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Ker Y Cheah et al.
PloS one, 9(6), e98921-e98921 (2014-06-07)
Grape seed procyanidins (PC) are flavan-3-ol oligomers and polymers known for their biological activity in the gut. Grape seed extract (GSE) have been reported to reduce intestinal injury in a rat model of mucositis. We sought to investigate effects of
Hendrik W van Deventer et al.
Journal of immunology (Baltimore, Md. : 1950), 190(9), 4861-4867 (2013-03-29)
Fibrocytes are circulating, hematopoietic cells that express CD45 and Col1a1. They contribute to wound healing and several fibrosing disorders by mechanisms that are poorly understood. In this report, we demonstrate that fibrocytes predispose the lung to B16-F10 metastasis by recruiting
Alexander K Filippov et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(36), 9340-9348 (2006-09-08)
We have shown previously that stimulation of heterologously expressed P2Y1 nucleotide receptors inhibits M-type K+ currents in sympathetic neurons. We now report that activation of endogenous P2Y1 receptors induces inhibition of the M-current in rat CA1/CA3 hippocampal pyramidal cells in
Amino acid and cDNA sequence of bovine phosducin, a soluble phosphoprotein from photoreceptor cells.
R H Lee et al.
The Journal of biological chemistry, 265(26), 15867-15873 (1990-09-15)
Vertebrate photoreceptor cells contain a soluble phosphoprotein, phosducin, which complexes with the beta, gamma subunits of the GTP-binding protein, transducin. Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of phosducin by protein kinase A. The complete amino acid sequence
Li-Hui Wang et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 13(1), 102-110 (2007-01-04)
Mothers against decapentaplegic homologue 4 (SMAD4) is a tumor suppressor gene associated with gastrointestinal carcinogenesis. The aim of the present study is to more precisely characterize its role in the development and progression of human gastric carcinoma. The expression of
Hussein M Khaled et al.
Urologic oncology, 21(5), 334-341 (2003-12-13)
Alterations of the p53 tumor suppressor gene are the most common genetic changes detected in human cancers as well as in papillary and invasive bladder cancer. Several studies have demonstrated an association between HPV infection and urological malignancies. In the
Lei Cai et al.
Oncotarget, 8(23), 37646-37656 (2017-04-22)
Pancreatic ductal adenocarcinoma (PDAC) has one of the poorest prognosis among malignancies. Thus, the identification of markers useful in developing innovative diagnostic and therapeutic methods is an imperative need. Folate receptor alpha (FRα) has been associated with prognosis in several
F Schaper et al.
Clinical and experimental immunology, 188(3), 412-419 (2017-03-01)
Autoantibodies to nuclear structures are a hallmark of systemic lupus erythematosus (SLE), including autoantibodies to nuclear protein high mobility group box 1 (HMGB1). HMGB1 consists of three separate domains: box A, box B and an acidic tail. Recombinant box A
Tomás Meroño et al.
Clinical science (London, England : 1979), 128(9), 609-618 (2014-12-03)
Iron overload (IO) has been associated with glucose metabolism alterations and increased risk of cardiovascular disease (CVD). Primary IO is associated with mutations in the HFE gene. To which extent HFE gene mutations and metabolic alterations contribute to the presence
J A Raper et al.
Journal of applied physiology (Bethesda, Md. : 1985), 117(11), 1371-1379 (2014-10-04)
Mitochondrial pyruvate dehydrogenase (PDH) regulates the delivery of carbohydrate-derived substrate to the mitochondrial tricarboxylic acid cycle and electron transport chain. PDH activity at rest and its activation during exercise is attenuated following high-fat (HFAT) compared with high-carbohydrate (HCHO) diets. Given
Norie Nakahara et al.
International journal of clinical pharmacology and therapeutics, 51(8), 660-671 (2013-06-06)
To evaluate the safety, pharmacokinetics and pharmacodynamics of fluticasone furoate (FF) and vilanterol (VI) administered alone or in combination in three Phase I studies in healthy Japanese male subjects. FF, VI and FF/VI inhalation powder in a novel dry powder
Timothy B Niewold et al.
Arthritis and rheumatism, 58(2), 541-546 (2008-02-02)
The type I interferon (IFN) pathway is activated in many patients with systemic lupus erythematosus (SLE), and high serum levels of IFN are associated with anti-SSA/Ro autoantibodies. To investigate the clinical features associated with type I IFN production in vivo
Tomaz Kocjan et al.
Radiology and oncology, 54(4), 409-418 (2020-09-06)
Background Adrenal vein sampling (AVS) is essential for diagnostics of primary aldosteronism, distinguishing unilateral from bilateral disease and determining treatment options. We reviewed the performance of AVS for primary aldosteronism at our center during first 15 years, comparing the initial
M J Fritzler et al.
Journal of clinical laboratory analysis, 9(3), 218-224 (1995-01-01)
The objective of the study was to determine the sensitivity and specificity of an indirect immunofluorescence (IIF) assay using transfected HEp-2 cells to detect anti-SS-A/Ro autoantibodies in human sera. Seventy-three sera having SS-A/Ro autoantibodies as determined by double immunodiffusion (ID)
Khaled Mahmoud et al.
Transplantation, 83(8), 1035-1040 (2007-04-25)
It has been shown that hepatocyte growth factor (HGF), besides its well-established hepatotrophic effect in liver regeneration, is involved in the regeneration of the kidney after injury. In the present study we investigated whether HGF can serve as a marker
B Auclair et al.
Pharmaceutical research, 15(4), 614-619 (1998-05-20)
To construct a pharmacokinetic (PK) model and to determine population PK parameters of nitroglycerin (GTN), 1,2-dinitroglycerin (1,2-GDN), and 1,3-dinitroglycerin (1,3-GDN). Data were obtained in thirty healthy volunteers following a single dose of a GTN reservoir transdermal patch. Blood samples were
M Merker et al.
Der Anaesthesist, 60(5), 432-440 (2010-12-15)
The aim of the present study was to conduct a meta-analysis of the results from randomized controlled trials investigating the relative efficacy of droperidol versus metoclopramide for the prevention of postoperative nausea and vomiting (PONV). A systematic literature search for
Jonathan A Ledermann et al.
The Lancet. Oncology, 17(11), 1579-1589 (2016-09-13)
In patients with platinum-sensitive recurrent serous ovarian cancer, maintenance monotherapy with the PARP inhibitor olaparib significantly improves progression-free survival versus placebo. We assessed the effect of maintenance olaparib on overall survival in patients with platinum-sensitive recurrent serous ovarian cancer, including
Saghi Riahizadeh et al.
Helicobacter, 15(6), 497-504 (2010-11-16)
Furazolidone is a much cheaper drug with a very low resistance against Helicobacter pylori compared to clarithromycin. We aim to evaluate safety and efficacy of a sequential furazolidone-based regimen versus clarithromycin-based therapy in H. pylori eradication for ulcer disease. Patients
Jun Liu et al.
American journal of physiology. Renal physiology, 300(2), F433-F440 (2010-12-03)
The renal vasopressin V(2) receptor (V(2)R) plays a critical role in physiological and pathophysiological processes associated with arginine vasopressin (AVP)-induced antidiuresis. Because clinical data suggests that females may be more prone to hyponatremia from AVP-mediated antidiuresis, we investigated whether there
Jameel Al-Ghazaly et al.
Clinical lymphoma, myeloma & leukemia, 20(3), e144-e153 (2020-01-28)
In a developing country like Yemen, data are limited regarding the outcome of imatinib treatment of chronic myeloid leukemia and the effect of nonadherence to imatinib treatment and previous duration of hydroxyurea treatment. A longitudinal cohort study, which included 164
N G Ahn et al.
The Journal of biological chemistry, 263(35), 18657-18663 (1988-12-15)
Five proteins from human placenta capable of inhibiting pancreatic phospholipase A2 were purified. Two of these proteins were identified as lipocortins I and II. The other three proteins were immunologically distinct from lipocortins I and II and had apparent subunit
A Capalbo et al.
Clinical endocrinology, 77(1), 113-119 (2012-02-24)
Polycystic ovary syndrome (PCOS) is a frequent condition, affecting about 15% of women of reproductive age. Because of its familial occurrence, a multifactorial model of susceptibility, including both genetic and environmental factors, has been proposed. However, the identification of genetic
Alba A Brandes et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 26(13), 2192-2197 (2008-05-01)
Standard therapy for glioblastoma (GBM) is temozolomide (TMZ) administration, initially concurrent with radiotherapy (RT), and subsequently as maintenance therapy. The radiologic images obtained in this setting can be difficult to interpret since they may show radiation-induced pseudoprogression (psPD) rather than
José Adélaïde et al.
Cancer research, 67(24), 11565-11575 (2007-12-20)
Basal and luminal are two molecular subtypes of breast cancer with opposite histoclinical features. We report a combined, high-resolution analysis of genome copy number and gene expression in primary basal and luminal breast cancers. First, we identified and compared genomic
Zia Fazili et al.
Clinical chemistry, 54(1), 197-201 (2007-12-28)
The 5,10-methylenetetrahydrofolate reductase (NADPH) (MTHFR) C677T polymorphism may affect whole-blood folate pattern measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and total folate measured by LC-MS/MS, microbiologic assay, and Bio-Rad radioassay (BR). We analyzed 171 whole blood hemolysates from 2 blood
Katherine Tarlock et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 25(16), 5038-5048 (2019-06-12)
KIT mutations (KIT+) are common in core binding factor (CBF) AML and have been associated with varying prognostic significance. We sought to define the functional and clinical significance of distinct KIT mutations in CBF pediatric AML. Following transfection of exon
E Kawasaki et al.
Diabetologia, 51(12), 2299-2302 (2008-10-14)
We analysed the association between humoral autoreactivity to zinc transporter-8 (ZnT8) and the SLC30A8 rs13266634 polymorphism (Arg325Trp), which is located at the most distal loop in the ZnT8 protein. Autoantibodies to ZnT8 were determined by RIA in 270 patients with
T J Stevens et al.
Arzneimittel-Forschung, 35(8), 1257-1260 (1985-01-01)
Khellin and khelloside (khellol glucoside) were examined in female cynomolgus monkeys to substantiate their ability to favorably modify serum lipoprotein cholesterol. Clinical chemistry parameters were also measured to obtain information indicative of possible drug toxicity. Both drugs were evaluated in
Roger D James et al.
The Lancet. Oncology, 14(6), 516-524 (2013-04-13)
Chemoradiation became the standard of care for anal cancer after the ACT I trial. However, only two-thirds of patients achieved local control, with 5-year survival of 50%; therefore, better treatments are needed. We investigated whether replacing mitomycin with cisplatin in
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