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Tomonori Hu et al.
Optics letters, 37(11), 2145-2147 (2012-06-05)
We report an efficient Q-switched Ho(3+)Pr(3+)-doped fluoride fiber laser, producing a peak power of 77 W, with pulse width of 78 ns. A slope efficiency of 20% with respect to the launched pump power was achieved. A TeO(2) acousto-optic modulator
R Kirisawa et al.
Veterinary immunology and immunopathology, 62(3), 197-208 (1998-06-27)
cDNA generated from lipopolysaccharide-stimulated bovine peripheral blood mononuclear cells was used to amplify and clone the bovine interleukin-1 receptor antagonist (IL-1ra) using primers derived from semi-conserved regions between human and mouse IL-1ra sequences. 5' and 3' terminal sequences of bovine
T Sekimoto et al.
Tissue antigens, 58(5), 345-348 (2002-02-15)
A new HLA-B*78 allele, B*7805, was identified in a healthy Japanese female. The results of her serological HLA class I typing showed an unusual Bw4/Bw6 pattern with strongly positive reactivity to anti-Bw6, i.e. A24, -, B52, -, Bw4, Bw6. In
Cardiac hormones are potent inhibitors of secreted frizzled-related protein-3 in human cancer cells.
William P Skelton et al.
Experimental and therapeutic medicine, 5(2), 475-478 (2013-02-15)
Secreted frizzled-related proteins (sFRPs) are secreted glycoproteins involved in neoplastic growth. Four hormones synthesized in the heart, namely vessel dilator, atrial natriuretic peptide (ANP), kaliuretic peptide (KP) and long-acting natriuretic peptide (LANP), have anticancer effects both in vitro and in
B Davidson et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 7(11), 3457-3464 (2001-11-14)
The purpose of this study was to analyze the expression of the high- and low-affinity nerve growth factor (NGF) receptors TrkA and p75 in effusions and in primary and metastatic tumors of serous ovarian carcinoma patients, as well as to
Elena Alina Demeter et al.
Frontiers in veterinary science, 6, 395-395 (2019-12-06)
Canine glioma is considered a potential model for human glioma, with recent studies of occurrence, therapy, and reclassification supporting the value of the canine model. The current diagnosis of canine glioma is based on morphologic criteria and immunohistochemistry (IHC), including
A Schambony et al.
Biochimica et biophysica acta, 1387(1-2), 206-216 (1998-09-28)
Although originally described in the male rodent genital tract, cysteine-rich secretory proteins (CRISPs) are expressed in a variety of mammalian tissue and cell types. The proteins of the male genital tract have been observed associated to spermatozoa and are believed
Guoqiang Xing et al.
Neuroscience letters, 454(1), 38-42 (2009-05-12)
Dysregulated brain glucose metabolism and lactate accumulation are seen following traumatic brain injury (TBI). The underlying molecular mechanism is poorly understood. Pyruvate dehydrogenase (PDH), the rate-limiting enzyme coupling cytosolic glycolysis to mitochondrial citric acid cycle, plays a critical role in
Francesco De Seta et al.
American journal of obstetrics and gynecology, 197(6), 613-613 (2007-08-07)
The objective of the study was to examine mannose-binding lectin gene (MBL2) polymorphisms in women with recurrent episodes of bacterial vaginosis (BV). Seventy-one women with at least 4 episodes of BV in the last 12 months and 130 healthy controls
Poornima Parameswaran et al.
Cell host & microbe, 22(3), 400-410 (2017-09-15)
Dengue, caused by four dengue virus serotypes (DENV-1 to DENV-4), is a highly prevalent mosquito-borne viral disease in humans. Yet, selection pressures driving DENV microevolution within human hosts (intrahost) remain unknown. We employed a whole-genome segmented amplification approach coupled with
E Alberdi et al.
The Journal of biological chemistry, 274(44), 31605-31612 (1999-10-26)
Pigment epithelium-derived factor (PEDF) has neuronal differentiation and survival activity on retinoblastoma and cerebellar granule (CG) cells. Here, we investigated the presence of PEDF receptors on retinoblastoma Y-79 and CG cells. PEDF radiolabeled with (l25)I remained biologically active and was
M J Harris et al.
Genome, 41(6), 789-796 (1999-01-30)
We tested for complementation between two Mendelian mutations in mice, Far (first arch) and lgGa (lidgap-Gates). Each of these mutations gives greater than 70% risk of the birth defect, open eyelids, in homozygotes and gives little or no risk in
Y Haraguchi et al.
The Journal of clinical investigation, 86(1), 347-350 (1990-07-01)
Argininemia results from a deficiency of arginase (EC 3.5.3.1), the last enzyme of the urea cycle in the liver. We examined the molecular basis for argininemia by constructing a genomic library followed by cloning and DNA sequencing. Discrete mutations were
Rafael Igual-Adell et al.
Expert opinion on pharmacotherapy, 5(12), 2615-2619 (2004-12-02)
Treatment of strongyloidiasis has been traditionally based on thiabendazole, despite its frequent gastrointestinal side effects and failure to achieve eradication of the parasite from faeces in approximately 30% of cases. Ivermectin has been shown to be more effective for treating
Janna M Schurer et al.
The American journal of tropical medicine and hygiene, 90(6), 1184-1190 (2014-03-19)
Residents of remote and Indigenous communities might experience higher exposure to some zoonotic parasites than the general North American population. Human sero-surveillance conducted in two Saulteaux communities found 113 volunteers exposed as follows: Trichinella (2.7%), Toxocara canis (4.4%), Echinococcus (4.4%)
S Mokuda et al.
Journal of endocrinological investigation, 35(9), 796-799 (2012-11-09)
The serum undercarboxylated osteocalcin (ucOC) level, a biochemical bone marker of vitamin K insufficiency, is often affected by anti-osteoporosis drugs. There have been no reports regarding the relationship between ucOC and teriparatide. We conducted a prospective observational study of 26
R Bigoni et al.
Canadian journal of physiology and pharmacology, 80(5), 407-412 (2002-06-12)
We have studied the effects of naloxone benzoylhydrazone (NalBzoH) at recombinant human OP4 receptors expressed in Chinese hamster ovary (CHO) cells (CHOhOP4) and native OP4 sites in isolated tissues from various species. In CHOhOP4 membranes, nociceptin (NC) and NalBzoH displaced
Najmeh Haseli et al.
Hepatitis monthly, 13(7), e10257-e10257 (2013-09-26)
Liver transplantation is considered as the standard treatment for both children and adults with end-stage liver diseases. Using this method, children who have no chance for life can live a much longer life .Shiraz Transplant Center is the major pediatric
Lee-Mei Ng et al.
Journal of bioscience and bioengineering, 122(5), 550-557 (2016-10-26)
Aquitalea sp. USM4 (JCM 19919) was isolated from a freshwater sample at Lata Iskandar Waterfall in Perak, Malaysia. It is a rod-shaped, gram-negative bacterium with high sequence identity (99%) to Aquitalea magnusonii based on 16S rRNA gene analysis. Aquitalea sp.
P E Noker et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 24(12), 1287-1293 (1986-12-01)
The disposition of 200 mg/kg of 14C-labelled sucrose octa-isobutyrate (14C-SOIB), a component of sucrose acetate isobutyrate (SAIB), a beverage emulsion stabilizer, was studied in rats, dogs and monkeys. After oral administration of 14C-SOIB to three rats, 3-15% of the dose
M Tada et al.
Gene, 90(2), 293-297 (1990-06-15)
A cDNA encoding D-amino acid oxidase (DAO;EC1.4.3.3) has been isolated from a BALB/c mouse kidney cDNA library by hybridization with the cDNA for the porcine enzyme. Analysis of the nucleotide (nt) sequence of the clone revealed that it has a
Young Suk Kim et al.
International journal of radiation oncology, biology, physics, 84(3), 661-667 (2012-03-15)
Recently, cells deficient in O(6)-methylguanine-DNA methyltransferase (MGMT) were found to show increased sensitivity to temozolomide (TMZ). We evaluated whether hypermethylation of MGMT was associated with survival in patients with glioblastoma multiforme (GBM). We retrospectively analyzed 93 patients with histologically confirmed
Kristin M Schroeder et al.
Pediatric research, 75(1-2), 205-209 (2013-11-07)
Diffuse intrinsic pontine glioma (DIPG) is a high-grade glioma that originates in the pons and is seen exclusively in children. Despite numerous efforts to improve treatment, DIPG remains incurable with 90% of children dying within 2 y of diagnosis, making
M Hausmann et al.
Zeitschrift fur Gastroenterologie, 46(3), 259-265 (2008-03-07)
5- Aminosalicylic acid (5-ASA) is metabolised in colonic mucosa by N-acetyltransferase 1 (NAT1). Common genetic polymorphisms in this enzyme result in rapid or slow acetylation. 5-ASA treatment causes side effects in up to 10 % of patients with ulcerative colitis
Manuel Barreto Miranda et al.
Journal of cancer research and clinical oncology, 140(5), 829-837 (2014-02-22)
We conducted a multicenter phase II study to assess the toxicity and efficacy of a combination of mitomycin C (MMC) and capecitabine in pretreated patients with metastatic or locally advanced gastric cancer. Thirty-nine patients (77 % male) between 33 and
J P Chism et al.
Drug metabolism and disposition: the biological fate of chemicals, 13(6), 651-657 (1985-11-01)
2-Nitrotoluene (2NT) induces DNA repair in the in vivo-in vitro hepatocyte unscheduled DNA synthesis assay in male, but not female, Fischer-344 rats. 3-Nitrotoluene (3NT) and 4-nitrotoluene (4NT) are inactive in both sexes. The structurally related rat hepatocarcinogen, 2,6-dinitrotoluene, which also
Mitsuaki Yanagida et al.
The Journal of biological chemistry, 279(3), 1607-1614 (2003-10-30)
Fibrillarin (FIB, Nop1p in yeast) is an RNA methyltransferase found not only in the fibrillar region of the nucleolus but also in Cajal bodies. FIB is essential for efficient processing of preribosomal RNA during ribosome biogenesis, although its precise function
Ioanna A Armata et al.
Journal of neurochemistry, 106(3), 1052-1065 (2008-05-10)
The DYT1 gene encodes for torsinA, a protein with widespread tissue distribution, involved in early onset dystonia (EOD). Numerous studies have focused on torsinA function but no information is available on its transcriptional regulation. We cloned mouse and human 5'-upstream
Mana Mirza et al.
International journal of cancer, 122(4), 889-897 (2007-10-26)
While the acquisition of invasiveness is a critical step in early stage breast carcinomas (DCIS), no established molecular markers reliably identify tumor progression. The metastasis gene osteopontin is subject to alternative splicing, which yields 3 messages, osteopontin-a, osteopontin-b and osteopontin-c.
Simon Gaul et al.
Journal of chromatography. A, 1216(36), 6433-6440 (2009-08-04)
Halogenated 1'-methyl-1,2'-bipyrroles (MBPs) are a class of marine halogenated natural products that have been detected in biota from all over the world. However, structures and standards of many mixed chlorinated/brominated MBPs are not available. For this reason, the known 2,3,3',4,4',5,5'-heptachloro-1'-methyl-1,2'-bipyrrole
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