E-64 (E3132) - Product Information Sheet
trans-EPOXYSUCCINYL-L-LEUCYLAMIDO-(4-
GUANIDINO)BUTANE
Sigma Prod. No. E 3132
CAS Number 66701-25-5
SYNONYMS: E 641; Proteinase Inhibitor
2. How to Use this Product
y Version: 08E-64, Protease Inhibitor N-[N-(L-3-Trans-carboxirane-2-carbonyl)-L-leucyl]-agmatine
sigma-aldrich.com 5
2.2. Parameters
Chemical Formula
C15 H27 N5
Fair, D.S., and Marlar, R. A., Blood, 67, 64 (1986).
3. Kisiel, W., J. Clin. Invest., 64, 761 (1979).
4. Weiss, P., et al., Thromb. Res., 45, 783 (1987).
5. Esmon, C. T., J. Biol. Chem., 264, 4743 (1989
).
3. Zittle, C. A., Solubility transformation of alpha-
lactalbumin. Arch. Biochem. Biophys., 64, 144-51
(1956).
4. Kronman, M. J. and Andreotti, R. E., Inter- and
Intramolecular Interactions
hydrochloride: aminopeptidases, such as
leucine aminopeptidase and alanyl
aminopeptidase2–5
• E-64 [N-(trans-Epoxysuccinyl)-L-leucine
4-guanidinobutylamide]: cysteine proteases, such
as calpain
mucin glycoproteins". Technische
Universität München, Dr. rer. nat. dissertation,
pp. 9, 64 (2022).
17. Yeung, A.T.Y. et al., MBio, 3(3), e00073-12
(2012).
Notice
We provide information
determining optimal working concentration by titration.
References
1. Fridovich, I., Ann. Rev. Biochem., 64, 97-112
(1995).
2. Lebovitz, R.M., et al., Proc. Natl. Acad. Sci. USA,
93, 9782-9787 (1996)
the optimal working dilutions by titration.
References
1. Fridovich, I., Ann. Rev. Biochem, 64, 97-112
(1995).
2. Lebovitz, R.M., et al., Proc. Natl. Acad. Sci. USA,
93, 9782-9787 (1996
Cysteine-116) in the Histidinol Binding
Site of Histidinol Dehydrogenase. Biochemistry,
25(17), 4778-4784 (1986).
5. Burger, E., et al., The Catalytically Active Form of
Histidinol Dehydrogenase from Salmonella
Leuconostoc (LG6P-DH) is highly specific for D-glucose-6-phosphate (Km = 36 μM, NADP as
coenzyme; 64 μM, NAD as coenzyme), but will use either NADP (Km = 7.4 μM; relative rate = 1.0) or
NAD (Km
1.0 mg/mL5% in methanol
drug standard
Catalog Number M9524
Lot Number SLBQ5023V
Storage Temperature –20 C
CAS RN 64-31-3
Synonyms: (5, 6)-7,8-Didehydro-4,5-epoxy-
17-methylmorphinan
J. Neuroscience (1996) 16:2701-2715.
5. J. Neuroscience (1998) 18:1056-1071.
6. J. of Neuroscience. (1998) 18(17):6963-6976.
7. Pancreas (1999) 18:53-64.
Important Note: During