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关键词:'75-91-2'
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Shigeyuki Yamada et al.
Japanese journal of clinical oncology, 43(7), 734-739 (2013-04-27)
We investigated the efficacy and toxicity of a docetaxel, ifosfamide and nedaplatin regimen as salvage therapy for patients with advanced testicular germ cell tumor. Eleven patients with advanced germ cell tumor refractory or relapsed after cisplatin-based chemotherapy were treated using
R N Gunawardane et al.
The Journal of cell biology, 151(7), 1513-1524 (2001-01-03)
The gamma-tubulin ring complex (gammaTuRC) is important for microtubule nucleation from the centrosome. In addition to gamma-tubulin, the Drosophila gammaTuRC contains at least six subunits, three of which [Drosophila gamma ring proteins (Dgrips) 75/d75p, 84, and 91] have been characterized
Michail N Elinson et al.
Molecular diversity, 14(4), 833-839 (2009-11-19)
Electrochemically induced catalytic multicomponent transformation of isatins, 4-hydroxyquinolin-2(1H)-one and malononitrile in ethanol in an undivided cell in the presence of sodium bromide as an electrolyte results in the formation of spirooxindoles with fused functionalized indole-3,4'-pyrano[3,2-c]quinoline] scaffold in 75-91% substance yields
George V Papatheodoridis et al.
Hepatology (Baltimore, Md.), 48(5), 1451-1459 (2008-10-17)
The diagnosis of hepatitis B e antigen (HBeAg)-negative chronic hepatitis B indicating therapeutic intervention currently requires serum hepatitis B virus (HBV) DNA >or=2,000 IU/mL. We evaluated the severity of liver histology and the presence of histological indication for treatment in
Dorleta Otaegui et al.
Biomedical chromatography : BMC, 29(8), 1249-1258 (2015-01-24)
IKH12 is a novel histone deacetylase 6 selective inhibitor. A rapid and sensitive liquid chromatography tandem mass spectrometry method was developed and validated for the quantification of IKH12 in rat plasma and tissue with kendine 91 as internal standard (IS).
Min-Hwang Chang et al.
The Journal of biological chemistry, 283(26), 18402-18410 (2008-04-29)
Glaucoma, cataracts, and proximal renal tubular acidosis are diseases caused by point mutations in the human electrogenic Na(+) bicarbonate cotransporter (NBCe1/SLC4A4) (1, 2). One such mutation, R298S, is located in the cytoplasmic N-terminal domain of NBCe1 and has only moderate
Michal Fornalczyk et al.
Organic & biomolecular chemistry, 10(16), 3332-3342 (2012-03-17)
Two approaches have been developed for the enantioselective Reformatsky reaction of ethyl iododifluoroacetate with ketones to form a quaternary carbon centre using (1R,2S)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol as the chiral ligand. Good yields and high enantioselectivities (80-91% ee) were achieved with a range of
M A Medinsky et al.
Toxicology letters, 23(1), 119-125 (1984-10-01)
2,3-Dichloropropene (2,3-DCP), a component of commercial fumigants and nematocides, was mixed with [14C]2,3-DCP and given to rats by peroral (p.o.) or intraperitoneal (i.p.) administration. Urine, feces, and expired air were collected over 72 h. Excretion of radioactivity in urine predominated
Andrew M Shaw et al.
The Analyst, 145(16), 5638-5646 (2020-07-09)
An evaluation of a rapid portable gold-nanotechnology measuring SARS-CoV-2 IgM, IgA and IgG antibody concentrations against spike 1 (S1), spike 2 (S) and nucleocapsid (N) was conducted using serum samples from 74 patients tested for SARS-CoV-2 RNA on admission to
Su-Young Kim et al.
Diagnostic microbiology and infectious disease, 88(2), 125-137 (2017-03-16)
Mycobacterium avium complex (MAC) was originally composed of 2 species, M. avium and M. intracellulare. However, several new species closely related to M. intracellulare have recently been identified. In addition, M. avium has been further subdivided into 4 subspecies. The
Manish M Subramaniam et al.
The American journal of gastroenterology, 104(2), 426-436 (2009-01-29)
We hypothesized that RUNX3 inactivation by promoter hypermethylation in colorectal polyps is an early molecular event in colorectal carcinogenesis. RUNX3 protein expression was analyzed immunohistochemically in 50 sporadic colorectal polyps comprising 19 hyperplastic polyps (HPs), 14 traditional serrated adenomas (TSAs)
Simrit Parmar et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 19(3), 474-480 (2012-12-12)
Dose intensity is important for disease control in patients undergoing allogeneic stem cell transplantation. We conducted a phase I/II controlled, adoptive, randomized study to determine the optimal dosing schedule of i.v. busulfan. Patients aged ≤75 years with advanced hematologic malignancies
Ragaa H M Salama et al.
Clinical biochemistry, 45(10-11), 766-769 (2012-05-01)
To investigate the role of bone morphogenetic protein-2 (BMP-2) in patients with urinary tract infection (UTI) and renal stone in relation to Tamm-Horsfall protein (THP) and osteopontin (OPN). ELISA kits were used to determine these markers in serum and urinary
A M Misrahi et al.
Human mutation, 12(1), 71-71 (2000-01-08)
Mutations of the transthyretin (TTR) gene are associated with familial amyloidotic polyneuropathy (FAP). Two new mutations were detected in French patients with TTR amyloidosis. The first patient was a 72 year old man who presented with severe and rapidly evolving
Sarah I Jacob et al.
Journal of veterinary internal medicine, 32(3), 1215-1233 (2018-03-25)
Metabolomics, the study of small-molecule metabolites, has increased understanding of human metabolic diseases, but has not been used to study equine metabolic syndrome (EMS). (1) To examine the serum metabolome of Welsh Ponies with and without insulin dysregulation before and
Oliver Teuffel et al.
British journal of haematology, 161(2), 192-203 (2013-02-13)
This systematic review and meta-analysis compared the efficacy of different anthracyclines and anthracycline dosing schedules for induction therapy in acute myeloid leukaemia in children and adults younger than 60 years of age. Twenty-nine randomized controlled trials were eligible for inclusion in
Dimitrios Haidopoulos et al.
Reproductive sciences (Thousand Oaks, Calif.), 16(7), 685-693 (2009-04-18)
To assess the role of p16( INK4A), bcl-2, and p53 in cervical cancer screening, we conducted a retrospective trial of prospectively collected data. Sixty two women with abnormal Pap smears were subjected to colposcopy and biopsies from any abnormal lesion.
E A Turova et al.
Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury, (4)(4), 19-22 (2012-09-22)
The assessment of the biological age is needed to estimate the level of health and the efficacy of measures being undertaken to slow down the ageing processes and prolong the active life of the patients. Earlier studies have demonstrated the
D M McNamara et al.
Circulation, 103(12), 1644-1648 (2001-03-29)
Activation of the renin-angiotensin and sympathetic nervous systems adversely affect heart failure progression. The ACE deletion allele (ACE D) is associated with increased renin-angiotensin activation; however, its influence on patient outcomes remains uncertain, and the pharmacogenetic interactions with beta-blocker therapy
Nagwa M Hassanein et al.
American journal of clinical pathology, 132(4), 573-580 (2009-09-19)
We compared the expression of CD123, the alpha chain of the interleukin-3 receptor, on normal B-cell precursors in bone marrow ("hematogones") from 75 specimens and on leukemic blasts in 45 newly diagnosed B-acute lymphoblastic leukemias (B-ALL) cases. We found that
Weifeng Li et al.
International immunopharmacology, 22(2), 311-317 (2014-07-27)
The quaternary ammonium salt, sanguinarine (SG) was reported to possess widespread anti-microbial and anti-inflammatory effects in experimental animals and it has been used to treat many inflammatory diseases. The aim of this study was to evaluate the anti-inflammatory effect and
M de Gasparo et al.
Journal of steroid biochemistry, 32(1B), 223-227 (1989-01-01)
The use of spironolactone in the treatment of hypertension has been limited by the occurrence of sexual side effects, mainly menstrual disturbances in women and gynaecomastia in men. In order to minimize this limitation on the use of an effective
Claudia Gagnon et al.
PloS one, 9(10), e109607-e109607 (2014-10-10)
To examine whether combined vitamin D and calcium supplementation improves insulin sensitivity, insulin secretion, β-cell function, inflammation and metabolic markers. 6-month randomized, placebo-controlled trial. Ninety-five adults with serum 25-hydroxyvitamin D [25(OH)D] ≤55 nmol/L at risk of type 2 diabetes (with
Qi Zhang et al.
Oncology letters, 17(4), 3799-3807 (2019-03-19)
The aim of the present study was to develop a procedure for the isolation of circulating tumor cells (CTCs), and to evaluate its application in the detection of epidermal growth factor receptor (EGFR) mutations, and potential heterogeneity in patients with
Yoshihiro Hattori et al.
Japanese journal of clinical oncology, 43(12), 1184-1189 (2013-10-31)
Pemetrexed has relatively mild toxicity and possibly can be administered long term to patients with non-small-cell lung cancer. We conducted a Phase II trial to evaluate the efficacy and safety of pemetrexed in chemotherapy-naïve elderly patients with advanced non-squamous non-small-cell
Meng-Wei Hsieh et al.
Electrophoresis, 31(13), 2272-2278 (2010-07-02)
A dynamic reaction cell ICP-MS was used as a CE detector for the speciation analysis of arsenic and selenium. Samples containing arsenite, arsenate, monomethylarsonic acid, dimethylarsinic acid, arsenobetaine, selenite, selenate, selenocysteine, selenomethione, and Se-methylselenocysteine were subjected to electrophoretic separation before
H Siddique et al.
International journal of clinical practice, 68(11), 1333-1337 (2014-05-20)
Our aim is to assess the impact of inpatient diabetes services on glycaemic control in patient with diabetes admitted to a secondary care hospital in UK. We performed a retrospective analysis of all diabetes mellitus (DM) in-patients who were seen
Gustavo Calle Astudillo et al.
Acta gastroenterologica Latinoamericana, 43(3), 189-197 (2013-12-07)
To evaluate the diagnostic utility of routine gastric biopsies taken at random versus targeted biopsies with methylene blue staining for the diagnosis of intestinal metaplasia. We performed a validation study in 376 patients. We performed 2 antral biopsies, 2 gastric
Andrew T Taylor et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 51(3), 391-396 (2010-02-13)
Studies in rats showed that the pharmacokinetics of the tricarbonyl core radiopharmaceutical (99m)Tc(CO)(3)-nitrilotriacetic acid, (99m)Tc(CO)(3)(NTA), were essentially identical to those of (131)I ortho-iodohippuran ((131)I-OIH), the clinical gold standard for the measurement of effective renal plasma flow. Our objective was to
A Tsuboi et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(19), 8409-8418 (1999-09-24)
We have characterized two separate odorant receptor (OR) gene clusters to examine how olfactory neurons expressing closely linked and homologous OR genes project their axons to the olfactory bulb. Murine OR genes, MOR28, MOR10, and MOR83, share 75-95% similarities in
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