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Natalie Cortes et al.
Life sciences, 122, 42-50 (2014-12-23)
Amaryllidaceae alkaloids exhibit a wide range of physiological effects, of which the acetylcholinesterase (AChE) inhibitory activity is the most relevant. However, scientific evidence related to their neuroprotective effectiveness against glutamate-induced toxicity has been lacking. Thus, the purpose of this study
Complete oxidation of CO, ethanol, and ethyl acetate over copper oxide supported on titania and ceria modified titania.
Larsson PO and Andersson A.
J. Catal., 179(1), 72-89 (1998)
Franziska Janusch et al.
Environmental toxicology and pharmacology, 38(3), 792-799 (2014-10-13)
The application of antibiotics including fluoroquinolones to farming animals is widespread and may lead to the development of antibiotic resistance and other environmental effects. To calculate environmental loads and for a proper risk assessment it is necessary to determine the
Xingwang Zhang et al.
Journal of pharmaceutical sciences, 103(6), 1711-1719 (2014-04-05)
Oral delivery of anticancer drugs remains challenging because of limited water-solubility and/or poor permeability. Here, we aimed to enhance the oral bioavailability of tripterine (TRI, a plant-derived anticancer compound) using lipid nanospheres (LNs) and to determine the mechanisms of oral
Q Q He et al.
Organic & biomolecular chemistry, 13(13), 4070-4079 (2015-03-05)
This study investigated the unexpected decomposition and associated intermediates of compound 1, a specific member of a drug discovery library based on a monosaccharide scaffold. LC/MS and NMR spectroscopic analyses indicated that, under acidic conditions, 1 can be converted into
Matthäus Mlynek et al.
Journal of chromatography. A, 1284, 112-117 (2013-03-08)
The behaviour of PMMA standards in mixtures composed of two binary critical eluents was investigated. It was found that combinations of two critical eluents do not result in a molar mass independent elution (critical conditions). When mixing two binary critical
Abhishek Bhanot et al.
Pakistan journal of biological sciences : PJBS, 16(22), 1612-1617 (2014-02-12)
To explore in vitro anticancer potential of Aerva lanata L. (flowering aerial part). The study was performed with 5 different human cell lines for the study of lung, leukaemia, prostate, colon and cervix cancer by using Sulphorhodamine B (SRB) assay.
Man-Jeong Paik et al.
Sleep & breathing = Schlaf & Atmung, 18(3), 517-523 (2014-01-10)
The apnea-hypopnea index (AHI) is closely related with the severity of daytime sleepiness, but excessive daytime sleepiness (EDS) is not presented on all patients with obstructive sleep apnea (OSA). It is unclear why daytime sleepiness is not always present in
Nrupa Borkar et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 89, 216-223 (2014-12-17)
Apomorphine, a subcutaneously administered drug for Parkinson's disease with short half-life requires frequent administration leading to patient non-compliance. This study aimed at synthesising and purifying lipophilic diesters of apomorphine, and investigating their in vitro degradation in biorelevant media before and
Lorraine Aparecida Pinto et al.
Naunyn-Schmiedeberg's archives of pharmacology, 388(3), 305-317 (2014-11-25)
The purpose of the present study was to evaluate the gastroprotective and healing effects of the methanolic extract of the seed of the papaya Carica papaya L. (MECP) in rats. Models of acute gastric ulcer induction by ethanol and indomethacin
Yang Yang et al.
Environmental science & technology, 48(20), 12362-12369 (2014-09-16)
Disinfectants inactivate pathogens in source water; however, they also react with organic matter and bromide/iodide to form disinfection byproducts (DBPs). Although only a few DBP classes have been systematically analyzed for toxicity, iodinated and brominated DBPs tend to be the
Stuart J Khan et al.
Chirality, 26(11), 739-746 (2014-12-17)
Ibuprofen and naproxen are commonly used members of a class of pharmaceuticals known as 2-arylpropionic acids (2-APAs). Both are chiral chemicals and can exist as either of two (R)- and (S)-enantiomers. Enantioselective analyses of effluents from municipal wastewater treatment plants
Matthew Fankhauser et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(21), 5547-5557 (2014-04-29)
It has been recognized for almost a decade that concentrations of signaling androgens sufficient to activate the androgen receptor are present in castration-resistant prostate cancer tissue. The source of these androgens is highly controversial, with three competing models proposed. We
Marianne de Villiers et al.
The FEBS journal, 281(20), 4731-4753 (2014-08-27)
N-substituted pantothenamides are analogues of pantothenic acid, the vitamin precursor of CoA, and constitute a class of well-studied bacterial growth inhibitors that show potential as new antibacterial agents. Previous studies have highlighted the importance of pantothenate kinase (PanK; EC 2.7.1.33)
Rosa María González Paredes et al.
Journal of chromatography. A, 1359, 52-59 (2014-08-13)
A method based on the coupling of in situ extraction and derivatization of chlorophenols (CPs) (2-chlorophenol, 4-chloro-3-methylphenol, 2,4-dichlorophenol, and 2,4,6-trichlorophenol) from soils, accomplishing their preconcentration by means of automated microextraction by packed sorbent (MEPS), is proposed. After extraction and acylation
Katerina Naumoska et al.
Journal of chromatography. A, 1381, 229-238 (2015-01-20)
Three TLC methods were used for an initial screening of some common plant triterpenoids and phytosterols in cuticular wax extracts of different vegetables (zucchini, eggplant, tomato, red pepper, mangold, spinach, lettuce, white-colored radicchio di Castelfranco, raddichio Leonardo, white cabbage, red
Adrian Weisz et al.
Journal of chromatography. A, 1380, 120-129 (2015-01-17)
Three low-level subsidiary color impurities (A, B, and C) often present in batches of the color additive D&C Red No. 33 (R33, Acid Red 33, Colour Index No. 17200) were separated from a portion of R33 by spiral high-speed counter-current
Laishram Shantikumar Singh et al.
BMC microbiology, 14, 278-278 (2014-11-20)
Actinomycetes have provided a wealth of bioactive secondary metabolites with interesting activities such as antimicrobial, antiviral and anticancer. The study aims at isolation, characterization and the antimicrobial potentiality of Streptomyces sannanensis SU118 obtained from Phoomdi, a unique habitat of Loktak
Nuria Ortuño et al.
The Science of the total environment, 499, 27-35 (2014-09-01)
The constant increase in the production of electronic devices implies the need for an appropriate management of a growing number of waste electrical and electronic equipment. Thermal treatments represent an interesting alternative to recycle this kind of waste, but particular
Gabriel B Akanni et al.
Journal of the science of food and agriculture, 95(5), 1094-1102 (2014-11-06)
The cladodes of Opuntia ficus-indica (prickly pear cactus) have a low protein content; for use as a balanced feed, supplementation with other protein sources is therefore desirable. We investigated protein enrichment by cultivation of the yeasts Candida utilis and Kluyveromyces
Christy Echakachi Manyi-Loh et al.
Pakistan journal of pharmaceutical sciences, 26(5), 897-906 (2013-09-17)
The growing problem of antibiotic resistance by Helicobacter pylori demands the search for novel compounds, especially from natural sources. We evaluated the anti-H. pylori activity of six local honeys at different concentrations as well as their solvent extracts by the
Susana Grimalt et al.
Analytical and bioanalytical chemistry, 407(11), 3083-3091 (2015-01-30)
The feasibility of the production of a reference material for pesticide residue analysis in a cucumber matrix was investigated. Cucumber was spiked at 0.075 mg/kg with each of the 15 selected pesticides (acetamiprid, azoxystrobin, carbendazim, chlorpyrifos, cypermethrin, diazinon, (α + β)-endosulfan, fenitrothion, imazalil
Cristiane dos Santos Giuberti et al.
Journal of liposome research, 23(3), 220-227 (2013-05-11)
Recent studies using long-circulating and pH-sensitive liposomes containing cisplatin (SpHL-CDDP) have resulted in a formulation with improved pharmacokinetic, toxicity and tumor localization properties. In this study, SpHL-CDDP were prepared in both laboratory and pilot scales. This study evaluated the possibility
Yung-Chih Kuo et al.
International journal of pharmaceutics, 479(1), 138-149 (2015-01-07)
Lactoferrin (Lf) and folic acid (FA) were crosslinked on poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) for transporting etoposide across the blood-brain barrier (BBB) and treating human brain malignant glioblastoma. Lf- and FA-grafted PLGA NPs (Lf/FA/PLGA NPs) were employed to permeate the monolayer
Shupeng Yang et al.
Analytical and bioanalytical chemistry, 407(13), 3579-3589 (2015-03-17)
Ochratoxin A (OTA) is a mycotoxin that frequently contaminates a wide variety of food and feedstuffs. The metabolism of OTA greatly affects fate and toxicity in humans and animals, because of its possible carcinogenic character (International Agency for Research on
Ariel R Topletz et al.
Molecular pharmacology, 87(3), 430-441 (2014-12-11)
All-trans-retinoic acid (atRA), the active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs). The primary hydroxylated metabolites formed from atRA by CYP26A1, and the subsequent metabolite 4-oxo-atRA, bind to RARs and potentially have
Jie Zhu et al.
Microbial cell factories, 14, 35-35 (2015-04-17)
A key pathway for ester biosynthesis in yeast is the condensation of an alcohol with acetyl-CoA by alcohol-O-acetyltransferase (AATase). This pathway is also prevalent in fruit, producing short and medium chain volatile esters during ripening. In this work, a series
Yogini Jaiswal et al.
Journal of agricultural and food chemistry, 62(29), 7302-7316 (2014-06-19)
Cyperus rotundus L. is a plant species commonly found in both India and China. The caused destruction of this plant is of critical concern for agricultural produce. Nevertheless, it can serve as a potential source of the commercially important sesquiterpenoid
K J S Anand et al.
British journal of anaesthesia, 101(5), 680-689 (2008-08-30)
Relationships between plasma morphine concentrations and neonatal responses to endotracheal tube (ETT) suctioning are unknown in preterm neonates. Ventilated preterm neonates (n=898) from 16 centres were randomly assigned to placebo (n=449) or morphine (n=449). After an i.v. loading dose (100
Jiali Gu et al.
Applied microbiology and biotechnology, 99(4), 1709-1718 (2014-08-12)
Methyl (R)-o-chloromandelate (R-CMM) is an intermediate for the platelet aggregation inhibitor clopidogrel. Its preparation through enzymatic resolution of the corresponding ester has been hindered by the lack of an enzyme with satisfying enantioselectivity and activity. In the present work, we
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