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显示 1-30 共 54 条结果 关于 "69-72-7" 范围 论文
Eva-Katrin Bentz et al.
Reproductive sciences (Thousand Oaks, Calif.), 14(7), 705-709 (2007-11-15)
The relation between genetic variation of the androgen metabolism and transsexualism is unknown. In a case-control study of 100 male-to-female (MtF) transsexuals, 47 female-to-male (FtM) transsexuals, and 1670 controls, the authors assess allele and genotype frequencies of the steroid 5-alpha
M M Elhadidy et al.
Epidemiology and infection, 143(11), 2367-2372 (2014-11-28)
Escherichia coli O157:H7 strains (n = 33) recovered from different food sources in Egypt were characterized using molecular assays to identify strain genotypes associated with various levels of pathogenic potential. Genotypic characterization included: lineage-specific polymorphism assay (LSPA-6), Shiga-toxin-encoding bacteriophage insertion
Yu-mei Liu et al.
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 47(12), 1089-1095 (2012-02-18)
To investigate the role of endothelial progenitor cells (EPC) in the injury of rat optic nerve. An experimental study. The rat model of optic nerve injury was created by fluid percussion brain injury device (FPI). On hundred and eight rats
Cynthia F Bartels et al.
Genetic testing and molecular biomarkers, 14(6), 881-891 (2010-12-17)
CHARGE syndrome is an autosomal dominant multisystem disorder caused by mutation in the CHD7 gene, encoding chromodomain helicase DNA-binding protein 7. Molecular diagnostic testing for CHD7 mutation has been available in a clinical setting since 2005. We report here the
Enrique Sánchez-Lemus et al.
Neurochemical research, 31(4), 555-561 (2006-06-08)
In rat striatal slices labelled with [(3)H]-adenine and in the presence of 1 mM 3-isobutyl-1-methylxantine (IBMX), cyclic [(3)H]-AMP ([(3)H]-cAMP) accumulation induced by the dopamine D(1) receptor agonist SKF-81297 (1 microM; 177 +/- 13% of basal) was inhibited by the general
Meng-Zhong Liu et al.
American journal of clinical pathology, 129(5), 728-734 (2008-04-23)
AIB1, a candidate oncogene in breast cancer, is commonly amplified and overexpressed in several types of human cancers. In this study, expression and amplification of AIB1 in nasopharyngeal carcinoma (NPC) were studied by immunohistochemical analysis and fluorescence in situ hybridization
Hong-Qiang Guo et al.
Journal of cancer research and therapeutics, 11(2), 319-323 (2015-07-08)
It is important to identify some tumor-related factors for early detection, treatment, and evaluation of prognosis in colorectal cancer (CRC). In our study, we investigated the clinical and prognostic role of activating transcription factor 7 (ATF7) in CRC. Expression of
Jörg Balss et al.
Acta neuropathologica, 116(6), 597-602 (2008-11-06)
A recent study reported on mutations in the active site of the isocitrate dehydrogenase (IDH1) gene in 12% of glioblastomas. All mutations detected resulted in an amino acid exchange in position 132. We analyzed the genomic region spanning wild type
Jörg Balss et al.
Acta neuropathologica, 116(6), 597-602 (2008-11-06)
A recent study reported on mutations in the active site of the isocitrate dehydrogenase (IDH1) gene in 12% of glioblastomas. All mutations detected resulted in an amino acid exchange in position 132. We analyzed the genomic region spanning wild type
Mélanie Bousquenaud et al.
The international journal of cardiovascular imaging, 28(6), 1407-1415 (2011-11-26)
The rat myocardial infarction (MI) model is widely used to study left ventricular (LV) remodeling. In this study, acipimox-enhanced (18)F-Fluorodeoxyglucose (FDG) gated-positron emission tomography (PET) was assessed for characterizing and predicting early remodeling in the rat infarct model. Nineteen Wistar
Miao-jing Fan et al.
Zhonghua bing li xue za zhi = Chinese journal of pathology, 40(10), 679-682 (2012-02-11)
To investigate epidermal growth factor receptor (EGFR) gene mutations in exons 19 and 21 of patients with non-small cell lung cancer (NSCLC) and to analyze the relationship of EGFR mutations with clinicopathological features and prognosis. The EGFR gene exons 19
N Goldaracena et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 14(12), 2788-2795 (2014-10-04)
Outcomes of living versus deceased donor liver transplantation in patients with chronic liver disease and hepatorenal syndrome (HRS) was compared using a matched pair study design. Thirty patients with HRS receiving a live donor liver transplantation (LDLT) and 90 HRS
Tuomas Peltonen et al.
Atherosclerosis, 216(1), 35-43 (2011-02-15)
There is increasing evidence that renin-angiotensin system (RAS) may play a major role in the actively regulated fibrocalcific process in aortic valve stenosis (AS), but the gene expression or function of (pro)renin receptor ((P)RR), prorenin and renin or angiotensin converting
Delia Aguado et al.
Veterinary anaesthesia and analgesia, 47(1), 103-110 (2019-10-23)
To compare a Parasympathetic Tone Activity (PTA) monitor with cardiovascular changes in invasive mean arterial pressure (IMAP) and heart rate (HR) when evaluating the response to nociceptive stimuli in anaesthetized dogs. Prospective experimental study. A group of nine (seven male
Qiujin Shen et al.
The Lancet. Oncology, 13(8), 817-826 (2012-06-29)
Hepatocellular carcinoma (HCC) is prevalent worldwide and improvements in timely and effective diagnosis are needed. We assessed whether measurement of Dickkopf-1 (DKK1) in serum could improve diagnostic accuracy for HCC. We analysed data for patients with HCC, chronic hepatitis B
Jiske J L'Ami et al.
Veterinary journal (London, England : 1997), 196(2), 253-259 (2012-10-16)
A single dose of 40 μg/kg bodyweight (BW) of oromucosal detomidine gel was administered sublingually to 10 healthy Dutch Warmblood mares aged 7 ± 4 years (mean ± SD) and BW 580 ± 69 kg. Blood and urine samples were
Sylvain Pilorge et al.
American journal of hematology, 89(4), 399-403 (2014-01-01)
Gemtuzumab ozogamicin (fGO), a humanized anti-CD33 monoclonal antibody linked to calicheamicin in combination with intensive chemotherapy gives high response rates in adult acute myeloid leukemia (AML) patients in relapse. However, reduced intensity chemotherapy in combination with fractionated GO has not
Yinghui Li et al.
Cancer investigation, 23(8), 660-664 (2005-12-27)
Centrosomes regulate cell division by forming bipolar mitotic spindles and, thus, play an essential role in the maintenance of chromosomal stability. Centrosomal amplification has been found commonly among tumor cells. Previous studies have suggested that a STK15 (serine/threonine kinase 15)
J Barbier et al.
Clinical and experimental pharmacology & physiology, 34(8), 796-798 (2007-06-30)
1. beta(3)-Adrenoceptors (AR) have been reported to be present in numerous species, where they mediate multiple responses. 2. The aim of the present study was to determine whether beta(3)-AR are present in intact rat heart and the functional implications of
Andrei Molotkov et al.
The Journal of biological chemistry, 278(38), 36085-36090 (2003-07-10)
Vitamin A (retinol) is a nutrient that is essential for developmental regulation but toxic in large amounts. Previous genetic studies have revealed that alcohol dehydrogenase Adh1 is required for efficient clearance of excess retinol to prevent toxicity, thus demonstrating that
Carol L Shields et al.
Cornea, 34(1), 42-48 (2014-10-25)
To describe the clinical features, treatment, and outcome of patients with iris metastasis. Retrospective case series of 160 tumors in 107 eyes of 104 patients with iris metastasis from systemic cancer. The median age at presentation with iris metastasis was
C Samuel Bradford et al.
General and comparative endocrinology, 146(3), 275-290 (2005-12-27)
Two full-length cDNAs, encoding delta (delta) and mu (mu) opioid receptors, were cloned from the brain of the rough-skinned newt Taricha granulosa, complementing previous work from our laboratory describing the cloning of newt brain kappa (kappa) and ORL1 opioid receptors.
Yuan-Yuan Jiao et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(1-2), 249-258 (2012-11-20)
8-Chloro-adenosine (8CA) has shown promise in hematologic and solid tumor models and is in a phase I clinical trial. However, 8CA is intensively metabolized shortly after i.v. administration, with a t(1/2β) of approximately 1h. Many carriers have failed to encapsulate
Hsiang-Yu Lin et al.
Journal of inherited metabolic disease, 33(5), 619-624 (2010-09-08)
Newborn screening for Fabry disease in Taiwan Chinese has revealed a high incidence of the late-onset GLA mutation IVS4 + 919G→A (∼1 in 1,500-1,600 males). We studied 94 adults with this mutation [22 men, 72 women; mean age: men 57.8 ± 6.0 (range 42-68)
Kenneth L Clark et al.
Molecular therapy. Nucleic acids, 2, e65-e65 (2013-01-17)
Lung pathology in cystic fibrosis is linked to dehydration of the airways epithelial surface which in part results from inappropriately raised sodium reabsorption through the epithelial sodium channel (ENaC). To identify a small-interfering RNA (siRNA) which selectively inhibits ENaC expression
Kenneth S Bode et al.
Journal of spinal disorders & techniques, 28(10), E590-E594 (2013-11-20)
Randomized trial. This study described practical magnetic resonance imaging (MRI) characteristics to assist in the identification of these tumors including the corresponding statistics. Identification of vascular spinal tumors using MRI allows the opportunity for angiography and preoperative embolization (PE) to
A A Izzo et al.
Neuroscience, 91(4), 1575-1580 (1999-07-03)
The effect of muscarinic cholinoceptor antagonists was investigated on the ascending neural pathways activated by electrical stimulation in the guinea-pig ileum. For comparison, prejunctional and postjunctional effects of muscarinic cholinoceptor antagonists were also studied on circular smooth muscle. A two-compartment
F Murray et al.
European journal of pharmacology, 397(2-3), 263-270 (2000-06-14)
[3H]MK-801 binding in vivo was used to determine the occupancy of NMDA receptor ligands shown to allosterically modulate binding in vitro. ED(50) values (mg/kg) were obtained for the channel blockers (+)-5-methyl-10,11-dihydro-5,4-dibenzo[a,d]cyclohepten-5,10-imine maleate ((+)-MK-801, 0.2), 1-(1-phenylcyclohexyl)piperidine (phencyclidine, PCP, 1.7) and ketamine
Jesper B Andersen et al.
Gastroenterology, 142(4), 1021-1031 (2011-12-20)
Cholangiocarcinoma is a heterogeneous disease with a poor outcome that accounts for 5%-10% of primary liver cancers. We characterized its genomic and genetic features and associated these with patient responses to therapy. We profiled the transcriptomes from 104 surgically resected
A D Kelion et al.
Heart (British Cardiac Society), 87(2), 115-120 (2002-01-18)
The "warm up" effect in angina may represent ischaemic preconditioning, which is mediated by adenosine A(1) receptors in most models. To investigate the effect of a selective A(1) agonist, GR79236 (GlaxoSmithKline), on exercise induced angina and ischaemic left ventricular dysfunction
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