CN
Search Within
75-60-5
应用筛选条件
关键词:'75-60-5'
显示 1-30 共 477 条结果 关于 "75-60-5" 范围 论文
Fumiaki Uchiumi et al.
Genes to cells : devoted to molecular & cellular mechanisms, 13(12), 1229-1247 (2008-12-17)
The metabolism of poly(ADP-ribose) plays important roles in the nuclear function of mammalian cells. Previously, we analyzed expression of the poly(ADP-ribose) glycohydrolase (PARG) gene during HL-60 cell differentiation and found that expression was greatly reduced by 4 h after 12-O-tetradecanoyl-phorbol-13-acetate
Maria Luigia Randi et al.
Aging clinical and experimental research, 23(1), 17-21 (2011-04-19)
JAK2V617F mutation occurs in 90% of polycythemia vera (PV) and in 50% of essential thrombocythemia (ET) patients. 253 consecutive patients affected by myeloproliferative disorders (MPD, 121 PV, 132 ET) were evaluated and stratified in 4 age groups: 18-39, 40-59, 60-75
Quan-Ming Zeng et al.
Biotechnology letters, 32(9), 1251-1254 (2010-05-19)
5'-O-beta-D-Galactosyl-floxuridine, a potential novel prodrug, was synthesized with a yield of 75% through beta-galactosidase-catalyzed transgalactosylation. This enzyme displayed absolute regioselectivity toward the 5'-position of floxuridine. For the reaction, the optimal conditions were pH 6.5 at 45 degrees C for 60
Morteza Zendehdel et al.
Neuroscience letters, 739, 135408-135408 (2020-10-08)
The aim of the current study was to determine effects of intracerebroventricular (ICV) and intraperitoneal (i.p.) administration of Methylamine (MET) and possible interactions with nitric oxide (NO) and TAAR1 pathways in 24-h fasted (FD24) and ad libitum layer-type chicken. In
Bin Tian et al.
International journal of pharmaceutics, 475(1-2), 385-392 (2014-09-15)
The purpose of this work was to compare the effect of temperature and relative humidity (RH) on the physical stability and dissolution of solid dispersions. Cinnarizine-Soluplus(®) solid dispersions (SDs) at three different drug loadings (10, 20 and 35 wt%) were
Oliver Teuffel et al.
British journal of haematology, 161(2), 192-203 (2013-02-13)
This systematic review and meta-analysis compared the efficacy of different anthracyclines and anthracycline dosing schedules for induction therapy in acute myeloid leukaemia in children and adults younger than 60 years of age. Twenty-nine randomized controlled trials were eligible for inclusion in
Christine J Andrews et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 25(5), 792-804 (2017-09-01)
Deep dermal burn injuries require extensive medical care; however, the water temperatures and durations of exposure that result in a severe scald injury are unknown. This study used a porcine burn model to investigate the time and temperature threshold for
A Kovarik et al.
The Journal of biological chemistry, 268(13), 9917-9926 (1993-05-05)
The 5'-sequences flanking the human MUC1 gene have been analyzed for their ability to direct expression of a reporter gene (the chloramphenicol acetyltransferase gene (CAT)) in cell lines that normally express or do not express the MUC1 gene. A construct
Boris Böll et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(12), 1522-1529 (2013-03-20)
Older patients with Hodgkin lymphoma (HL) account for approximately 20% of all HL patients. ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) chemotherapy is regarded as standard of care in these patients. However, little is known on feasibility and efficacy of ABVD
Céline Devroye et al.
Neuropharmacology, 89, 375-381 (2014-12-03)
The serotonin(2C) receptor (5-HT(2C)R) is known to control dopamine (DA) neuron function by modulating DA neuronal firing and DA exocytosis at terminals. Recent studies assessing the influence of 5-HT(2C)Rs on cocaine-induced neurochemical and behavioral responses have shown that 5-HT2CRs can
Cláudia Malheiros Coutinho-Camillo et al.
Cancer genetics, 208(7-8), 382-389 (2015-06-02)
Aberrations in the apoptotic mechanisms that cause excessive or deficient programmed cell death have been linked to a wide array of pathological conditions. In this study, using real-time reverse transcriptase-PCR, we analyzed the expression of apoptosis-regulating miRNAs (miR-15a, miR-16, miR-17-5p
Dominic P Geraghty et al.
British journal of pharmacology, 137(6), 919-927 (2002-11-02)
1. Activation of vanilloid receptors on sensory nerve terminals in the commissural nucleus of the solitary tract (cNTS) of rats with capsaicin, produces respiratory slowing. In this study, we used microinjection techniques employing pungent and non-pungent vanilloids to further characterize
Diane C Homeyer et al.
Medical mycology, 53(3), 285-294 (2015-01-30)
Invasive fungal wound infections (IFIs) are increasingly reported in trauma patients and cause considerable morbidity and mortality despite standard of care treatment in trauma centers by experienced medical personnel. Topical agents such as oil of melaleuca, also known as tea
Sebastian Dorawa et al.
International journal of molecular sciences, 23(14) (2022-07-28)
We present a structural and functional analysis of the DNA polymerase of thermophilic Thermus thermophilus MAT72 phage vB_Tt72. The enzyme shows low sequence identity (<30%) to the members of the type-A family of DNA polymerases, except for two yet uncharacterized
C Wicker-Planquart et al.
FEBS letters, 296(1), 61-66 (1992-01-13)
The sequence of rat pancreatic lipase mRNA was determined. The data have been assigned the following accession number, X61925, in the EMBL data library. The total length of the messenger is 1531 nucleotides, plus a poly(A) stretch of about 60
S Marquette et al.
International journal of pharmaceutics, 470(1-2), 41-50 (2014-05-06)
Antibodies (Abs) require the development of stable formulations and specific delivery strategies given their susceptibility to a variety of physical and chemical degradation pathways. In this study, the encapsulation of an antibody into polylactide-co-glycolide (PLGA) based microspheres was explored to
Takafumi Ito et al.
International urology and nephrology, 47(1), 131-135 (2014-10-10)
We have previously reported the results of mizoribine (MZR) treatment for elderly patients with membranous nephropathy (MN). Here, we retrospectively compared these patients with those who had been initially treated with prednisolone (PSL) alone. The subjects were patients with MN
Sheila M G Marra et al.
American journal of rhinology & allergy, 25(5), e196-e199 (2011-12-22)
This study was designed to analyze spirometric parameters and cytokine (interferon [IFN] gamma and IL-5) levels in induced sputum from patients with asthma or allergic rhinitis (AR) and nonatopic subjects. Thirty-three subjects aged 18-60 years were enrolled in the present
Christel Rousseaux et al.
Carcinogenesis, 34(11), 2580-2586 (2013-07-12)
Epidemiological evidences suggested that 5-aminosalicylic acid (5-ASA) therapy may prevent the development of colorectal cancer in inflammatory bowel disease patients. Our aim is to investigate whether peroxisome proliferator-activated receptor-γ (PPARγ) mediates the antineoplastic effects of 5-ASA. HT-29 and Caco-2 cells
C E Scharping et al.
Carcinogenesis, 14(5), 1041-1047 (1993-05-01)
The hepatic microsomal metabolism of the carcinogenic 8-methylquinoline (8MQ) and its noncarcinogenic isomer, 6-methylquinoline (6MQ), were compared for preparations from control rats and rats pretreated with phenobarbital or 3-methylcholanthrene. For each compound the alcohol was the major metabolite, constituting 50-75%
Claudia Muratori et al.
Scientific reports, 6, 36835-36835 (2016-11-12)
Electroporation by nanosecond electric pulses (nsEP) is an emerging modality for tumor ablation. Here we show the efficient induction of apoptosis even by a non-toxic nsEP exposure when it is followed by a 30-min chilling on ice. This chilling itself
Niwat Chawachart et al.
Extremophiles : life under extreme conditions, 18(6), 1023-1034 (2014-07-31)
GH10 xylanase from Thermoascus aurantiacus strain SL16W (TasXyn10A) showed high stability and activity up to 70-75 °C. The enzyme's half-lives were 101 h, 65 h, 63 min and 6 min at 60, 70, 75 and 80 °C, respectively. The melting
Stavros G Manios et al.
Meat science, 101, 25-32 (2014-12-03)
The effect of common handling practices (i.e., freezing, thawing and cooking) of beef patties on the survival of Salmonella spp. and Escherichia coli O157:H7, was evaluated. Inoculated ground beef was stored at -22 °C for 5 and 75 days. After
A Bevilacqua et al.
Proceedings of the National Academy of Sciences of the United States of America, 85(3), 831-835 (1988-02-01)
beta-Glucuronidase activity increases 60-fold from the 4-cell to the blastocyst stage during in vitro development of mouse preimplantation embryos, secondary to a 13-fold increase in beta-glucuronidase mRNA. Injections of antisense RNA from a beta-glucuronidase cDNA clone lacking the 5'-untranslated region
G P Moore et al.
Biochimica et biophysica acta, 397(2), 468-477 (1975-08-26)
Two enzymic forms of kynurenine formamidase (EC 3.5.1.9) from Drosophila melanogaster were separated and partially purified by pH fractionation, (NH4) 2SO4 fractionation and Sephadex G-75 gel filtration. The enzymes were also separated by DEAE-cellulose ion-exchange chromatography and distinguished by their
Haim Matzkin et al.
Urologic oncology, 30(4), 379-385 (2010-03-02)
Preoperative planning (PP) and intraoperative planning (IoP) are established (125)I-brachytherapy techniques for the treatment of localized prostate cancer. We prospectively compared the effects of each method on reducing PSA levels. One hundred eighty patients treated with brachytherapy as monotherapy without
Marc C Chamberlain
Expert review of neurotherapeutics, 12(8), 929-936 (2012-09-26)
One hundred patients, aged 36-84 years (median 62 years) with recurrent glioblastoma (GBM), were treated previously with surgery, concurrent radiotherapy and temozolomide and postradiotherapy temozolomide followed by single-agent bevacizumab (BEV) at either first (60 patients) or second recurrence (40 patients).
Dong Wook Kang et al.
Bioorganic & medicinal chemistry, 18(22), 8092-8105 (2010-10-13)
As an extension of our analysis of the effect of halogenation on thiourea TRPV1 agonists, we have now modified selected 4-hydroxy(or 4-amino)-3-methoxyphenyl acetamide TRPV1 agonists by 5- or 6-halogenation on the aromatic A-region and evaluated them for potency for TRPV1
Mei-Yu Zhang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(4), 597-604 (2013-05-30)
To observe the analgesic effect of sinomenine on the neuropathic pain rat model induced by SSNI, and discuss its impact on monoamine neurotransmitters in striatal extracellular fluid. Male SD rats were randomly divided into the sham operation group, the SSNI
Erwin L van Dijk et al.
RNA (New York, N.Y.), 13(7), 1027-1035 (2007-06-05)
The human exosome is a 3'-5' exoribonuclease complex that functions both in the nucleus and in the cytoplasm to either degrade or process RNA. Little is known yet about potential differences among core exosome complexes in these different cellular compartments
1/16