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显示 31-60 共 183 条结果 关于 "75-36-5" 范围 论文
Clinton F Stewart et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 25(18), 2594-2600 (2007-06-20)
To study the association between UDP-glucuronosyltransferase 1A1 (UGT1A1) genotypes and severe toxicity as well as irinotecan disposition in pediatric patients with solid tumors receiving low-dose, protracted irinotecan (15 to 75 mg/m2 daily for 5 days for 2 consecutive weeks). Seventy-four
Nagwa M Hassanein et al.
American journal of clinical pathology, 132(4), 573-580 (2009-09-19)
We compared the expression of CD123, the alpha chain of the interleukin-3 receptor, on normal B-cell precursors in bone marrow ("hematogones") from 75 specimens and on leukemic blasts in 45 newly diagnosed B-acute lymphoblastic leukemias (B-ALL) cases. We found that
Muhammad Yasir et al.
Scientific reports, 9(1), 7063-7063 (2019-05-10)
Melimine and Mel4 are chimeric cationic peptides with broad-spectrum antimicrobial activity. They have been shown to be highly biocompatible in animal models and human clinical trials. The current study examined the mechanism of action of these two antimicrobial peptides against
Y Zeng et al.
The Journal of biological chemistry, 273(44), 28921-28930 (1998-10-24)
Histone deacetylase-2 (HDAC2) is a component of a complex that mediates transcriptional repression in mammalian cells. A mouse HDAC2 cDNA was used to identify several recombinant clones containing the entire mouse HDAC2 gene. The mouse HDAC2 gene spans over 36
Yo Sasaki et al.
Cancer, 94(6), 1777-1786 (2002-03-29)
Hepatocellular carcinoma (HCC) is a vascular-rich tumor. The tumor vessels in HCC were demonstrated to have alpha-smooth muscle actin positive smooth muscle cells (SMCs). However, it is unclear whether the SMCs in the wall of the tumor vessels are differentiated
Yong-jian Shi et al.
Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 29(9), 1802-1805 (2009-09-26)
To detect the expressions of receptor-interacting protein (RIP) and caspase-8 and investigate their roles in oral squamous cell carcinoma (OSCC) and oral precancerous lesions. SABC immunohistochemical methods were used to detect the expressions of RIP and caspase-8 in 22 specimens
Yoshiaki Ikuta et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 11(22), 8079-8088 (2005-11-22)
There are no available tumor markers detecting primary melanoma at an early stage. The identification of such serum markers would be of significant benefit for an early diagnosis of melanoma. We recently identified glypican-3 (GPC3) as a novel tumor marker
Y Zeng et al.
The Journal of biological chemistry, 273(44), 28921-28930 (1998-10-24)
Histone deacetylase-2 (HDAC2) is a component of a complex that mediates transcriptional repression in mammalian cells. A mouse HDAC2 cDNA was used to identify several recombinant clones containing the entire mouse HDAC2 gene. The mouse HDAC2 gene spans over 36
T Saeki et al.
Molecular endocrinology (Baltimore, Md.), 5(12), 1955-1963 (1991-12-01)
Expression of transforming growth factor alpha (TGF alpha) mRNA and protein can be stimulated by estrogens such as 17 beta-estradiol (E2) in estrogen-responsive rodent and human breast cancer cells. To ascertain if E2 can directly regulate TGF alpha expression through
Ulrike Lass et al.
PloS one, 7(7), e41298-e41298 (2012-07-31)
To investigate the dynamics of inter- and intratumoral molecular alterations during tumor progression in recurrent gliomas. To address intertumoral heterogeneity we investigated non-microdissected tumor tissue of 106 gliomas representing 51 recurrent tumors. To address intratumoral heterogeneity a set of 16
Dorota Koczkodaj et al.
Polskie Archiwum Medycyny Wewnetrznej, 110(6), 1395-1403 (2004-04-01)
In a group of 75 untreated patients with a typical B cell chronic lymphocytic leukaemia (B-CLL) (CD19+, CD5/CD19+, CD23/CD19+), the frequency and clinical significance of TP53 gene deletion and chromosome 12 trisomy were assessed. The studies of peripheral blood lymphocytes
P Huber et al.
Genomics, 32(1), 21-28 (1996-02-15)
Vascular endothelial cadherin (VE-cadherin) is located strictly at endothelial junctions and appears to be a major adhesive component of cell to cell contacts. Genomic clones spanning 36 kb and encompassing the mouse VE-cadherin gene have been isolated and characterized. The
T Almeida et al.
Neuroscience, 122(1), 111-121 (2003-11-05)
Electrophysiological recordings were used to investigate the effects of ATP analogues on theta-burst-induced long-term potentiation (LTP) in rat hippocampal slices. alpha,beta-Methylene ATP (alpha,beta-MeATP; 20 microM) decreased LTP from 36+/-9% to 17+/-5%, an effect prevented by adenosine A(1) receptor blockade in
P Wangemann et al.
The Journal of membrane biology, 170(1), 67-77 (1999-07-10)
Receptors were identified pharmacologically in functional studies where K+ secretion was monitored as transepithelial current (Isc). Further, receptors were identified as transcripts by cloning and sequencing of reverse-transcriptase polymerase chain reaction (RT-PCR) products. Isc under control conditions was 796 +/-
Fernanda Bernardi Bertonha et al.
Molecular oncology, 9(2), 450-462 (2014-12-03)
A significant association between DNA losses on 22q13.31 and head and neck squamous cell carcinomas (HNSCC) was previously reported by our group. Our data indicated that PHF21B gene, mapped on 22q13.31 and encoding a protein with function of chromatin-mediated transcriptional
Yusuke Yamamoto et al.
Oncology reports, 30(4), 1687-1694 (2013-07-12)
Glutathione S-transferases (GSTs) have been reported to be activated in several types of cancers, including esophageal squamous cell carcinoma (ESCC). The aim of the present study was to investigate whether GSTP1 protein expression is a useful predictor of the clinical
Andrew Emmanuel et al.
Gastrointestinal endoscopy, 90(1), 127-136 (2019-03-03)
Few large Western series examine risk factors for recurrence after endoscopic resection (ER) of large (≥20 mm) colorectal laterally spreading tumors. Recurrence beyond initial surveillance is seldom reported, and differences between residual/recurrent adenoma and late recurrence are not scrutinized. We report
M K Tee et al.
Human molecular genetics, 4(11), 2109-2116 (1995-11-01)
Complement component C4 is encoded by two nearly identical genes, C4A and C4B, that encode a C4 precursor that is proteolytically cleaved into the alpha, beta and gamma subunits of the mature protein. C4 is expressed primarily in liver and
Yoshihiro Ohishi et al.
Human pathology, 43(6), 808-817 (2011-11-15)
We recently have demonstrated nuclear localization of E-cadherin in ovarian adult granulosa cell tumors (Histopathology 2011;58:423). The purpose of the present study is to investigate the diagnostic utility of E-cadherin nuclear staining for the differential diagnosis between ovarian adult granulosa
Chang-Yin Li et al.
Journal of ethnopharmacology, 162, 225-230 (2015-01-13)
Hydroxysafflor yellow A (HSYA), the major active marker compound isolated from Carthamus tinctorius L., has been demonstrated to possess various attractive pharmacological activities. However, there is a lack of information about the complete clinical pharmacokinetic profiles of HSYA following the
José M López et al.
Bone, 43(2), 405-409 (2008-06-10)
Craniotubular hyperostosis are a group of high bone mass disorders related to mutations in the LRP5 and SOST genes, although other causative genes remain to be identified. Little is known about the bone turnover and the response to T3 or
José M López et al.
Bone, 43(2), 405-409 (2008-06-10)
Craniotubular hyperostosis are a group of high bone mass disorders related to mutations in the LRP5 and SOST genes, although other causative genes remain to be identified. Little is known about the bone turnover and the response to T3 or
Prima Buranasin et al.
PloS one, 13(8), e0201855-e0201855 (2018-08-10)
Delayed gingival wound healing is widely observed in periodontal patients with diabetes. However, the molecular mechanisms of the impaired function of gingival fibroblasts in diabetes remain unclear. The purpose of this study was to investigate changes in the properties of
Marc C Chamberlain
Expert review of neurotherapeutics, 12(8), 929-936 (2012-09-26)
One hundred patients, aged 36-84 years (median 62 years) with recurrent glioblastoma (GBM), were treated previously with surgery, concurrent radiotherapy and temozolomide and postradiotherapy temozolomide followed by single-agent bevacizumab (BEV) at either first (60 patients) or second recurrence (40 patients).
Jan Astermark et al.
Blood, 107(8), 3167-3172 (2005-12-29)
The aim of the Malmö International Brother Study (MIBS) is to evaluate host genetic factors associated with the development of inhibitory antibodies in patients with hemophilia. Factor VIII gene mutations and genetic polymorphisms of the IL1beta, IL4, and IL10 genes
M A Cürük et al.
Hemoglobin, 25(2), 241-245 (2001-08-02)
Beta-thalassemia is the most common genetic abnormality causing health problems worldwide. Cukurova, in the southern part of Turkey, being on the Mediterranean, is in the thalassemic belt. Since there is no cure for the disease at present, the frequency of
P J Willems et al.
American journal of medical genetics, 38(1), 111-131 (1991-01-01)
Fucosidosis is a rare, autosomal recessive, lysosomal storage disorder caused by a severe deficiency of alpha-L-fucosidase in all tissues. We have conducted a review of fucosidosis, compiling data from published reports and an international questionnaire survey. Seventy-seven patients affected with
Alina S Gerrie et al.
British journal of haematology, 161(6), 802-810 (2013-04-19)
Dexamethasone ± thalidomide with infusion of cisplatin, doxorubicin, cyclophosphamide, and etoposide [D(T)PACE] is generally reserved as salvage therapy for aggressive multiple myeloma (MM) or plasma cell leukaemia (PCL) resistant to conventional therapies. The efficacy and durability of this potentially toxic regimen in
Se Joon Woo et al.
JAMA ophthalmology, 139(1), 68-76 (2020-11-20)
Neovascular age-related macular degeneration is the leading cause of blindness in individuals 50 years or older. The availability of a ranibizumab biosimilar product (SB11) may facilitate access to an effective alternative to this treatment. To demonstrate equivalence of efficacy, similar
Wen-Kang Liu et al.
Onkologie, 33(5), 241-245 (2010-05-27)
Endometrial cancer is the 4th most common gynecological cancer. The expression of prostate stem cell antigen (PSCA), piwi-like 1 (PIWIL1), and T-box 2 (TBX2) in endometrial cancer remains to be elucidated. The expression of PSCA, PIWIL1, and TBX2 was examined
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