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L Pucci et al.
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 20(5), 461-469 (2003-11-25)
The glycoprotein IIIa (beta3 integrin) is an integral part of two glicoprotein receptors of platelets and, respectively, endothelium and vascular smooth muscle cells. The gene encoding the GPIIIa, a receptor for fibrinogen, vWF and fibronectin, shows polymorphism (PlA1/PlA2); the PlA2
Laura M Divine et al.
Oncotarget, 7(47), 77291-77305 (2016-10-21)
The receptor tyrosine kinase AXL promotes migration, invasion, and metastasis. Here, we evaluated the role of AXL in endometrial cancer. High immunohistochemical expression of AXL was found in 76% (63/83) of advanced-stage, and 77% (82/107) of high-grade specimens and correlated
P Rheault et al.
Biochimica et biophysica acta, 1447(1), 17-24 (1999-09-29)
17beta-Hydroxysteroid dehydrogenases (17beta-HSDs) play a crucial role in the control of active sex steroid intracellular levels. Seven types of 17beta-HSD have been described. In this study, we report the cloning and characterization of the mouse type 5 17beta-HSD belonging to
Zhikai Guo et al.
The Journal of antibiotics, 70(4), 414-422 (2016-10-13)
Isofuranonaphthoquinones (IFQs) and Isoindolequinones (IIQs) comprise a small family of natural products, with the latter ones are especially uncommon in nature. Here we report the discovery of seven new IFQs, IFQ A-G (1-7), and three new IIQs, IIQ A-C (8-10)
E Restrepo-Pineda et al.
Parasitology, 135(5), 547-553 (2008-04-23)
In Colombia, Plasmodium resistance to antimalarials such as chloroquine and antifolates is a serious problem. As a result, the national Colombian health authorities are monitoring the efficacy of alternative drugs and schemes. The study of genetic polymorphisms related with drug
Yelko Rodríguez-Carrasco et al.
Food chemistry, 146, 212-219 (2013-11-02)
An analytical protocol based on QuEChERS and gas chromatography-tandem mass spectrometry (GC-MS/MS) was successfully applied for the determination of trichothecenes, patulin and zearalenone in 182 milled grain-based samples. The analytical method was validated following the SANCO 1495/2011 document. LOQs were
M T Chauvet et al.
FEBS letters, 163(2), 257-260 (1983-11-14)
The vasopressin precursor is composed of 3 domains, namely vasopressin, MSEL-neurophysin and a glycopeptide. Processing occurs during axonal transport from hypothalamus to neurohypophysis from which the 3 fragments can be isolated. The glycopeptide fragment of the rat vasopressin precursor has
T Vermeire et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 25(7), 907-907 (2018-12-07)
Mumps used to affect children between 2 and 15 years old. The mumps-measles-rubella (MMR) vaccine is available, with vaccine coverage rate of about 85% after two vaccine doses. Recently new mumps outbreaks have emerged in highly vaccinated populations; the causes for
J Blaisdell et al.
Drug metabolism and disposition: the biological fate of chemicals, 26(3), 278-283 (1998-04-04)
Two members of the canine cytochrome P4502C subfamily [CYP2C21 and CYP2C41 (sequence has been submitted to Genbank with accession number AF016248)] were cloned from three beagle liver cDNA libraries. The two canine CYP2C cDNAs exhibited 70% nucleotide and amino acid
Yvonne G Lin et al.
Cancer, 109(2), 332-340 (2006-12-13)
EphA2 is overexpressed in the majority of ovarian cancers and predicts poor clinical outcome. Based on EphA2's emerging role in angiogenesis, we hypothesized that tumors overexpressing EphA2 demonstrate greater microvessel density (MVD) and matrix metalloproteinase (MMP) expression. After Institutional Review
Fabien Praz et al.
JACC. Cardiovascular interventions, 12(14), 1356-1365 (2019-05-28)
The aim of this study was to investigate the technical success and efficacy of mitral valve edge-to-edge repair using extended clip arms. A new iteration of the MitraClip system, the MitraClip XTR, was introduced in 2018 with the aim of
R N Dickerson et al.
JPEN. Journal of parenteral and enteral nutrition, 13(4), 359-361 (1989-07-01)
Pentobarbital therapy has been associated with decreased urinary nitrogen excretion and resting energy expenditure in stressed patients. The metabolic effects of pentobarbital in sepsis were investigated in 29 well-nourished rats who underwent superior vena caval cannulation, cecal ligation, and puncture.
Ursula Ehmer et al.
Hepatology (Baltimore, Md.), 55(6), 1912-1921 (2012-01-04)
Gilbert syndrome (GS) is characterized by intermittent unconjugated hyperbilirubinemia without structural liver damage, affecting about 10% of the white population. In GS the UGT1A1*28 variant reduces bilirubin conjugation by 70% and is associated with irinotecan and protease inhibitor side effects.
Ursula Ehmer et al.
Hepatology (Baltimore, Md.), 55(6), 1912-1921 (2012-01-04)
Gilbert syndrome (GS) is characterized by intermittent unconjugated hyperbilirubinemia without structural liver damage, affecting about 10% of the white population. In GS the UGT1A1*28 variant reduces bilirubin conjugation by 70% and is associated with irinotecan and protease inhibitor side effects.
Hanna L M Koskela et al.
The New England journal of medicine, 366(20), 1905-1913 (2012-05-18)
T-cell large granular lymphocytic leukemia is a rare lymphoproliferative disorder characterized by the expansion of clonal CD3+CD8+ cytotoxic T lymphocytes (CTLs) and often associated with autoimmune disorders and immune-mediated cytopenias. We used next-generation exome sequencing to identify somatic mutations in
I Saint Girons et al.
The Journal of biological chemistry, 262(2), 622-629 (1987-01-15)
The adk gene encoding adenylate kinase in Escherichia coli was cloned in pBR322. Adenylate kinase represented about 4% of total proteins in extracts of cells containing the pBR322:adk plasmid. This allowed preparation of more than 90% pure enzyme in a
K J Tinckam et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 15(2), 417-426 (2015-01-24)
Donor-specific HLA antibodies (DSA) have an adverse effect on short-term and long-term lung transplant outcomes. We implemented a perioperative strategy to treat DSA-positive recipients, leading to equivalent rejection and graft survival outcomes. Pretransplant DSA were identified to HLA-A, B, C
Freya Droege et al.
Journal of clinical medicine, 9(3) (2020-03-18)
Hereditary hemorrhagic telangiectasia (HHT) is characterized by mucocutaneous telangiectases and visceral vascular malformations. Individuals suffering from HHT have a significantly increased risk of bacterial infections, but the mechanisms involved in this are not clear. White blood cell subpopulations were estimated
Josué C Lima-Junior et al.
PloS one, 7(5), e36419-e36419 (2012-06-01)
The antibody response generated during malaria infections is of particular interest, since the production of specific IgG antibodies is required for acquisition of clinical immunity. However, variations in antibody responses could result from genetic polymorphism of the HLA class II
Sarah Egert et al.
European journal of nutrition, 52(1), 281-288 (2012-03-01)
To investigate the influence of dietary proteins (casein, soy protein) and skimmed milk on the plasma kinetics of green tea (GT) catechins. In a randomized cross-over design with one-week intervals, 24 healthy normal-weight women consumed a test drink containing 1.75
Michael R DeBaun et al.
American journal of human genetics, 70(3), 604-611 (2002-01-29)
Beckwith-Wiedemann syndrome (BWS) is a congenital cancer-predisposition syndrome associated with embryonal cancers, macroglossia, macrosomia, ear pits or ear creases, and midline abdominal-wall defects. The most common constitutional abnormalities in BWS are epigenetic, involving abnormal methylation of either H19 or LIT1
K T Patton et al.
Histopathology, 47(6), 597-601 (2005-12-06)
To analyse annexin I expression in prostatic carcinoma. Annexin I belongs to a family of structurally related calcium and phospholipid-binding proteins implicated in signal transduction, DNA replication, cell proliferation and apoptosis. The decreased expression of annexin I, II and VII
T P Tuomainen et al.
Circulation, 100(12), 1274-1279 (1999-09-24)
Background-Homozygosity for a relatively common Cys282Tyr mutation of the human hemochromatosis-associated (HFE) gene was recently found to account for most cases of hereditary hemochromatosis. Because excess iron has been postulated to enhance risk of vascular disease, we studied whether occurrence
Sakhawat Hussain Rahman et al.
Digestive diseases and sciences, 50(7), 1376-1383 (2005-07-29)
Epidemiological studies have demonstrated a variety of potential environmental factors that may alter susceptibility to chronic pancreatitis (CP) through oxidative/xenobiotic stress; however, a direct causal and mechanistic role has not been established. We aimed (1) to determine the prevalence of
Ann Catherine Archer et al.
Applied microbiology and biotechnology, 99(19), 8113-8123 (2015-05-26)
The objective of this study was to characterize native Lactobacillus fermentum isolates for their probiotic attributes. Accordingly, 12 L. fermentum isolates selected from indigenous fermented dairy products and infant fecal samples were evaluated for their probiotic properties by in vitro
Laurence M M Crombag et al.
The European respiratory journal, 53(2) (2018-12-24)
Guidelines recommend endosonography for mediastinal nodal staging in patients with resectable nonsmall cell lung cancer (NSCLC). We hypothesise that a systematic endobronchial ultrasound (EBUS) evaluation combined with an oesophageal investigation using the same EBUS bronchoscope (EUS-B) improves mediastinal nodal staging
John S Ikonomidis et al.
Circulation, 114(1 Suppl), I365-I370 (2006-07-06)
Marfan syndrome (MFS) is known to cause ascending thoracic aortic aneurysms (ATAAs). Transforming growth factor beta (TGF-beta) has recently been implicated in this process. Imbalances between the matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs) have also been shown to
Guoliang Yu et al.
Anesthesiology, 133(2), 408-425 (2020-05-21)
Dorsal root ganglion field stimulation is an analgesic neuromodulation approach in use clinically, but its mechanism is unknown as there is no validated animal model for this purpose. The authors hypothesized that ganglion stimulation is effective in reducing pain-like behaviors
Harshi Weerakoon et al.
PloS one, 10(4), e0121537-e0121537 (2015-04-09)
Records on gallstones and associated ailments in Sri Lankan community are scarce, despite frequent detection of gallstone disease. Identification of the chemical composition of gallstones in the local setting is important in defining aetiopathogenic factors which in turn are useful
Matteo Castrichini et al.
Journal of clinical medicine, 9(4) (2020-03-29)
Sacubitril/valsartan reduces mortality in heart failure with reduced ejection fraction (HFrEF) patients, partially due to cardiac reverse remodeling (RR). Little is known about the RR rate in long-lasting HFrEF and the evolution of advanced echocardiographic parameters, despite their known prognostic
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