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A Wuyts et al.
Journal of immunology (Baltimore, Md. : 1950), 163(11), 6155-6163 (1999-11-26)
Chemokines are important mediators of leukocyte migration during the inflammatory response. Post-translational modifications affect the biological potency of chemokines. In addition to previously identified NH2-terminally truncated forms, COOH-terminally truncated forms of the CXC chemokine murine granulocyte chemotactic protein-2 (GCP-2) were
Meera Mahalingam et al.
The American Journal of dermatopathology, 32(8), 774-779 (2010-08-12)
The overlap in histopathologic features and immunoprofile of eccrine and apocrine neoplasms confounds basic issues relating to lineage of these entities. We evaluated expression of follicular stem-cell markers, cytokeratin (CK) 15 and nestin, in 78 benign and 23 malignant adnexal
Erica Miraglia et al.
Reproduction (Cambridge, England), 141(1), 47-54 (2010-10-23)
Nitric oxide (NO), a modulator of several physiological processes, is involved in different human sperm functions. We have investigated whether NO may stimulate the motility of human spermatozoa via activation of the soluble guanylate cyclase (sGC)/cGMP pathway. Sperm samples obtained
Erich H Schneider et al.
Naunyn-Schmiedeberg's archives of pharmacology, 393(7), 1251-1267 (2020-04-22)
The effects of 100 μM of 3',5'-cGMP, cAMP, cCMP, and cUMP as well as of the corresponding membrane-permeant acetoxymethyl esters on anti-CD3-antibody (OKT3)-induced IL-2 production of HuT-78 cutaneous T cell lymphoma (Sézary lymphoma) cells were analyzed. Only 3',5'-cGMP significantly reduced IL-2
A Pardanani et al.
Leukemia, 26(4), 693-699 (2011-09-14)
Recent studies suggest a powerful prognostic value for plasma cytokine levels in primary myelofibrosis (interleukin (IL)-2R, IL-8, IL-12, IL-15 and C-X-C motif chemokine 10 (CXCL10)) and large-cell lymphoma (IL-2R, IL-8, IL-10, IL-12, CXCL9 and CXCL10). To examine the possibility of
Phumisak Louwakul et al.
Journal of endodontics, 41(4), 508-512 (2015-02-05)
Capping inflamed dental pulp tissue is currently a controversial issue. To reduce pulp inflammation and stimulate pulp healing, a pulp-capping material containing fluocinolone acetonide (PCFA) has been developed. This study was aimed to evaluate the inflammatory response and hard tissue
Marcel Dautzenberg et al.
The Journal of physiology, 589(Pt 19), 4731-4744 (2011-08-10)
Nitric oxide (NO) blunts the myogenic response (MR) in renal blood flow (RBF) autoregulation. We sought to clarify the roles of NO synthase (NOS) isoforms, i.e. neuronal NOS (nNOS) from macula densa, endothelial NOS (eNOS) from the endothelium, and inducible
L J Walker et al.
Clinical and experimental immunology, 135(3), 490-496 (2004-03-11)
Anti-Saccharomyces cerevisiae antibodies (ASCAs) have been proposed as serological markers, which may differentiate Crohn's disease (CD) from ulcerative colitis (UC) and predict disease phenotype. Their importance in pathogenesis is unproven. We investigated the relationship between ASCAs, disease phenotype and NOD2/CARD15
Marta Del Campo et al.
Annals of clinical and translational neurology, 5(10), 1163-1175 (2018-10-24)
Frontotemporal lobar degeneration (FTLD) is the second most prevalent dementia in young patients and is characterized by the presence of two main protein aggregates in the brain, tau (FTLD-Tau) or TDP43 (FTLD-TDP), which likely require distinct pharmacological therapy. However, specific
Nicole Berwald et al.
The American journal of emergency medicine, 32(7), 768-771 (2014-05-06)
The benefit of antibiotic prophylaxis for simple hand lacerations (lacerations that do not involve special structures) has not been adequately studied. To assess the feasibility of a randomized controlled trial to determine the role of antibiotic prophylaxis in emergency department
Young Suk Kim et al.
International journal of radiation oncology, biology, physics, 84(3), 661-667 (2012-03-15)
Recently, cells deficient in O(6)-methylguanine-DNA methyltransferase (MGMT) were found to show increased sensitivity to temozolomide (TMZ). We evaluated whether hypermethylation of MGMT was associated with survival in patients with glioblastoma multiforme (GBM). We retrospectively analyzed 93 patients with histologically confirmed
Boon Chew et al.
European journal of nutrition, 58(3), 1223-1235 (2018-02-25)
We studied the health benefits of low calorie cranberry beverage consumption on glucoregulation, oxidative damage, inflammation, and lipid metabolism in overweight but otherwise healthy humans. 78 overweight or obese men and women (30-70 years; BMI 27-35 kg/m2) with abdominal adiposity (waist: hip > 0.8
Anjali Saqi et al.
American journal of clinical pathology, 123(3), 394-404 (2005-02-18)
Carcinoids of different organs appear morphologically indistinguishable. We studied the usefulness of differential expression of CDX2 and thyroid transcription factor-1 (TTF-1) in 78 gastrointestinal and pulmonary carcinoids and their metastases (n = 10). CDX2 staining of gastric biopsy specimens with
V Rebours et al.
Gut, 58(1), 97-103 (2008-08-30)
The prevalence and natural history of hereditary pancreatitis (HP) remain poorly documented. The aims of this study were to assess genetic, epidemiological, clinical and morphological characteristics of HP in an extensive national survey. A cohort comprising all HP patients was
D P Eisinger et al.
Genomics, 16(3), 638-644 (1993-06-01)
Adipose differentiation-related protein (ADRP) is a novel 50-kDa membrane-associated protein whose message levels are induced rapidly and maximally after triggering adipocyte differentiation. The gene encoding mouse ADRP has been isolated and characterized from four overlapping lambda phage clones. The gene
A Räisänen-Sokolowski et al.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 18(8), 735-743 (1999-10-08)
Mice with target gene deletions were used in an immunosuppressed, heterotopic mouse cardiac transplant model to investigate the effects of simultaneous deficiencies of ICAM-1 and P-selectin on late cardiac rejection. To determine the contribution of donor sources of ICAM-1 and
K Plna et al.
Carcinogenesis, 18(8), 1457-1462 (1997-08-01)
32P-Postlabelling analysis of allyl glycidyl ether-treated DNA after adduct enrichment on anion-exchange cartridges revealed two major and one minor DNA adducts. The major adducts were shown to originate from alkylation at N-7-guanine and N-1-adenine, respectively, while the minor adduct was
O Saramäki et al.
The American journal of pathology, 159(6), 2089-2094 (2001-12-26)
Gain of the long arm of chromosome 8 (8q) is one of the most common gains found in the advanced prostate cancer by comparative genomic hybridization. We have previously identified a putative target gene for the 8q gain, EIF3S3, that
Julie E Bines et al.
The Lancet. Infectious diseases, 15(12), 1389-1397 (2015-09-01)
Despite the success of rotavirus vaccines, suboptimal vaccine efficacy in regions with a high burden of disease continues to present a challenge to worldwide implementation. A birth dose strategy with a vaccine developed from an asymptomatic neonatal rotavirus strain has
Thomas P Gunnarsson et al.
American journal of physiology. Cell physiology, 318(6), C1252-C1263 (2020-04-09)
Essential hypertension is associated with impairments in vascular function and sympathetic nerve hyperactivity; however, the extent to which the lower limbs are affected remains unclear. We examined the leg vascular responsiveness to infusion of acetylcholine (ACh), sodium nitroprusside (SNP), and
Goro Sasaki et al.
The Journal of clinical endocrinology and metabolism, 88(7), 3431-3436 (2003-07-05)
The 5alpha-reductase-2 encoded by the SRD5A2 gene plays a critical role in male sex differentiation by converting testosterone into 5alpha dihydrotestosterone in the peripheral target tissues. In this study, we examined the SRD5A2 gene in 81 Japanese patients with micropenis
B Davidson et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 7(11), 3457-3464 (2001-11-14)
The purpose of this study was to analyze the expression of the high- and low-affinity nerve growth factor (NGF) receptors TrkA and p75 in effusions and in primary and metastatic tumors of serous ovarian carcinoma patients, as well as to
C Ortalda et al.
The Journal of small animal practice, 57(4), 205-209 (2016-02-18)
To assess efficacy of a gel compound containing guar, glycerine, triclosan and ethanol (Pawcare®, JOKER Technologies, Kerzers, Switzerland) in decreasing bacterial and yeast loads on the paws of dogs with erythematous, greasy and/or malodorous pododermatitis. In 20 dogs, each with
Yao Huang et al.
Chemosphere, 253, 126648-126648 (2020-04-17)
Catalyzed H2O2 propagations (CHP) have demonstrated great potential in the remediation of chlorinated aliphatic hydrocarbons (CAHs) like trichloroethene (TCE) contaminated groundwater. However, the importation of highly unstable H2O2 into subsurface environment remains challenging. In this work, the in-situ H2O2 generation
Jyh-Ming Liou et al.
Lancet (London, England), 381(9862), 205-213 (2012-11-20)
Whether sequential treatment can replace triple therapy as the standard treatment for Helicobacter pylori infection is unknown. We compared the efficacy of sequential treatment for 10 days and 14 days with triple therapy for 14 days in first-line treatment. For
I Splawski et al.
Circulation, 102(10), 1178-1185 (2000-09-07)
Long-QT Syndrome (LQTS) is a cardiovascular disorder characterized by prolongation of the QT interval on ECG and presence of syncope, seizures, and sudden death. Five genes have been implicated in Romano-Ward syndrome, the autosomal dominant form of LQTS: KVLQT1, HERG
K A Mir et al.
The British journal of surgery, 96(10), 1205-1209 (2009-09-05)
Foot ulcer is a significant cause of morbidity in diabetics. Genetic make-up can determine inflammatory and healing responses. This study examined the hypothesis that specific polymorphisms of the heat-shock protein 70 gene could predispose to the severity of diabetic foot
Nuno Melo Beirão et al.
Retina (Philadelphia, Pa.), 31(7), 1373-1377 (2011-03-02)
Vitreous amyloid deposits are one of the most common ocular manifestations of familial amyloidosis ATTR V30M (FAP-I), which can be the only manifestation of the disease and can appear even after liver transplantation. Removal by vitrectomy is usually performed, but
Shimako Yoshitake et al.
Neurochemistry international, 62(3), 314-323 (2013-01-01)
The purpose of this study was to examine the effects of stress and the role of locally infused anxiogenic-like neuropeptides galanin, CCK-8, vasopressin, substance P and neurokinin A, and anxiolytic-like peptides NPY, nociceptin/orphanin FQ, somatostatin and neurotensin, on modulation of
J T George et al.
Clinical endocrinology, 86(5), 731-738 (2017-02-12)
Gonadotropin-inhibitory hormone (GnIH, human homologue of RFRP-3) suppresses gonadotropin secretion in animal models, but its effects have not been studied in the human. We tested the hypotheses that exogenous GnIH inhibits LH secretion (i) in postmenopausal women and (ii) in
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