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Karen M Chisholm et al.
Applied immunohistochemistry & molecular morphology : AIMM, 24(9), 627-632 (2016-10-18)
Hirschsprung disease (HD) is a congenital malformation resulting from the lack of migration of ganglion cells in the colon. The absence of ganglion cells in rectal suction biopsies aids in diagnosis, but evaluation of these small biopsies can be difficult.
Lianqun Jia et al.
Clinica chimica acta; international journal of clinical chemistry, 360(1-2), 37-45 (2005-06-01)
It is generally accepted that apolipoprotein (apo) A-I is the dominant structural apolipoprotein of HDL particles and different HDL subclasses have distinct but interrelated metabolic functions. HDL is known to directly affect the atherogenic process hence changes in HDL subclasses
S Aharinejad et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 7(8), 2012-2019 (2007-07-10)
Knowledge on interplay between the cardiac molecular response to transplantation-induced stress and primary graft dysfunction (PGD) is limited. A cDNA array identified HIF-1, EGR-1, NAB-2, VEGF-A and uPA as mediators of cardiac tissue response to transplantation-induced stress. mRNA expression of
T Hiratsuka
Biochemistry, 26(11), 3168-3173 (1987-06-02)
When myosin subfragment 1 (S-1) reacts with the bifunctional reagents with cross-linking spans of 3-4.5 A, p-nitrophenyl iodoacetate and p-nitrophenyl bromoacetate, the 20-kilodalton (20-kDa) segment of the heavy chain is cross-linked to the 26-kDa segment via the reactive thiol SH2.
Chrystelle Derache et al.
The FEBS journal, 279(24), 4466-4478 (2012-10-19)
Greglin is an 83-residue serine protease inhibitor purified from the ovaries of the locust Schistocerca gregaria. Greglin is a strong inhibitor of subtilisin and human neutrophil elastase, acting at sub-nanomolar and nanomolar concentrations, respectively; it also inhibits neutrophil cathepsin G, α-chymotrypsin and
Silvia Damian et al.
Oncology, 84(6), 371-377 (2013-05-29)
The effectiveness of palonosetron without delayed dexamethasone dosing against emesis was investigated in patients scheduled to receive the corticosteroid-containing combination of doxorubicin and paclitaxel (AT) for 3 cycles. Chemo-naïve women with breast cancer receiving doxorubicin (60 mg/m(2)) and paclitaxel (200
Anisleidy Rivero et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 907, 168-172 (2012-10-02)
A general procedure to study the biodegradation of endosulfan under laboratory conditions by white rot fungi isolated from native sources growing in YNB (yeast nitrogen base) media with 1% of glucose is presented. The evaluation of endosulfan biodegradation as well
Grzegorz S Nowakowski et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 33(3), 251-257 (2014-08-20)
Lenalidomide has significant single-agent activity in relapsed diffuse large B-cell lymphoma (DLBCL). We demonstrated that lenalidomide can be safely combined with R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone); this new combination is known as R2CHOP. The goal of this
Harshad Lade et al.
International journal of environmental research and public health, 12(6), 6894-6918 (2015-06-19)
A microbial consortium that is able to grow in wheat bran (WB) medium and decolorize the carcinogenic azo dye Congo red (CR) was developed. The microbial consortium was immobilized on polyurethane foam (PUF). Batch studies with the PUF-immobilized microbial consortium
Toshimasa Suzuka et al.
The Journal of organic chemistry, 67(10), 3355-3359 (2002-05-11)
Enantioselective addition of aryllithiums 2a-d (Ar = Ph (a), 2-MeC(6)H(4) (b), 2-MeOC(6)H(4) (c), 1-naphthyl (d)) to 6-(dimethylamino)fulvene (1) in the presence of (-)-sparteine in toluene at -78 degrees C generated chiral cyclopentadienyllithiums (4) substituted with an N,N-dimethylamino(aryl)methyl group, where the
Luping Wang et al.
Cancer letters, 200(1), 57-67 (2003-10-11)
The extracellular matrix protein 1 (ECM1) is a secreted protein that has been implicated with cell proliferation, angiogenesis and differentiation. In the present study, we used immunohistochemical staining to examine the expression of ECM1 in a panel of human tumors
Ian M Bell et al.
Journal of medicinal chemistry, 45(12), 2388-2409 (2002-05-31)
A series of macrocyclic 3-aminopyrrolidinone farnesyltransferase inhibitors (FTIs) has been synthesized. Compared with previously described linear 3-aminopyrrolidinone FTIs such as compound 1, macrocycles such as 49 combined improved pharmacokinetic properties with a reduced potential for side effects. In dogs, oral
Byung Hyun Byun et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(7), 1053-1059 (2013-05-15)
We evaluated the potential of (18)F-FDG PET/CT and diffusion-weighted imaging (DWI) to monitor the histologic response in patients with extremity osteosarcoma receiving neoadjuvant chemotherapy, using sequential PET/CT and MR imaging. We prospectively registered 28 patients with high-grade osteosarcoma treated with
Kazuyuki Matsumoto et al.
Journal of gastroenterology, 54(11), 1019-1028 (2019-04-30)
Recently, therapeutic antibodies against programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) have shown promising clinical results for several solid tumors, including pancreatic cancer. In this study, we evaluated the relationship between the PD-L1 expression of surgical resected and fine-needle aspiration (FNA) specimens
Stefan Herget-Rosenthal et al.
Clinical chemistry, 50(3), 552-558 (2004-01-08)
Acute tubular necrosis (ATN) has high mortality, especially in patients who require renal replacement therapy (RRT). We prospectively studied the diagnostic accuracy of the urinary excretion of low-molecular-weight proteins and enzymes as predictors of a need for RRT in ATN.
Ana Pamplona et al.
Nature medicine, 13(6), 703-710 (2007-05-15)
Cerebral malaria claims more than 1 million lives per year. We report that heme oxygenase-1 (HO-1, encoded by Hmox1) prevents the development of experimental cerebral malaria (ECM). BALB/c mice infected with Plasmodium berghei ANKA upregulated HO-1 expression and activity and
Danielle M P Cronin et al.
American journal of clinical pathology, 137(3), 367-376 (2012-02-18)
Myeloid leukemia cutis (LC) and blastic plasmacytoid dendritic cell neoplasm (BPDCN) are morphologically indistinguishable malignancies that frequently manifest in the skin. Separating myeloperoxidase-negative LC from BPDCN may be particularly challenging. We identified a panel of immunohistochemical stains to distinguish myeloid
Kenji Tomizawa et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 40(7), 881-885 (2013-07-19)
To perform a retrospective analysis of UFT and oral leucovorin combination adjuvant chemotherapy for Stage III colon cancer patients over 76 years old, in order to evaluate both treatment efficacy and toxicity. Between 2002 and 2011, 333 Stage III colon
V Rebours et al.
Gut, 58(1), 97-103 (2008-08-30)
The prevalence and natural history of hereditary pancreatitis (HP) remain poorly documented. The aims of this study were to assess genetic, epidemiological, clinical and morphological characteristics of HP in an extensive national survey. A cohort comprising all HP patients was
Lichao Zhao et al.
American journal of clinical pathology, 137(2), 304-309 (2012-01-21)
We evaluated the detection rates of PAX8 and WT1 immunostaining in 68 (45 as cell blocks, 23 as smears) serous effusion specimens that had a cytologic diagnosis of metastatic carcinoma of ovarian origin. Of the cases, 58 (85%) were positive
Olivier Fitoussi et al.
Haematologica, 96(8), 1136-1143 (2011-05-07)
As rituximab combined with CHOP improves complete remission and overall survival in diffuse large B-cell lymphoma, intensified chemotherapy followed by autologous stem-cell transplantation has also been advocated for high-risk patients. The aim of this study was to establish whether or
E Zamora-Rojas et al.
Meat science, 95(3), 503-511 (2013-06-25)
A handheld micro-electro-mechanical system (MEMS) based spectrometer working in the near infrared region (NIR) (1600-2400nm) was evaluated for in-situ and non-destructive prediction of main fatty acids in Iberian pig (IP) carcasses. 110 IP carcasses were measured. Performance of the instrument
Shiri Klein et al.
Cancer research, 78(6), 1471-1483 (2017-12-21)
CXCR4 expression in neuroblastoma tumors correlates with disease severity. In this study, we describe mechanisms by which CXCR4 signaling controls neuroblastoma tumor growth and response to therapy. We found that overexpression of CXCR4 or stimulation with CXCL12 supports neuroblastoma tumorigenesis.
H J DeAizpurua et al.
Diabetes, 41(9), 1182-1187 (1992-09-01)
To detect serum antibodies to GAD in subjects with IDDM, three recombinant mBGAD 67 peptides encompassing the full-length protein were used in an ELISA. In this study 7 of 9 (78%) preclinical IDDM subjects (ICA+ first-degree relatives of a person
M Kondo et al.
DNA sequence : the journal of DNA sequencing and mapping, 7(2), 71-82 (1997-01-01)
The male-enhanced antigen-2 (Mea-2) gene was originally identified with a monoclonal histocompatibility Y (H-Y) antibody (mAb4VII). There is no report of the full length cDNA encode for Mea-2 product until this report. In this study, we isolated the full length
Ankur R Sangoi et al.
The American journal of surgical pathology, 35(5), 678-686 (2011-04-15)
The diagnosis of metastatic clear cell renal cell carcinoma (CC-RCC) can be difficult because of its morphologic heterogeneity and the increasing use of small image-guided biopsies that yield scant diagnostic material. This is further complicated by the degree of morphologic
Erica Miraglia et al.
Reproduction (Cambridge, England), 141(1), 47-54 (2010-10-23)
Nitric oxide (NO), a modulator of several physiological processes, is involved in different human sperm functions. We have investigated whether NO may stimulate the motility of human spermatozoa via activation of the soluble guanylate cyclase (sGC)/cGMP pathway. Sperm samples obtained
J Bylund et al.
Biochemical and biophysical research communications, 280(3), 892-897 (2001-02-13)
cDNA of a novel human cytochrome P450 was cloned from human liver by reverse transcription-polymerase chain reaction and designated CYP4F12. The open reading frame coded for 524 amino acids, and the sequence could be aligned with 78-83% amino acid identity
M Ormaechea et al.
The Journal of urology, 183(2), 714-717 (2009-12-22)
We report the preliminary results of endoscopic treatment of vesicoureteral reflux in children using polyacrylate polyalcohol copolymer. We performed a prospective multicenter review of pediatric patients treated with subureteral injection of a new nonabsorbable substance. Only patients with 1 year
A Z Kirkel' et al.
Voprosy meditsinskoi khimii, 32(2), 118-125 (1986-03-01)
Oxidation of p-nitro- and p-dimethylaminomethyl derivatives of benzylamine, catalyzed by amine oxidases from human placenta and blood serum, was studied. The amine oxidase activity was estimated by means of a spectrophotometric procedure involving measurement of aldehyde formed during the reaction
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