76-59-5

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Phase 2 trial of high-dose rituximab with high-dose cytarabine mobilization therapy and high-dose thiotepa, busulfan, and cyclophosphamide autologous stem cell transplantation in patients with central nervous system involvement by non-Hodgkin lymphoma.

Yi-Bin Chen et al.

Cancer, 121(2), 226-233 (2014-09-11)

High-dose thiotepa, busulfan, and cyclophosphamide (TBC) with autologous stem cell transplantation (ASCT) has been used in patients with central nervous system (CNS) involvement by non-Hodgkin lymphoma (NHL). Despite limited penetration into the CNS, rituximab is active in primary CNS NHL.

Associations between cerebral small-vessel disease and Alzheimer disease pathology as measured by cerebrospinal fluid biomarkers.

Maartje I Kester et al.

JAMA neurology, 71(7), 855-862 (2014-05-14)

It remains unclear if and how associations between cerebral small-vessel disease and Alzheimer disease (AD) pathology lead to cognitive decline and dementia. To determine associations between small-vessel disease and AD pathology. Cross-sectional study from January 2002 to December 2012 using

Molecular genetics of pseudoxanthoma elasticum: type and frequency of mutations in ABCC6.

Sara Miksch et al.

Human mutation, 26(3), 235-248 (2005-08-09)

Pseudoxanthoma elasticum (PXE) is a systemic heritable disorder that affects the elastic tissue in the skin, eye, and cardiovascular system. Mutations in the ABCC6 gene cause PXE. We performed a mutation screen in ABCC6 using haplotype analysis in conjunction with

NECESSITY OF MULTIMODAL TREATMENT OF ACROMEGALY AND OUTCOMES.

Diane Mary Donegan et al.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 24(7), 668-676 (2018-07-27)

Uncontrolled acromegaly is associated with increased morbidity and mortality. Despite multimodal therapeutic options, adequate control can be challenging and lead to prolonged exposure to growth hormone excess. The aim of this study was to assess treatment patterns and outcomes in

BCNU wafer placement with temozolomide (TMZ) in the immediate postoperative period after tumor resection followed by radiation therapy with TMZ in patients with newly diagnosed high grade glioma: final results of a prospective, multi-institutional, phase II trial.

Stuart H Burri et al.

Journal of neuro-oncology, 123(2), 259-266 (2015-05-08)

Temozolomide (TMZ) and BCNU have demonstrated anti-glioma synergism in preclinical models. We report final data from a prospective, multi-institutional study of BCNU wafers and early TMZ followed by radiation therapy with TMZ in patients with newly diagnosed malignant glioma. 65

Phenylephrine impairs host defence mechanisms to infection: a combined laboratory study in mice and translational human study.

Roeland F Stolk et al.

British journal of anaesthesia, 126(3), 652-664 (2021-01-24)

Immunosuppression after surgery is associated with postoperative complications, mediated in part by catecholamines that exert anti-inflammatory effects via the β-adrenergic receptor. Phenylephrine, generally regarded as a selective α-adrenergic agonist, is frequently used to treat perioperative hypotension. However, phenylephrine may impair

Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial.

Marcia S Brose et al.

Lancet (London, England), 384(9940), 319-328 (2014-04-29)

Patients with radioactive iodine ((131)I)-refractory locally advanced or metastatic differentiated thyroid cancer have a poor prognosis because of the absence of effective treatment options. In this study, we assessed the efficacy and safety of orally administered sorafenib in the treatment

A 48-week randomized phase 2b study evaluating cenicriviroc versus efavirenz in treatment-naive HIV-infected adults with C-C chemokine receptor type 5-tropic virus.

Melanie Thompson et al.

AIDS (London, England), 30(6), 869-878 (2015-12-05)

To compare the efficacy, safety, and anti-inflammatory effects of cenicriviroc (CVC), an oral, once-daily C-C chemokine receptor types 5 and 2 antagonist, with those of efavirenz (EFV) in treatment-naive, HIV-1-infected adults. A 48-week, randomized, double-blind, double-dummy phase 2b trial at

[Relationship of epidermal growth factor receptor gene mutations, clinicopathologic features and prognosis in patients with non-small cell lung cancer].

Miao-jing Fan et al.

Zhonghua bing li xue za zhi = Chinese journal of pathology, 40(10), 679-682 (2012-02-11)

To investigate epidermal growth factor receptor (EGFR) gene mutations in exons 19 and 21 of patients with non-small cell lung cancer (NSCLC) and to analyze the relationship of EGFR mutations with clinicopathological features and prognosis. The EGFR gene exons 19

Phenotypic heterogeneity of N370S homozygotes with type I Gaucher disease: an analysis of 798 patients from the ICGG Gaucher Registry.

C Fairley et al.

Journal of inherited metabolic disease, 31(6), 738-744 (2008-11-04)

Gaucher disease is a lysosomal storage disorder caused by a deficiency of the enzyme acid beta-glucosidase. The most prevalent mutant genotype in type I Gaucher disease, N370S/N370S, is commonly thought to confer a mild phenotype presenting in adulthood. To characterize

Whole-Body Cryostimulation Limits Overreaching in Elite Synchronized Swimmers.

Karine Schaal et al.

Medicine and science in sports and exercise, 47(7), 1416-1425 (2014-10-15)

Elite athletes frequently undergo periods of intensified training (IT) within their normal training program. These periods can lead athletes into functional overreaching, characterized by high perceived fatigue, impaired sleep, and performance. Because whole-body cryostimulation (WBC) has been proven to be

Parallel-group 8-week study on chlorthalidone effects in hypertensives with low kidney function.

Massimo Cirillo et al.

Hypertension (Dallas, Tex. : 1979), 63(4), 692-697 (2014-01-08)

Short-term effects of chlorthalidone are unknown in low kidney function. The effects of 8-week treatment with 25-mg chlorthalidone on the top of ongoing treatment were compared between control hypertensives and low kidney function hypertensives as assessed by estimated glomerular filtration

Superoxide generation and leukocyte accumulation: key elements in the mediation of leukotriene B₄-induced itch by transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1.

Elizabeth S Fernandes et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(4), 1664-1673 (2012-12-29)

The underlying mechanisms of itch are poorly understood. We have investigated a model involving the chemoattractant leukotriene B₄ (LTB₄) that is up-regulated in common skin diseases. Intradermal injection of LTB4 (0.1 nmol/site) into female CD1 mice induced significant scratching movements

Prognostic Factors in Sudden Sensorineural Hearing Loss.

Gamze Atay et al.

Balkan medical journal, 33(1), 87-93 (2016-03-12)

Sudden sensorineural hearing loss (SSNHL) is still a complex and challenging process which requires clinical evidence regarding its etiology, treatment and prognostic factors. Therefore, determination of prognostic factors might aid in the selection of proper treatment modality. The aim of

Early bispectral index and sedation requirements during therapeutic hypothermia predict neurologic recovery following cardiac arrest.

Nicholas E Burjek et al.

Critical care medicine, 42(5), 1204-1212 (2013-12-25)

To test the hypothesis that low bispectral index scores and low sedative requirements during therapeutic hypothermia predict poor neurologic outcome. Observational study of a prospectively collected cohort. Cardiovascular ICU. One hundred sixty consecutive cardiac arrest patients treated with therapeutic hypothermia.

High levels of serum soluble CD27 correlated with renal dysfunction.

T Nakatsuji

Clinical and experimental medicine, 2(4), 192-196 (2003-03-08)

CD27 is expressed on lymphocytes, but also on renal tubules. On the damaged renal tubules, CD27 is cleaved into soluble CD27 (sCD27) and cytoplasmic tail CD27. Renal tubule apoptosis is induced by the CD27 ligand, Siva, binding to the truncated

Inverse relationship between APC gene mutation in gastric adenomas and development of adenocarcinoma.

Jae-Hyuk Lee et al.

The American journal of pathology, 161(2), 611-618 (2002-08-07)

Gastric cancer is common among the world, but genetic mechanisms of gastric carcinogenesis are not well understood. Gastric polypoid adenomas and flat dysplasias are regarded as precursor lesions. However, a detailed molecular study of these lesions has not been done

An open-label, single-arm, phase 2 trial of panitumumab plus FOLFIRI as second-line therapy in patients with metastatic colorectal cancer.

Allen L Cohn et al.

Clinical colorectal cancer, 10(3), 171-177 (2011-08-23)

This prospective analysis evaluated the effect of tumor KRAS status on efficacy of second-line panitumumab plus folinic acid/5-fluorouracil/irinotecan (FOLFIRI). This phase 2, open-label, single-arm study enrolled patients with unresectable, measurable metastatic colorectal cancer (mCRC) after failure of first-line treatment with

Identification of imidazoline-receptor binding sites in cortex and medulla of the bovine adrenal gland. Colocalization with MAO-A and MAO-B.

P R King et al.

Annals of the New York Academy of Sciences, 881, 161-170 (1999-07-23)

The distribution and relative densities of imidazoline-receptor binding sites (I-RBS) in bovine adrenal gland were determined using [3H]clonidine, [3H]2-(2-benzofuranyl)-2-imidazoline ([3H]2-BFI), and [3H]rilmenidine. In light of strong evidence that I-RBS and monoamine amine oxidase enzymes are linked, the selective radioligands [3H]RO41-1049

Safety and immunogenicity of the tetravalent, live-attenuated dengue vaccine Butantan-DV in adults in Brazil: a two-step, double-blind, randomised placebo-controlled phase 2 trial.

Esper G Kallas et al.

The Lancet. Infectious diseases, 20(7), 839-850 (2020-03-30)

The Butantan Institute has manufactured a lyophilised tetravalent live-attenuated dengue vaccine Butantan-DV, which is analogous to the US National Institutes of Health (NIH) TV003 admixture. We aimed to assess the safety and immunogenicity of Butantan-DV. We did a two-step, double-blind

Effects of body size and hypertension treatments on cardiovascular event rates: subanalysis of the ACCOMPLISH randomised controlled trial.

Michael A Weber et al.

Lancet (London, England), 381(9866), 537-545 (2012-12-12)

In previous clinical trials in high-risk hypertensive patients, paradoxically higher cardiovascular event rates have been reported in patients of normal weight compared with obese individuals. As a prespecified analysis of the Avoiding Cardiovascular Events through Combination Therapy in Patients Living

CYP2E1, GSTM1 and GSTT1 genetic polymorphisms and susceptibility to antituberculosis drug-induced hepatotoxicity: a nested case-control study.

S-W Tang et al.

Journal of clinical pharmacy and therapeutics, 37(5), 588-593 (2012-02-18)

The pathogenic mechanism of antituberculosis drug-induced hepatotoxicity (ATDH) is thought to involve drug-metabolizing enzymes including N-acetyl transferase2 (NAT2), cytochrome P4502E1 (CYP2E1) and glutathione S-transferase (GST) M1, T1. The associations between genetic polymorphisms of those genes and ATDH have been reported

Genome-Wide Analysis of the NAC Transcription Factor Gene Family Reveals Differential Expression Patterns and Cold-Stress Responses in the Woody Plant Prunus mume.

Xiaokang Zhuo et al.

Genes, 9(10) (2018-10-17)

NAC transcription factors (TFs) participate in multiple biological processes, including biotic and abiotic stress responses, signal transduction and development. Cold stress can adversely impact plant growth and development, thereby limiting agricultural productivity. Prunus mume, an excellent horticultural crop, is widely

Intraluminal Thrombi in the Cervico-Cephalic Arteries.

Ravinder-Jeet Singh et al.

Stroke, 50(2), 357-364 (2019-01-01)

Background and Purpose- Intraluminal thrombus (ILT) is an uncommon finding among patients with ischemic stroke. We report clinical-imaging manifestations, treatment offered, and outcome among patients with ischemic stroke/transient ischemic attack and ILT in their cervico-cephalic arteries. Methods- Sixty-one of 3750

The role of efferent cholinergic transmission for the insulinotropic and glucagonostatic effects of GLP-1.

Astrid Plamboeck et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 309(5), R544-R551 (2015-07-03)

The importance of vagal efferent signaling for the insulinotropic and glucagonostatic effects of glucagon-like peptide-1 (GLP-1) was investigated in a randomized single-blinded study. Healthy male participants (n = 10) received atropine to block vagal cholinergic transmission or saline infusions on

Autoantibodies against C-reactive protein: clinical associations in systemic lupus erythematosus and primary antiphospholipid syndrome.

Maria A Figueredo et al.

The Journal of rheumatology, 33(10), 1980-1986 (2006-10-03)

To investigate the prevalence of anti-C-reactive protein (CRP) autoantibodies in patients with systemic lupus erythematosus (SLE) and non-SLE patients with persistent antiphospholipid antibodies (aPL) and their association with clinical manifestations. Sera of 137 patients with SLE, 127 with persistent aPL

[Association between estrogen receptor beta gene polymorphism and intrahepatic cholestasis of pregnancy in the Uygurs and the Hans pregnant women].

Yan Yin et al.

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 46(3), 269-272 (2012-07-18)

To investigate the distribution of estrogen receptor beta (ERbeta) gene polymorphisms between the Uygurs and the Hans in Urumqi and the association of the polymorphisms with intrahepatic cholestasis of pregnancy (ICP). ICP cases and controls from a hospital were recruited

Clinical and diagnostic imaging findings in 37 rescued dogs with heartworm disease in Germany.

Imke Maerz

Veterinary parasitology, 283, 109156-109156 (2020-06-12)

Canine dirofilariasis is currently uncommon in Germany, but its prevalence appears to be increasing due to rehoming of dogs from endemic areas. As part of staging of the disease, this case series describes clinical, radiological and echocardiographic findings in 37

Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue.

Hiroki Takanari et al.

Cardiovascular research, 99(1), 203-214 (2013-04-30)

In excitable cells, KIR2.x ion-channel-carried inward rectifier current (IK₁) is thought to set the negative and stable resting membrane potential, and contributes to action potential repolarization. Loss- or gain-of-function mutations correlate with cardiac arrhythmias and pathological remodelling affects normal KIR2.x

A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study.

Lidia Sabater et al.

The Lancet. Neurology, 13(6), 575-586 (2014-04-08)

Autoimmunity might be associated with or implicated in sleep and neurodegenerative disorders. We aimed to describe the features of a novel neurological syndrome associated with prominent sleep dysfunction and antibodies to a neuronal antigen. In this observational study, we used

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