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关键词:'70-11-1'
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Marc Clement et al.
Journal of autoimmunity, 56, 23-33 (2014-10-04)
CD31, a trans-homophilic inhibitory receptor expressed on both T- and B-lymphocytes, drives the mutual detachment of interacting leukocytes. Intriguingly, T cell CD31 molecules relocate to the immunological synapse (IS), where the T and B cells establish a stable interaction. Here
Haruka Kinosada et al.
PLoS pathogens, 13(1), e1006120-e1006120 (2017-01-04)
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia-lymphoma (ATL) and inflammatory diseases. To enhance cell-to-cell transmission of HTLV-1, the virus increases the number of infected cells in vivo. HTLV-1 bZIP factor (HBZ) is constitutively expressed in HTLV-1
Raleigh Tenney et al.
Journal of cellular physiology, 202(1), 160-166 (2004-09-25)
Interleukin 11 (IL-11) is an anti-inflammatory cytokine with receptors located on most cell types and tissues throughout the body. Its anti-inflammatory properties are mediated through suppression of cytokine synthesis, in large part by prevention of NF-kappaB activation. As adipose tissue
Young Cha et al.
FEBS letters, 584(19), 4241-4246 (2010-09-18)
Previous research indicated that ZAP70, a Syk family tyrosine kinase, is expressed in mouse embryonic stem cells (mESCs) and regulates the Janus kinase 1 (JAK1)/signal transducer and activator of transcription 3 (STAT3) signaling through consolidating SHP1 enzymatic activity. In this
Hong Mei et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 37(10), 13369-13376 (2016-07-28)
Ribosomal S6 kinase 1 (S6K1) that acts downstream of the mammalian target of rapamycin (mTOR) plays an important role in cell proliferation, protein translation, and cell survival. The gene RPS6KB1 encoding for S6K1 had been found to be alternatively spliced
N Fusaki et al.
The Journal of biological chemistry, 272(10), 6214-6219 (1997-03-07)
The Src family protein-tyrosine kinase, Fyn, is associated with the T cell receptor (TCR) and plays an important role in TCR-mediated signaling. We found that a human T cell leukemia virus type 1-infected T cell line, Hayai, overexpressed Fyn. To
Adrian Wiestner et al.
Blood, 101(12), 4944-4951 (2003-02-22)
The presence or absence of somatic mutations in the expressed immunoglobulin heavy chain variable regions (IgVH) of chronic lymphocytic leukemia (CLL) cells provides prognostic information. Patients whose leukemic cells express unmutated IgVH regions (Ig-unmutated CLL) often have progressive disease, whereas
Bernard A Fang et al.
Biochimica et biophysica acta, 1845(1), 1-19 (2013-11-26)
N-myc down-regulated gene 1 (NDRG1) is a known metastasis suppressor in multiple cancers, being also involved in embryogenesis and development, cell growth and differentiation, lipid biosynthesis and myelination, stress responses and immunity. In addition to its primary role as a
Shu Iwata et al.
Antimicrobial agents and chemotherapy, 64(11) (2020-08-21)
Four Providencia rettgeri isolates and one Providencia stuartii isolate were obtained from urine samples of five patients in 2018 in Japan. All of the isolates were resistant to imipenem and meropenem, and three were highly resistant to both carbapenems, with
Sing-Huang Tan et al.
Oncology reports, 18(5), 1225-1230 (2007-10-05)
The purpose was to validate the use of RUNX3 as a potential biomarker for detection of cancer in serum samples and to determine its sensitivity alone and in combination with p16, RASSF1A and CDH1 using methylation-specific polymerase chain reaction (MSP).
S H Shaw et al.
American journal of medical genetics, 81(5), 364-376 (1998-10-01)
We completed a systematic genome-wide search for evidence of loci linked to schizophrenia using a collection of 70 pedigrees containing multiple affected individuals according to three phenotype classifications: schizophrenia only (48 pedigrees; 70 sib-pairs); schizophrenia plus schizoaffective disorder (70 pedigrees;
Dimitri S Monos et al.
Human immunology, 66(5), 554-562 (2005-06-07)
Substantial evidence has been accumulated suggesting that T cells in patients with epithelial ovarian carcinoma (EOC) exhibit an antigen-driven immune response directed against the tumor cells. In the context of human leukocyte antigen (HLA), this suggests its possible involvement in
T Imamura et al.
The Journal of biological chemistry, 276(47), 43663-43667 (2001-09-08)
The insulin and the endothelin type A (ETA) receptor both can couple into the heterotrimeric G protein alpha(q/11) (Galpha(q/11)), leading to Galpha(q/11) tyrosine phosphorylation, phosphatidylinositol 3-kinase activation, and subsequent stimulation of glucose transport. In this study, we assessed the potential
F L S Castro et al.
Poultry science, 98(4), 1716-1722 (2018-11-20)
This study evaluated the effects of crystalline arginine (Arg) on performance and body composition in male broilers. A total of 600 1-day-old Ross 308 broilers were distributed in a completely randomized design, with 5 treatments and 6 replicates of 20
Sara Margolin et al.
Genetic testing, 8(2), 127-132 (2004-09-04)
The mutation frequency of BRCA1 and BRCA2 in women with breast cancer varies according to family history, age at diagnosis and ethnicity. The contribution of BRCA1 and BRCA2 mutations in breast cancer populations, unselected for age and family history, has
R D Soede et al.
Journal of immunology (Baltimore, Md. : 1950), 166(7), 4293-4301 (2001-03-20)
Dissemination of T cell hybridomas in mice, a model for in vivo migration of memory T cells and for T lymphoma metastasis, depends on the chemokine stromal cell-derived factor-1 (SDF-1) and the integrin LFA-1 and correlates well with invasion into
F Bressolle et al.
British journal of anaesthesia, 106(4), 558-565 (2011-02-12)
Nalbuphine is an opioid analgesic agent widely used for control of mild-to-severe pain. However, limited data are available on the pharmacokinetics of this drug in children. The aim of this study was to characterize the population pharmacokinetics of nalbuphine in
Brian M Freed et al.
Arthritis and rheumatism, 63(12), 3733-3739 (2011-11-19)
Although rheumatoid arthritis (RA) has long been associated with an HLA-DRB1 shared epitope, a systematic search for other epitopes has never been conducted. In addition, the relationship between these epitopes and the binding of citrullinated autoantigens has not been investigated.
S Vijayalaxmi et al.
Applied biochemistry and biotechnology, 171(2), 382-395 (2013-07-11)
The alkaliphilic Bacillus halodurans strain PPKS-2 was shown to produce extracellular extreme alkaliphilic, halotolerent, detergent, and thermostable mannanase activity. The cultural conditions for the maximum enzyme production were optimized with respect to pH, temperature, NaCl, and inexpensive agro wastes as
A Rebane et al.
Biochimica et biophysica acta, 1446(3), 426-430 (1999-10-19)
A novel snoRNA, designated as U82, was found from the sequence analysis of the 5th intron of human and mouse nucleolin gene. The snoRNA U82 has characteristic boxes C, D and D' and 11 nucleotides (nt) antisense complementarity to the
Alison Morilla et al.
Leukemia & lymphoma, 49(11), 2108-2115 (2008-11-21)
ZAP-70, CD38 and IGHV mutations have all been reported to have prognostic impact in chronic lymphocytic leukemia (CLL), both individually and in paired combinations. We aimed to determine whether the combination of all three factors provided more refined prognostic information
Marit Habicher et al.
Journal of cardiothoracic and vascular anesthesia, 29(3), 646-655 (2015-01-13)
Parameters such as central venous oxygen saturation (ScvO2) are used increasingly to monitor adequate hemodynamic treatment. However, it still remains challenging to identify patients with assumed adequate circulatory status quantified by ScvO2 who suffer from macro- and microcirculatory hypoperfusion. The
I Del Giudice et al.
Leukemia, 20(7), 1231-1237 (2006-04-28)
B-prolymphocytic leukemia (B-PLL) is a rare disease with poor prognosis. To further characterize the biological features of this disease, we analyzed immunoglobulin heavy chain (IgVH) mutations, ZAP-70 and CD38 in 19 cases with de novo B-PLL. Immunoglobulin heavy chain genes
Fangjia Lu et al.
NPJ vaccines, 2, 4-4 (2017-12-22)
Biodegradable nanoparticles with functionalized surfaces are attractive candidates as vaccine adjuvants. Nano-11 are cationic dendrimer-like α-D-glucan nanoparticles with a diameter of 70-80 nm. Mice injected with antigen formulated with Nano-11 developed antibody titers that were similar or greater than antigen with
Michael Linnebank et al.
Neuro-oncology, 10(4), 548-552 (2008-05-24)
Glioblastoma multiforme (GBM) is the most frequent primary brain tumor in adults. Prognosis is poor. Using a series of 214 GBM patients, we observed an effect of the variant 5,10-methylenetetrahydrofolate reductase (MTHFR) c.677C>T on overall survival. This effect was strongest
K Sugiura et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 10(12), 1126-1131 (1999-12-14)
The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese-type, non-insulin-dependent diabetes mellitus (NIDDM) in humans. We have previously identified 11 quantitative trait loci (QTLs) responsible for NIDDM susceptibility on Chromosomes (Chrs) 1, 5, 7, 8, 9
T J Cole et al.
Genomics, 13(4), 974-982 (1992-08-01)
In this paper we report the isolation and characterization of the mouse CREB gene. It is composed of 11 exons and 10 introns and spans a region of 70 kb. BR-A and BR-B, the two alpha-helical regions of the proposed
M J Seraj et al.
Cancer research, 60(11), 2764-2769 (2000-06-13)
We previously showed that introduction of a normal, neomycin-tagged human chromosome 11 reduces the metastatic capacity of MDA-MB-435 (435) human breast carcinoma cells by 70-90% without affecting tumorigenicity, suggesting the presence of one or more metastasis suppressor genes encoded on
Zaiguo Li et al.
The Journal of organic chemistry, 72(22), 8376-8382 (2007-10-05)
Two analogues (1, 2) of free cholesterol and one analogue (3) of the immunosuppressive sphingolipid FTY720 containing a boron dipyrromethene chromophore (BODIPY) were synthesized. The synthetic routes involved preparation of boron dipyrromethene moieties (5, 11), bearing a phenylethynyl group at
Csaba Csutoras et al.
Bioorganic & medicinal chemistry, 12(10), 2687-2690 (2004-04-28)
The N-demethylation of 3-deoxymorphine (1) was investigated using methyl chloroformate and hydrazine. 3-Deoxynormorphine (2) was obtained in 70% yield, and 3-deoxydihydronormorphine (3) was also obtained as a side product. The mu, delta, and kappa receptor binding affinity of a series
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