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A B Czuppon et al.
Biochemistry international, 11(1), 21-34 (1985-07-01)
Five glycoproteinmolecules with the molecular masses of 17 000; 38 000; 42 000; 50 000 and 67 000 were purified by high performance liquid chromatography following solubilization of isolated porcine zonae pellucidae by treatment with lithium-3,5-diiodosalicylate. The N-terminal amino acid
Cynthia Kucher et al.
The American Journal of dermatopathology, 26(6), 452-457 (2004-12-25)
Desmoplastic melanoma (DMM) is an uncommon melanoma variant with a distinct morphology, including a prominent spindle cell component with fibrosis, as well as a distinct immunohistochemical profile. Histologically, the spindle cell component of DMM can be confused with sclerotic/desmoplastic nevi
Cynthia Kucher et al.
The American Journal of dermatopathology, 26(6), 452-457 (2004-12-25)
Desmoplastic melanoma (DMM) is an uncommon melanoma variant with a distinct morphology, including a prominent spindle cell component with fibrosis, as well as a distinct immunohistochemical profile. Histologically, the spindle cell component of DMM can be confused with sclerotic/desmoplastic nevi
V Barresi et al.
Acta neuropathologica, 112(5), 617-626 (2006-07-20)
Caveolin-1 (Cav-1) protein has been documented in several neoplasms with a controversial role in cell proliferation, tumour development and progression. The aim of the present study was to investigate the Cav-1 immunohistochemical expression in human meningiomas. Sixty-two cases, classified as
Y X Sun et al.
Cellular and molecular life sciences : CMLS, 59(10), 1734-1743 (2002-12-12)
We compared the effects ofAlzheimer's peptide (Abeta1-42), a,-antichymotrypsin (ACT) and an ACT/Abeta1-42 mixture on human glioma DK-MG cells. The solution of Abeta (5 microM) formed by 2-h incubation at room temperature induced tumour necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 levels
Kyoichi Kaira et al.
Annals of surgical oncology, 16(12), 3473-3481 (2009-09-25)
The purpose of this study was to evaluate the prognostic value of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in resectable non-small-cell lung cancer (NSCLC) patients with N1 and N2 nodal involvement. A total of
Constantinos T Sofocleous et al.
Annals of surgical oncology, 19(13), 4262-4269 (2012-07-04)
To assess the predictive value of examinations of tissue adherent to multitined electrodes on local tumor progression-free survival (LPFS) and overall survival (OS) after liver tumor radiofrequency ablation (RFA). An institutional review board-approved, Health Insurance Portability and Accountability Act-compliant review
Benjamin Saltman et al.
Surgery, 140(6), 899-905 (2006-12-26)
Genetic screening studies suggest that genetic changes underlie progression from well differentiated to anaplastic thyroid cancers. The aim of this study is to determine to what extent cell cycle/apoptosis regulators contribute to cancer progression. Tissue microarrarys (TMAs) were constructed from
Hemal H Patel et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 16(11), 1468-1470 (2002-09-03)
Opioids and volatile anesthetics produce marked cardioprotective effects against myocardial infarction via the activation of ATP-sensitive potassium (K(ATP)) channels, however, the effect of combined treatment with both drugs is unknown. We examined the hypothesis that opioids and volatile anesthetics potentiate
J Fleischmann et al.
International journal of cancer, 84(6), 614-617 (1999-11-24)
We report the generation of 2 monoclonal antibodies (MAbs), 2B12 and 3E6, suitable for the detection of human dUTPase in routinely processed paraffin sections by immunohistochemistry. Using these MAbs, we observed nuclear expression of dUTPase in the proliferation zones of
Sara Massironi et al.
Endocrine, 58(2), 360-367 (2017-02-18)
Small-intestine neuroendocrine neoplasms are heterogeneous neoplasms arising from endocrine cells of the intestinal mucosa. Ki-67 is the main determinant of prognosis in neuroendocrine neoplasms. However, the search for new prognostic makers represents a key point with regard to small-intestine neuroendocrine
Kervin O Evans et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 153, 333-343 (2015-09-04)
Octadecyl ferulate was prepared using solid acid catalyst, monitored using Supercritical Fluid Chromatography and purified to a 42% yield. Differential scanning calorimetry measurements determined octadecyl ferulate to have melting/solidification phase transitions at 67 and 39°C, respectively. AFM imaging shows that
A W Tolcher et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 26(1), 58-64 (2014-10-26)
This phase Ib trial investigated the safety, tolerability, and recommended phase II dose and schedule of the MEK inhibitor trametinib in combination with the mammalian target of rapamycin (mTOR) inhibitor everolimus. Secondary objectives included pharmacokinetic (PK) characterization and evaluation of
Hsiang-Yu Lin et al.
Journal of inherited metabolic disease, 33(5), 619-624 (2010-09-08)
Newborn screening for Fabry disease in Taiwan Chinese has revealed a high incidence of the late-onset GLA mutation IVS4 + 919G→A (∼1 in 1,500-1,600 males). We studied 94 adults with this mutation [22 men, 72 women; mean age: men 57.8 ± 6.0 (range 42-68)
Isamu Okamoto et al.
The American journal of pathology, 160(2), 441-447 (2002-02-13)
Cell surface adhesion molecules are crucial for the development and/or pathogenesis of various diseases including cancer. CD44 has received much interest as a major adhesion molecule that is involved in tumor progression. We have previously demonstrated that the ectodomain of
Krisztina Z Hanley et al.
Cancer cytopathology, 126(4), 236-242 (2018-01-10)
Twenty-seven percent of neuroendocrine tumors (NETs) are associated with distant metastases, and in some patients, the primary site is unknown. Orthopedia homeobox protein (OTP) has been described as a useful marker for lung carcinoids (LCs) and for separating low-grade typical
Jiayu Liu et al.
Oncology letters, 19(3), 1890-1898 (2020-03-21)
Pituitary adenomas (PAs) are a common subtype of intracranial tumors. The aim of the present study was to analyse the clinical and pathological features of different types of pituitary adenomas (PAs) according to the 2017 World Health Organisation Endocrine Organ
E Hudson et al.
European journal of cancer care, 19(3), 324-328 (2009-11-17)
The objectives of this study are to evaluate patient outcomes in clinical practice using gemcitabine and carboplatin (GCarbo) as first-line treatment in metastatic transitional cell carcinoma (TCC) of the urothelium, and to review the published evidence on the use of
Jessica L Fletcher et al.
Journal of neuropathology and experimental neurology, 73(6), 536-547 (2014-05-09)
Hypomyelination is a poorly understood feature of many neurodegenerative lysosomal storage diseases, including fucosidosis in children and animals. To gain insight into hypomyelination in fucosidosis, we investigated lysosomal storage, oligodendrocyte death, and axonal and neuron loss in CNS tissues of
M Garcia-Gila et al.
Clinical and experimental immunology, 127(3), 455-462 (2002-04-23)
Apoptosis is a regulated event crucial to the development and proliferation of normal and malignant B cells. We have studied the role of signals delivered via alpha4 integrin on apoptosis triggered by three different pathways on these cells. For apoptosis
Brian J Gebhardt et al.
American journal of clinical oncology, 37(6), 535-538 (2013-02-23)
To evaluate the efficacy of definitive radiotherapy (RT) for the treatment of base of the tongue cancer in a private practice. We retrospectively reviewed the medical records of 48 patients with squamous cell carcinoma of the base of the tongue
Fengyuan Liu et al.
Food chemistry, 350, 129259-129259 (2021-02-24)
Cereals and legumes are rich in folate. However, due to the instability of folate, processing and digestion can induce significant folate loss. In this paper, folate bioaccessibility of faba bean, oat, rye and wheat flours and pastes was studied using
A Sita-Lumsden et al.
BJOG : an international journal of obstetrics and gynaecology, 120(8), 1012-1015 (2013-06-14)
The Uterine Artery Pulsatility Index (UAPI) is an ultrasound measure of tumour vascularity. In this study, we hypothesised that a UAPI ≤ 1 (high vascularity) would identify women with gestational trophoblastic neoplasia (GTN) at increased risk of resistance to first-line
Orna Levran et al.
Journal of human genetics, 56(2), 147-155 (2010-12-17)
The opioid system is involved in the action of opiate drugs, opioid addiction, pain experience and analgesia. Individual differences in opioid effect may be attributed in part to genetic variations. Long-range cis regulatory elements and intronic variants are potential sources
Chang Hee Jung et al.
Clinical endocrinology, 77(5), 699-706 (2012-01-04)
The ratio of apolipoprotein B (apoB) to apolipoprotein A1 (apoA1) has been reported to be associated with the metabolic syndrome (MetS). However, the optimal cut-off value of apoB/A1 ratio for detecting subjects with MetS has remained undetermined. In the present
Ko-Shing Chang et al.
Biosensors & bioelectronics, 31(1), 137-143 (2011-11-01)
A silicon nanowire field-effect transistor (SiNW-FET) coated with a polyvinyl chloride (PVC) membrane containing valinomycin (VAL) was employed as a biosensor (referred to as VAL-PVC/SiNW-FET) to detect the K(+)-efflux from live chromaffin cells. The detection sensitivity of K(+) with the
L Fan et al.
Journal of neurochemistry, 76(5), 1275-1281 (2001-03-10)
An improved differential display technique was used to search for changes in gene expression in the superior frontal cortex of alcoholics. A cDNA fragment was retrieved and cloned. Further sequence of the cDNA was determined from 5' RACE and screening
Miguel A López-González et al.
Acta otorrinolaringologica espanola, 63(3), 165-172 (2011-12-14)
Idiopathic sudden sensorineural hearing loss is a hearing disorder of unknown cause. The spontaneous recovery rate ranges from 50 to 75% of the patients. Scientific experiments on animals support the present study in patients with sudden deafness treated with sounds.
K D Fulcher et al.
Biology of reproduction, 48(3), 674-682 (1993-03-01)
A cDNA proposed to encode the mouse laminin receptor (MLR) was isolated from a mouse round spermatid expression library. The cDNA contained complete coding and 3' untranslated regions but was missing the first 42 bases from the 5' untranslated region.
D J Meyer et al.
The Biochemical journal, 274 ( Pt 2), 409-414 (1991-03-01)
Glutathione transferases (GSTs) of a novel class, which it is proposed to term Theta, were purified from rat and human liver. Two, named GST 5-5 and GST 12-12, were obtained from the rat, and one, named GST theta, was from
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