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Topical niacinamide and barrier enhancement.
Donald Bissett
Cutis, 70(6 Suppl), 8-12 (2002-12-25)
Yong-Hoon Kim et al.
American journal of hypertension, 28(1), 50-57 (2014-06-22)
Endothelial nitric oxide synthase (eNOS) is involved in blood pressure (BP) regulation through the production of nitric oxide. Sirtuin I (SIRT1), an NAD-dependent protein deacetylase, promotes vascular relaxation through deacetylation and activation of eNOS. β-Lapachone (βL) increases the cellular NAD(+)/NADH
Involvement of androgen receptor and glucose-regulated protein 78 kDa in human hepatocarcinogenesis.
Xia Jiang et al.
Experimental cell research, 323(2), 326-336 (2014-03-04)
Previous studies demonstrated that androgen receptor (AR) is expressed in human hepatocellular carcinoma (HCC), one of the male-dominant diseases. Glucose-regulated protein 78 kDa (GRP78/Bip), which has a role in cancer development, is one of the androgen response genes in prostate
K Mizrahi et al.
Bone marrow transplantation, 49(7), 942-949 (2014-04-30)
The influence of TNF-α and Fas-ligand (FasL) on viability and function was evaluated in fresh- and expanded-umbilical cord blood (UCB) cells. CD34(+) progenitors and T cells display outstanding survival, whereas ~30% and >50% B lymphocytes and myeloid cells undergo spontaneous
Is India ready to lead the battle for fair access to medicines?
Lancet Oncology
The Lancet. Oncology, 14(6), 437-437 (2013-05-04)
Kento Kitada et al.
Journal of diabetes and its complications, 28(5), 604-611 (2014-07-06)
Kidney cells in patients with diabetic nephropathy are reported to be senescent. However, the mechanisms that regulate cellular senescence in the diabetic kidney are still unknown. In the present study, we evaluated the contribution of high glucose to renal cell
Katsumi Shibata et al.
Journal of nutritional science and vitaminology, 60(4), 261-268 (2014-10-10)
The adverse effects of D-tryptophan and the possibility of it being a surrogate index for predicting adverse effects in rats were investigated. Male rats were fed one of several test diets (20% casein diets with 0% (control), 0.1%, 0.2%, 0.3%
Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis
Wei Z, et al.
Nature Communications, 9(1), 4468-4468 (2018)
M V Gammons et al.
British journal of cancer, 111(3), 477-485 (2014-07-11)
Current therapies for metastatic melanoma are targeted either at cancer mutations driving growth (e.g., vemurafenib) or immune-based therapies (e.g., ipilimumab). Tumour progression also requires angiogenesis, which is regulated by VEGF-A, itself alternatively spliced to form two families of isoforms, pro-
Yong-Hui Ding et al.
Drug design, development and therapy, 9, 425-464 (2015-01-28)
Ovarian cancer is a leading killer of women, and no cure for advanced ovarian cancer is available. Alisertib (ALS), a selective Aurora kinase A (AURKA) inhibitor, has shown potent anticancer effects, and is under clinical investigation for the treatment of
Pilot study of sorafenib in relapsed or refractory peripheral and cutaneous T-cell lymphoma.
Juliet Fraser Gibson et al.
British journal of haematology, 167(1), 141-144 (2014-06-04)
Anna Louise Hillberg et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(3), 503-518 (2014-06-12)
Encapsulation of cells in biocompatible polymer matrices represents a powerful tool for cell-based therapies and therapeutic delivery systems. This technology has successfully been used to deliver pancreatic islets to humans for the treatment of Type 1 diabetes. However, the clinical
Nayeli Torres-Ramírez et al.
Life sciences, 93(25-26), 975-985 (2013-11-05)
Excessive energy uptake of dietary carbohydrates results in their storage as fat and requires glucose-6-phosphate dehydrogenase (G6PD)-mediated NADPH production. We sought to assess whether the nicotinamide-induced reduction of G6PD activity might modulate redox balance and lipid accumulation in 3T3-L1 cells.
Yuichi Honma et al.
Journal of UOEH, 36(4), 229-235 (2014-12-17)
The prognosis of advanced hepatocellular carcinoma (HCC) has remained very poor.It has recently been reported that the molecular targeting agent sorafenib can improve the prognosis of patients with advanced HCC. However, the detailed mechanisms of sorafenib, especially its direct effects
Qi-Han Fu et al.
Journal of cancer research and clinical oncology, 140(8), 1429-1440 (2014-04-29)
Combination therapy of sorafenib and transarterial chemoembolization (TACE) showed benefits for hepatocellular carcinoma (HCC). This systematic review aims for evaluation of efficacy and safety between sorafenib plus TACE and TACE alone for HCC. We systematically searched multi-databases to identify eligible
Sirtuins: Longevity focuses on NAD+.
Heinrich Jasper
Nature chemical biology, 9(11), 666-667 (2013-10-22)
Ann-Lii Cheng et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(32), 4067-4075 (2013-10-02)
Open-label, phase III trial evaluating whether sunitinib was superior or equivalent to sorafenib in hepatocellular cancer. Patients were stratified and randomly assigned to receive sunitinib 37.5 mg once per day or sorafenib 400 mg twice per day. Primary end point
Xiaobin Feng et al.
The American journal of gastroenterology, 109(12), 1891-1899 (2014-11-19)
The objective of this study was to evaluate the efficacy of combined therapy using Sorafenib and radiofrequency ablation (RFA) with curative intent for all detectable lesions in patients with Barcelona Clinic Liver Cancer (BCLC) Stage 0-B1 hepatocellular carcinoma (HCC). One
Pamela Biondani et al.
Anticancer research, 34(5), 2395-2398 (2014-04-30)
Only scanty data are available to evaluate the impact of sequential TKIs on overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC). This retrospective study investigated the efficacy of the sequence sorafenib-sunitinib (SO-SU) and vice versa (SU-SO) in
Tomasz Szkudelski
Experimental biology and medicine (Maywood, N.J.), 237(5), 481-490 (2012-05-24)
Administration of both streptozotocin (STZ) and nicotinamide (NA) has been proposed to induce experimental diabetes in the rat. STZ is well known to cause pancreatic B-cell damage, whereas NA is administered to rats to partially protect insulin-secreting cells against STZ.
Maryam Parvini et al.
In vitro cellular & developmental biology. Animal, 51(3), 310-318 (2014-11-28)
Despite the enormous progress in studying retinal cell differentiation from human embryonic stem cells (hESCs), none of the reported protocols have produced a cost-effective eye field cells with the capability to further differentiate into retinal derivatives. In this study, by
Da Li et al.
Cell cycle (Georgetown, Tex.), 13(21), 3442-3449 (2014-12-09)
BRCA mutations are the main known hereditary factor for breast cancer. Notably, poly (ADP-ribose) polymerase 1 (PARP1) expression status plays a critical role in breast cancer progression and the clinical development of PARP1 inhibitors to treat BRCA-mutated breast cancer has
Patrick Wray et al.
Journal of pharmaceutical sciences, 103(7), 1995-2004 (2014-05-08)
In this study of multi-layer tablets, the dissolution of biphasic and zero-order release formulations has been studied primarily using attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopic imaging as well as UV-Vis detection of dissolved drug in the effluent stream and
Pancreatic atrophy--a new late toxic effect of sorafenib.
Ségolène Hescot et al.
The New England journal of medicine, 369(15), 1475-1476 (2013-10-11)
Zuzana Kočí et al.
Cell biochemistry and function, 32(7), 597-604 (2014-09-25)
Adipose tissue is an abundant source of autologous adult stem cells that may bring new therapeutic perspectives on the treatment of diabetes and its complications. It is unclear whether adipose tissue-derived stromal cells (ASCs) of diabetic patients, constantly influenced by
Farhad Ravandi et al.
Blood, 121(23), 4655-4662 (2013-04-25)
Patients received 5-azacytidine (AZA) 75 mg/m(2) intravenously daily for 7 days and sorafenib 400 mg orally twice daily continuously; cycles were repeated at ~1-month intervals. Forty-three acute myeloid leukemia (AML) patients with a median age of 64 years (range, 24-87
Chiaki Hiratsuka et al.
Journal of nutritional science and vitaminology, 60(4), 255-260 (2014-10-10)
We have previously reported that dietary supplementation with up to 5.0 g/d of L-tryptophan (L-Trp) for 21 d has no adverse effects, judging from the levels of general blood variables, in healthy women. We performed a randomized, double-blind, placebo-controlled, crossover
Xingyou Wan et al.
Cell death & disease, 11(8), 649-649 (2020-08-20)
The folate-coupled metabolic enzyme MTHFD2 (the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase) confers redox homeostasis and drives cancer cell proliferation and migration. Here, we show that MTHFD2 is hyperacetylated and lysine 88 is the critical acetylated site. SIRT3, the major deacetylase in mitochondria
Frank Preugschat et al.
Archives of biochemistry and biophysics, 564, 156-163 (2014-09-25)
hCD157 catalyzes the hydrolysis of nicotinamide riboside (NR) and nicotinic acid riboside (NAR). The release of nicotinamide or nicotinic acid from NR or NAR was confirmed by spectrophotometric, HPLC and NMR analyses. hCD157 is inactivated by a mechanism-based inhibitor, 2'-deoxy-2'-fluoro-nicotinamide
Angel E Alsina et al.
The American surgeon, 80(7), 680-684 (2014-07-06)
Recurrence of hepatocellular carcinoma (HCC) remains a main detriment to long-term survival in liver transplants (LTx) for HCC. The study aims to review the use of sorafenib in recurrent HCC LTx in the Model End Stage Liver Disease era. Two
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