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62336
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Takao Saito
Nihon rinsho. Japanese journal of clinical medicine, 71(9), 1618-1622 (2013-11-12)
In advanced chronic kidney disease(CKD), chylomicrons(CM) and very low density lipoprotein(VLDL) are accumulated by the inactivity of lipoprotein lipase(LPL). CM remnants are incompletely absorbed into liver and the conversion of intermediate lipoprotein (IDL) to cholesterol-rich low density lipoprotein(LDL) is impaired
Masashi Moteki et al.
Rinsho byori. The Japanese journal of clinical pathology, 60(8), 734-739 (2012-12-04)
Many risk factors for coronary arterial diseases have been reported. Lipoprotein lipase (LPL) mass in serum has been suggested to be a new risk factor, but remains to be proven. The cardio-ankle vascular index (CAVI) was developed as a new
Peng-Yeh Lai et al.
Biochemical and biophysical research communications, 430(3), 1132-1139 (2012-12-15)
Adipose tissue is composed of adipocytes, which differentiate from precursor cells in a process called adipogenesis. Many signal molecules are involved in the transcriptional control of adipogenesis, including the Notch pathway. Previous adipogenic studies of Notch have focused on Notch1
Dong Hee Han et al.
The Korean journal of internal medicine, 28(5), 609-613 (2013-09-07)
We report the case of a patient who experienced extreme recurrent gestational hyperlipidemia. She was diagnosed with partial lipoprotein lipase (LPL) deficiency but without an associated LPL gene mutation in the presence of the apolipoprotein E3/2 genotype. This is the
Atsuko Takagi et al.
Nihon rinsho. Japanese journal of clinical medicine, 71(9), 1569-1576 (2013-11-12)
Human LPL is a glycoprotein enzyme with a molecular mass of 61 kDa, and it plays a key role in regulating the triglyceride (TG) levels in circulation by hydrolyzing TGs in TG-rich lipoproteins at the first step in their metabolism.
Laura J den Hartigh et al.
American journal of physiology. Heart and circulatory physiology, 306(1), H109-H120 (2013-10-29)
Postprandial lipemia is characterized by a transient increase in circulating triglyceride-rich lipoproteins such as very low-density lipoprotein (VLDL) and has been shown to activate monocytes in vivo. Lipolysis of VLDL releases remnant particles, phospholipids, monoglycerides, diglycerides, and fatty acids in
Mikael Larsson et al.
The Journal of biological chemistry, 288(47), 33997-34008 (2013-10-15)
Apolipoproteins (apo) C-I and C-III are known to inhibit lipoprotein lipase (LPL) activity, but the molecular mechanisms for this remain obscure. We present evidence that either apoC-I or apoC-III, when bound to triglyceride-rich lipoproteins, prevent binding of LPL to the
Janine J Geerling et al.
Diabetes, 63(3), 880-891 (2013-11-26)
Metformin is the first-line drug for the treatment of type 2 diabetes. Besides its well-characterized antihyperglycemic properties, metformin also lowers plasma VLDL triglyceride (TG). In this study, we investigated the underlying mechanisms in APOE*3-Leiden.CETP mice, a well-established model for human-like
Hydrolysis of diglyceride and glyceryl monoester diethers with "lipoprotein lipase".
H Greten et al.
Biochimica et biophysica acta, 210(1), 39-45 (1970-06-09)
Severe hypertriglyceridemia in an infant of Arab descent.
Doron M Behar et al.
The Israel Medical Association journal : IMAJ, 15(1), 53-54 (2013-03-15)
Mohammad Reza Bakhtiarizadeh et al.
Gene, 521(1), 122-128 (2013-03-26)
The objective of this study was to gain insight into the underlying mechanisms of fat deposition. Two sheep breeds with large fat-tail (Lori-Bakhtiari) and with thin-tail (Zel) were used as models. To determine important and key candidate lipid metabolism related
Elena Makoveichuk et al.
Biochemical and biophysical research communications, 441(4), 941-946 (2013-11-14)
Lipoprotein lipase (LPL) and angiopoietin-like protein 4 (Angptl4) were studied in 3T3-L1 adipocytes. Transfections of the adipocytes with Angptl4 esiRNA caused reduction of the expression of Angptl4 to about one fourth of that in cells treated with vehicle only. This
Karine Gontier et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 164(3), 499-505 (2013-01-03)
In waterfowl, the response to overfeeding differs from one genotype to the other. Pekin ducks generally store lipids in the peripheral tissues while Muscovy and mule ducks promote hepatic lipid storage. A possible reason for these various susceptibilities to hepatic
Dahai Zhang et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(12), 2830-2838 (2013-10-12)
During diabetes mellitus, coronary lipoprotein lipase increases to promote the predominant use of fatty acids. We have reported that high glucose stimulates active heparanase secretion from endothelial cells to cleave cardiomyocyte heparan sulfate and release bound lipoprotein lipase for transfer
[TG-rich lipoprotein metabolism and regulatory factors].
Daisaku Masuda
Nihon rinsho. Japanese journal of clinical medicine, 71(9), 1514-1516 (2013-11-12)
Alexander Bartelt et al.
Biochimica et biophysica acta, 1831(5), 934-942 (2012-12-12)
Efficient storage of dietary and endogenous fatty acids is a prerequisite for a healthy adipose tissue function. Lipoprotein lipase (LPL) is the master regulator of fatty acid uptake from triglyceride-rich lipoproteins. In addition to LPL-mediated fatty acid uptake, adipocytes are
Virginia L Gaveglio et al.
FEBS letters, 587(7), 950-956 (2013-02-27)
The aim of the present research was to analyze the pathways for phosphatidic acid metabolism in purified nuclei from liver. Lipid phosphate phosphatase, diacylglycerol lipase, monoacylglycerol lipase and PA-phospholipase type A activities were detected. The presence of lysophosphatidic acid significantly
Ying Wang et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(5), 894-902 (2013-03-09)
After diabetes mellitus, transfer of lipoprotein lipase (LPL) from cardiomyocytes to the coronary lumen increases, and this requires liberation of LPL from the myocyte surface heparan sulfate proteoglycans with subsequent replenishment of this reservoir. At the lumen, LPL breaks down
Rakel Nyrén et al.
BMC physiology, 12, 14-14 (2012-11-29)
Lipoprotein lipase (LPL) hydrolyzes triglycerides in plasma lipoproteins and enables uptake of lipolysis products for energy production or storage in tissues. Our aim was to study the localization of LPL and its endothelial anchoring protein glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein
Kris Richardson et al.
American journal of human genetics, 92(1), 5-14 (2012-12-19)
Genome-wide association studies (GWAS) have identified hundreds of genetic variants that are associated with lipid phenotypes. However, data supporting a functional role for these variants in the context of lipid metabolism are scarce. We investigated the association of the lipoprotein
Dae Hyun Kim et al.
Endocrinology, 155(4), 1255-1267 (2014-01-21)
Excessive production of triglyceride-rich very low-density lipoproteins (VLDL-TG) contributes to hypertriglyceridemia in obesity and type 2 diabetes. To understand the underlying mechanism, we studied hepatic regulation of VLDL-TG production by (forkhead box O6) FoxO6, a forkhead transcription factor that integrates
Alon Zahavi et al.
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 17(1), 110-111 (2013-01-23)
We report the case of a 12-week-old boy presenting with increased cholesterol and triglyceride levels. Examination revealed lipemia retinalis. Genetic evaluation demonstrated lipoprotein lipase deficiency. The patient was treated with dietary restrictions, which resulted in rapid clinical improvement.
Purified human lipoprotein lipase: positional specificity.
P Nilsson-Ehle et al.
Biochimica et biophysica acta, 248(1), 114-120 (1971-10-05)
Elke C G Jackson et al.
The Journal of pharmacology and experimental therapeutics, 347(3), 582-588 (2013-09-18)
Human platelet activation by collagen occurs in a dose-dependent manner. High concentrations of collagen bind to a pair of receptors, the α2β1 integrin and glycoprotein (GP)VI/Fc-receptor γ-chain (FcRγ), which stimulate a cascade of events including Syk, LAT, Btk, Gads, and
Verónica Miksztowicz et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(3), 669-675 (2014-01-25)
To assess the phospholipase activity of endothelial (EL) and hepatic lipase (HL) in postheparin plasma of subjects with metabolic syndrome (MS)/obesity and their relationship with atherogenic and antiatherogenic lipoproteins. Additionally, to evaluate lipoprotein lipase (LPL) and HL activity as triglyceride
Q Renli et al.
Animal : an international journal of animal bioscience, 6(8), 1246-1252 (2012-12-12)
Experiments were conducted to determine the effects of Newcastle disease on chicken fat metabolism. Thirty black-bone chickens were infected intraocularly with the Newcastle disease virus (NDV). Six birds were killed at 0, 12, 24, 48 and 72 h post infection
Ku-Lung Hsu et al.
Journal of medicinal chemistry, 56(21), 8257-8269 (2013-10-25)
We have previously shown that 1,2,3-triazole ureas (1,2,3-TUs) act as versatile class of irreversible serine hydrolase inhibitors that can be tuned to create selective probes for diverse members of this large enzyme class, including diacylglycerol lipase-β (DAGLβ), a principal biosynthetic
M B Mazzucco et al.
The Journal of endocrinology, 217(3), 303-315 (2013-03-14)
Metabolic alterations in obese and overweight mothers impact the placenta and the fetus, leading to anomalies in fetal growth and lipid accretion. The primary aim of the study was to examine the effect of a saturated fat-rich diet (FD) on
Guo-Ping Tian et al.
Biochemical and biophysical research communications, 443(2), 428-434 (2013-12-07)
Atherosclerosis is a lipid disorder disease characterized by chronic blood vessel wall inflammation driven by the subendothelial accumulation of macrophages. Studies have shown that lipoprotein lipase (LPL) participates in lipid metabolism, but it is not yet known whether post-transcriptional regulation
Seon-Joo Park et al.
Biological trace element research, 151(2), 294-300 (2012-12-04)
This study investigated the anti-obesity effects of Jeju ground water containing the vanadium components S1 (8.0 ± 0.9 μg/l) and S3 (26.0 ± 2.09 μg/l) on the differentiation of 3 T3-L1 preadipocytes and obesity in mice that were fed a
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