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Michel R Nasr et al.
American journal of clinical pathology, 133(1), 41-48 (2009-12-22)
The optimal use of transcription factors to determine B-lineage specificity in B-acute lymphoblastic leukemia/lymphoma (B-ALL) has not been fully investigated. We undertook an extensive immunohistochemical study of a panel of B-cell transcription factors in B- and T-ALL and Burkitt lymphoma
Stéphanie Raymond et al.
AIDS (London, England), 22(14), F11-F16 (2008-08-30)
Replacing phenotypic assays with simple genotypic predictions of HIV-1 coreceptor usage would make the clinical use of CCR5 antagonists easier. Paired genotypic and phenotypic determination of HIV-1 coreceptor usage was performed to assess several genotypic approaches for detecting CXCR4-using and
M C Yagmurdur et al.
International surgery, 93(3), 163-168 (2008-10-03)
The study group was derived from the archive materials of 55 invasive ductal breast cancer (IDC) patients who had undergone breast-preserving surgery (partial mastectomy/ axillary dissection). All patients included in the study had clinically T(1)-2, N0-M0 invasive ductal carcinoma. Genomic
K B S Chow et al.
Prostaglandins, leukotrienes, and essential fatty acids, 70(5), 423-429 (2004-04-06)
The ability of prostacyclin analogues to stimulate adenylyl cyclase (AC) and phospholipase C (PLC) in Chinese hamster ovary (CHO) cells expressing cloned human (hIP) or cloned mouse (mIP) prostacyclin receptors has been compared. For hIP, the order of potency (pEC(50))
Okko T Pyykkö et al.
Journal of neurology, neurosurgery, and psychiatry, 83(11), 1119-1124 (2012-09-08)
To investigate the association of apolipoprotein E (APOE) genotype, especially the APOE4 allele, to (1) idiopathic normal pressure hydrocephalus (iNPH) and (2) amyloid-β (Aβ) plaques in cortical brain biopsies of presumed NPH patients with and without a final clinical diagnosis
W Yang et al.
DNA sequence : the journal of DNA sequencing and mapping, 12(4), 239-251 (2002-03-28)
The actions of platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) are mediated through the PAF receptor (PAFr), which is a member of G-protein coupled superfamily of receptors. Our laboratory has data showing PAF has a role(s) in reproduction in domestic animals. Porcine, bovine
Yu Han et al.
Food chemistry, 342, 128537-128537 (2020-11-14)
Three water-soluble polysaccharides (UPPs 1-3) were obtained from edible green alga Ulva pertusa. The chemico-physical analyses indicated that UPPs 1-3 possessed molecular weights of 376.7 kDa, 57.21 kDa, and 131.13 kDa, with sulfate contents of 26.01 ± 8.13%, 9.86 ± 3.24%, and 13.32 ± 6.56%, respectively, and composed of
Ozgur Mete et al.
Virchows Archiv : an international journal of pathology, 447(6), 938-946 (2005-09-01)
Among the epithelial renal tumours with eosinophilic cytoplasm, the main differential diagnostic problem arises between renal oncocytomas (ROs) and eosinophilic variants of chromophobe renal cell carcinomas (RCCs). We investigated the possible role of anti-mitochondrial (AMA), anti-caveolin 1 (CAV1), anti-CD63 (CD63)
D M McNamara et al.
Circulation, 103(12), 1644-1648 (2001-03-29)
Activation of the renin-angiotensin and sympathetic nervous systems adversely affect heart failure progression. The ACE deletion allele (ACE D) is associated with increased renin-angiotensin activation; however, its influence on patient outcomes remains uncertain, and the pharmacogenetic interactions with beta-blocker therapy
T Masaki et al.
DNA research : an international journal for rapid publication of reports on genes and genomes, 7(3), 187-193 (2000-07-25)
TREB5/hXBP-1/HTF is a basic region leucine zipper protein which binds to a cyclic AMP responsive element (CRE)-like element in both human T-cell leukemia virus type 1 and human major histocompatibility complex (MHC) class II genes. To analyze the structure and
Wei Meng et al.
Molecular biology international, 2012, 701814-701814 (2012-04-25)
Promoter hypermethylation, a widely studied epigenetic event known to influence gene expression levels, has been proposed as a potential biomarker in multiple types of cancer. Clinical diagnostic biomarkers are needed for reliable prediction of bladder cancer recurrence. In this paper
V Soukup et al.
Urologia internationalis, 80(4), 413-418 (2008-07-01)
To evaluate the prognostic value of T1 subclassification and fascin-1 expression in T1 human urothelial cell carcinoma of the bladder. In a prospective study with 105 consecutive patients, T1 tumors were subclassified into 2 groups according to the depth of
P E Noker et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 24(12), 1287-1293 (1986-12-01)
The disposition of 200 mg/kg of 14C-labelled sucrose octa-isobutyrate (14C-SOIB), a component of sucrose acetate isobutyrate (SAIB), a beverage emulsion stabilizer, was studied in rats, dogs and monkeys. After oral administration of 14C-SOIB to three rats, 3-15% of the dose
Andrew Preston et al.
Journal of immunological methods, 341(1-2), 19-29 (2008-11-22)
The spontaneous formation of the neurotoxic carcinogen acrylamide in a wide range of cooked foods has recently been discovered, leading to dietary exposure estimates of 30.8 microg of acrylamide day(-1) for an average 77 kg human male. This is considerably
Shingo Inaguma et al.
Oncotarget, 8(16), 26744-26754 (2017-05-04)
Mesothelin (MSLN) is a glycophosphatidylinositol (GPI)-linked cell surface protein highly expressed in several types of malignant tumors sometimes in association with increased tumor aggressiveness and poor clinical outcome. In the present study, 1562 tumors were immunohistochemically analyzed for mesothelin expression
Andrea Morelli et al.
JAMA, 310(16), 1683-1691 (2013-10-11)
β-Blocker therapy may control heart rate and attenuate the deleterious effects of β-adrenergic receptor stimulation in septic shock. However, β-Blockers are not traditionally used for this condition and may worsen cardiovascular decompensation related through negative inotropic and hypotensive effects. To
G J Tangelder et al.
The American journal of physiology, 268(2 Pt 2), H909-H915 (1995-02-01)
A method is presented to assess in vivo in transparent tissues the leukocyte subtypes that roll in microvessels. In nine rabbits anesthetized with ketamine-xylazine, leukocyte nuclei were stained in situ with acridine yellow (3 mg/kg i.v. for 5 min). Intravital
Engineered viruses to select genes encoding secreted and membrane-bound proteins in mammalian cells.
Pierre Moffatt et al.
Nucleic acids research, 30(19), 4285-4294 (2002-10-05)
We have developed a functional genomics tool to identify the subset of cDNAs encoding secreted and membrane-bound proteins within a library (the 'secretome'). A Sindbis virus replicon was engineered such that the envelope protein precursor no longer enters the secretory
N Hamajima et al.
Gene, 180(1-2), 157-163 (1996-11-21)
We have isolated cDNA clones encoding dihydropyrimidinase (DHPase) from human liver and its three homologues from human fetal brain. The deduced amino acid (aa) sequence of human DHPase showed 90% identity with that of rat DHPase, and the three homologues
Harry R Davis et al.
Arteriosclerosis, thrombosis, and vascular biology, 27(4), 841-849 (2007-01-16)
The objective of this study was to determine whether the deficiency of Niemann-Pick C1 Like 1 (Npc1l1) prevents atherosclerosis in apoE null mice. Npc1l1(-/-)/apoE null-/- mice were generated and found to have a significant reduction in cholesterol absorption (-77%) compared
Zitian Huo et al.
American journal of translational research, 12(8), 4354-4370 (2020-09-12)
Small-cell lung cancer (SCLC) is a poorly differentiated neuroendocrine neoplasm with inadequate therapeutic options. Fasudil is a Rho-associated protein kinase 1 and 2 (ROCK1/2) inhibitor whose clinical indications remain limited in cardiocerebrovascular diseases. This study aimed to report a possible
Sakhawat Hussain Rahman et al.
Digestive diseases and sciences, 50(7), 1376-1383 (2005-07-29)
Epidemiological studies have demonstrated a variety of potential environmental factors that may alter susceptibility to chronic pancreatitis (CP) through oxidative/xenobiotic stress; however, a direct causal and mechanistic role has not been established. We aimed (1) to determine the prevalence of
F Beuschlein et al.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 113(4), 214-218 (2005-05-14)
The use of growth hormone (GH) in patients with GH deficiency induced by pituitary adenoma is widely accepted, but the safety of this mitogenic hormone, particularly in patients with residual tumor after neurosurgery, continues to be a concern. Since the
Emranul Huq et al.
American journal of physical anthropology, 166(1), 95-106 (2018-01-11)
We hypothesized that the vertical leaper Galago senegalensis will have epaxial extensor muscles with a fast fiber phenotype to facilitate rapid spinal extension during leaping in comparison to the slow-moving quadruped Nycticebus coucang. To test this, we determined the percentage
L Tarnow et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 16(8), 1653-1656 (2001-07-31)
An XbaI polymorphism in the gene encoding the glucose transporter, GLUT-1, is associated with development of diabetic nephropathy in Chinese type 2 diabetic patients. In addition, an amino acid variant (K121Q) in the gene encoding the glycoprotein plasma cell differentiating
René Schramm et al.
Immunology, 120(3), 315-324 (2006-12-05)
Lymphocyte homing to peripheral lymph nodes is governed by adhesion molecules, including lymphocyte function-associated antigen 1 (LFA-1). Statins are 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and exert anti-inflammatory effects, e.g. inhibition of LFA-1. It is still not known whether statin compounds
N Ali et al.
The Journal of biological chemistry, 268(9), 6161-6167 (1993-03-25)
In pursuit of the physiological role of inositol 1,3,4,5-tetrakisphosphate 3-phosphatase, which also attacks inositol pentakisphosphate and inositol hexakisphosphate with much higher affinity (Nogimori, K., Hughes, P.J., Glennon, M.C., Hodgson, M.E., Putney, J.W., Jr., and Shears, S.B. (1991) J. Biol. Chem.
Akihide Ohkuchi et al.
Hypertension in pregnancy, 28(1), 95-108 (2009-01-24)
It was recently reported that both a high soluble fms-like tyrosine kinase 1 (sFlt1): placental growth factor (PlGF) ratio (sFlt1:PlGF ratio) and high soluble endoglin (sEng) levels are related to the later occurrence of preeclampsia. We compared the serum sFlt1:PlGF
M V Marsh et al.
Xenobiotica; the fate of foreign compounds in biological systems, 11(10), 655-663 (1981-10-01)
1. 14C-Labelled benzoic acid, salicylic acid and 2-naphthylacetic acid were administered orally to horses, and urinary metabolites investigated by chromatographic and mass spectral techniques. 2. [14C]Benzoic acid (5 mg/kg) was eliminated rapidly in the urine, and quantitatively recovered in 24
Laurence Faivre et al.
American journal of medical genetics. Part A, 123A(2), 204-207 (2003-11-05)
Weill-Marchesani syndrome (WMS) is a rare condition characterized by short stature, brachydactyly, joint stiffness, and characteristic eye abnormalities including microspherophakia, ectopia of lens, severe myopia, and glaucoma. Both autosomal recessive (AR) and autosomal dominant (AD) modes of inheritance have been
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