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A Azau et al.
Perfusion, 29(6), 496-504 (2014-03-13)
We hypothesized that the optimization of renal haemodynamics by maintaining a high level of mean arterial blood pressure (MAP) during cardiopulmonary bypass (CPB) could reduce the rate of acute kidney injury (AKI) in high-risk patients. In this randomized, controlled study
Jessy El Hayek et al.
The Journal of nutrition, 143(2), 154-160 (2012-12-21)
The 2007 to 2009 Canadian Health Measures Survey reported vitamin D status in a representative sample of Canadians (6-79 y); however, children <6 y were not assessed. Our objective was to measure vitamin D intake from food and supplements, sun
Berit Flatø et al.
Arthritis and rheumatism, 46(4), 986-994 (2002-04-16)
To assess the frequency of sacroiliitis and the radiographic and clinical outcome in juvenile idiopathic arthritis (JIA) and determine patient characteristics, early disease variables, and genetic markers that predict development of sacroiliitis. We performed a retrospective cohort study of 314
P A Bejarano et al.
Applied immunohistochemistry & molecular morphology : AIMM, 8(3), 189-194 (2000-09-12)
Thyroid transcription factor-1 (TTF-1), a member of the NKx2 family of homeodomain transcription factors, is a mediator of thyroid-specific transcription of the thyroglobulin (TG) gene. The combined immunohistochemical profile of TTF-1, TG, cytokeratin 7 (CK7), and cytokeratin 20 (CK20) in
Kristen A Mehl et al.
Journal of applied physiology (Bethesda, Md. : 1985), 98(6), 2219-2225 (2005-05-17)
Moderate-intensity treadmill running can alter male Apc(Min/+) mouse polyp formation. This purpose of this study was to examine whether exercise mode differentially affects Apc(Min/+) mouse intestinal polyp development in male and female mice. Male and female Apc(Min/+) mice were randomly
Hui-Hui Lin et al.
Urologic oncology, 28(6), 597-602 (2009-02-03)
To identify a better set of DNA methylation markers to detect superficial, low grade cancer cell in urine sediment for improving cancer treatment, morbidity, and mortality. Methylation-specific PCR (MSP) assay was used to detect promoter hypermethylation in 4 genes (E-cadherin
N Koyanagi et al.
Cancer research, 54(7), 1702-1706 (1994-04-01)
The search for compounds active against solid tumors has led us to the discovery of a novel sulfonamide, E7010 (N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4- methoxybenzenesulfonamide), which inhibits tubulin polymerization. When administered orally, E7010 showed good antitumor activity against various rodent tumors and human tumor
Steve Hartland et al.
Digestive diseases and sciences, 49(9), 1545-1550 (2004-10-16)
The proinflammatory cytokine interleukin-1 has been implicated in host susceptibility to Helicobacter pylori-associated disease. Recent studies suggest that this susceptibility may be under genetic control. It remains to be determined whether the relationship between IL-1 gene polymorphism and gastrointestinal disease
Vanja Sikirica et al.
The patient, 8(3), 269-281 (2014-10-26)
Attention-deficit/hyperactivity disorder (ADHD) is a neurobehavioral disorder characterized by inattention, impulsivity, and hyperactivity, the levels of which are inappropriately high for an individual's developmental age. The objective of this study was to explore the unmet needs of children/adolescents with ADHD
Domenico Russo et al.
Microscopy research and technique, 73(2), 128-139 (2009-09-03)
Spinal ganglia (SG) neurons are commonly classified according to various specific features. The most widespread classification based on morphological and ultrastructural features subdivides SG neurons into light and small dark neurons. Using immunohistochemical, histochemical and lectin methods, it is possible
Turan Calhan et al.
Helicobacter, 18(5), 378-383 (2013-04-23)
An ideal second-line therapeutic regimen for the treatment of patients who do not respond to standard triple therapy is currently being investigated. In this study, we aimed to investigate the efficacy of two levofloxacin-containing second-line therapies for Helicobacter pylori (H.
Manish M Subramaniam et al.
The American journal of gastroenterology, 104(2), 426-436 (2009-01-29)
We hypothesized that RUNX3 inactivation by promoter hypermethylation in colorectal polyps is an early molecular event in colorectal carcinogenesis. RUNX3 protein expression was analyzed immunohistochemically in 50 sporadic colorectal polyps comprising 19 hyperplastic polyps (HPs), 14 traditional serrated adenomas (TSAs)
Ravinder-Jeet Singh et al.
Stroke, 50(2), 357-364 (2019-01-01)
Background and Purpose- Intraluminal thrombus (ILT) is an uncommon finding among patients with ischemic stroke. We report clinical-imaging manifestations, treatment offered, and outcome among patients with ischemic stroke/transient ischemic attack and ILT in their cervico-cephalic arteries. Methods- Sixty-one of 3750
Kun-Ming Chen et al.
Chemical research in toxicology, 25(2), 374-380 (2011-11-24)
Tobacco smoking is an etiological factor of ovarian cacner; however, the mechanisms remain largely undefined. Therefore, as an initial investigation, we examined the carcinogenicity and DNA adducts formation in the ovary of mice treated with DB[a,l]P, a tobacco smoke constituent
R L Wolff
Reproduction, nutrition, developpement, 28(6A), 1489-1507 (1988-01-01)
Weaned rats (21-day old, 44 +/- 2 g) were distributed into 3 groups. The first group was raised on a laboratory diet for 7 or 20 days (control group). The second was fed a diet containing 0.07% fat for 1
Justin A Bishop et al.
Human pathology, 41(1), 20-25 (2009-09-11)
Recent advances in the treatment of pulmonary adenocarcinoma have increased the need for accurate typing of non-small cell carcinomas. Immunohistochemistry for thyroid transcription factor-1 is widely used in the diagnosis of pulmonary adenocarcinomas because it marks approximately 75% of lung
Daniela Merlotti et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 22(10), 1510-1517 (2007-07-04)
This randomized study compared different intravenous bisphosphonates in PDB. Zoledronate was superior with respect to pamidronate in achieving biochemical remission, with therapeutic response maintained in most patients at 15 mo. Single neridronate and zoledronate infusion showed a similar efficacy in
Nadine Beydoun et al.
Journal of medical imaging and radiation oncology, 58(3), 369-376 (2013-10-15)
Androgen deprivation therapy (ADT) is an important component of modern prostate cancer treatment. Survival benefits from neo-adjuvant and adjuvant hormones may take years to manifest, and balancing this with potential morbidity of therapy can be challenging. This study aimed to
Contribution of genetic factors to renal lesions in the stroke-prone spontaneously hypertensive rat.
Bruna Gigante et al.
Hypertension (Dallas, Tex. : 1979), 42(4), 702-706 (2003-07-23)
Stroke-prone spontaneously hypertensive rats (SHRSP) develop renal lesions more frequently than the closely related control strain, the stroke-resistant SHR. The aim of this study was to investigate the contribution of genetic factors to the enhanced susceptibility to renal damage of
Stephen Z Levine et al.
Schizophrenia research, 145(1-3), 125-127 (2013-02-12)
The treatment and measurement of negative symptoms are currently at issue in schizophrenia, but the clinical meaning of symptom severity and change is unclear. To offer a clinically meaningful interpretation of severity and change scores on the Scale for the
Ying-Ying Hu et al.
European journal of radiology, 133, 109348-109348 (2020-10-26)
To evaluate the treatment-dependent changes in FDG uptake in the adenoid, palatine tonsils, and thymus in paediatric patients with lymphoma. Eight hundred PET/CT scans of 212 paediatric patients between 2007 and 2019 (mean age, 11.9 years; median follow-up, 26.2 months)
Abbas Agaimy et al.
The American journal of surgical pathology, 32(10), 1553-1559 (2008-08-30)
Multifocal gastrointestinal stromal tumors (GISTs) are observed in patients with germline KIT or PDGFRA mutations, and in those with neurofibromatosis 1. However, the pathogenesis of apparently sporadic multifocal gastric GISTs in adults is poorly understood. We analyzed 27 GISTs from
S J Zürcher et al.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 31(2), 335-349 (2019-12-01)
We investigated associations between bone mineral content (BMC) and bone-related biomarkers (BM) in pre-and early pubertal children of both sexes. In this population, we found that bone turnover markers explain a small part of BMC variance. It is still debated
Siham Sikander et al.
The lancet. Psychiatry, 6(2), 128-139 (2019-01-29)
The Thinking Healthy Programme (THP), which is endorsed by WHO, is an evidence-based intervention for perinatal depression. We adapted THP for delivery by volunteer peers (laywomen from the community) to address the human resource needs in bridging the treatment gap
J Hall et al.
The Journal of biological chemistry, 262(23), 11046-11051 (1987-08-15)
In order to define the interaction domain on Rhodospirillum rubrum cytochrome c2 for the photosynthetic reaction center, positively charged lysine amino groups on cytochrome c2 were modified to form negatively charged carboxydinitrophenyl lysines. The reaction mixture was separated into six
M L Rothenberg et al.
Gynecologic oncology, 82(2), 317-322 (2001-09-05)
The aim of this study was to evaluate the 2-year survival rate in a group of women in complete clinical remission (cCR) from Stage III ovarian cancer following front-line therapy who were then treated with a 6-month course of altretamine.
Eoin P Flanagan et al.
Annals of neurology, 76(1), 54-65 (2014-05-20)
To highlight a specific under-recognized radiological feature of spondylotic myelopathy often resulting in misdiagnosis. Patients evaluated between January 1, 1996 and December 31, 2012 who met the following criteria were included: (1) spondylotic myelopathy was suspected, (2) gadolinium enhancement was
M Cornelissen et al.
Apoptosis : an international journal on programmed cell death, 7(1), 41-47 (2002-01-05)
Loss of plasma membrane asymmetry, resulting in the exposure of phosphatidylserine (PS), is considered to be an 'early' event in apoptosis. It is generally accepted to precede nuclear condensation, independent of the apoptosis inductive agent. In the present study we
Sandeep Ankolekar et al.
Stroke, 44(11), 3120-3128 (2013-09-05)
The practicalities of doing ambulance-based trials where paramedics perform all aspects of a clinical trial involving patients with ultra-acute stroke have not been assessed. We performed a randomized controlled trial with screening, consent, randomization, and treatment performed by paramedics prior
A Titia Lely et al.
Journal of hypertension, 28(12), 2414-2421 (2010-09-11)
Renin-angiotensin-aldosterone system blockade is a cornerstone in cardiovascular protection. Angiotensin-converting enzyme (ACE)-DD genotype has been associated with resistance to angiotensin-converting enzyme inhibition (ACEi), but data are conflicting. As sodium intake modifies the effect of ACEi as well as the genotype-phenotype
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