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Yuming Hu et al.
Journal of chromatographic science, 50(9), 785-791 (2012-05-31)
A high-performance liquid chromatographic method coupled with electrospray mass spectrometry was developed for the simultaneous determination of dolasetron and its major metabolite, hydrodolasetron, in human plasma. A new sample pretreatment method, i.e., salt induced phase separation extraction (SIPSE), was proposed
Rouhollah Khodadust et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 68(8), 979-987 (2014-12-03)
The objective of this study was to develop and evaluate the anticancer activity and the safety of a combinational drug delivery system using polyamidoamine (PAMAM) dendrimer-coated iron oxide nanoparticles for doxorubicin and poly I:C delivery in vitro. Dendrimer-coated magnetic nanoparticles
Elena Geromichalou et al.
European journal of medicinal chemistry, 96, 47-57 (2015-04-16)
Recent science evidenced the interlinkage of oxidative stress and cancer. Due to the inherent complexity of cancer and its accompanying effect of oxidative stress, novel molecules, containing combinatorial functionalities should be targeted. Herein, we synthesized gemcitabine-5'-O-lipoate derived from a regioselective
Franziska Kaplan et al.
Micron (Oxford, England : 1993), 44, 317-330 (2012-09-11)
The osmotic potential and effects of plasmolysis on photosynthetic oxygen evolution and chlorophyll fluorescence were studied in two Arctic Zygnema sp. (strain B, strain G) and two Antarctic Zygnema sp. (strain E, strain D). Antarctic strain D was newly characterized
Elie Simard et al.
PloS one, 10(8), e0128881-e0128881 (2015-08-08)
Increased blood glucose concentrations promote reactions between glucose and proteins to form advanced glycation end-products (AGE). Circulating AGE in the blood plasma can activate the receptor for advanced end-products (RAGE), which is present on both endothelial and vascular smooth muscle
Antibiotic Disc Assay for Measuring Cell Wall Function in Synechocystis sp. PCC6803
Cheregi O and Funk C
Bio-protocol, 6(24), 283-291 (2016)
Sarah Afshordel et al.
Pharmacological research, 91, 69-77 (2014-12-17)
Alterations in small GTPase mediated signal transduction pathways have emerged as a central step in the molecular pathogenesis of glioblastoma (GBM), the most common malignant brain tumor in adults. Farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate (GGPP) are derived from mevalonate, whose production
V P Stankov-Jovanović et al.
Journal of pharmaceutical and biomedical analysis, 111, 78-90 (2015-04-12)
Extracts of different polarity obtained from various plant parts (root, leaf, flower and fruit) of Seseli rigidum were studied by different antioxidant assays: DPPH and ABTS radical scavenging activity, by total reducing power method as well as via total content
Meral Turabik et al.
Environmental science and pollution research international, 21(14), 8387-8397 (2014-03-29)
The oxidative degradation of imidacloprid (ICP) has been carried out by electrochemical advanced oxidation processes (EAOPs), anodic oxidation, and electro-Fenton, in which hydroxyl radicals are generated electrocatalytically. Carbon-felt cathode and platinum or boron-doped diamond (BDD) anodes were used in electrolysis
Jun Wang et al.
Chemosphere, 132, 166-171 (2015-04-10)
The susceptibility of vitellogenin (Vtg) to degradation is a major problem affecting the robustness of enzyme-linked immunosorbent assay (ELISA) for goldfish (Carassius auratus) Vtg. In this study, a phospholipoglycoprotein with molecular mass of ∼420kDa was purified from goldfish egg extracts
R Mark Jones et al.
Human vaccines & immunotherapeutics, 11(1), 124-132 (2014-12-09)
Malaria transmission blocking vaccines (TBV) directed against proteins expressed on sexual stages of Plasmodium falciparum in the mosquito midgut are considered an effective means to reduce malaria transmission. Antibodies induced by TBV block sporogonic development in the mosquito, and thus
Zilan Zhou et al.
International journal of pharmaceutics, 487(1-2), 81-90 (2015-04-14)
A dual functional nano-scaled drug carrier, comprising of a targeting ligand and pH sensitivity, has been made in order to increase the specificity and efficacy of the drug delivery system. The nanoparticles are made of a tri-block copolymer, poly(d,l lactide-co-glycolide)
Gang Ren et al.
Pharmaceutical biology, 52(8), 944-950 (2014-02-21)
Searching for polymorphonuclear neutrophils (PMNs) respiratory burst inhibitors is an important topic in the treatment of human diseases associated with inflammation. To investigate the inhibitory effects of phenolics isolated from Artocarpus styracifolius Pierre (Moraceae) on respiratory burst induced by phorbol
Wenyuan Zhang et al.
Connective tissue research, 56(1), 25-34 (2014-10-22)
Natural silk fibroin fiber scaffolds have excellent mechanical properties, but degrade slowly. In this study, we used poly(lactide-co-glycolide) (PLGA, 10:90) fibers to adjust the overall degradation rate of the scaffolds and filled them with collagen to reserve space for cell
Claudia-Crina Toma et al.
Molecules (Basel, Switzerland), 20(6), 9560-9574 (2015-05-29)
This study was performed to evaluate the phenolic profile, antioxidant and diuretic effects of black cumin and lady-in-a-mist seeds. In the phenolic profile, differences between the two species are significant. Qualitative and quantitative analyses of the phenolic compounds were performed
Anna Louise Hillberg et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(3), 503-518 (2014-06-12)
Encapsulation of cells in biocompatible polymer matrices represents a powerful tool for cell-based therapies and therapeutic delivery systems. This technology has successfully been used to deliver pancreatic islets to humans for the treatment of Type 1 diabetes. However, the clinical
Nien-Chi Huang et al.
Acta biomaterialia, 28, 55-63 (2015-09-13)
Gene delivery into cells can be facilitated by adding plasmid DNA/transfection reagent complexes in culture medium or pre-adsorbing the complexes on the substrate before cell seeding. Using transfection reagents, however, often causes cytotoxicity. Effective delivery of naked plasmid without any
Jeong-Yong Cho et al.
Bioscience, biotechnology, and biochemistry, 79(2), 260-270 (2014-10-29)
Changes in chemical constituent contents and DPPH radical-scavenging activity in fruits of pear (Pyrus pyrifolia) cultivars during the development were investigated. The fruits of seven cultivars (cv. Niitaka, Chuhwangbae, Wonhwang, Hwangkeumbae, Hwasan, Manpungbae, and Imamuraaki) were collected at 15-day intervals
D S Morais et al.
Biomedical materials (Bristol, England), 10(5), 055008-055008 (2015-09-24)
The aim of this work was to develop a bioactive bone substitute with an effective antibacterial ability based on a cerium (Ce) doped glass-reinforced hydroxyapatite (GR-HA) composite. Developed composites were physicochemically characterized, using x-ray diffraction (XRD) analysis, SEM, energy dispersive
Pitchaon Maisuthisakul et al.
Journal of food science and technology, 51(8), 1453-1462 (2014-08-13)
Qualitative analysis of hydrolysable extract from mango (Mangifera indica Linn. cultivar Chok-Anan) seed kernel was performed by means of reversed phase high-performance liquid chromatography coupled to diode array detection and electrospray ionization mass spectrometry (RPHPLC-DAD-ESI-MS). The main phenolic compound was
J Correa-Betanzo et al.
Food chemistry, 165, 522-531 (2014-07-21)
Wild blueberries are rich in polyphenols and have several potential health benefits. Understanding the factors that affect the bioaccessibility and bioavailability of polyphenols is important for evaluating their biological significance and efficacy as functional food ingredients. Since the bioavailability of
Yang Wu et al.
The journal of gene medicine, 16(5-6), 109-121 (2014-07-02)
In the present study, a well-defined glucose and guanidine based copolymer, galactosylated 2-hydroxypropyl methacrylamide-s-3-guanidinopropyl methacrylamide (HPMA-s-GPMA) abbreviated as GGH was prepared and self-assembled with small hairpin RNA (shRNA) to inhibit human telomerase reverse transcriptase (hTERT) gene expression in vitro to
Xia Zhang et al.
Journal of integrative plant biology, 55(3), 262-276 (2012-11-28)
Saline-alkali soil seriously threatens agriculture productivity; therefore, understanding the mechanism of plant tolerance to alkaline-salt stress has become a major challenge. Halophytic Puccinellia tenuiflora can tolerate salt and alkaline-salt stress, and is thus an ideal plant for studying this tolerance
Ehsan Karimi et al.
Biological research, 48, 9-9 (2015-03-13)
The present study was conducted in order to evaluate the fatty acid profile, anti-oxidant and anti-bacterial activities from the microwave aqueous extract of the leaves of three different varieties of Labisia pumila Benth. The chemical analysis of the extract showed
Pedro Mena et al.
Natural product communications, 10(6), 1019-1024 (2015-07-23)
This work aimed to assess the effect of combining two pomegranate (Punica granatum L.) cultivars at different rates on the ellagitannin content, antioxidant capacity, and total phenolic content of varietal pomegranate juices. Widely distinct juices made from Mollar de Elche
Hamid Reza Nouri et al.
Immunologic research, 62(3), 280-291 (2015-05-11)
Liposome-protamine-DNA nanoparticles (LPD) are safe, effective, and non-toxic adjuvants that induce Th1-like immune responses. We hypothesized that encapsulation of allergens into liposomes could be an appropriate option for immunotherapy. The present study evaluated the immunotherapeutic potential of a recombinant hybrid
Hye Jung Han et al.
Colloids and surfaces. B, Biointerfaces, 130, 93-100 (2015-04-26)
The aim of this study was to optimize extraction conditions for jujube pulp and seed in order to obtain maximum active ingredient yield and antioxidant activity, as well as to prepare chitosan nanoparticles loaded with jujube pulp and seed extracts
Radia Bousoumah et al.
Analytical and bioanalytical chemistry, 407(29), 8713-8723 (2015-09-24)
Multi-residue methods permitting the high-throughput and affordable simultaneous determination of an extended range of endocrine disrupting chemicals (EDCs) with reduced time and cost of analysis is of prime interest in order to characterize a whole set of bioactive compounds. Such a
M Hedenstierna et al.
Alimentary pharmacology & therapeutics, 41(6), 532-543 (2015-01-30)
A sustained viral response (SVR) after interferon-based therapy of chronic hepatitis C virus (HCV) infection is regarded to represent a cure. Previous studies have used different markers to clarify whether an SVR truly represents a cure, but no study has
J R Vergara-Salinas et al.
Food chemistry, 171, 62-69 (2014-10-14)
Pressurized hot water extracts obtained at different temperatures possess different compositions and antioxidant activities and, consequently, different bioactivities. We characterized two pressurized hot water extracts from grape pomace obtained at 100°C (GPE100) and 200°C (GPE200) in terms of antioxidant activity
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