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Irena Baranowska et al.
Journal of chromatographic science, 52(1), 88-94 (2013-01-18)
This paper reports the development of a method for simultaneously determining five preservatives in cosmetics, cleaning agents and pharmaceuticals by fast liquid chromatography. Methylisothiazolinone, methylchloroisothiazolinone, benzyl alcohol, sodium benzoate and methylparaben were separated on a Chromolith Fast Gradient reversed-phase 18e
Mari Paz Castanedo-Tardana et al.
Dermatitis : contact, atopic, occupational, drug, 24(1), 2-6 (2013-01-24)
The preservative methylisothiazolinone (MI) is the American Contact Dermatitis Society Contact Allergen of the Year for 2013. Because the use of MI in cosmetics and toiletries in the United States rises, MI exposure also rises. Although it might seem likely
R Poon et al.
Archives of toxicology, 85(11), 1419-1427 (2011-03-30)
Biocides are added to biodiesels to inhibit and remove microbial growth. The effects of 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT), a candidate biodiesel biocide, were studied using freshly isolated rat alveolar macrophages (AM) and NR8383 cell line. CMIT markedly inhibited phagocytic oxidative burst as
Delayed hypersensitivity to methylchloroisothiazolinone/methylisothiazolinone not detected by the baseline series of the Spanish group.
Laura Cuesta et al.
Contact dermatitis, 62(4), 250-251 (2010-05-04)
Follow-up of the monitored levels of preservative sensitivity in Europe: overview of the years 2001-2008.
Cecilia Svedman et al.
Contact dermatitis, 67(5), 312-314 (2012-10-09)
M D Lundov et al.
The British journal of dermatology, 165(6), 1178-1182 (2011-07-23)
In the early 2000s the preservative methylisothiazolinone (MI) was released as an individual preservative for industrial products and, in 2005, it was permitted for use in cosmetic products. Up until then MI had been used only in combination with methylchloroisothiazolinone
Two cases of airborne allergic contact dermatitis caused by methylisothiazolinone in paint.
Michael D Lundov et al.
Contact dermatitis, 65(3), 176-179 (2011-08-11)
Julien Mutschler et al.
Toxicology in vitro : an international journal published in association with BIBRA, 23(3), 439-446 (2009-05-16)
Assessment of skin sensitization hazard of chemicals currently depends on in vivo methods. Considering the forthcoming European Union ban on in vivo testing of cosmetic/toiletry ingredients, the search for alternative non-animal approaches is an urgent challenge for investigators today. For
Leena Ackermann et al.
Contact dermatitis, 64(1), 49-53 (2010-12-21)
Antimicrobials constitute the second most common cause of contact allergy to cosmetics. Methylisothiazolinone (MI), previously always used together with methylchloroisothiazolinone (MCI), has recently been approved in the EU for use on its own in cosmetics and also various industrial products.
Anja P Mose et al.
Contact dermatitis, 67(5), 293-297 (2012-05-04)
Painters are among the occupational groups that most commonly experience occupational contact dermatitis, but few investigations exist concerning this occupation. To characterize painters with contact dermatitis and identify the most common allergens associated with the occupation. Materials and methods. All
Concomitant contact allergy to methylchloroisothiazolinone/methylisothiazolinone and formaldehyde-releasing preservatives.
Barry N Statham et al.
Contact dermatitis, 62(1), 56-57 (2010-02-09)
Magnus Bruze et al.
Contact dermatitis, 69(5), 263-270 (2013-10-15)
Methylisothiazolinone (MI) is used as a preservative in occupational and household products, and cosmetics. It is a part of the preparation of methylchloroisothiazolinone (MCI)/MI, which is patch tested in water in the European baseline series. However, this preparation fails to
Identifying the optimal patch test concentration for methylchloroisothiazolinone and methylisothiazolinone.
E Davies et al.
Contact dermatitis, 60(5), 288-289 (2009-04-29)
Determination of antimicrobial agents in non-formalin adhesives for wallpaper
Nakashima H, et al.
Journal of Health Science, 46(6), 447-454 (2000)
Presumed primary contact sensitization to methylisothiazolinone from paint: a chemical that became airborne.
Jeanette Kaae et al.
Contact dermatitis, 66(6), 341-342 (2012-05-10)
Allergic contact dermatitis caused by methylisothiazolinone from different sources, including 'mislabelled' household wet wipes.
Lucie Vanneste et al.
Contact dermatitis, 69(5), 311-312 (2013-10-15)
Michael D Lundov et al.
Contact dermatitis, 69(5), 271-275 (2013-10-15)
The prevalence of contact allergy to the isothiazolinone preservative methylchloroisothiazolinone (MCI) in combination with methylisothiazolinone (MI) and MI alone has increased in the last couple of years. To investigate the prevalence of contact allergy to MI, MCI/MI and benzisothiazolinone (BIT)
Methylisothiazolinone is categorised as a strong sensitiser in the Murine Local Lymph Node Assay.
David W Roberts
Contact dermatitis, 69(5), 261-262 (2013-10-15)
Eleanor Higgins et al.
Dermatitis : contact, atopic, occupational, drug, 24(2), 73-76 (2013-03-12)
The isothiazolinones methylchloroisothiazolinone and methylisothiazolinone (MCI/MI) are the active ingredients in a frequently used preservative in cosmetic, household, and industrial products. This study reviewed our department's cases of allergic contact dermatitis caused by MCI/MI, outlining their clinical presentation and possible
Methylchloroisothiazolinone and methylisothiazolinone contact allergy: a new 'epidemic'.
Rachel Urwin et al.
Contact dermatitis, 68(4), 253-255 (2013-03-21)
Christina L Burnett et al.
International journal of toxicology, 29(4 Suppl), 187S-213S (2010-07-22)
Methylisothiazolinone (MIT) is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%. MIT is a colorless, clear liquid with a mild odor that is completely soluble in water; mostly soluble
A Spawn et al.
Neuroscience, 205, 194-204 (2012-01-17)
Methylisothiazolinone (MIT) is a commonly used biocide known to be neurotoxic in vitro. Brief exposure of cortical neurons in culture to MIT results in increased neurodegeneration, whereas chronic exposure of developing neurons in culture to low concentrations of MIT has
Airborne exposure to preservative methylisothiazolinone causes severe allergic reactions.
Michael Dyrgaard Lundov et al.
BMJ (Clinical research ed.), 345, e8221-e8221 (2012-12-06)
Airborne exposure to methylchloroisothiazolinone and methylisothiazolinone from a toilet cleaner.
Michael D Lundov et al.
Contact dermatitis, 68(4), 252-253 (2013-03-21)
Paula Maio et al.
Cutaneous and ocular toxicology, 31(2), 151-153 (2011-11-05)
Several preservatives are currently allowed in cosmetic products in the EU. However, only a few of them are strongly represented on the market: formaldehyde, parabens, formaldehyde releasers and methylchoroisothiazolinone/methylisothiazolinone (MCI/MI). MCI/MI has been widely used during recent years for the
Kevin H Gardner et al.
Archives of dermatology, 146(8), 886-890 (2010-06-23)
Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI), a common preservative in some brands of moist toilet paper (baby wipes and moist towelettes), has been reported to be a cause of allergic contact dermatitis. However, few cases have been reported in the United States. We report
Michael D Lundov et al.
Contact dermatitis, 64(6), 330-336 (2011-04-21)
Methylisothiazolinone (MI) used alone is a new preservative causing a high prevalence of contact allergy. The eliciting threshold of MI is unknown. The combination of MI and phenoxyethanol enhances the antimicrobial efficacy of MI. The eliciting doses of MI contact
Juan García-Gavín et al.
Contact dermatitis, 63(2), 96-101 (2010-07-16)
A few cases on primary sensitization by, and occupational contact dermatitis from, methylisothiazolinone in paints and glues have been published. In cosmetics, methylisothiazoline (MI) is permitted in a concentration of 100 p.p.m., while 15 p.p.m. for the mixture of methylchloroisothiazolinone
Allergic contact dermatitis caused by methylisothiazolinone from a 'waist reduction belt'.
Wolfgang Uter et al.
Contact dermatitis, 66(6), 347-348 (2012-05-10)
Airborne and systemic dermatitis, mimicking atopic dermatitis, caused by methylisothiazolinone in a young child.
Olivier Aerts et al.
Contact dermatitis, 68(4), 250-251 (2013-03-21)
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