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M Argun et al.
Eye (London, England), 28(6), 752-760 (2014-03-08)
Under conditions of oxidative stress, cell apoptosis is triggered through the mitochondrial intrinsic pathway. Increased levels of reactive oxygen species (ROS) are linked to excess cell loss and mediate the initiation of apoptosis in a diverse range of cell types.
Suresh Gadde et al.
Advanced healthcare materials, 3(9), 1448-1456 (2014-03-25)
Liver X receptors (LXRs) attenuate inflammation by modulating the expression of key inflammatory genes, making LXRs and their ligands particularly attractive candidates for therapeutic intervention in cardiovascular, metabolic, and/or inflammatory diseases. Herein, enhanced proresolving activity of polymeric nanoparticles (NPs) containing
Chun-ling Dai et al.
Journal of neural transmission (Vienna, Austria : 1996), 122(4), 607-617 (2014-09-23)
Intraneuronal accumulation of abnormally hyperphosphorylated tau in the brain is a histopathological hallmark of Alzheimer's disease and a family of related neurodegenerative disorders collectively called tauopathies. At present there is no effective treatment available for these progressive neurodegenerative diseases which
Anais Berthelot-Ricou et al.
Fertility and sterility, 100(3), 882-888 (2013-06-13)
To assess the genotoxicity of three oocyte vitrification protocols. Murine assay. Biogenotoxicology research laboratory. CD1 female mice. Three mouse oocyte groups were exposed to three commercialized human oocyte vitrification protocols. Protocols 1 and 2 contained dimethyl sulfoxide and ethylene glycol
Rifat J Hussain et al.
Physiology & behavior, 138, 113-117 (2014-12-03)
Our laboratory has previously shown that antidepressants regulate glucocorticoid receptor (GR) expression in the prefrontal cortex (PFC). To determine if PFC GR are involved in antidepressant effects on behavior or hypothalamic-pituitary-adrenocortical (HPA) axis activity, we treated floxed GR male mice
Lei Han et al.
ACS applied materials & interfaces, 7(26), 14463-14470 (2015-06-16)
As substitutes for natural peroxidases, most nanomaterial-based enzyme mimetics (nanozymes) have unique properties such as high stability, low-cost, large surface area, and high catalytic activity. However, they usually work in acidic conditions and thus impede their real applications. In this
Suk Ho Bhang et al.
Biomaterials, 55, 33-43 (2015-05-03)
At high concentrations, manganese (Mn) promotes cellular neurodevelopment but causes toxicity. Here, we report that Mn ion at high concentrations can be delivered to pheochromocytoma 12 (PC12) cells using gold nanoparticles (AuNPs) to enhance cellular neurodevelopment without toxicity. Mn(2+) release
Federica Villa et al.
Current microbiology, 71(1), 106-114 (2015-05-11)
The effects of two commercially available immobilized enzymes (namely the glycosidase pectinase and the protease subtilisin A) at sub-lethal concentrations were investigated in terms of their influence on biofilm genesis, on the composition of the biofilm matrix, and their antibiotic
Mark R Battig et al.
Biomaterials, 35(27), 8040-8048 (2014-06-24)
While the discovery of highly potent biologics has led to the development of promising therapies for various human diseases, biologics can cause severe toxicity if delivered inappropriately. Thus, great efforts have been made to synthesize polymeric systems for safe and
Baokun Tang et al.
Journal of chromatographic science, 53(5), 836-840 (2014-09-18)
Three flavones (quercetin, myricetin and amentoflavone) were extracted from Chamaecyparis obtusa leaves using deep eutectic solvents (DESs) as additives to conventional extractions solvents. Sixteen DESs were synthesized from different salts and hydrogen bond donors. In addition, C. obtusa was extracted
Guang Yang et al.
ACS nano, 9(2), 1161-1174 (2015-01-21)
Nanocarriers have attracted broad attention in cancer therapy because of their ability to carry drugs preferentially into cancer tissue, but their application is still limited due to the systemic toxicity and low delivery efficacy of intravenously delivered chemotherapeutics. In this
Jaspreet Singh Kochhar et al.
Pharmaceutical research, 31(7), 1724-1734 (2014-01-23)
To fabricate microneedle arrays directly off a photomask using a simple photolithographical approach and evaluate their potential for delivering collagen. A simple photolithographical approach was developed by using photomask consisting of embedded micro-lenses that govern microneedle geometry in a mould
Chunfeng Wang et al.
Materials science & engineering. C, Materials for biological applications, 45, 261-269 (2014-12-11)
Lipase from Candida rugosa (CRL) was chemically and physically immobilized onto four types of rod-shaped mesoporous silica (RSMS). RSMS prepared using surfactant P123 and poly(ethylene glycol) as co-templates was functionalized with (3-aminopropyl)triethoxysilane (APTES) to obtain P-RSMS by post-synthesis grafting. Tetraethoxysilane
Sandra Flessau et al.
Physical chemistry chemical physics : PCCP, 16(22), 10444-10455 (2014-05-03)
The optical properties of single colloidal semiconductor nanoparticles (NPs) are considerably influenced by the direct environment of the NPs. Here, the influence of different liquid and solid glycol matrices on CdSe-based NPs is investigated. Since the fluorescence of individual NPs
Suzanne M D'Addio et al.
Molecular pharmaceutics, 12(5), 1554-1563 (2015-03-27)
Tuberculosis (TB) remains a major global health concern, and new therapies are needed to overcome the problems associated with dosing frequency, patient compliance, and drug resistance. To reduce side effects associated with systemic drug distribution and improve drug concentration at
Micky Fu Xiang Lee et al.
Journal of chromatography. A, 1394, 71-80 (2015-04-04)
A thermo-responsive random copolymer, POEGMA (poly(oligoethylene glycol) methacrylate) grafted on cationized agarose adsorbent was used for size selective protein adsorption. The effects of OEGMA300 ((oligoethylene glycol) methyl ether methacrylate, Mn=300g/mol) content and temperature on the adsorption of bovine serum albumin
K Bhattacharya et al.
Dalton transactions (Cambridge, England : 2003), 44(19), 9221-9229 (2015-04-25)
Research on energy storage devices has created a niche owing to the ever increasing demand for alternative energy production and its efficient utilisation. Here, a novel composite of Fe3O4 nanospheres and carbon quantum dots (C-dots) have been synthesized by a
Inas H Hafez et al.
Scientific reports, 4, 6295-6295 (2014-09-16)
Cost reduction and improved durability are the two major targets for accelerating the commercialization of polymer electrolyte membrane fuel cells (PEFCs). To achieve these goals, the development of a novel method to fabricate platinum (Pt)-based electrocatalysts with a high mass
Positive propylene glycol result in a patient with ethylene glycol poisoning.
Zengliu Su et al.
Clinical chemistry, 60(4), 697-698 (2014-04-01)
Camelia Ungureanu et al.
Bioelectrochemistry (Amsterdam, Netherlands), 107, 14-24 (2015-09-29)
Implant-associated infections are a major cause of morbidity and mortality. This study was performed using titanium samples coated by anodization with a titanium dioxide (TiO2) shielded nanotube layer. TiO2/Ti surface was modified by simple immersion in torularhodin solution and by
Nandi J Reddy et al.
Clinical toxicology (Philadelphia, Pa.), 48(10), 967-973 (2011-01-05)
Ethylene glycol, diethylene glycol and methanol are widely available chemicals and are found in a variety of common household products including antifreeze, windshield washer fluid, brake fluid and lubricants. Following ingestion of these glycols and methanol, patients frequently develop an
Zhen Liu et al.
Biomaterials, 56, 206-218 (2015-05-03)
Since understanding the healthy status of gastrointestinal tract (GI tract) is of vital importance, clinical implementation for GI tract-related disease have attracted much more attention along with the rapid development of modern medicine. Here, a multifunctional theranostic system combining X-rays/CT/photothermal/photoacoustic
Venkata N K B Adusumalli et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 16(11), 2312-2316 (2015-06-16)
An intense single-band blue emission at λ=450 nm is observed from Tm(3+) ions through Ce(3+) sensitization, for the first time, in colloidal Ce(3+) /Tm(3+) -doped NaYF4 nanocrystals. The intense Tm(3+) emission through broad-band excitation is advantageous for developing luminescent nanocomposites
Akshaya Kumar Swain et al.
ACS applied materials & interfaces, 7(15), 8013-8022 (2015-03-31)
In light of the growing interest in the search for cheap and effective solutions for cancer treatment, we report a simple one pot synthesis of polymer stabilized iron oxide-graphene (PIG) that could be realized on a large scale. The structural
V K Kolli et al.
Human & experimental toxicology, 33(10), 1051-1065 (2013-12-19)
The efficacy of methotrexate (MTX), a widely used chemotherapeutic drug, is limited by its gastrointestinal toxicity and the mechanism of which is not clear. The present study investigates the possible role of mitochondrial damage in MTX-induced enteritis. Small intestinal injury
Baozhang Li et al.
Sensors (Basel, Switzerland), 14(6), 9889-9899 (2014-06-06)
We have developed a highly sensitive flexible pressure sensor based on a piezopolymer and silver nanowires (AgNWs) composite. The composite nanofiber webs are made by electrospinning mixed solutions of poly(inylidene fluoride) (PVDF) and Ag NWs in a cosolvent mixture of
Soo Kyung Cha et al.
Reproductive sciences (Thousand Oaks, Calif.), 21(7), 859-868 (2014-01-10)
The aim of this study was to evaluate the effectiveness of improving angiogenesis at graft sites on the survival of follicles in transplanted ovarian tissue. Matrigel containing 5 × 10
Emma Puighermanal et al.
Hippocampus, 25(7), 858-875 (2014-12-30)
Increasing evidences suggest that dopamine facilitates the encoding of novel memories by the hippocampus. However, the role of dopamine D2 receptors (D2R) in such regulations remains elusive due to the lack of the precise identification of hippocampal D2R-expressing cells. To
Chris J Malajczuk et al.
Biochimica et biophysica acta, 1828(9), 2041-2055 (2013-05-28)
Molecular dynamics (MD) simulations have been used to investigate the interactions of a variety of hydroxylated cryosolvents (glycerol, propylene glycol and ethylene glycol), methanol and dimethyl sulfoxide (DMSO) in aqueous solution with a 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) bilayer in its fluid phase
Zhixun Xie et al.
PloS one, 9(4), e94685-e94685 (2014-04-16)
We report a novel electrochemical immunosensor that can sensitively detect avian influenza virus H5 subtype (AIV H5) captured by graphene oxide-H5-polychonal antibodies-bovine serum albumin (GO-PAb-BSA) nanocomposite. The graphene oxide (GO) carried H5-polychonal antibody (PAb) were used as signal amplification materials.
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