion. The primary aim of the study was to examine the effect of a saturated fat-rich diet (FD) on
M R Probst et al.
The Journal of biological chemistry, 269(34), 21650-21656 (1994-08-26)
Microsomal arylacetamide deacetylase (DAC) competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens in many species and tissues. Activity determination and immunoblot analysis of DAC in human
S J Cai et al.
Biochemistry, 28(23), 8966-8971 (1989-11-14)
The structure of the human hepatic triglyceride lipase gene was determined from multiple cosmid clones. All the exons, exon-intron junctions, and 845 bp of the 5' and 254 bp of the 3' flanking DNA were sequenced. Comparison of the exon
Yasuhiro Seki et al.
Biochemical and biophysical research communications, 443(4), 1141-1147 (2014-01-02)
Lung cancer is one of the most frequent causes of cancer-related death worldwide. However, molecular markers for lung cancer have not been well established. To identify novel genes related to lung cancer development, we surveyed publicly available DNA microarray data
Mark J White et al.
Infection and immunity, 82(4), 1559-1571 (2014-01-24)
Staphylococcus aureus is an important human pathogen that employs a large repertoire of secreted virulence factors to promote disease pathogenesis. Many strains of S. aureus possess a plc gene that encodes a phosphatidylinositol (PI)-specific phospholipase C (PI-PLC) capable of hydrolyzing
A novel self-activation mechanism of Candida antarctica lipase B
Luan B and Zhou R
Physical Chemistry Chemical Physics, 19(24), 15709-15714 (2017)
Robert Zimmermann et al.
Science (New York, N.Y.), 306(5700), 1383-1386 (2004-11-20)
Mobilization of fatty acids from triglyceride stores in adipose tissue requires lipolytic enzymes. Dysfunctional lipolysis affects energy homeostasis and may contribute to the pathogenesis of obesity and insulin resistance. Until now, hormone-sensitive lipase (HSL) was the only enzyme known to
T Giller et al.
The Journal of biological chemistry, 267(23), 16509-16516 (1992-08-15)
We have isolated cDNAs coding for two novel human pancreatic lipase (hPL)-related human proteins, referred to as hPL-related proteins 1 and 2 (hPLRP1 and hPLRP2) and for hPL. The two novel proteins show an amino acid sequence identity to hPL
Verónica Miksztowicz et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(3), 669-675 (2014-01-25)
To assess the phospholipase activity of endothelial (EL) and hepatic lipase (HL) in postheparin plasma of subjects with metabolic syndrome (MS)/obesity and their relationship with atherogenic and antiatherogenic lipoproteins. Additionally, to evaluate lipoprotein lipase (LPL) and HL activity as triglyceride
Matthew K Ross et al.
Journal of biochemical and molecular toxicology, 21(4), 187-196 (2007-10-16)
Carboxylesterases (CEs) are traditionally regarded as xenobiotic metabolizing enzymes that hydrolyze esterified xenobiotics to alcohol and carboxylic acid products. However, there is a growing appreciation for the role of CEs in the processing of endobiotics, including cholesteryl esters and triacylglycerols.
Christopher M Jenkins et al.
The Journal of biological chemistry, 279(47), 48968-48975 (2004-09-15)
Genetic knockout of hormone-sensitive lipase in mice has implicated the presence of other intracellular triacylglycerol (TAG) lipases mediating TAG hydrolysis in adipocytes. Despite intense interest in these TAG lipases, their molecular identities thus far are largely unknown. Sequence data base
R A Hegele et al.
Human mutation, 1(4), 320-324 (1992-01-01)
Human hepatic lipase (HL) is a 477 residue glycoprotein that hydrolyzes triglycerides from plasma lipoproteins. Familial HL deficiency is a rare recessive disorder that is characterized by premature atherosclerosis and abnormal circulating lipoproteins. While studying the HL gene from the
Properties and purification of adipose tissue lipase.
W S LYNN et al.
The Journal of biological chemistry, 235, 1912-1916 (1960-07-01)
Marzia Foddai et al.
Natural product communications, 9(2), 181-184 (2014-04-03)
Pancreatic triacylglycerol lipase (PL), alpha-amylase and alpha-glucosidase are interesting pharmacological targets for the management of dyslipidemia, atherosclerosis, and obesity-diabetes. Limonium spp (Plumbaginaceae) are endemic to Sardinia, Italy. Comparable with acarbose, aqueous extracts (AE) of L. contortirameum and L. virgatum, and
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