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M Inzinger et al.
The British journal of dermatology, 165(3), 640-645 (2011-05-14)
Few studies have directly compared the clinical efficacy of psoralen plus ultraviolet A (PUVA) vs. biologics in the treatment of psoriasis. To compare the clinical efficacy of PUVA and biologic therapies for psoriasis under daily life conditions. Data from a
A Liu et al.
Clinical genetics, 91(1), 54-62 (2016-08-17)
Mutations in PCDH19, which encodes protocadherin 19, have been identified in epilepsy, mainly in affected females. We summarized the clinical spectrum of female epilepsy patients with PCDH19 mutations in a Chinese population. We screened for PCDH19 mutations in 75 girls
New polyhydroxylated sterols from Palythoa tuberculosa and their apoptotic activity in cancer cells.
Abdulrahman M Elbagory et al.
Steroids, 101, 110-115 (2015-06-23)
The chemical study on the total extract of the zoanthid Palythoa tuberculosa, collected from the Red Sea, resulted in the isolation of seven polyhydroxylated sterols (1-7), six of which, palysterols A-F (2-7), are new. Their chemical structures were elucidated on
Kurt A Jaeckle et al.
Journal of neuro-oncology, 99(1), 73-80 (2010-01-12)
Irinotecan has radiosensitizing effects and shows synergism with nitrosoureas. We performed a Phase II study of RT and irinotecan, followed by BCNU plus irinotecan in newly-diagnosed GBM. The MTD for patients receiving enzyme-inducing anticonvulsants (EIAC) was as follows: irinotecan 400
Feng Zeng et al.
Planta medica, 76(14), 1596-1599 (2010-03-24)
Two unusual prenylated and C-methylated flavanones, (±)-5,4'-dihydroxy-2'-methoxy-6',6''- dimethypyrano-(2'',3'':7,8)-6-methyflavanone ( 1) and (2 S)-5,7,4'-trihydroxy-2'-methoxy-8,5'- di(3-methyl-2-butenyl)-6-methyflavanone ( 2), and 10 known compounds were isolated from the stems and roots of TRIPTERYGIUM WILFORDII. Their structures were elucidated based on spectroscopic analyses including 1- and
Monika Korabiowska et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 17(12), 1539-1544 (2004-07-17)
Adenomatous polyposis coli gene (APC) defects have been demonstrated for the first time in familial adenomatous polyposis. Recent reports indicate that the APC gene is an intermediary between cell adhesion molecules and the cytoskeleton and that it may function as
Timothy J Jorgensen et al.
Cancer chemotherapy and pharmacology, 59(6), 725-732 (2006-09-13)
ABT-751 is an orally active antimitotic agent that is currently in Phase II clinical trials. This agent binds to the colchicine site on ss-tubulin and inhibits polymerization of microtubules. This disruption of microtubule dynamics leads to a block in the
Antonius A Miller et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 3(10), 1159-1165 (2008-10-02)
We investigated dose-dense docetaxel and cisplatin in patients with measurable non-small cell lung cancer in a randomized phase II study without [A] or with [B] a putative chemoprotective agent, BNP7787. Chemotherapy-naive patients with stage IIIB (effusion) or IV, performance status
L A Andoh et al.
Epidemiology and infection, 144(15), 3288-3299 (2016-06-24)
Poultry are possible sources of non-typhoidal Salmonella serovars which may cause foodborne human disease. We conducted a cross-sectional study to determine the prevalence of Salmonella serovars in egg-laying hens and broilers at the farm level and their susceptibility to antimicrobials
Skander Mulder et al.
Translational research : the journal of laboratory and clinical medicine, 222, 17-27 (2020-05-22)
The mineralocorticoid receptor antagonist spironolactone significantly reduces albuminuria in subjects with diabetic kidney disease, albeit with a large variability between individuals. Identifying novel biomarkers that predict response to therapy may help to tailor spironolactone therapy. We aimed to identify a
Akiko Tozawa-Ono et al.
Human cell, 25(1), 24-28 (2012-02-04)
Heat shock protein 27 (hsp27) is expressed by squamous cell carcinoma of the uterine cervix. Results from an earlier study by our group indicted that hsp27 may be a diagnostic marker for cervical intraepithelial neoplasia (CIN) and carcinoma. p16 expression
K Hanew et al.
European journal of endocrinology, 134(1), 67-72 (1996-01-01)
The effect of GHRH-antagonist [(N-Ac-Tyr1, D-Arg2) GRF-(1-29)-NH2] on plasma GH morning and evening secretion was evaluated in 14 normal subjects (10 males, 4 females, aged 19-25 years). Plasma GH was determined using a high sensitivity IRMA kit (detection limit, 0.006
A Guberman et al.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 17(3), 311-316 (1990-08-01)
Clobazam, a novel benzodiazepine, was used as an add-on agent in 47 adult patients with intractable epilepsy and a variety of seizure types. A greater than 75% reduction in seizure frequency was observed in 42% (18) of the patients and
R Izaguirre-Avila et al.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 8(2), 169-177 (2002-07-18)
Acetylsalicylic acid inhibits thromboxane A2 production and reduces the risk of vascular occlusive events by 20% to 25%. Ticlopidine inhibits ADP-dependent platelet aggregation and reduces the same risk by 30% to 35%, but produces some adverse effects. Clopidogrel is a
Marc C Chamberlain
Expert review of neurotherapeutics, 12(8), 929-936 (2012-09-26)
One hundred patients, aged 36-84 years (median 62 years) with recurrent glioblastoma (GBM), were treated previously with surgery, concurrent radiotherapy and temozolomide and postradiotherapy temozolomide followed by single-agent bevacizumab (BEV) at either first (60 patients) or second recurrence (40 patients).
L R Schwarz et al.
European journal of biochemistry, 55(3), 617-623 (1975-07-15)
Binding and transport characteristics for uptake of taurocholic acid by isolated rat liver cells were studied. 1. An adsorption of taurocholate to the cell surface is terminated in less than 15 s. A Ks of 0.55 mM and a total
V Siguret et al.
La Revue de medecine interne, 25(4), 271-274 (2004-03-31)
Allelic variants of the gene coding for cytochrome P450 isoform 2C9 (CYP2C9), 2C9*2 and 2C9*3, were shown to increase sensitivity to warfarin in adults. In the elderly, the maintenance dose is influenced by acquired factors including comorbidities and polymedication. The
Ahmed A Al-Qahtani et al.
Journal of chemotherapy (Florence, Italy), 26(3), 139-145 (2013-10-05)
The objectives of this study were to determine the prevalences, genotypes, and clonal relationships of extended-spectrum beta-lactamase (ESBL)-producing strains in 98 Klebsiella pneumoniae isolates from Riyadh. The prevalence of ESBLs in these strains was 37·75%. All isolates that were confirmed
Guang-Ming Huang et al.
World journal of gastroenterology, 21(20), 6194-6205 (2015-06-03)
To investigate the effect of gambogic acid (GA) on apoptosis in the HT-29 human colon cancer cell line. H-29 cells were used for in vitro experiments in this study. Relative cell viability was assessed using MTT assays. Cell apoptosis was
Zachary C Landis et al.
ASAIO journal (American Society for Artificial Internal Organs : 1992), 61(2), 127-132 (2014-12-11)
The optimal timing of left ventricular assist device (LVAD) implantation in the management of advanced heart failure remains controversial. We hypothesize that in patients with cardiogenic shock, the severity of end-organ dysfunction as determined by the sequential organ failure assessment
Soo-Jin Yeom et al.
Biochimie, 93(10), 1659-1667 (2011-07-07)
Mannose-6-phosphate isomerase catalyzes the interconversion of mannose-6-phosphate and fructose-6-phosphate. The gene encoding a putative mannose-6-phosphate isomerase from Thermus thermophilus was cloned and expressed in Escherichia coli. The native enzyme was a 29 kDa monomer with activity maxima for mannose 6-phosphate at
Taofic Mounajjed et al.
Human pathology, 44(4), 542-550 (2012-10-20)
Glypican-3 (GPC3) is a plasma membrane-bound proteoglycan that can be overexpressed in certain malignancies but has been particularly linked to hepatocellular carcinoma (HCC). GPC3 is currently used as an immunohistochemical marker for HCC, but its expression in epithelial neoplasms of
T Mimori et al.
Proceedings of the National Academy of Sciences of the United States of America, 92(16), 7267-7271 (1995-08-01)
We identified an autoantibody that reacts with calpastatin [an inhibitor protein of the calcium-dependent neutral protease calpain (EC 3.4.22.17)]. In early immunoblot studies, sera from patients with rheumatoid arthritis (RA) recognized unidentified 60-, 45-, and 75-kDa proteins in HeLa cell
J A Weidanz et al.
British journal of haematology, 95(4), 645-653 (1996-12-01)
The major pathways of glucose metabolism in the malaria parasite, Plasmodium falciparum, have now been elucidated, and the structures and properties of parasite-specific enzymes are presently being investigated. Little is known, however, about the enzymes catalysing monosaccharide interconversions in the
Carla Filì et al.
Leukemia research, 76, 33-38 (2018-12-12)
The hypomethylating agent Decitabine (DAC) is a valuable treatment option in acute myeloid leukemia (AML), particularly in elderly patients (pts) not suitable for intensive chemotherapy (CHT). However, limited data are available about efficacy and safety of DAC in clinical practice.
Vicente Valero et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29(2), 149-156 (2010-12-01)
Docetaxel-trastuzumab (TH) is effective therapy for HER2-amplified metastatic breast cancer (MBC). Preclinical findings of synergy between docetaxel, carboplatin, and trastuzumab (TCH) prompted a phase III randomized trial comparing TCH with TH in patients with HER2-amplified MBC. Two hundred sixty-three patients
Alireza Khataee et al.
Ultrasonics sonochemistry, 27, 379-388 (2015-07-19)
Pure and erbium (Er)-doped ZnO samples were synthesized through a sonochemical method and characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), UV-Vis spectroscopy, and X-ray photoelectron spectroscopy (XPS) analysis. The synthesized samples were used as
Matthew R Smith et al.
Journal of Crohn's & colitis, 8(8), 890-897 (2014-02-11)
The role of mycophenolate mofetil (MMF) as an immunomodulatory drug in managing inflammatory bowel disease (IBD) is yet to be fully defined. We reviewed our experience of MMF in treating patients with IBD. Retrospective analysis was performed on all patients
Joshua D Lambert et al.
Carcinogenesis, 29(10), 2019-2024 (2008-08-08)
The green tea (Camellia sinensis) catechin, (-)-epigallocatechin-3-gallate (EGCG), has shown cancer-preventive activity in animal models. Previously, we have reported the bioavailability of EGCG in rats and mice. Here, we report that cotreatment of HT-29 human colon cancer cells with genistein
Bibhu Ranjan Das et al.
Pathology oncology research : POR, 21(3), 675-687 (2015-02-01)
Somatic mutations of EGFR and KRAS gene represent the most common alterations currently known in NSCLC patients. This study explored the frequency, distribution pattern of EGFR and KRAS mutations in Indian patients. The frequencies of EGFR and KRAS mutations were
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