700001P

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Cationic liposome (DC-Chol/DOPE=1:2) and a modified ethanol injection method to prepare liposomes, increased gene expression.

Yoshie Maitani et al.

International journal of pharmaceutics, 342(1-2), 33-39 (2007-06-15)

Cationic liposomes composed of 3beta-[N-(N',N'-dimethylaminoethane)-carbamoyl] cholesterol (DC-Chol) and dioleoylphosphatidylethanolamine (DOPE) (DC-Chol/DOPE liposome, molar ratio, 1:1 or 3:2) prepared by the dry-film method have been often used as non-viral gene delivery vectors. The formulation and preparation of DC-Chol/DOPE liposomes, as well

A mechanistic explanation of the inhibitory role of the protein corona on liposomal gene expression.

Sara Palchetti et al.

Biochimica et biophysica acta. Biomembranes, 1862(3), 183159-183159 (2019-12-21)

The past three decades have witnessed fast advances in the use of cationic liposome-DNA complexes (lipoplexes) for gene delivery applications. However, no lipoplex formulation has reached into the clinical practice so far. The primary drawback limiting clinical use of lipoplexes

Cabazitaxel-Loaded Nanocarriers for Cancer Therapy with Reduced Side Effects

Kommineni N, et al.

Pharmaceutics, 11(3) (2019)

Non-viral dried powders for respiratory gene delivery prepared by cationic and chitosan loaded liposomes.

C Colonna et al.

International journal of pharmaceutics, 364(1), 108-118 (2008-09-09)

The aim of this work was to investigate lipid-based dried powders as transfection competent carriers capable of promoting the expression of therapeutic genes. The lipid-based vectors were prepared by combining different cationic lipids 1,2-dioleoyl-3-trimethylammoniumpropane chloride (DOTAP), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)

Cationic nanoliposomes meet mRNA: efficient delivery of modified mRNA using hemocompatible and stable vectors for therapeutic applications

Michel T, et al.

Molecular Therapy, 8, 459-468 (2017)

Lipid-encapsulated oral therapeutic peptide vaccines reduce tumour growth in an orthotopic mouse model of colorectal cancer.

Milda Naciute et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 152, 183-192 (2020-05-08)

The aim of this study was to develop an oral vaccine that could be used to treat colorectal cancer. Oral vaccines are technically challenging to develop due to the harsh gastric environment but have numerous benefits including high patient acceptability

Pharmaceutical Chemistry ? I, 142-142 (2003)

Cationic cage-like complexes formed by DC-cholesterol, Quil-A, and phospholipid

Lendemans DG, et al.

Journal of Pharmaceutical Sciences, 94(8), 1794-1807 (2005)

Modulation of yeast hexokinase on bio-inspired membranes

Umakoshi H and Nishida A

Biochemical Engineering Journal, 69(5), 138-143 (2012)

ADP-ribosylation reactions, 948-948 (2001)

Preferential Adsorption of l-Histidine onto DOPC/Sphingomyelin/3β-[N-(N',N'-dimethylaminoethane)carbamoyl]cholesterol Liposomes in the Presence of Chiral Organic Acids.

Keishi Suga et al.

Langmuir : the ACS journal of surfaces and colloids, 33(15), 3831-3838 (2017-03-09)

We investigated the effect of organic acids such as mandelic acid (MA) and tartaric acid (TA) on the adsorption behavior of both histidine (His) and propranolol (PPL) onto liposomes. A cationic and heterogeneous liposome prepared using 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/sphingomyelin (SM)/3β-[N-(N',N'-dimethylaminoethane)carbamoyl]cholesterol (DC-Ch)

Tuning liposome composition to modulate corona formation in human serum and cellular uptake.

Keni Yang et al.

Acta biomaterialia, 106, 314-327 (2020-02-23)

Nano-sized objects such as liposomes are modified by adsorption of biomolecules in biological fluids. The resulting corona critically changes nanoparticle behavior at cellular level. A better control of corona composition could allow to modulate uptake by cells. Within this context

Cationic liposome (DC-Chol/DOPE= 1: 2) and a modified ethanol injection method to prepare liposomes, increased gene expression

Maitani Y, et al

International Journal of Pharmaceutics, 342(1-2), 33-39 (2007)

PLGA/liposome hybrid nanoparticles for short-chain ceramide delivery

Zou P, et al.

Pharmaceutical Research, 31(3), 684-693 (2014)

KSP siRNA/paclitaxel-loaded PEGylated cationic liposomes for overcoming resistance to KSP inhibitors: Synergistic antitumor effects in drug-resistant ovarian cancer.

Jinju Lee et al.

Journal of controlled release : official journal of the Controlled Release Society, 321, 184-197 (2020-02-09)

Despite the promising anticancer effects of kinesin spindle protein (KSP) inhibition, functional plasticity of kinesins induced resistance against KSP inhibitors in a variety of cancers, leading to clinical failure. Additionally, paclitaxel is a widely used anticancer agent, but drug resistance

Design of novel proliposome formulation for antioxidant peptide, glutathione with enhanced oral bioavailability and stability

Byeon JC, et al.

Drug delivery, 26(1), 216?225-216?225 (2019)

Effect of sugars on storage stability of lyophilized liposome/DNA complexes with high transfection efficiency.

Yoshie Maitani et al.

International journal of pharmaceutics, 356(1-2), 69-75 (2008-02-06)

Cationic lipid-based gene delivery systems have shown promise in transfecting cells in vitro and in vivo. However, liposome/DNA complexes tend to form aggregates after preparation. Lyophilization of these systems, therefore, has become of increasing interest. In this study, we investigated

Novel cholesterol-based cationic lipids as transfecting agents of DNA for efficient gene delivery

Ju J, et al.

International Journal of Molecular Sciences, 16(3), 5666-5681 (2015)

Ultrasound microbubble-mediated CRISPR/Cas9 knockout of C-erbB-2 in HEC-1A cells

Cai J, et al.

The Journal of International Medical Research, 47(5), 2199-2206 (2019)

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