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Marcela A S Pinhel et al.
Clinical chemistry and laboratory medicine, 46(4), 439-445 (2008-02-27)
Several factors participate in the pathogenesis of Alzheimer's disease (AD), including free radicals, which when out of balance with their antioxidant capacity contribute to the oxidative stress process and neuronal death. The glutathione S-transferase (GST) polymorphisms are associated with the
Jaroslav Meluzín et al.
Heart and vessels, 24(3), 157-163 (2009-05-26)
The purpose of this study was to determine the relationship between erectile dysfunction (ED), coronary artery disease (CAD), and T(-786)C and intron 4 a/b endothelial nitric oxide synthase (eNOS) polymorphisms in 419 patients with suspected or known CAD referred for
Timothy R Fennell et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 123, 181-194 (2018-10-15)
4-Methylimidazole (4-MeI) is a widely used chemical, also identified as a by-product of heating foods. In cancer bioassays, 4-MeI induced lung tumors in mice, but not in rats. To establish if metabolic differences could explain species difference in carcinogenicity, this
Neus Roca et al.
Clinical kidney journal, 14(7), 1826-1834 (2021-07-06)
Idiopathic focal segmental glomerulosclerosis (FSGS) has been linked to immunological and inflammatory response dysregulations. The aim of this study was to find endotypes of FSGS patients using a cluster (CL) analysis based on inflammatory and immunological variables, and to analyse
Kun Qian et al.
Public health nutrition, 23(14), 2485-2493 (2020-06-11)
To determine which set of BMI cut-offs is the most appropriate to define child and adolescent obesity in urban China. A cross-sectional study was carried out between 1 November and 31 December in 2017. Community Healthcare Center in Minhang District
Andrew F M Johnstone et al.
Toxicology in vitro : an international journal published in association with BIBRA, 69, 104989-104989 (2020-09-04)
The Hard-Soft Acid and Base hypothesis can be used to predict the potential bio-reactivity (electrophilicity) of a chemical with intracellular proteins, resulting in neurotoxicity. Twelve chemicals predicted to be neurotoxic were evaluated in vitro in rat dorsal root ganglia (DRG)
A Wang et al.
Animal genetics, 39(3), 207-216 (2008-03-29)
The human chromodomain protein, Y-like (CDYL) gene family consists of three members, one on the Y chromosome (CDY) and two on autosomes (CDYL and CDYL2). Studies in the human and mouse showed that genes in the CDYL family are abundantly
A Schürmann et al.
The Journal of biological chemistry, 269(22), 15683-15688 (1994-06-03)
A polymerase chain reaction-based cloning approach was employed in order to identify ADP-ribosylation factors (ARF) in murine 3T3-L1 cells and to study their expression before and after differentiation of cells to the adipocyte-like phenotype. Partial sequences comprising the effector domains
Wei Guo et al.
Blood, 100(1), 89-95 (2002-06-19)
Molecular events involved in specification of early hematopoietic system are not well known. In Xenopus, a paired-box homeodomain family (Mix.1-4) has been implicated in this process. Although Mix-like homeobox genes have been isolated from chicken (CMIX) and mice (Mml/MIXL1), isolation
Erdal Alkan et al.
Urolithiasis, 43(3), 243-248 (2015-01-13)
The objective of the study was to ascertain whether flexible ureteroscopy with holmium laser lithotripsy and/or extraction of stone fragments is as effective in obese patients as in non-obese patients. The patients were divided into four groups (group 1: normal
Hong Xie et al.
Oncotarget, 5(20), 10048-10057 (2014-10-11)
Telomerase activation through the induction of its catalytic component TERT is essential in carcinogenesis. The regulatory mechanism and clinical significance underlying cancer-specific TERT expression have been extensively investigated in various human malignancies, but little is known about these in Merkel
Jean-Sylvain Hermida et al.
The American journal of cardiology, 106(12), 1758-1762 (2010-12-04)
The familial prevalence of Brugada syndrome (BrS) in a consecutive series of patients was prospectively determined. BrS is genetically determined with autosomal dominant transmission. The familial prevalence of the BrS is unknown. A detailed pedigree of each family of patients
D F Barker et al.
American journal of medical genetics, 98(2), 148-160 (2001-02-27)
We have performed effective mutation screening of COL4A5 with a new method of direct, multiplex genomic amplification that employs a single buffer condition and PCR profile. Application of the method to a consecutive series of 46 United States patients with
U Haug et al.
British journal of cancer, 96(9), 1329-1334 (2007-04-05)
Stool testing based on tumour-derived markers might offer a promising approach for non-invasive colorectal cancer (CRC) screening. The aim of this study was to estimate the potential of a new test for faecal tumour M2-PK to discriminate patients with CRC
Ying Liu et al.
Arteriosclerosis, thrombosis, and vascular biology, 32(2), 378-385 (2011-12-14)
Syndecan 4 (Sdc4) modulates signal transduction and regulates activity of protein channels. Sdc4 is essential for the regulation of cellular permeability. We hypothesized that Sdc4 may regulate transient receptor potential canonical 6 (TRPC6) channels, a determinant of glomerular permeability, in
A Djarmati et al.
Acta neurologica Scandinavica, 116(6), 413-419 (2007-11-08)
Rett syndrome is a severe neurodevelopmental X-linked dominant disorder affecting 1/15,000 girls worldwide. Eight years ago, the MECP2 gene was associated with the devastating clinical features observed in Rett syndrome patients. To investigate the spectrum and the frequency of MECP2
Pei-Chien Tsai et al.
Annals of clinical and translational neurology, 8(11), 2121-2131 (2021-10-16)
Mutations in the colony-stimulating factor 1 receptor gene (CSF1R) were identified as a cause of adult-onset inherited leukoencephalopathy. The present study aims at investigating the frequency, clinical characteristics, and functional effects of CSF1R mutations in Taiwanese patients with adult-onset leukoencephalopathy.
C S Morrow et al.
Gene, 75(1), 3-11 (1989-01-30)
The complete human genomic glutathione-S-transferase-pi gene (GST-pi) was isolated from a lambda Charon 4A bacteriophage library which was screened by hybridization to a human GST-pi cDNA. We have sequenced 4261 bp which include the entire GST-pi gene as well as
C Borup et al.
Alimentary pharmacology & therapeutics, 45(11), 1433-1442 (2017-04-06)
Bile acid diarrhoea is underdiagnosed and better diagnostic tests are needed. Fasting serum fibroblast growth factor-19 (FGF19) has insufficient diagnostic value, but this may be improved by stimulation. To explore if an impaired FGF19 response identifies primary bile acid diarrhoea.
R Thuret et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 19(7), 1308-1311 (2008-03-22)
Chemotherapy has emerged as a standard treatment in patients with castration-refractory prostate cancer (CRPC). Consensus criteria are available to define response in CRPC as at least a 50% decline in serum prostate-specific antigen (PSA) confirmed 4 weeks later. The objective
Nicole A Stassen et al.
Surgery, 134(2), 351-356 (2003-08-30)
Interleukin (IL)-18 is a proinflammatory cytokine involved in the regulation of cell-mediated and innate immune responses to infection, trauma, and inflammation. Elevated levels of IL-18 have been noted to correlate with organ dysfunction after injury. This study evaluates the relationship
Jingzhong Ding et al.
American heart journal, 152(6), 1109-1115 (2006-12-13)
The 4G allele in the promoter region of the plasminogen activator inhibitor type 1 (PAI-1) gene is associated with higher plasma PAI-1 levels and activity, but its association with cardiovascular diseases is unclear. We investigated the association of polymorphisms and
Sandeep Ankolekar et al.
Stroke, 44(11), 3120-3128 (2013-09-05)
The practicalities of doing ambulance-based trials where paramedics perform all aspects of a clinical trial involving patients with ultra-acute stroke have not been assessed. We performed a randomized controlled trial with screening, consent, randomization, and treatment performed by paramedics prior
Salama A Salama et al.
Journal of the Society for Gynecologic Investigation, 13(8), 542-550 (2006-11-08)
The current study sought to investigate the effect of the estrogen metabolite 2-methoxyestradiol (2-MeOHE(2)) on apoptosis, cell proliferation, and collagen synthesis in human and rat leiomyoma cells. [(3)H] thymidine and [(3)H] proline incorporation studies were conducted. The expression of vascular
Zhenghao Zhang et al.
American journal of physiology. Heart and circulatory physiology, 297(2), H866-H873 (2009-06-30)
Systemic inflammation induces a multiple organ dysfunction syndrome that contributes to morbidity and mortality in septic patients. Since increasing plasma apolipoprotein A-I (apoA-I) and HDL may reduce the complications of sepsis, we tested the hypothesis that the apoA-I mimetic peptide
Tsuyoshi Kawakami et al.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 46(8), 855-864 (2011-07-01)
The aim of this study was to determine the concentrations of six phthalic acid diesters (PAEs) [di(2-ethylhexyl) phthalate (DEHP), di-n-butyl phthalate (DBP), butyl benzyl phthalate (BBP), diisononyl phthalate (DINP), di-n-octyl phthalate (DNOP), and diisodecyl phthalate (DIDP)], two non-phthalic plasticizers [di(2-ethylhexyl)
Xiaokang Zhuo et al.
Genes, 9(10) (2018-10-17)
NAC transcription factors (TFs) participate in multiple biological processes, including biotic and abiotic stress responses, signal transduction and development. Cold stress can adversely impact plant growth and development, thereby limiting agricultural productivity. Prunus mume, an excellent horticultural crop, is widely
Kohsuke Masutani et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 41(2), 371-379 (2003-01-29)
Cytokines have an important role in the pathogenesis and disease progression of immunoglobulin A (IgA) nephropathy. The aim of this study is to investigate the impact of gene polymorphisms of T helper cell subtype 1 (T(H)1)/T(H)2 cytokines, interferon-gamma (IFN-gamma), and
Sophie Queille et al.
Carcinogenesis, 28(3), 724-731 (2006-10-27)
Immunosuppressed renal transplant recipients (RTRs) are predisposed to non-melanoma skin cancers (NMSCs), predominantly squamous cell carcinomas (SCCs). We have analyzed skin lesions from RTRs with aggressive tumors for p53 gene modifications, the presence of Human Papillomas Virus (HPV) DNA in
Dora P Mitchell et al.
Journal of virology, 83(19), 10187-10197 (2009-07-25)
We have identified a spliced transcript that contains sequences from the HCMV UL29 and UL28 open reading frames. It contains amino-terminal UL29 sequences followed by UL28 sequences, and it includes a poly(A) signal derived from the 3'-untranslated region following the
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