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Michael J Lott et al.
Rapid communications in mass spectrometry : RCM, 29(15), 1381-1388 (2015-07-07)
Elemental analyzer systems generate N(2) and CO(2) for elemental composition and isotope ratio measurements. As quantitative conversion of nitrogen in some materials (i.e., nitrate salts and nitro-organic compounds) is difficult, this study tests a recently published method - thermal decomposition
Søs G Mathiassen et al.
The Journal of biological chemistry, 290(34), 21141-21153 (2015-07-15)
A mutation, L166P, in the cytosolic protein, PARK7/DJ-1, causes protein misfolding and is linked to Parkinson disease. Here, we identify the fission yeast protein Sdj1 as the orthologue of DJ-1 and calculate by in silico saturation mutagenesis the effects of
Johannes Numrich et al.
Journal of cell science, 128(13), 2278-2292 (2015-05-23)
Membrane fusion at the vacuole depends on a conserved machinery that includes SNAREs, the Rab7 homolog Ypt7 and its effector HOPS. Here, we demonstrate that Ypt7 has an unexpected additional function by controlling membrane homeostasis and nutrient-dependent signaling on the
Guy B P Ngassa et al.
Talanta, 147, 547-555 (2015-11-26)
This work describes the development of a low-cost and reliable adsorptive stripping voltammetric method for the detection of PNP in water. Organoclays were prepared by intercalation in various loading amounts of cetyltrimethylammonium ions (CTA(+)) in the interlayer space of a
Dongdong Zhang et al.
PloS one, 9(10), e109509-e109509 (2014-10-15)
In this study, a sensitive dual-label time-resolved reverse competitive chemiluminescent immunoassay was developed for simultaneous detection of chloramphenicol (CAP) and clenbuterol (CLE) in milk. The strategy was performed based on the distinction of the kinetic characteristics of horseradish peroxidase (HRP)
Philip Hasel et al.
Biochimica et biophysica acta, 1853(9), 2066-2076 (2014-12-30)
Neurodegenerative and neurological disorders are often characterised by pathological changes to dendrites, in advance of neuronal death. Oxidative stress, energy deficits and excitotoxicity are implicated in many such disorders, suggesting a potential vulnerability of dendrites to these situations. Here we
Nur Farhana Ahmad Sopian et al.
International journal of molecular sciences, 16(7), 15800-15810 (2015-07-18)
Dietary omega-3 fatty acids have been recognized to improve brain cognitive function. Deficiency leads to dysfunctional zinc metabolism associated with learning and memory impairment. The objective of this study is to explore the effect of short-term dietary omega-3 fatty acids
Sandra Noir et al.
The Plant cell, 27(5), 1461-1476 (2015-05-07)
A key step of the cell cycle is the entry into the DNA replication phase that typically commits cells to divide. However, little is known about the molecular mechanisms regulating this transition in plants. Here, we investigated the function of
Veerle Kersemans et al.
PloS one, 10(6), e0128537-e0128537 (2015-06-06)
Preclinical in vivo CT is commonly used to visualise vessels at a macroscopic scale. However, it is prone to many artefacts which can degrade the quality of CT images significantly. Although some artefacts can be partially corrected for during image
Piotr Bragoszewski et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(25), 7713-7718 (2015-06-10)
The content of mitochondrial proteome is maintained through two highly dynamic processes, the influx of newly synthesized proteins from the cytosol and the protein degradation. Mitochondrial proteins are targeted to the intermembrane space by the mitochondrial intermembrane space assembly pathway
Sanjib Kumar Karmee et al.
Waste management (New York, N.Y.), 41, 169-173 (2015-04-07)
Depletion of fossil fuels and environmental problems are encouraging research on alternative fuels of renewable sources. Biodiesel is a promising alternative fuel to be used as a substitute to the petroleum based diesel fuels. However, the cost of biodiesel production
Anna Marchenkova et al.
Molecular pain, 11, 71-71 (2015-11-19)
ATP-gated P2X3 receptors are important transducers of nociceptive stimuli and are almost exclusively expressed by sensory ganglion neurons. In mouse trigeminal ganglion (TG), P2X3 receptor function is unexpectedly enhanced by pharmacological block of natriuretic peptide receptor-A (NPR-A), outlining a potential
Yoshiya Yamamura et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(4), 353-360 (2015-03-31)
1. Chlorzoxazone (CLZ) is currently being used as a marker substrate in vitro/vivo studies to quantify cytochrome P450 2E1 (CYP2E1) activity in humans. Although in CLZ 6-hydroxylation several CYPs are responsible, previous studies have presented the monophasicity of the reaction in
Xintong Lv et al.
Molecular medicine reports, 12(5), 6663-6671 (2015-08-25)
Voltage-dependent calcium channels (VDCCs) are key elements in epileptogenesis. There are several binding-sites linked to calmodulin (CaM) and several potential CaM-dependent protein kinase II (CaMKII)-mediated phosphorylation sites in CaV1.2. The tremor rat model (TRM) exhibits absence‑like seizures from 8 weeks
Jan David et al.
SpringerPlus, 3, 156-156 (2014-05-03)
The positive effect of humic acids on the growth of plant roots is well known, however, the mechanisms and role of their physical structure in these processes have not been fully explained yet. In this work, South-Moravian lignite was oxidized
Miquel Cadevall et al.
Electrophoresis, 36(16), 1872-1879 (2015-05-23)
Between their many applications bismuth nanoparticles (BiNPs) are showing interest as pre-concentrators in heavy metals detection while being applied as working electrode modifiers used in electrochemical stripping analysis. From the different reported methods to synthesize BiNPs we are focused on
Manoj Kumar et al.
Molecular cancer therapeutics, 14(4), 899-908 (2015-02-07)
Abnormal choline metabolism is a hallmark of cancer and is associated with oncogenesis and tumor progression. Increased choline is consistently observed in both preclinical tumor models and in human brain tumors by proton magnetic resonance spectroscopy (MRS). Thus, inhibition of
Martin Nybo Andersen et al.
Channels (Austin, Tex.), 9(3), 121-128 (2015-06-05)
The voltage-gated Kv1.5 potassium channel, conducting the ultra-rapid rectifier K(+) current (IKur), is regulated through several pathways. Here we investigate if Kv1.5 surface expression is controlled by the 2 kinases PKC and AMPK, using Xenopus oocytes, MDCK cells and atrial
Chie Kobayashi et al.
Biological & pharmaceutical bulletin, 38(11), 1827-1830 (2015-08-25)
Overuse of vitamin A as a dietary supplement is a concern in industrialized countries. High-level dietary vitamin A is thought to shift immunity to a T helper 2 (Th2)-dominant one, resulting in the promotion of allergies. We have been studying
Sanjaya K Sahoo et al.
The Journal of biological chemistry, 290(22), 14057-14067 (2015-04-18)
The sarcoendoplasmic reticulum Ca(2+)-ATPase (SERCA) is responsible for intracellular Ca(2+) homeostasis. SERCA activity in muscle can be regulated by phospholamban (PLB), an affinity modulator, and sarcolipin (SLN), an uncoupler. Although PLB gets dislodged from Ca(2+)-bound SERCA, SLN continues to bind
Krista Peltoniemi et al.
FEMS microbiology ecology, 91(7) (2015-06-13)
Impacts of warming with open-top chambers on microbial communities in wet conditions and in conditions resulting from moderate water-level drawdown (WLD) were studied across 0-50 cm depth in northern and southern boreal sedge fens. Warming alone decreased microbial biomass especially
Ehsan Karimi et al.
Biological research, 48, 9-9 (2015-03-13)
The present study was conducted in order to evaluate the fatty acid profile, anti-oxidant and anti-bacterial activities from the microwave aqueous extract of the leaves of three different varieties of Labisia pumila Benth. The chemical analysis of the extract showed
Fanny Coumes et al.
Biomacromolecules, 16(11), 3666-3673 (2015-10-17)
Cancer vaccines are considered to be a promising tool for cancer immunotherapy. However, a well-designed cancer vaccine should combine a tumor-associated antigen (TAA) with the most effective immunomodulatory agents and/or delivery system to provoke intense immune responses against the TAA.
Chencheng Sun et al.
Chemosphere, 141, 243-249 (2015-08-19)
A nano-composite electrocatalyst of Pd nanoparticles (Pd-NPs) anchored on polyaniline (PANI) supported by mesoporous SBA-15 (Pd-NPs/PANI/SBA-15), was synthesized using an in situ chemical method. Transmission electron microscopy showed that the Pd-NPs were homogeneously dispersed. Fourier-transform infrared and X-ray photoelectron spectroscopies
Sahar Mohammad Bagheri et al.
Chemical biology & drug design, 86(5), 1215-1220 (2015-05-27)
A series of 4-hydroxycoumarin-derived compounds 8a-p containing N-benzyl-1,2,3-triazole motif were designed as AChE inhibitors. The title compounds were obtained conveniently using multicomponent click reaction. The in vitro anticholinesterase evaluation of synthesized compounds against AChE and BuChE showed that some of them
Tsubasa Oyama et al.
Journal of pharmaceutical and biomedical analysis, 116, 71-79 (2015-07-15)
A new pre-column derivatization reagent with a 6-methoxy-4-quinolone (6-MOQ) moiety for amino acid analysis, 2,5-dioxopyrrolidin-1-yl(2-(6-methoxy-4-oxoquinolin-1(4H)-yl)ethyl) carbonate (6-MOQ-EtOCOOSu), was designed and synthesized. 6-MOQ is a thermo/photostable fluorophore with a high proton-affinity site and sensitive determination could be carried out by a
Chad D Iverson et al.
Journal of chromatography. A, 1373, 17-24 (2014-12-04)
Most stationary phases for hydrophilic interaction liquid chromatography (HILIC) and reversed phase liquid chromatography (RPLC) are based on silica. Porous graphitic carbon (PGC) is an attractive alternative to silica-based phases due to its chemical and thermal stability, and unique selectivity.
Anas Al-Hussein et al.
Pharmaceutical development and technology, 20(1), 50-59 (2013-11-30)
The objective of this study was to investigate both the cryoprotective and lyoprotective effects of the polymer hydroxyethyl cellulose (HEC) on the model protein lactate dehydrogenase (LDH) during freeze thawing and freeze drying cycles. The effect of annealing on both
Benoît Chatin et al.
The Biochemical journal, 463(3), 339-349 (2014-08-05)
The major cardiac voltage-gated sodium channel Nav1.5 associates with proteins that regulate its biosynthesis, localization, activity and degradation. Identification of partner proteins is crucial for a better understanding of the channel regulation. Using a yeast two-hybrid screen, we identified dynamitin
Patrick Forny et al.
Human mutation, 35(12), 1449-1458 (2014-08-16)
Methylmalonyl-CoA mutase (MUT) is an essential enzyme in propionate catabolism that requires adenosylcobalamin as a cofactor. Almost 250 inherited mutations in the MUT gene are known to cause the devastating disorder methylmalonic aciduria; however, the mechanism of dysfunction of these
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