79-94-7

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Glucocorticoid receptor structure and function in an adrenocorticotropin-secreting small cell lung cancer.

D Gaitan et al.

Molecular endocrinology (Baltimore, Md.), 9(9), 1193-1201 (1995-09-01)

ACTH secretion by tumors of nonpituitary origin is characteristically resistant to negative feedback regulation by glucocorticoids. One possible mechanism for the phenomenon could be a structural defect in the intracellular glucocorticoid receptor (GR). We studied the GR in DMS-79 cells

cis-Acting elements and trans-acting proteins in the transcriptional inhibition of gonadotropin-releasing hormone gene by human chorionic gonadotropin in immortalized hypothalamic GT1-7 neurons.

Z Lei et al.

The Journal of biological chemistry, 272(22), 14365-14371 (1997-05-30)

We investigated the cis-acting elements and trans-acting proteins required for the transcriptional inhibition of the gonadotropin-releasing hormone (GnRH) gene by human chorionic gonadotropin (hCG) in GT1-7 neurons. Transient transfection of GT1-7 neurons with the 5'-flanking region of the rat GnRH

Dengue virus infections among Haitian and expatriate non-governmental organization workers--Léogane and Port-au-Prince, Haiti, 2012.

Stephanie J Salyer et al.

PLoS neglected tropical diseases, 8(10), e3269-e3269 (2014-10-31)

In October 2012, the Haitian Ministry of Health and the US CDC were notified of 25 recent dengue cases, confirmed by rapid diagnostic tests (RDTs), among non-governmental organization (NGO) workers. We conducted a serosurvey among NGO workers in Léogane and

Structure and sequence of the human homeobox gene HOX7.

J E Hewitt et al.

Genomics, 11(3), 670-678 (1991-11-01)

A cosmid containing the human sequence HOX7, homologous to the murine Hox-7 gene, was isolated from a genomic library, and the positions of the coding sequences were determined by hybridization. DNA sequence analysis demonstrated two exons that code for a

Triamcinolone acetonide as an adjuvant to membrane peeling surgery: a pilot study.

Anirudh Paspulati et al.

Ophthalmic surgery, lasers & imaging retina, 44(1), 41-45 (2013-02-20)

To evaluate the clinical outcome and complications of intravitreal injections of triamcinolone acetonide as adjuvant to reduce postoperative macular edema in patients undergoing pars plana vitrectomy for epiretinal membranes. This retrospective comparative study included 22 patients (22 eyes) who underwent

Immunohistochemical localization of human kallikreins 6, 10 and 13 in benign and malignant prostatic tissues.

C D Petraki et al.

Prostate cancer and prostatic diseases, 6(3), 223-227 (2003-09-13)

Human kallikreins 6, 10 and 13 (hK6, hK10 and hK13) are expressed by many normal, mainly glandular tissues, including prostatic epithelium. Some kallikreins may function as tumor suppressors or are downregulated during cancer progression. The aim of this study was

Staphylococcus aureus and MRSA Growth and Biofilm Formation after Treatment with Antibiotics and SeNPs.

Kristyna Cihalova et al.

International journal of molecular sciences, 16(10), 24656-24672 (2015-10-27)

Methicillin-resistant Staphylococcus aureus (MRSA) is a dangerous pathogen resistant to β-lactam antibiotics. Due to its resistance, it is difficult to manage the infections caused by this strain. We examined this issue in terms of observation of the growth properties and

Expression of keratinocyte growth factor receptor (KGFR/FGFR2 IIIb) in human uterine cervical cancer.

Gulnar Kurban et al.

Oncology reports, 11(5), 987-991 (2004-04-08)

Keratinocyte growth factor receptor (KGFR), also known as FGFR2 IIIb, is a splice variant of FGFR-2. KGFR is expressed in many types of epithelial cell and is activated with four known ligands [FGF-1, FGF-3, FGF-7 (also known as KGF) and

Impaired Release of Neutrophil Extracellular Traps and Anemia-Associated T Cell Deficiency in Hereditary Hemorrhagic Telangiectasia.

Freya Droege et al.

Journal of clinical medicine, 9(3) (2020-03-18)

Hereditary hemorrhagic telangiectasia (HHT) is characterized by mucocutaneous telangiectases and visceral vascular malformations. Individuals suffering from HHT have a significantly increased risk of bacterial infections, but the mechanisms involved in this are not clear. White blood cell subpopulations were estimated

Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms.

Daisuke Nonaka et al.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 21(2), 192-200 (2007-12-18)

Thyroid-specific transcription factors, Pax8, TTF-1, and TTF-2, are crucial for thyroid organogenesis and differentiation. Compared with TTF-1, the other two markers have scarcely been investigated in surgical pathology. The goal of this study is to evaluate the expressions of these

KOC (K homology domain containing protein overexpressed in cancer): a novel molecular marker that distinguishes between benign and malignant lesions of the pancreas.

Rhonda K Yantiss et al.

The American journal of surgical pathology, 29(2), 188-195 (2005-01-13)

KOC (K homology domain containing protein overexpressed in cancer) is a novel oncofetal RNA-binding protein highly expressed in pancreatic carcinomas. Recently, Corixa Corporation developed a monoclonal antibody specific for KOC that can be used with standard immunohistochemical techniques. The purposes

Expression and intracellular localization of FKHRL1 in mammary gland neoplasms.

Gui-Shan Jin et al.

Acta medica Okayama, 58(4), 197-205 (2004-11-24)

FKHRL1 (FOXO3a), a member of the Forkhead family of genes, has been considered to be involved in the development of breast tumors; however, the in vivo expression and activation status of FKHRL1 in breast tumors still remains unclear. We immunohistochemically

Thyroid transcription factor-1, thyroglobulin, cytokeratin 7, and cytokeratin 20 in thyroid neoplasms.

P A Bejarano et al.

Applied immunohistochemistry & molecular morphology : AIMM, 8(3), 189-194 (2000-09-12)

Thyroid transcription factor-1 (TTF-1), a member of the NKx2 family of homeodomain transcription factors, is a mediator of thyroid-specific transcription of the thyroglobulin (TG) gene. The combined immunohistochemical profile of TTF-1, TG, cytokeratin 7 (CK7), and cytokeratin 20 (CK20) in

Vitamin D receptor is highly expressed in precancerous lesions and esophageal adenocarcinoma with significant sex difference.

Zhongren Zhou et al.

Human pathology, 45(8), 1744-1751 (2014-06-22)

Bile acid reflux into the esophagus is important in the development of esophageal adenocarcinoma (EAC). Recently, vitamin D receptor (VDR) was recognized as a bile acid receptor as well as a vitamin receptor. Expression of VDR is reported to influence

Claudin-18 as a Marker for Identifying the Stomach and Pancreatobiliary Tract as the Primary Sites of Metastatic Adenocarcinoma.

Wan-Ting Li et al.

The American journal of surgical pathology, 44(12), 1643-1648 (2020-09-15)

Identification of the primary site of cancer is essential for the treatment of patients with cancer. Numerous immunohistochemical markers have been developed to determine the differentiation of tumor cells and suggest possible primary sites, but markers of gastric and pancreatic

Clinical characteristics of hospital-onset Pneumocystis pneumonia and genotypes of Pneumocystis jirovecii in a single tertiary centre in Korea.

Tark Kim et al.

BMC infectious diseases, 15, 102-102 (2015-04-18)

Pneumocystis pneumonia (PCP) may develop as a clinical manifestation of nosocomial pneumonia by means of either reactivation of resident P. jirovecii or de novo infection. However, there have been no studies describing the clinical characteristics of hospital-onset PCP. A retrospective

Psoriasis and vitamin A. Plasma transport and skin content of retinol, dehydroretinol and carotenoids in adult patients versus healthy controls.

O Rollman et al.

Archives of dermatological research, 278(1), 17-24 (1985-01-01)

The vitamin-A status of 107 patients with psoriasis and 37 healthy controls was investigated. The mean serum level of retinol-binding protein (RBP) was normal in the 79 patients with chronic plaque psoriasis covering 25% or less of the skin surface.

Mutation-specific IDH1 antibody differentiates oligodendrogliomas and oligoastrocytomas from other brain tumors with oligodendroglioma-like morphology.

David Capper et al.

Acta neuropathologica, 121(2), 241-252 (2010-11-12)

Isocitrate dehydrogenase 1 (IDH1) mutations are frequent in astrocytomas, oligoastrocytomas and oligodendrogliomas. We previously reported the generation of a mutation-specific antibody that specifically detects R132H mutated IDH1 protein (clone H09). Here, we investigate the feasibility of H09 immunohistochemistry to differentiate

Imatinib mesylate for the treatment of steroid-refractory sclerotic-type cutaneous chronic graft-versus-host disease.

Kristin Baird et al.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 21(6), 1083-1090 (2015-03-17)

Sclerotic skin manifestations of chronic graft-versus-host disease (ScGVHD) lead to significant morbidity, including functional disability from joint range of motion (ROM) restriction. No superior second-line therapy has been established for steroid-refractory disease. Imatinib mesylate is a multikinase inhibitor of several

Enzyme assay and clinical assessment in subjects with a Chinese hotspot late-onset Fabry mutation (IVS4 + 919G→A).

Hsiang-Yu Lin et al.

Journal of inherited metabolic disease, 33(5), 619-624 (2010-09-08)

Newborn screening for Fabry disease in Taiwan Chinese has revealed a high incidence of the late-onset GLA mutation IVS4 + 919G→A (∼1 in 1,500-1,600 males). We studied 94 adults with this mutation [22 men, 72 women; mean age: men 57.8 ± 6.0 (range 42-68)

Polymer-Scaffolded Synthesis of Periodic Mesoporous Organosilica Nanomaterials for Delivery Systems in Cancer Cells.

Mohamed F Attia et al.

ACS biomaterials science & engineering, 6(12), 6671-6679 (2020-12-16)

We developed four types of para-phenylene-bridged periodic mesoporous organosilica NPs (p-P PMO NPs) with tailored physical parameters including size, morphology, porosity, and surface area using a new polymer-scaffolding approach. The particles have been formulated to facilitate the codelivery of small-molecule

Response to angiotensin-converting enzyme inhibition is selectively blunted by high sodium in angiotensin-converting enzyme DD genotype: evidence for gene-environment interaction in healthy volunteers.

A Titia Lely et al.

Journal of hypertension, 28(12), 2414-2421 (2010-09-11)

Renin-angiotensin-aldosterone system blockade is a cornerstone in cardiovascular protection. Angiotensin-converting enzyme (ACE)-DD genotype has been associated with resistance to angiotensin-converting enzyme inhibition (ACEi), but data are conflicting. As sodium intake modifies the effect of ACEi as well as the genotype-phenotype

Efficient detection of hereditary nonpolyposis colorectal cancer gene carriers by screening for tumor microsatellite instability before germline genetic testing.

J P Terdiman et al.

Gastroenterology, 120(1), 21-30 (2001-02-24)

The optimal strategy for the detection of hereditary nonpolyposis colorectal cancer (HNPCC) gene carriers remains uncertain. We evaluated whether microsatellite instability (MSI) analysis or MSH2 and MLH1 protein immunostaining of tumors will screen individuals efficiently for germline MSH2 and MLH1

Detailed characterisation of circulatory nitric oxide and free radical indices--is there evidence for abnormal cardiovascular homeostasis in young women with polycystic ovary syndrome?

G R Willis et al.

BJOG : an international journal of obstetrics and gynaecology, 121(13), 1596-1603 (2014-05-13)

To assess circulating biochemical indices of endothelial function and nitro-oxidative stress in women with polycystic ovary syndrome (PCOS). Case-control study. Seventeen women with PCOS and eighteen age- and body mass index-matched healthy volunteers. Nitric oxide (NO) metabolite levels were assessed

Detection of cancer cells in effusions from patients diagnosed with gynaecological malignancies. Evaluation of five epithelial markers.

B Davidson et al.

Virchows Archiv : an international journal of pathology, 435(1), 43-49 (1999-08-04)

The detection of malignant cells in pleural, peritoneal, and pericardial fluids of cancer patients marks the presence of metastatic disease and is associated with a grave prognosis. We evaluated five epithelial markers for the detection of cancer cells in 94

Biology and grading of pleomorphic xanthoastrocytoma-what have we learned about it?

Rachael Vaubel et al.

Brain pathology (Zurich, Switzerland), 31(1), 20-32 (2020-07-04)

Pleomorphic xanthoastrocytoma (PXA) is a rare astrocytoma predominantly affecting children and young adults. We performed comprehensive genomic characterization on a cohort of 67 patients with histologically defined PXA (n = 53, 79%) or anaplastic PXA (A-PXA, n = 14, 21%), including copy number analysis

Tetrabromobisphenol A (TBBPA) Alters ABC Transport at the Blood-Brain Barrier.

Ronald E Cannon et al.

Toxicological sciences : an official journal of the Society of Toxicology, 169(2), 475-484 (2019-03-05)

Tetrabromobisphenol A (TBBPA, CAS No. 79-94-7) is a brominated flame retardant used in 90% of epoxy coated circuit boards. Exposures to TBBPA can induce neurotoxicity and disrupt MAPK, estrogen, thyroid, and PPAR-associated signaling pathways. Because these pathways also regulate transporters

Factor XIII and tranexamic acid but not recombinant factor VIIa attenuate tissue plasminogen activator-induced hyperfibrinolysis in human whole blood.

Daniel Dirkmann et al.

Anesthesia and analgesia, 114(6), 1182-1188 (2011-11-23)

Hyperfibrinolysis is a pathological state that often results in depletion of coagulation factors and platelets and can contribute to bleeding. Factor XIII (FXIII) and thrombin activatable fibrinolysis inhibitor have key roles in protecting clots against fibrinolysis. We tested the hypotheses

Analysis of the structure of ribonuclease A in native and partially denatured states by time-resolved noradiative dynamic excitation energy transfer between site-specific extrinsic probes.

D R Buckler et al.

Biochemistry, 34(49), 15965-15978 (1995-12-12)

Formation of local structure and overall chain dimensions in the 124-residue, four-disulfide protein bovine pancreatic ribonuclease A (RNase A) under conditions favoring either the native or partially folded states have been studied by nonradiative excitation energy transfer measurements. Three RNase

Duration of time that beef cattle are fed a high-grain diet affects the recovery from a bout of ruminal acidosis: short-chain fatty acid and lactate absorption, saliva production, and blood metabolites.

T Schwaiger et al.

Journal of animal science, 91(12), 5743-5753 (2013-10-26)

This study was conducted to determine if the duration of time that beef cattle are fed a high-grain diet affects short-chain fatty acid (SCFA) absorption, saliva production, and blood metabolites before, during, and following an induced bout of ruminal acidosis.

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