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Michelle T Ma et al.
Dalton transactions (Cambridge, England : 2003), 44(11), 4884-4900 (2014-10-30)
Due to its long half-life (78 h) and decay properties (77% electron capture, 23% β(+), Emax = 897 keV, Eav = 397 keV, Eγ = 909 keV, Iγ = 100%) (89)Zr is an appealing radionuclide for immunoPET imaging with whole
Toshiyuki Furutani et al.
The Journal of organic chemistry, 67(13), 4599-4601 (2002-06-22)
A practical synthesis of methyl (2R,3S)-3-(4-methoxyphenyl)glycidate (-)-2, a key intermediate for diltiazem (1), was developed. Treatment of methyl (E)-4-methoxycinnamate 3 with chiral dioxirane, generated from chiral ketone 4, provided (-)-2 in 77% ee and 89% yield. The crude mixture of
Joris Muris et al.
Contact dermatitis, 67(2), 94-100 (2012-04-03)
Exposure to palladium (Pd) may lead to clinical allergic reactions. With frequent nickel (Ni) exposure and cross-reactivity between Ni and Pd at the T cell recognition level, positive Pd reactions on patch testing are surprisingly uncommon. PdCl(2) is often used
Ramaswamy Govindan et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 4(2), 220-226 (2009-01-31)
To assess the efficacy and toxicity of carboplatin, etoposide, and exisulind as initial therapy for extensive stage small cell lung cancer. The Cancer and Leukemia Group B conducted a phase II study of carboplatin (area under the curve 6) day
S J Childs
Clinical pharmacokinetics, 16 Suppl 1, 32-37 (1989-01-01)
The fluoroquinolones in general, and particularly enoxacin, show great promise in the treatment of urinary tract infection. Orally administered enoxacin achieves high concentrations in the serum and urine as well as in prostate tissue, kidney and perirenal fat and muscle.
Yoshiaki Oshima et al.
Masui. The Japanese journal of anesthesiology, 54(8), 875-880 (2005-08-18)
Continuous epidural administration of droperidol at 2.5 mg x day(-1) or less was performed in 837 patients after surgery. In 4 of these patients, an extrapyramidal reaction occurred. Patient 1 was a 10-year-old girl who developed the symptom 29 hours
Frederic Tissot et al.
American journal of respiratory and critical care medicine, 188(9), 1100-1109 (2013-06-21)
Life-threatening intraabdominal candidiasis (IAC) occurs in 30 to 40% of high-risk surgical intensive care unit (ICU) patients. Although early IAC diagnosis is crucial, blood cultures are negative, and the role of Candida score/colonization indexes is not established. The aim of
Pyoeng Gyun Choe et al.
Journal of Korean medical science, 25(10), 1427-1430 (2010-10-05)
Hyperbilirubinemia is frequently observed in Caucasian HIV patients treated with atazanavir. UDP-glucuronosyltransferase 1A1 polymorphism, UGT1A1*28, which is associated with atazanavir-induced hyperbilirubinemia, is less common in Asians than in Caucasians. However, little is known about the incidence of atazanavir-associated hyperbilirubinemia in
L Lund et al.
The Journal of urology, 191(5), 1347-1350 (2013-11-23)
We evaluate whether aspiration and sclerosing of hydrocele testis is an effective treatment. Men with symptomatic hydrocele testis were included in this prospective, double-blind, randomized study with polidocanol and placebo. Patients were randomized to active treatment or placebo at the
C M Parsons et al.
The British journal of nutrition, 46(1), 77-86 (1981-07-01)
1. The relative potencies of three lysine, one tryptophan and six methionine analogues to their corresponding l-amino acids were determined. 2. Male poults, 9 d of age, were used in five 14 d experiments. Experimental diets were formed by adding
Gerald Holtmann et al.
Gastroenterology, 126(4), 971-979 (2004-04-02)
In patients with functional dyspepsia, altered alpha-adrenoreceptor function and depression are prevalent, features that are linked to a G-protein beta 3 (GNB3) subunit gene polymorphism (C825T). We aimed to assess the association of specific G-protein beta 3 subunit genotypes with
E Dahl et al.
The Journal of biological chemistry, 271(30), 17903-17910 (1996-07-26)
A new gap junction gene isolated from the mouse genome codes for a connexin protein of 261 amino acids. Because of its theoretical molecular mass of 30.366 kDa, it is named connexin-30. Within the connexin gene family, this protein is
Anastasia Papaporfyriou et al.
Chest, 146(4), 951-958 (2014-06-06)
Osteopontin (OPN) is a phosphorylated acidic glycoprotein that can function as both an extracellular matrix molecule and a cytokine. Published data support that OPN is upregulated in surgical lung tissue samples of patients with COPD. The aim of this study
L M Sabatini et al.
Molecular biology and evolution, 10(3), 497-511 (1993-05-01)
Human histatins are a family of low-M(r), neutral to very basic, histidine-rich salivary polypeptides. They probably function as part of the nonimmune host defense system in the oral cavity. A 39-kb region of DNA containing the HIS1 and HIS2 genes
Bing Wang et al.
Developmental neuroscience, 42(2-4), 124-134 (2020-12-11)
The striatal, primary sensorimotor cortical, and thalamic neurons are highly vulnerable to hypoxia-ischemia (HI) in term newborns. In a piglet model of HI that exhibits similar selective regional vulnerability, we tested the hypothesis that early treatment with sulforaphane, an activator
Johanna Louhimo et al.
International journal of cancer, 101(6), 545-548 (2002-09-19)
In colorectal cancer, stage is considered to be the strongest prognostic factor, but also serum tumour markers have been reported to be of prognostic value. The aim of our study was to investigate the prognostic value of serum carcinoembryonic antigen
H Uchiyama et al.
Blood, 80(9), 2306-2314 (1992-11-01)
In multiple myeloma, malignant plasma cells are localized in marrow and rarely circulate in peripheral blood. To investigate the role of adhesion proteins in this process, we determined the expression and function of adhesion molecules on cell lines derived from
R Pawliczak et al.
The Journal of biological chemistry, 276(48), 44613-44621 (2001-09-26)
The effect of nitric oxide on p11 expression was studied in an immortalized human bronchial epithelial cell line (BEAS-2B cells). Three nitric oxide donors were used: spermine NONOate (SP), (+/-)-S-nitroso-N-acetylpenicillamine (SNAP), and S-nitrosoglutathione (SNOG). All three nitric oxide donors had
Daisuke Nonaka et al.
The American journal of surgical pathology, 37(8), 1236-1241 (2013-05-30)
Autonomic neurons and chromaffin cells, which constitute the autonomic nervous system, are derived from a common progenitor from the neural crest, and its development is controlled by a network of transcription factors, including the master regulator, Phox2b, and its downstream
Virginie Fabrès et al.
Journal of veterinary internal medicine, 33(2), 499-507 (2019-02-17)
Acute pancreatitis (AP) is associated with a high death rate in dogs, but accurate predictors of early death are still lacking. To develop a scoring system for prediction of short-term case fatality in dogs with AP. One hundred sixty-nine dogs
E Wesley Ely et al.
Critical care medicine, 35(1), 112-117 (2006-11-30)
To test for an association between apolipoprotein E (APOE) genotypes and duration of intensive care unit delirium. Prospective, observational cohort study. A 541-bed, community-based teaching hospital. Fifty-three mechanically ventilated intensive care unit patients. None. All patients were managed with standardized
Kris V Kowdley et al.
Lancet (London, England), 381(9883), 2100-2107 (2013-03-19)
The uridine nucleotide analogue sofosbuvir is a selective inhibitor of hepatitis C virus (HCV) NS5B polymerase. We assessed the safety and efficacy of sofosbuvir in combination with pegylated interferon alfa-2a (peginterferon) and ribavirin in non-cirrhotic treatment-naive, patients with HCV. For
Tamás Szerafin et al.
Circulation research, 99(5), e12-e17 (2006-08-19)
Based on findings of experimental models of diabetes mellitus (DM) showing increased expression of vascular cyclooxygenase-2 (COX-2), we hypothesized that in patients with DM changes in COX-2-dependent prostaglandin synthesis affect vasomotor responses of coronary arterioles. Arterioles were dissected from the
Zhenwen Chen et al.
European journal of clinical investigation, 42(3), 310-320 (2011-09-02)
Topoisomerase IIα (topo IIα) protein expression has prognostic significance in many cancers. However, it is still unclear whether topo IIα protein expression and gene alterations play roles as prognostic factors in diffuse large B-cell lymphoma (DLBCL). We selected 102 patients
Alain Sauvanet et al.
Annals of surgery, 260(2), 364-371 (2014-03-22)
To assess the feasibility and outcomes of parenchyma-sparing pancreatectomy (PSP), including enucleation (EN), resection of uncinate process (RUP), and central pancreatectomy (CP), as an alternative to standard pancreatectomy for presumed noninvasive intraductal papillary and mucinous neoplasms (IPMNs). Pancreaticoduodenectomy and distal
Jeffrey N Weitzel et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 14(7), 1666-1671 (2005-07-21)
Approximately 12% of the U.S. population is Hispanic, with the majority residing in urban centers such as Los Angeles. The prevalence of BRCA mutations among high-risk Hispanic families is unknown. One hundred and ten unrelated probands of Hispanic origin, with
Drew A Graham et al.
Journal of applied physiology (Bethesda, Md. : 1985), 107(4), 1059-1067 (2009-08-22)
Cyclooxygenase (COX)-derived vasoconstrictory prostanoids contribute to impaired endothelium-dependent vasorelaxation in aging male (m) spontaneously hypertensive rats (SHR); however, vasomotor responses in aging female (f) SHR and sex differences in aging SHR are unknown. Examining mechanisms governing dysfunction in aging fSHR
Ellyn E Ritchie et al.
Chemosphere, 90(7), 2129-2135 (2012-12-06)
Soil eco-toxicity testing was conducted in support of Canada's Chemical Management Plan (CMP) to fill data gaps for organic chemicals known to primarily partition to soil, and of which the persistence and inherent toxicity are uncertain. Two compounds representative of
Santiago Palacio et al.
International journal of stroke : official journal of the International Stroke Society, 10(5), 686-691 (2013-05-23)
It remains controversial whether dual antiplatelet therapy reduces stroke more than aspirin alone. We aimed to assess the effects of adding clopidogrel to aspirin on the occurrence of stroke and major haemorrhage in patients with vascular disease. Meta-analysis of published
Demidmaa Tuvdendorj et al.
Surgery, 149(5), 645-653 (2011-02-22)
We recently showed that mechanisms of protein turnover in skeletal muscle are unresponsive to amino acid (AA) infusion in severely burned pediatric patients at 6 months postinjury. In the current study, we evaluated whether oxandrolone treatment affects mechanisms of protein
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