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R K Gill et al.
Oncogene, 30(35), 3784-3791 (2011-05-03)
LKB1/STK11 is a tumor suppressor and a negative regulator of mammalian target of rapamycin signaling. It is inactivated in 30% of lung cancer cell lines but only 5-15% of primary lung adenocarcinomas. There is evidence that homozygous deletion (HD) of
Gunnar Juliusson et al.
Leukemia & lymphoma, 52 Suppl 2, 46-49 (2011-05-27)
Hairy cell leukemia is often reported as a disease of young males. The male predominance is strong, 4:1, but the median age in the Swedish national compulsory cancer registry is similar to that of follicular lymphoma, i.e. 62 years. The
Nattapat Suchatanugal et al.
Journal of separation science, 44(2), 666-675 (2020-11-17)
In this study, thin-layer chromatography was applied for selective extraction of volatile compounds in perfume prior to analysis with solid phase microextraction and gas chromatography-mass spectrometry. The standard compounds were desorbed from the thin-layer chromatography plate and extracted at 80°C
Elif Sare Koytak et al.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 19(4), 245-249 (2009-01-03)
Several lines of evidence suggest that peroxisome proliferator-activated receptor alpha may be involved in hepatocarcinogenesis. L162V polymorphism of the peroxisome proliferator-activated receptor alpha gene enhances the transactivation activity of this transcription factor. The aim of this study was to determine
Cuihong Jia et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 42(10), 1961-1974 (2022-06-16)
We found that blood vitronectin (VTN) leaks into the brain and exacerbates tissue loss after stroke by increasing pro-inflammatory IL-6 expression in female, but not male, mice. VTN signals through integrins and downstream focal adhesion kinase (FAK). Here, a two
Fakhrozaman Pezeshkpoor et al.
Journal of drugs in dermatology : JDD, 11(11), e66-e69 (2012-11-09)
Common warts caused by the human papillomavirus (HPV) are considered to be the most common infectious skin disease. No individual treatment for common warts is effective as monotherapy in eradicating the lesions. The aim of this study is to evaluate
Anna Melissa Schlitter et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 28(9), 1249-1264 (2015-06-27)
Intraductal tubulopapillary neoplasm is a well-established entity in the pancreas. A similar, if not identical, tumor occurs also in the biliary tract. We conducted a multicenter study of 20 such lesions, focusing on their clinicopathologic characteristics and molecular profile. Biliary
E Sehayek et al.
Journal of lipid research, 42(8), 1250-1256 (2001-08-03)
We examined the effect of hyodeoxycholic acid (HDCA) on plasma cholesterol levels and atherosclerosis in mice. In wild-type C57BL/6 mice, feeding increasing amounts of HDCA resulted in i) progressive decrease in dietary cholesterol absorption, ii) increased concentrations of HDCA in
Amanda A Braun et al.
Neurobiology of learning and memory, 118, 55-63 (2014-12-03)
Both egocentric route-based learning and spatial learning, as assessed by the Cincinnati water maze (CWM) and Morris water maze (MWM), respectively, are impaired following an 80% dopamine (DA) loss in the neostriatum after 6-hydroxydopamine (6-OHDA) administration in rats. The dorsolateral
Timothy R Fennell et al.
Xenobiotica; the fate of foreign compounds in biological systems, 48(11), 1142-1156 (2017-11-08)
1. 2-Ethylhexyl-p-methoxycinnamate (EHMC) is commonly used as an ingredient in sunscreens, resulting in potential oral and dermal exposure in humans. 2. Clearance and metabolism of EHMC in hepatocytes and disposition and metabolism of EHMC in rodents following oral (8-800 mg/kg) intravenous
M L Kruzel et al.
Clinical and experimental immunology, 130(1), 25-31 (2002-09-26)
Mice injected with endotoxin develop endotoxaemia and endotoxin-induced death, accompanied by the oxidative burst and overproduction of inflammatory mediators. Lactoferrin, an iron binding protein, provides a natural feedback mechanism to control the development of such metabolic imbalance and protects against
Measurable Cytokine Concentrations in Pig Seminal Plasma Are Modified by Semen Handling and Storage.
Lorena Padilla et al.
Biology, 9(9) (2020-09-11)
Sample handling and storing are critical steps for the reliable measurement of circulating biomolecules in biological fluids. This study evaluates how cytokine measurements in pig seminal plasma (SP) vary depending on semen handling and SP storage. Thirteen cytokines (GM-CSF, IFNγ
Ying Liu et al.
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 33(6), 427-431 (2010-10-29)
To investigate the expression and role of O(6)-methylguanine DNA methyltransferase (MGMT) and p53 in non-small cell lung cancer (NSCLC) and the association with prognosis. Immunohistochemical method was used to investigate the expression of MGMT and p53 in NSCLC specimens from
Mary E Cooley et al.
Journal of pain and symptom management, 49(1), 13-26 (2014-06-01)
Distressing symptoms interfere with the quality of life in patients with lung cancer. Algorithm-based clinical decision support (CDS) to improve evidence-based management of isolated symptoms seems promising, but no reports yet address multiple symptoms. This study examined the feasibility of
Ziyan Hu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(32), 3937-3942 (2011-11-29)
A rapid and sensitive method based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the simultaneous determination of codeine, ephedrine, guaiphenesin and chlorpheniramine in beagle dog plasma has been developed and validated. Following liquid-liquid extraction, the analytes were separated on a
E E Hermel et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 34(9), 1191-1195 (2001-08-22)
Neonatal handling has long-lasting effects on behavior and stress reactivity. The purpose of the present study was to investigate the effect of neonatal handling on the number of dopaminergic neurons in the hypothalamic nuclei of adult male rats as part
Miho Suzuki et al.
Clinical and experimental rheumatology, 35(6), 893-898 (2017-04-20)
Obese rheumatoid arthritis patients often have higher disease activity and a poorer response to treatment than do non-obese patients. The present study aims to clarify the influence of obesity on the action of IL-6 and to evaluate the efficacy of
B Uehleke et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 19(8-9), 665-671 (2012-04-06)
Silexan, a novel lavender oil preparation for oral use, has been authorized in Germany for the treatment of states of restlessness during anxious mood. An open-label, exploratory trial was performed to assess the potential of the medicinal product in the
R A Popp et al.
Biochemical genetics, 20(1-2), 199-208 (1982-02-01)
The primary structures of the alpha globins from CE/J, DBA/2J, and a stock of Potter's mice were determined to identify the amino acid substitutions associated with the unique isoelectric focusing patterns of these hemoglobins. In addition, the primary structures of
Sarina A Piha-Paul et al.
Oncotarget, 5(7), 1846-1855 (2014-04-20)
Bevacizumab and temsirolimus are active agents in gynecologic tumors. Temsirolimus attenuates upregulation of HIF-1α levels, a resistance mechanism for antiangiogenics, and targets the PI3-kinase/AKT/mTOR axis, commonly aberrant in these tumors. We analyzed safety and responses in 41 patients with gynecologic
Lacey Johnson et al.
Transfusion, 53(10), 2268-2277 (2013-01-26)
Platelet (PLT) concentrates frozen in dimethyl sulfoxide (DMSO) can be stored for extended periods at -80°C. PLTs are frozen in a hyperconcentrated state to avoid postthaw washing and minimize residual DMSO. Consequently, PLTs require reconstitution upon thawing. Although plasma, saline
K S Barron et al.
Arthritis and rheumatism, 38(5), 684-689 (1995-05-01)
Although HLA-B27 is strongly associated with susceptibility to Reiter's syndrome (RS), recent data suggest that an additional modifying or susceptibility gene(s) acts in concert with HLA-B27 to contribute to disease pathogenesis. The recently described TAP genes (transporters associated with antigen
Mark A Hearris et al.
Journal of applied physiology (Bethesda, Md. : 1985), 126(6), 1587-1597 (2019-05-03)
We examined the effects of graded muscle glycogen on exercise capacity and modulation of skeletal muscle signaling pathways associated with the regulation of mitochondrial biogenesis. In a repeated-measures design, eight men completed a sleep-low, train-low model comprising an evening glycogen-depleting
Thomas J Neuhaus et al.
European journal of pediatrics, 167(9), 1037-1047 (2007-12-13)
The hypothesis was tested that oral antibiotic treatment in children with acute pyelonephritis and scintigraphy-documented lesions is equally as efficacious as sequential intravenous/oral therapy with respect to the incidence of renal scarring. A randomised multi-centre trial was conducted in 365
Amalia Lamana et al.
PloS one, 10(11), e0142683-e0142683 (2015-11-17)
The T allele of rs7574865 in STAT4 confers risk of developing autoimmune disorders. However, its functional significance remains unclear. Here we analyze how rs7574865 affects the transcription of STAT4 and its protein expression. We studied 201 patients (80% female; median
M Y M Ng et al.
Journal of medical genetics, 42(3), 235-239 (2005-03-04)
The FOXC2 gene on 16q24 is mutated in lymphoedema distichiasis (LD), in which varicose veins (VV) are a common feature. We hypothesised that this gene might be implicated in the development of VV in the normal population, therefore, after performing
Spyridon Katsanos et al.
Orthopedics, 40(3), e417-e424 (2017-01-12)
This prospective study included 152 elderly patients (mean age, 80 years; range, 72-88 years) with a hip fracture treated surgically. Comorbidities were evaluated, and B-type natriuretic peptide was measured at baseline and at postoperative days 4 and 5 in addition
D H Swenson et al.
Chemical research in toxicology, 6(4), 480-485 (1993-07-01)
Methods for direct synthesis of N-(purin-8-yl)arylamines were investigated. N-(Purin-8-yl)arylamines are adducts from reaction of electrophilic metabolites of arylamines with DNA and have not been readily available by direct synthesis. Ability to generate significant quantities of this class of DNA adduct
Piotr Jankowski et al.
Cardiology journal, 27(5), 533-540 (2020-05-22)
The highest priority in preventive cardiology is given to patients with established coronary artery disease (CAD). The aim of the study was to assess the current implementation of the guidelines for secondary prevention in everyday clinical practice by evaluating control
S L Pulley et al.
Journal of dairy science, 98(9), 6188-6201 (2015-07-06)
The objective was to determine the incidence of LH surges and ovulatory responses in lactating dairy cows enrolled in a timed artificial insemination (TAI) program. Cows were assigned randomly to 2 presynchronization treatments: (1) Pre10 (n=37): 2 injections of PGF2α
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