70-53-1

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Genetic analysis of TTF-2 gene in children with congenital hypothyroidism and cleft palate, congenital hypothyroidism, or isolated cleft palate.

Massimo Tonacchera et al.

Thyroid : official journal of the American Thyroid Association, 14(8), 584-588 (2004-08-24)

Homozygous null mice for thyroid transcription factor (TTF)-2 gene exhibit cleft palate and thyroid malformation. We performed a genetic analysis of the TTF-2 gene in 2 children with congenital hypothyroidism (CH) and cleft palate, 45 children with thyroid dysgenesis, 19

[Multiresidue analysis of pesticides in agricultural products by GC/MS, GC-ECD and GC-FTD using acetonitrile extraction and clean-up with mini-columns].

Harumi Kondo et al.

Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan, 44(3), 161-167 (2003-09-13)

An analytical method was developed for determination of organochlorine, pyrethroid and nitrogen-containing pesticide residues in agricultural products by GC/MS, GC-ECD and GC-FTD. Pesticides were extracted with acetonitrile, and the organic layer was cleaned up on C18 and ENVI-Carb/LC-NH2 cartridges. Pesticides

Molecular analysis of the ERGIC-53 gene in 35 families with combined factor V-factor VIII deficiency.

M Neerman-Arbez et al.

Blood, 93(7), 2253-2260 (1999-03-26)

Combined factor V-factor VIII deficiency (F5F8D) is a rare, autosomal recessive coagulation disorder in which the levels of both coagulation factors V and VIII are diminished. The F5F8D locus was previously mapped to a 1-cM interval on chromosome 18q21. Mutations

High molecular weight insulin-like growth factor binding protein complex. Purification and properties of the acid-labile subunit from human serum.

R C Baxter et al.

The Journal of biological chemistry, 264(20), 11843-11848 (1989-07-15)

In the human circulation, the insulin-like growth factors (IGFs) circulate as part of a growth hormone-dependent 125- to 150-kDa complex. This complex has been postulated to contain, in addition to IGFs and one or more IGF-binding proteins, an acid-labile subunit

Continuous clindamycin infusion, an innovative approach to treating bone and joint infections.

Valérie Zeller et al.

Antimicrobial agents and chemotherapy, 54(1), 88-92 (2009-10-21)

The feasibility, safety, and efficacy of prolonged, continuous, intravenous clindamycin therapy were retrospectively evaluated for 70 patients treated for bone and joint infections, 40% of whom were treated as outpatients. The median treatment duration was 40 days, the median daily

Region of elongation factor 1A1 involved in substrate recognition by Legionella pneumophila glucosyltransferase Lgt1: identification of Lgt1 as a retaining glucosyltransferase.

Yury Belyi et al.

The Journal of biological chemistry, 284(30), 20167-20174 (2009-05-30)

Lgt1 is one of the glucosyltransferases produced by the Gram-negative bacterium Legionella pneumophila. This enzyme modifies eukaryotic elongation factor 1A (eEF1A) at serine 53, which leads to inhibition of protein synthesis and death of target cells. Here we studied the

IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL).

I Del Giudice et al.

Leukemia, 20(7), 1231-1237 (2006-04-28)

B-prolymphocytic leukemia (B-PLL) is a rare disease with poor prognosis. To further characterize the biological features of this disease, we analyzed immunoglobulin heavy chain (IgVH) mutations, ZAP-70 and CD38 in 19 cases with de novo B-PLL. Immunoglobulin heavy chain genes

Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor.

P Franzén et al.

Cell, 75(4), 681-692 (1993-11-19)

A cDNA clone encoding a 53 kd serine/threonine kinase receptor with an overall structure similar to that of the type II receptor for transforming growth factor beta (TGF beta) was obtained. 125I-TGF beta 1 bound to porcine endothelial cells transfected

A novel HLA (HLA-A*0201) transgenic rabbit model for preclinical evaluation of human CD8+ T cell epitope-based vaccines against ocular herpes.

Aziz A Chentoufi et al.

Journal of immunology (Baltimore, Md. : 1950), 184(5), 2561-2571 (2010-02-04)

We introduced a novel humanized HLA-A*0201 transgenic (HLA Tg) rabbit model to assess the protective efficacy of a human CD8(+) T cell epitope-based vaccine against primary ocular herpes infection and disease. Each of the three immunodominant human CD8(+) T cell

Phaeochromocytoma in the Hong Kong Chinese population.

Joyce S Y Yau et al.

Hong Kong medical journal = Xianggang yi xue za zhi, 16(4), 252-256 (2010-08-05)

To review the clinical manifestations of phaeochromocytoma in a Hong Kong Chinese population. Retrospective review. SETTING. Five public hospitals in Hong Kong. Seventeen patients with operated phaeochromocytoma between 1994 and 2003 were reviewed retrospectively. Six patients (35%) were men, 11

Development of an Automated Column Solid-Phase Extraction Cleanup of QuEChERS Extracts, Using a Zirconia-Based Sorbent, for Pesticide Residue Analyses by LC-MS/MS.

Bruce D Morris et al.

Journal of agricultural and food chemistry, 63(21), 5107-5119 (2015-02-24)

A new, automated, high-throughput, mini-column solid-phase extraction (c-SPE) cleanup method for QuEChERS extracts was developed, using a robotic X-Y-Z instrument autosampler, for analysis of pesticide residues in fruits and vegetables by LC-MS/MS. Removal of avocado matrix and recoveries of 263

A phase Ib GOELAMS study of the mTOR inhibitor RAD001 in association with chemotherapy for AML patients in first relapse.

S Park et al.

Leukemia, 27(7), 1479-1486 (2013-01-17)

The mTORC1 signaling pathway is constitutively activated in almost all acute myelogenous leukemia (AML) patients. We conducted a phase Ib trial combining RAD001 (everolimus), an allosteric inhibitor of mTORC1, and conventional chemotherapy, in AML patients under 65 years of age

The expression of p53, c-erbB-1 and c-erbB-2 molecules and their correlation with prognostic markers in patients with head and neck tumors.

Bijan Khademi et al.

Cancer letters, 184(2), 223-230 (2002-07-20)

Molecular prognostic and predictive factors have extensively been studied in different cancers during the past decades, some of which were found to be useful in diagnosis, follow up or even treatment of some malignant tumors. To assess the significance of

Topical treatment of dermatophytosis and cutaneous candidosis with flutrimazole 1% cream: double-blind, randomized comparative trial with ketoconazole 2% cream.

A del Palacio et al.

Mycoses, 42(11-12), 649-655 (2000-02-19)

In a double-blind, randomized study the efficacy and tolerance of flutrimazole 1% cream were compared with ketoconazole 2% cream, applied once daily for 4 weeks, in 60 patients with culturally proven dermatophytosis (47 patients) or cutaneous candidosis (13 patients). Both

Enhanced expression of a recombinant bacterial laccase at low temperature and microaerobic conditions: purification and biochemical characterization.

Mahdi Mohammadian et al.

Journal of industrial microbiology & biotechnology, 37(8), 863-869 (2010-05-18)

Laccases (benzenediol oxygen oxidoreductase; EC 1.10.3.2) have many biotechnological applications because of their oxidation ability towards a wide range of phenolic compounds. Within recent years, researchers have been highly interested in the identification and characterization of laccases from bacterial sources.

Diagnostic value of differential expression of CK19, Galectin-3, HBME-1, ERK, RET, and p16 in benign and malignant follicular-derived lesions of the thyroid: an immunohistochemical tissue microarray analysis.

J E Barroeta et al.

Endocrine pathology, 17(3), 225-234 (2007-02-20)

Several immunohistochemical markers have been used to aid in the diagnosis of follicular-derived lesions of the thyroid (FDLT). In this study we analyze the diagnostic efficacy of an immunopanel of antibodies to cytokeratin-19 (CK19), galectin-3 (GAL-3), HBME-1, anti-MAP kinase (ERK)

The CR1 C5507G polymorphism is not involved in susceptibility to idiopathic pulmonary fibrosis in two European populations.

Z Kubistova et al.

Tissue antigens, 72(5), 483-486 (2008-10-22)

Idiopathic pulmonary fibrosis (IPF), a severe lung disease with unknown aetiology, is thought to have an important genetic component. Single nucleotide polymorphism, C5507G, of the complement receptor 1 (CR1) gene, which affects the number of CR1 molecules on erythrocytes, has

Localization of thrombin cleavage sites in the amino-terminal region of bovine protein S.

B Dahlbäck et al.

The Journal of biological chemistry, 261(11), 5111-5115 (1986-04-15)

Protein S is a vitamin K-dependent plasma protein. It functions as a cofactor to activated protein C in the inactivation of factors Va and VIIIa by limited proteolysis. Protein S is very sensitive to proteolysis by thrombin which reduces its

Poly(Ionic Liquid) Semi-Interpenetrating Network Multi-Responsive Hydrogels.

Alexandru Tudor et al.

Sensors (Basel, Switzerland), 16(2), 219-219 (2016-02-11)

Herein we describe poly(ionic liquid) hydrogel actuators that are capable of responding to multiple stimuli, namely temperature, ionic strength and white light irradiation. Using two starting materials, a crosslinked poly ionic liquid (PIL) and a linear poly(N-isopropylacrylamide-co-spiropyran-co-acrylic acid), several semi-interpenetrating

Targeted mutation reveals a central role for SR-BI in hepatic selective uptake of high density lipoprotein cholesterol.

M L Varban et al.

Proceedings of the National Academy of Sciences of the United States of America, 95(8), 4619-4624 (1998-05-16)

Scavenger receptor BI (SR-BI) is a cell surface receptor that binds high density lipoproteins (HDL) and mediates selective uptake of HDL cholesteryl esters (CE) in transfected cells. To address the physiological role of SR-BI in HDL cholesterol homeostasis, mice were

Contact dermatitis of the feet: a study of 53 cases.

Rosana Lazzarini et al.

Dermatitis : contact, atopic, occupational, drug, 15(3), 125-130 (2005-02-24)

Contact dermatitis of the feet is a common dermatosis that very often makes patients unable to perform daily activities. The differential diagnosis should be made with other dermatoses, such as tinea, atopic dermatitis, psoriasis, dyshidrosis, and nummular eczema. It is

Second-line chemotherapy with paclitaxel and doxifluridine after failure of S-1 in elderly patients with unresectable advanced or recurrent gastric cancer.

Tomomi Yakabe et al.

Journal of cancer research and clinical oncology, 137(10), 1499-1504 (2011-08-11)

There is no standard second-line treatment for patients with unresectable advanced or recurrent gastric cancer (URGC) in the event that first-line treatment fails. Moreover, the benefits of second-line chemotherapy in elderly patients remain uncertain. The aim of this study was

Mice transgenically overexpressing sulfonylurea receptor 1 in forebrain resist seizure induction and excitotoxic neuron death.

C Hernández-Sánchez et al.

Proceedings of the National Academy of Sciences of the United States of America, 98(6), 3549-3554 (2001-03-15)

The ability of the sulfonylurea receptor (SUR) 1 to suppress seizures and excitotoxic neuron damage was assessed in mice transgenically overexpressing this receptor. Fertilized eggs from FVB mice were injected with a construct containing SUR cDNA and a calcium-calmodulin kinase

Preventive administration of UDCA after liver transplantation for primary biliary cirrhosis is associated with a lower risk of disease recurrence.

Alexie Bosch et al.

Journal of hepatology, 63(6), 1449-1458 (2015-08-19)

Recurrence of primary biliary cirrhosis (PBC) after liver transplantation (LT) is not rare and can occasionally lead to severe graft dysfunction and retransplantation. Ursodeoxycholic acid (UDCA) is a safe and effective treatment for PBC. However, whether preventive administration of UDCA

Copeptin is independently associated with vascular calcification in chronic kidney disease stage 5.

Edyta Golembiewska et al.

BMC nephrology, 21(1), 43-43 (2020-02-09)

Vascular calcification (VC) is an independent predictor of cardiovascular disease (CVD) present in 30-70% of patients with chronic kidney disease (CKD). Copeptin is a sensitive surrogate marker of arginine vasopressin (AVP), which is involved in many pathophysiologic processes in CKD.

Improvement in the selectivity and metabolic stability of the serotonin 5-HT(1A) ligand, S 15535: a series of cis- and trans-2-(arylcycloalkylamine) 1-indanols.

Jean-Louis Peglion et al.

Journal of medicinal chemistry, 45(1), 165-176 (2002-01-05)

S 15535 (1) displays a distinctive profile of agonist and antagonist (weak partial agonist) activity at pre- and postsynaptic 5-HT(1A) receptors, respectively. It has proven to be active in several models predictive of anxiolytic, antidepressant, and procognitive properties. In an

Binding of intact parathyroid hormone to rat osteosarcoma cells: major contribution of binding sites for the carboxyl-terminal region of the hormone.

L G Rao et al.

Endocrinology, 117(4), 1632-1638 (1985-10-01)

Most studies of PTH receptor binding have been carried out with amino-terminal radioligands which only detect binding within that region of the hormone molecule. We studied the binding of electrolytically labeled intact bovine PTH [bPTH-(1-84)], and its amino-terminal fragment, bPTH-(1-34)

Oral dimenhydrinate versus placebo in children with gastroenteritis: a randomized controlled trial.

Serge Gouin et al.

Pediatrics, 129(6), 1050-1055 (2012-05-16)

To evaluate the efficacy and safety of oral dimenhydrinate in the treatment of acute gastroenteritis. This was a randomized, double-blind, placebo-controlled trial conducted in the emergency department of a pediatric university-affiliated center. Children 1 to 12 years old who presented

Low-frequency spectra of the hexamethylbenzene/tetracyanoethylene electron donor-acceptor complexes in solution studied by terahertz time-domain spectroscopy.

Kohji Yamamoto et al.

Physical chemistry chemical physics : PCCP, 7(9), 1945-1952 (2005-05-07)

We have measured the frequency dependent extinction coefficients and refractive indices of electron donor-acceptor (EDA) complexes consisting of hexamethylbenzene (HMB; electron donor) and tetracyanoethylene (TCNE; electron acceptor) in the low-frequency region by terahertz time-domain spectroscopy (THz-TDS). A mixture of the

Brain-derived neurotrophic factor (Val66Met) polymorphism does not influence recovery from a post-traumatic vegetative state: a blinded retrospective multi-centric study.

Sergio Bagnato et al.

Journal of neurotrauma, 29(11), 2050-2059 (2012-06-20)

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that influences neuronal plasticity throughout life. Emergence from a vegetative state (VS) after a traumatic brain injury (TBI) implies that the brain undergoes plastic changes. A common polymorphism in the BDNF gene--BDNF Val66Met

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