70800

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Identification of a novel ligand binding motif in the transthyretin channel.

Luis Mauricio T R Lima et al.

Bioorganic & medicinal chemistry, 18(1), 100-110 (2009-12-04)

The design of therapeutic compounds targeting transthyretin (TTR) is challenging due to the low specificity of interaction in the hormone binding site. Such feature is highlighted by the interactions of TTR with diclofenac, a compound with high affinity for TTR

[An interesting peroxidase staining.--utilization of blended substrate of mixed 2, 7-FDA and Laurent's acid-- (author's transl)].

Y Niwa et al.

Rinsho byori. The Japanese journal of clinical pathology, 29(6), 613-616 (1981-06-01)

Fluorescent nucleotide triphosphate substrates for snake venom phosphodiesterase.

S E Pollack et al.

Analytical biochemistry, 127(1), 81-88 (1982-11-15)

Fluorescent nucleotides: application in a fluorescence immune assay.

R R Kardost et al.

Molecular immunology, 19(1), 159-170 (1982-01-01)

A fluorescence immune assay designed to measure anti-nucleotide antibody activity is described based on the synthesis of a fluorescent nucleotide probe possessing a low fluorescence quantum yield when free in aqueous solution (neutral pH). The fluorophore, AmNS (1-naphthylamine-5-sulfonic acid), was

Synthesis and characterization of stacked and quenched uridine nucleotide fluorophores.

G Dhar et al.

The Journal of biological chemistry, 274(21), 14568-14572 (1999-05-18)

Intramolecular aromatic interactions in aqueous solution often lead to stacked conformation for model organic molecules. This designing principle was used to develop stacked and folded uridine nucleotide analogs that showed highly quenched fluoroscence in aqueous solution by attaching the fluorophore

Evidence for a ppGpp-binding site on Escherichia coli RNA polymerase: proximity relationship with the rifampicin-binding domain.

P S Reddy et al.

Molecular microbiology, 15(2), 255-265 (1995-01-01)

On amino acid starvation, Escherichia coli cells exhibit an adaptive facility termed the stringent response. This is characterized by the production of high levels of a regulatory nucleotide, ppGpp, and concomitant curtailment in rRNA synthesis. Various studies reported earlier indicated

Small molecules as potent biphasic modulators of protein liquid-liquid phase separation.

W Michael Babinchak et al.

Nature communications, 11(1), 5574-5574 (2020-11-06)

Liquid-liquid phase separation (LLPS) of proteins that leads to formation of membrane-less organelles is critical to many biochemical processes in the cell. However, dysregulated LLPS can also facilitate aberrant phase transitions and lead to protein aggregation and disease. Accordingly, there

Synthesis and characterization of fluorescent dinucleotide substrate for the DNA-dependent RNA polymerase from Escherichia coli.

S C Tyagi et al.

The Journal of biological chemistry, 262(22), 10684-10688 (1987-08-05)

New fluorescent derivatives of dinucleoside monophosphates, (5'-AmNS)UpA/ApU/GpU/CpA, with a fluorophore, 1-aminonaphthalene-5-sulfonic acid (AmNS), attached to the first nucleotide of the dinucleoside monophosphates via a 5'-secondary amine linkage were synthesized in good yield. The chemical structure of (5'-AmNS)ApU was proved by

Catalytic Production of Oxo-fatty Acids by Lipoxygenases Is Mediated by the Radical-Radical Dismutation between Fatty Acid Alkoxyl Radicals and Fatty Acid Peroxyl Radicals in Fatty Acid Assembly.

Yuta Takigawa et al.

Chemical & pharmaceutical bulletin, 68(3), 258-264 (2020-03-03)

Oxo-octadecadienoic acids (OxoODEs) act as peroxisome proliferator-activated receptor (PPAR) agonists biologically, and are known to be produced in the lipoxygenase/linoleate system. OxoODEs seem to originate from the linoleate alkoxyl radicals that are generated from (E/Z)-hydroperoxy octadecadienoic acids ((E/Z)-HpODEs) by a

HPLC-MSn and GC-MS methods to study sunlight and UV-lamp degradations of 1-amino-5-naphthalene sulfonate.

V Gianotti et al.

Chemosphere, 67(10), 1993-1999 (2007-01-26)

HPLC-DAD, HPLC-MS/MS, GC-MS and spectrophotometric methods are employed to investigate the degradation process of sodium 1-amino-5-naphthalene sulfonate (1A5NS) aqueous solutions, when exposed to sunlight and UV-lamp (254 nm) irradiations. Experimental results show that both sunlight and 254 nm UV-lamp irradiations

Controlling {beta}-amyloid oligomerization by the use of naphthalene sulfonates: trapping low molecular weight oligomeric species.

Astria D Ferrão-Gonzales et al.

The Journal of biological chemistry, 280(41), 34747-34754 (2005-07-26)

Aggregation of proteins and peptides has been shown to be responsible for several diseases known as amyloidoses, which include Alzheimer disease (AD), prion diseases, among several others. AD is a neurodegenerative disorder caused primarily by the aggregation of beta-amyloid peptide

Fluorescence of intramolecular and intermolecular interactions of aminonaphthyl-sulfonate with nucleotides.

J Fick et al.

European journal of biochemistry, 126(2), 367-372 (1982-08-01)

Fluorescence studies of the intramolecular and intermolecular interactions between aminonaphthylsulfonate and nucleotides of uracil or adenine are described. The fluorescence originates solely from the naphthyl moiety and is intramolecularly quenched by the base, uracil being more effective than adenine. The

An arginine residue is essential for stretching and binding of the substrate on UDP-glucose-4-epimerase from Escherichia coli. Use of a stacked and quenched uridine nucleotide fluorophore as probe.

U Bhattacharyya et al.

The Journal of biological chemistry, 274(21), 14573-14578 (1999-05-18)

In the previous paper we demonstrated that uridine-5'-beta-1-(5-sulfonic acid) naphthylamidate (UDPAmNS) is a stacked and quenched fluorophore that shows severalfold enhancement of fluorescence in a stretched conformation. UDPAmNS was found to be a powerful competitive inhibitor (Ki = 0.2 mM)

Interactions of pyridoxal kinase and aspartate aminotransferase emission anisotropy and compartmentation studies.

Y T Kim et al.

The Journal of biological chemistry, 263(27), 13712-13717 (1988-09-25)

Physical interactions between pyridoxal kinase and aspartate aminotransferase were detected by means of emission anisotropy and affinity chromatography techniques. Binding of aspartate aminotransferase (apoenzymes) to pyridoxal kinase tagged with a fluorescent probe was detected by emission anisotropy measurements at pH

Nucleotide modification at the gamma-phosphate leads to the improved fidelity of HIV-1 reverse transcriptase.

Brent A Mulder et al.

Nucleic acids research, 33(15), 4865-4873 (2005-09-06)

The mechanism by which HIV-1 reverse transcriptase (HIV-RT) discriminates between the correct and incorrect nucleotide is not clearly understood. Chemically modified nucleotides containing 1-aminonaphthalene-5-sulfonate (ANS) attached to their gamma-phosphate were synthesized and used to probe nucleotide selection by this error

Structure and Bioactive Properties of Novel Textile Dyes Synthesised by Fungal Laccase.

Jolanta Polak et al.

International journal of molecular sciences, 21(6) (2020-03-21)

Novel sustainable processes involving oxidative enzymatic catalysts are considered as an alternative for classical organic chemistry. The unique physicochemical and bioactive properties of novel bio-products can be obtained using fungal laccase as catalyst. Among them are textile biodyes synthesised during

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