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显示 1-30 共 76 条结果 关于 "64-43-7" 范围 论文
Geraldo Barroso Cavalcanti et al.
Cytometry. Part B, Clinical cytometry, 78(4), 253-259 (2010-03-04)
p53 is a cell cycle checkpoint control protein that assesses DNA damage and acts as a transcription factor regulating genes, which control cell growth, DNA repair, and apoptosis. p53 mutations have been found in a wide variety of different cancers
Shi et al.
Chirality, 12(7), 574-580 (2000-06-22)
Chiral trifluoromethanesulfonamide 4, diphenylphosphoramides 5 and 6, and phenylthiophosphoramide 7 were prepared from the reaction of trifluoromethanesulfonic anhydride, diphenylphosphinic chloride, and diphenylthiophosphinic chloride with (R)-(+)-1,1'-binaphthyl-2, 2'-diamine, respectively. They were used as catalytic chiral ligands in the asymmetric addition reaction of
I Fiorini et al.
Journal of medicinal chemistry, 37(10), 1427-1438 (1994-05-13)
A novel class of ligands specific for MBR receptors has been identified: 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives. The majority of newly synthesized esters 37-64 as well as some intermediate ketones showed micro- or nanomolar affinity for [3H]PK 11195 binding inhibition. A SAR study
Sean R Williamson et al.
The American journal of surgical pathology, 37(8), 1131-1139 (2013-05-08)
Clear cell papillary renal cell carcinoma (CCPRCC) shares morphologic overlap with clear cell renal cell carcinoma, although it lacks chromosome 3p and VHL gene abnormalities. Rare cases have been reported in von Hippel-Lindau (VHL) patients (germline mutation of the VHL
Ian F Pollack et al.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 27(1), 87-94 (2010-08-21)
Recent studies have demonstrated a high frequency of IDH mutations in adult "secondary" malignant gliomas arising from preexisting lower grade lesions, often in young adults, but not in "primary" gliomas. Because pediatric malignant gliomas share some molecular features with adult
Amanda J Jenkins et al.
Journal of forensic and legal medicine, 16(2), 64-66 (2009-01-13)
Hydrocodone (HC) has received renewed interest in the US due to reported increases in opiate related deaths involving psychotherapeutic drugs. The relative contribution of dihydrocodeine (DHC) in these deaths is unknown since little testing of this compound is performed. The
J O Boyle et al.
Cancer research, 53(19), 4477-4480 (1993-10-01)
To establish a genetic model of the progression of head and neck squamous carcinoma we have defined the incidence and timing of p53 mutations in this type of cancer. We sequenced the conserved regions of the p53 gene in 102
Adrienne R Newburg et al.
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 36(3), 493-504 (2017-01-22)
This study was performed to determine the frequency, predictors, and outcomes of ultrasound (US) correlates for non-mass enhancement. From January 2005 to December 2011, a retrospective review of 5837 consecutive breast magnetic resonance imaging examinations at our institution identified 918
R H Hill et al.
Environmental research, 71(2), 99-108 (1995-11-01)
We measured 12 analytes in urine of 1000 adults living in the United States to establish reference range concentrations for pesticide residues. We frequently found six of these analytes: 2,5-dichlorophenol (in 98% of adults); 2,4-dichlorophenol (in 64%); 1-naphthol (in 86%);
Jean K Mah et al.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 38(3), 465-474 (2011-04-26)
We carried out a population-based study of dystrophin mutations in patients followed by members of the Canadian Paediatric Neuromuscular Group (CPNG) over a ten-year period. We aimed to describe the changes in diagnostic testing for dystrophinopathy and to determine the
K A Iczkowski et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 11(8), 774-779 (1998-08-28)
We compared the expression of inhibin A, chromogranin, synaptophysin, S-100 protein, cytokeratins AE1/AE3, 7, and 20, and estrogen and progesterone receptors in testicular sex cord-stromal tumors: 11 Sertoli cell tumors, 3 Sertoli cell adenomas (nodules), 26 benign Leydig cell tumors
M H Lyda et al.
Human pathology, 31(8), 980-987 (2000-09-15)
The histologic classification of pulmonary neoplasms can have important implications regarding appropriate management of patients. Although the histologic classification of lung tumors is predominantly based on morphology, ancillary studies such as immunohistochemistry can be used in difficult cases, and the
Marietta Charakida et al.
The lancet. Diabetes & endocrinology, 2(8), 648-654 (2014-05-27)
Excess body fat is associated with an increase in risk of type 2 diabetes and hypertension in adulthood and these risks can adversely affect progression of arterial disease. We aimed to assess the impact of lifelong patterns of adiposity on
N M Alazhary et al.
European review for medical and pharmacological sciences, 19(11), 2026-2030 (2015-07-01)
Congenital heart diseases (CHDs) are the leading cause of infant deaths worldwide. Angiotensin-converting enzyme (ACE) gene I/D polymorphism is associated with many cardiovascular diseases. The precise relationship between this polymorphism and CHDs is not clear. The aim of this work
Ulrike Lass et al.
PloS one, 7(7), e41298-e41298 (2012-07-31)
To investigate the dynamics of inter- and intratumoral molecular alterations during tumor progression in recurrent gliomas. To address intertumoral heterogeneity we investigated non-microdissected tumor tissue of 106 gliomas representing 51 recurrent tumors. To address intratumoral heterogeneity a set of 16
Steinunn Thordardottir et al.
Alzheimer's research & therapy, 10(1), 45-45 (2018-05-12)
The range of onset ages within some PSEN1 families is wide, and a few cases of reduced penetrance of PSEN1 mutations have been reported. However, published data on reduced penetrance have been limited to clinical histories, often collected retrospectively and
Amit Kumar Sharma et al.
Indian journal of biochemistry & biophysics, 51(5), 358-364 (2015-01-30)
Anticancer potential of Piper longum fruit against human cancer cell lines (DU-145 prostate, A549 lung, THP-1 leukemia, IGR-OVI-1 ovary and MCF-7 breast) as well as its in vitro and in vivo biochemical efficacy in A1Cl3-induced hepatotoxicity were evaluated in the
Ulla Wilking et al.
Breast cancer research and treatment, 125(2), 553-561 (2010-07-16)
This retrospective study investigates the correlation of intra-individual HER2 status between primary breast cancers and corresponding recurrences in a population derived cohort. The REMARK criteria were used as reference. In 151 breast cancer patients, primary tumors were analyzed for HER2
Youxin Yang et al.
Cell cycle (Georgetown, Tex.), 5(13), 1443-1447 (2006-07-21)
The etiology and significance of genomic instability (GIN), a hallmark of human cancers, remains controversial. The paradigm that inactivation of tumor suppressors [e.g. p53 or adenomatous polyposis coli (APC) genes] leads to GIN is largely based on experiments in vitro
Yu-Lin Zhu et al.
Zhongguo shi yan xue ye xue za zhi, 15(6), 1144-1149 (2007-12-20)
This study was aimed to detect the expression levels of preferentially expressed antigen of melanoma (PRAME) gene in acute leukemia (AL) and to evaluate the clinical significance of PRAME gene. The quantitative detection method was established by SYBR Green I
S F Paul Man et al.
Therapeutic advances in respiratory disease, 3(2), 73-80 (2009-05-26)
Several studies suggest that inhaled and oral corticosteroids repress systemic inflammation in chronic obstructive pulmonary disease (COPD). However, the cytokines that may respond to these medications are unclear. We used data from 41 patients with a history of stable moderate
Yasuhiro Oki et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 19(24), 6882-6890 (2013-10-08)
To evaluate the safety and efficacy of panobinostat plus everolimus in patients with relapsed Hodgkin and non-Hodgkin lymphoma. The concept was supported by the single-agent clinical activity of histone deacetylase inhibitors and mTOR inhibitors, and on the in vitro mechanism-based
Gabriele Meroni et al.
Microorganisms, 7(12) (2020-01-01)
Staphylococcus pseudintermedius is a commensal bacterium frequently isolated from canine skin and recognized as a zoonotic agent especially for dog-owners. This study focused on (a) the antibiotic-resistance phenotypes; (b) the ability to produce biofilm (slime); and (c) the dissemination of
Y Miyagoe et al.
The Journal of biological chemistry, 269(11), 8268-8279 (1994-03-18)
We have explored the template and factor requirements for transcription of the gene encoding the murine complement component C4, expressed predominantly but not exclusively in liver and mononuclear phagocytes. Competition experiments in transcription assays with liver nuclear extracts show that
Roger L Snowden
Chemistry & biodiversity, 5(6), 958-969 (2008-07-12)
Using a novel, acid-mediated cyclization methodology, a direct access to Cetalox ((+/-)-1; a commercially important ambergris-type odorant) and various structurally related didehydro (i.e., 19, 26, and 30) and tetradehydro (i.e., 28 and 37/38) analogues is described. Treatment of either (E,E)-14
Faraz Kazmi et al.
Xenobiotica; the fate of foreign compounds in biological systems, 44(7), 606-614 (2014-01-11)
1. Rose bengal (4,5,6,7-tetrachloro-2',4',5',7'-tetraiodofluorescein) is being developed for the treatment of cutaneous melanoma and hepatocellular carcinoma. Interestingly, rose bengal can generate singlet oxygen species upon exposure to light. 2. We evaluated rose bengal as an in vitro inhibitor of cytochrome
Leona A Doyle et al.
Journal of cutaneous pathology, 38(9), 697-703 (2011-07-15)
Epithelioid fibrous histiocytoma (EFH) represents a morphologic variant of cutaneous fibrous histiocytoma (FH) but can lack many characteristic features. The presence of epithelioid cytomorphology may mimic other dermal neoplasms. Our anecdotal experience of epithelial membrane antigen (EMA) expression in some
Jochen Greiner et al.
International journal of cancer, 108(5), 704-711 (2003-12-30)
Specific immunotherapies for patients with acute myeloid leukemia (AML) using leukemia-associated antigens (LAA) as target structures might be a therapeutic option to enhance the graft-vs.-leukemia effect observed after allogeneic stem cell transplantation or to prolong a complete remission (CR) achieved
L Zahradova et al.
Neoplasma, 59(4), 440-449 (2012-04-12)
In a phase II clinical study, pretreated multiple myeloma patients with relapsing or stable disease received autologous anticancer vaccine containing dendritic cells loaded with Id-protein. Patients received a total of 6 vaccine doses intradermally in monthly intervals. No clinical responses were observed.
David Sanford et al.
British journal of haematology, 171(4), 471-477 (2015-07-25)
Treatment of acute promyelocytic leukaemia (APL) with arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) is highly effective first-line therapy, although approximately 5-10% of patients relapse. Tamibarotene is a synthetic retinoid with activity in APL patients who relapse after chemotherapy
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