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显示 1-30 共 159 条结果 关于 "76-22-2" 范围 论文
L Pucci et al.
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 20(5), 461-469 (2003-11-25)
The glycoprotein IIIa (beta3 integrin) is an integral part of two glicoprotein receptors of platelets and, respectively, endothelium and vascular smooth muscle cells. The gene encoding the GPIIIa, a receptor for fibrinogen, vWF and fibronectin, shows polymorphism (PlA1/PlA2); the PlA2
Alexander Schneider et al.
Gastroenterology, 123(4), 1026-1030 (2002-10-03)
Tropical pancreatitis, including tropical calcific pancreatitis and fibrocalculous pancreatic diabetes, is endemic in parts of Asia and Africa. In a preliminary study, we found serine protease inhibitor, Kazal type 1 (SPINK1) mutations in 6 of 8 patients with fibrocalculous pancreatic
Mellone N Marchong et al.
Molecular cancer research : MCR, 2(9), 495-503 (2004-09-24)
Retinoblastoma is initiated by loss of both RB1 alleles. Previous studies have shown that retinoblastoma tumors also show further genomic gains and losses. We now define a 2.62 Mbp minimal region of genomic loss of chromosome 16q22, which is likely
John Okombo et al.
Antimicrobial agents and chemotherapy, 54(8), 3302-3307 (2010-06-03)
Resistance to the amino alcohol quinine has been associated with polymorphisms in pfnhe, a sodium hydrogen exchanger. We investigated the role of this gene in quinine resistance in vitro in isolates from Kenya. We analyzed pfnhe whole-gene polymorphisms, using capillary
Lei Fu et al.
Zhonghua yi xue za zhi, 88(28), 1983-1985 (2008-12-10)
To investigate the mutations of the mismatch repair genes hMLH1 and hMSH2 in hereditary nonpolyposis colorectal cancer (HNPCC). The DNA samples of 76 probands of HNPCC families underwent PCR amplification and sequencing on 35 exons in hMLH1 and hMSH2 genes.
Dmytro Kornyeyev et al.
Journal of molecular and cellular cardiology, 52(1), 21-31 (2011-10-11)
Calsequestrin (Casq2) is a low affinity Ca(2+)-binding protein located in sarcoplasmic reticulum (SR) of cardiac myocytes. Casq2 acts as a Ca(2+) buffer regulating free Ca(2+) concentration in the SR lumen and plays a significant role in the regulation of Ca(2+)
K Daniilidou et al.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 18(1), 195-201 (2013-04-25)
To investigate the PTEN and p53 gene expression in endometrioid and serous papillary endometrial carcinomas and clarify their prognostic significance by studying the PTEN and p53 expression in relation to tumor stage and grade. Archival pathological sections of 61 cases
Hiroki Utsunomiya et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 10(17), 5850-5856 (2004-09-10)
Intratumoral metabolism and synthesis of estrogens are considered to play important roles in the pathogenesis and/or development of human endometrial carcinoma. Steroid sulfatase hydrolyzes biologically inactive estrogen sulfates to active estrogens, whereas estrogen sulfotransferase sulfonates estrogens to estrogen sulfates. However
Hiroki Utsunomiya et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 10(17), 5850-5856 (2004-09-10)
Intratumoral metabolism and synthesis of estrogens are considered to play important roles in the pathogenesis and/or development of human endometrial carcinoma. Steroid sulfatase hydrolyzes biologically inactive estrogen sulfates to active estrogens, whereas estrogen sulfotransferase sulfonates estrogens to estrogen sulfates. However
E Volikos et al.
Journal of medical genetics, 43(5), e18-e18 (2006-05-02)
LKB1/STK11 germline mutations cause Peutz-Jeghers syndrome (PJS). The existence of a second PJS locus is controversial, the evidence in its favour being families unlinked to LKB1 and the low frequency of LKB1 mutations found using conventional methods in several studies.
N G Seidah et al.
The Journal of biological chemistry, 256(15), 7977-7984 (1981-08-10)
The isolation and complete purification of a human glycopeptide representing the major immunoreactive form of the pituitary NH2-terminal segment of pro-opiomelanocortin is presented. The complete sequence of this peptide was determined following CNBr fragmentation and it is shown to be
O Tominaga et al.
British journal of cancer, 84(1), 57-63 (2001-01-05)
p53 antibodies have been found in the sera of patients with various types of cancer. The presence of these antibodies is generally associated with p53 accumulation in the tumour that is believed to trigger this humoral response. The recent discovery
Heather C Stuart et al.
American journal of surgery, 207(5), 673-680 (2014-05-06)
Up to 44% of primary hyperparathyroidism patients have elevated parathyroid hormone (ePTH) with normal calcium postparathyroidectomy (PTx). The question is whether the surgical approach affects the incidence of this phenomenon. Patients with hyperparathyroidism and presumed single-gland disease on preoperative imaging
Laëtitia Duché et al.
BMC pediatrics, 8, 29-29 (2008-07-18)
Numerous short-statured children are evaluated for growth hormone (GH) deficiency (GHD). In most patients, GH provocative tests are normal and are thus in retrospect unnecessary. A retrospective cohort study was conducted to identify predictors of growth hormone (GH) deficiency (GHD)
Gianni Allais et al.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 32 Suppl 1, S99-104 (2011-05-06)
Menstrually related migraine (MRM) is a particularly difficult-to-treat pain condition, associated with substantial disability. Aim of this study was to compare the efficacy and safety of frovatriptan and zolmitriptan in the treatment of MRM attacks, analyzing data from a multicenter
Cory Yamashita et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 1(5), 388-391 (2004-03-16)
The discovery of a genetic test for hereditary hemochromatosis has identified many individuals who are homozygous for the C282Y mutation of the HFE gene with a normal transferrin saturation and serum ferritin level. The long-term prognosis, rate of iron accumulation
Salma Derbel et al.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 5(1), 47-51 (2005-12-27)
Diabetes mellitus (DM) and abnormal glucose tolerance (IGT) are common in cystic fibrosis (CF). The loss of pancreatic beta-cells due to pancreatic fibrosis is thought to be one of the principal causes of diabetes in CF, but the aetiology of
Amandine Le Bourgeois et al.
European journal of haematology, 90(3), 177-186 (2013-01-11)
This retrospective analysis aimed to assess hematopoietic and immune recovery in a cohort of 53 patients [males: n = 33; median age: 59 yr (range: 22-70)] who received a FB2 (fludarabine 120-150 mg/m² + IV busulfan 6.4 mg/kg + antithymocyte
Eun Young Lee et al.
Thrombosis research, 111(1-2), 29-32 (2003-12-04)
To investigate whether the anti-beta(2)-glycoprotein I (anti-beta(2)GPI) antibody may provide additional information in patients with thrombosis in conjunction with the lupus anticoagulant (LAC) or anticardiolipin (aCL) antibody. We selected 235 patients whose plasma were tested for the presence of all
J A Leary et al.
International journal of cancer, 64(3), 189-195 (1995-06-22)
The genetic events involved in the development of metastases of epithelial ovarian cancer are largely unknown. One gene postulated to play a role in tumour metastasis suppression is NME1 (nm23-H1), and an inverse relationship between NME1 expression and metastatic potential
Rebekka Heitmar et al.
Investigative ophthalmology & visual science, 54(4), 2807-2811 (2013-03-16)
To establish the optimal flash settings for retinal vessel oxygen saturation parameters using dual-wavelength imaging in a multiethnic group. Twelve healthy young subjects (mean age 32 years [SD 7]; three Mediterranean, two South Asian, and seven Caucasian individuals) underwent retinal
Iris Schrijver et al.
The Journal of molecular diagnostics : JMD, 10(4), 368-375 (2008-06-17)
A disparity between Caucasian and Hispanic mutation detection for cystic fibrosis continues to exist, although the carrier frequency is only moderately lower in Hispanics. We aimed to identify exonic rearrangements that remained undetected by conventional methods. In seven of 32
F Ducray et al.
Neurology, 72(2), 156-161 (2009-01-14)
alpha-Internexin (INA) is a proneural gene encoding a neurofilament interacting protein that is upregulated in some gliomas, particularly oligodendrogliomas. INA expression was evaluated by immunohistochemistry in a series of 122 gliomas, and correlated to the 1p19q codeletion, a favorable prognostic
Arie Perry et al.
Journal of neuropathology and experimental neurology, 61(8), 702-709 (2002-08-03)
Malignant peripheral nerve sheath tumors (MPNSTs) are diagnostically challenging neoplasms for which sensitive and specific immunohistochemical markers are lacking. Although limited to date, previous studies have suggested that NF1 (17q), NF2 (22q), p16 (9p), and EGFR (7p) alterations may be
Ahmad-Ali Nikibakhsh et al.
Pneumologia (Bucharest, Romania), 61(2), 84-87 (2012-07-13)
Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis in children. Several risk factors play important role in pathogenesis of HSP. We aimed to study the MEFV gene mutations (M694V, V726A, M680I, and A744S) in Iranian children with HSP. 50
Norihisa Uemura et al.
International journal of cancer, 124(9), 2106-2115 (2009-01-15)
To develop a prognostic biomarker for esophageal squamous cell carcinoma (ESCC), we examined the proteomic profile of ESCC using two-dimensional difference gel electrophoresis (2D-DIGE), and identified proteins associated with prognosis by mass spectrometry. The prognostic performance of the identified proteins
G Alkorta-Aranburu et al.
Molecular genetics and metabolism, 113(4), 315-320 (2014-10-13)
Single gene mutations that primarily affect pancreatic β-cell function account for approximately 1-2% of all cases of diabetes. Overlapping clinical features with common forms of diabetes makes diagnosis of monogenic diabetes challenging. A genetic diagnosis often leads to significant alterations
Gianluca Tomasello et al.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 17(4), 711-717 (2013-11-28)
We previously studied a dose-dense TCF (TCF-dd) regimen demonstrating its feasibility and an activity comparable to epirubicin-based chemotherapy and TCF q3w in terms of overall survival and time to progression (TTP). We report here the final results of a phase
C P A Van de Ligt et al.
Journal of animal science, 80(9), 2412-2419 (2002-09-28)
This study was conducted to evaluate potential interactive effects of supplemental Cr and dietary protein levels in growing pigs. Thirty-six individually penned barrows, 22 to 63 kg, were used in a 2 x 3 factorial arrangement of supplemental Cr (0
Erdal Sag et al.
Seminars in arthritis and rheumatism, 51(1), 95-100 (2020-12-29)
Juvenile dermatomyositis (JDM) is the most common inflammatory myopathy of childhood. To analyze clinical features, paraclinical examinations, MSAs, treatment response and long-term outcome in a JDM cohort METHODS: 58 patients (35F, 23 M) from a tertiary referral center in the last
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