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关键词:'70-34-8'
显示 1-30 共 107 条结果 关于 "70-34-8" 范围 论文
Vladimira Vroblova et al.
European journal of haematology, 84(6), 513-517 (2010-02-06)
It is widely accepted that expression of ZAP-70 in chronic lymphocytic leukemia (CLL) remains stable in time. However, data supporting this notion are surprisingly scarce. Therefore, we assessed expression of ZAP-70 in serial samples taken during the course of the
I Del Giudice et al.
Leukemia, 20(7), 1231-1237 (2006-04-28)
B-prolymphocytic leukemia (B-PLL) is a rare disease with poor prognosis. To further characterize the biological features of this disease, we analyzed immunoglobulin heavy chain (IgVH) mutations, ZAP-70 and CD38 in 19 cases with de novo B-PLL. Immunoglobulin heavy chain genes
J A Zoladz et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 65(3), 441-448 (2014-06-17)
It has been demonstrated that physical training increases serum brain-derived neurotrophic factor (BDNF) in healthy people. The aim of this study was to establish the effect of physical training on the basal serum level of the BDNF in the Parkinson's
Amira F A Hussein et al.
Antiviral research, 177, 104782-104782 (2020-03-31)
Influenza A viruses (IAVs) cause seasonal flu and occasionally pandemics. The current therapeutics against IAVs target two viral proteins - neuraminidase (NA) and M2 ion-channel protein. However, M2 ion channel inhibitors (amantadine and rimantadine) are no longer recommended by CDC
Michael P Hutchens et al.
American journal of physiology. Renal physiology, 303(3), F377-F385 (2012-05-25)
Emerging evidence suggests that renal endothelial function may be altered in ischemia-reperfusion injury. Acute kidney injury is sexually dimorphic, and estrogen protects renal tubular function after experimental ischemic injury. This study tested the hypothesis that during ischemia-reperfusion, estrogen alters glomerular
Sam R J Hoare et al.
Peptides, 23(5), 989-998 (2002-06-27)
Parathyroid hormone 1 (PTH1) receptor antagonists might be of benefit in hypercalcemia of malignancy (HHM) and hyperparathyroidism. We previously identified bovine tuberoinfundibular peptide (7-39) (bTIP(7-39)) as a high-affinity PTH1 receptor antagonist. Mouse TIP(7-39) is an antagonist (rPTH1 K(B)=44 nM, rPTH2=940
Yangyang Feng et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 65(11), 1988-1993 (2012-05-18)
The anaerobic treatability of purified terephthalic acid (PTA) wastewater in a novel, rapid mass-transfer fluidized bed reactor using brick particles as porous carrier materials was investigated. The reactor operation was stable after a short 34 day start-up period, with chemical
G Klaus et al.
Endocrinology, 135(4), 1307-1315 (1994-10-01)
We investigated possible interaction of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] and PTH on: 1) proliferation (monolayer culture) and colony formation (agarose stabilized suspension cultures); 2) expression of 1,25-(OH)2D3 receptor (VDR); and 3) cAMP response to PTH, using primary cultures of chondrocytes from
Giuseppe Cancello et al.
Clinical breast cancer, 15(4), 259-265 (2015-05-03)
The aggressive biological behavior and the lack of target therapy prompts the search for new therapeutic approaches for triple-negative breast cancers. We evaluated the efficacy in terms of Ki-67 variation and clinical response but also the toxicity of a neoadjuvant
C Fairley et al.
Journal of inherited metabolic disease, 31(6), 738-744 (2008-11-04)
Gaucher disease is a lysosomal storage disorder caused by a deficiency of the enzyme acid beta-glucosidase. The most prevalent mutant genotype in type I Gaucher disease, N370S/N370S, is commonly thought to confer a mild phenotype presenting in adulthood. To characterize
Kevin J Cummings et al.
The Journal of physiology, 589(Pt 8), 2055-2064 (2011-04-14)
Based on previous studies in adult animals, devoid of 5-HT neurones, showing altered thermoregulation in cold stress (4°C) and a reduced ventilatory response to CO₂, we hypothesized that neonatal mice lacking 60-70% of their 5-HT neurones (Pet-1(-/-)) would have: (1)
R L McKee et al.
Endocrinology, 127(1), 76-82 (1990-07-01)
In the design and biological evaluation of PTH antagonists, certain analogs, although antagonists in vitro, possess partial agonist properties in vivo that preclude their utility as antagonists. In an effort to identify weak agonism of PTH analogs, an attempt was
David J Maron et al.
The American journal of cardiology, 111(11), 1557-1562 (2013-03-30)
In the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) study, a revascularization strategy trial with optimal medical therapy in both arms, the low-density lipoprotein (LDL) cholesterol goal was 60 to 85 mg/dl; this was revised to <70 mg/dl
L G Rao et al.
Endocrinology, 117(4), 1632-1638 (1985-10-01)
Most studies of PTH receptor binding have been carried out with amino-terminal radioligands which only detect binding within that region of the hormone molecule. We studied the binding of electrolytically labeled intact bovine PTH [bPTH-(1-84)], and its amino-terminal fragment, bPTH-(1-34)
Julian D Harris et al.
Human molecular genetics, 11(1), 43-58 (2002-01-05)
Apolipoprotein E (apoE) is a 34 kDa glycoprotein with multiple actions that help protect against the development of atherosclerosis. Here, we have assessed the atheroprotective potential of an [E1(-), E3(-), polymerase(-)] adenovirus vector expressing human apoE, comparing intramuscular and intravenous
Yang Hu et al.
Experimental and therapeutic medicine, 17(5), 3717-3726 (2019-04-17)
The determination of potential transplantable substrates and substitution cells for corneal endothelium transplantation may compensate for the shortage of cornea donors. Appropriate biodegradable and biocompatible tissue-engineered substratum with seed cells for endothelial keratoplasty has been increasingly studied. In the present
Katherine D Dietzel et al.
Journal of chromatography. A, 1093(1-2), 11-20 (2005-10-20)
Jet Propellant 8 (JP-8) jet fuel is a kerosene-based fuel containing hundreds of hydrocarbons used by the military in NATO countries. Previous rodent inhalation studies carried out with aerosolized JP-8 never evaluated the exposure chamber atmosphere. For this reason, our
T Ashley et al.
Chromosoma, 102(2), 112-120 (1993-01-01)
A "hot spot" of meiotic recombination has been found in males on murine chromosome 8 using nonisotopic hybridization of a series of probes to mitotic and meiotic chromosomes. The sequences responsible for this enhanced recombination are the telomeric repeats. Mice
M R Roby et al.
Environmental health perspectives, 69, 215-220 (1986-11-01)
The excretion and tissue distribution of [1-14C]dichloroacetonitrile and [2-14C]dichloroacetonitrile were studied in male Fischer 344 rats and male B6C3F1 mice. Three dose levels of dichloroacetonitrile (DCAN) (0.2, 2, or 15 mg/kg) were administered to rats and two dose levels of
D K Kim et al.
Bioorganic & medicinal chemistry, 7(8), 1715-1725 (1999-09-11)
A series of 2-amino-9-(3-acyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purin es (1-8) and 2-amino-9-(3-alkoxycarbonyl-oxymethyl-4-alkoxycarbonyloxybut -1-yl)purines (9-12) were synthesized as potential prodrugs of penciclovir. Treatment of 6-deoxypenciclovir with trimethyl orthoacetate or triethyl orthopropionate (1.2 equiv) in DMF in the presence of p-TsOH.H2O (0.1 equiv) followed by quenching
Gregory J Riely et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 12(3 Pt 1), 839-844 (2006-02-10)
In patients with non-small cell lung cancer (NSCLC), mutations in the epidermal growth factor receptor (EGFR) tyrosine kinase domain have been associated with sensitivity to erlotinib and gefitinib. We undertook this study to explore the relationship between EGFR mutation type
James E Anderson et al.
Water environment research : a research publication of the Water Environment Federation, 81(4), 357-364 (2009-05-19)
Membrane bioreactors (MBRs) have been installed at automotive plants to treat metalworking fluid (MWF) wastewaters, which are known to contain toxic and/or recalcitrant organic compounds. A laboratory study was conducted to evaluate treatment of a simulated wastewater prepared from a
Francesca Vitali et al.
Animals : an open access journal from MDPI, 10(2) (2020-02-23)
Etorphine-azaperone immobilisation was evaluated for translocation of Masai giraffes. Nine giraffes were darted with 0.012 ± 0.001 mg/kg etorphine and 0.07 ± 0.01 mg/kg azaperone. Once ataxic, giraffes were roped for recumbency and restrained manually. Naltrexone (3 mg/mg etorphine) was
Erica Miraglia et al.
Reproduction (Cambridge, England), 141(1), 47-54 (2010-10-23)
Nitric oxide (NO), a modulator of several physiological processes, is involved in different human sperm functions. We have investigated whether NO may stimulate the motility of human spermatozoa via activation of the soluble guanylate cyclase (sGC)/cGMP pathway. Sperm samples obtained
S Hossein Fatemi et al.
Cellular and molecular neurobiology, 22(2), 139-152 (2002-10-05)
1. Autism is a severe neurodevelopmental disorder with potential genetic and environmental etiologies. Recent genetic linkage reports and biochemical analysis of postmortem autistic cerebellum point to Reelin, an important secretory extracellular protein, as being involved in the pathology of autism.
Netta Mäkinen et al.
European journal of human genetics : EJHG, 21(11), 1300-1303 (2013-02-28)
Uterine leiomyomas, or fibroids, are the most common human tumors. Based on histopathology, they can be divided into common leiomyomas and various relatively rare subtypes that mimic malignancy in one or more aspects. Recently, we showed that exon 2 of
Phoenix A Ho et al.
Blood, 116(5), 702-710 (2010-04-24)
Recent studies of WT1 mutations in acute myeloid leukemia (AML) mostly report an association with unfavorable clinical outcome. We screened 842 patients treated on 3 consecutive pediatric AML trials for WT1 zinc-finger mutations. Eighty-five mutations were detected in 70 of
Shiva S Forootan et al.
Human pathology, 38(9), 1321-1329 (2007-06-30)
The levels of Id-1 (inhibitor of DNA binding or inhibitor of cell differentiation) expression in a series of prostate cell lines and in an archival set of prostate tissues were examined. Western blot analysis showed that the level of Id-1
Eric L Greidinger et al.
Arthritis and rheumatism, 54(2), 661-669 (2006-02-03)
To test whether immunizing mice with autoantigens closely linked to mixed connective tissue disease (MCTD) could induce an MCTD-like clinical syndrome distinguishable from systemic lupus erythematosus (SLE). Transgenic and knockout C57BL/6-derived mice were immunized subcutaneously at age 8-12 weeks with
Jordan Stubleski et al.
Environment international, 95, 86-92 (2016-08-21)
Poly- and perfluoroalkyl substances (PFASs) are a group of man-made fluorinated chemicals which have, at background levels, been associated with negative health effects in humans. Thus far, most human biomonitoring studies have evaluated the general change in PFAS concentration over
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