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Gianni Bramante et al.
Biochemical and biophysical research communications, 404(4), 1083-1087 (2011-01-05)
The gastrointestinal hormone gastrin is generated from an 80 amino acid precursor (progastrin) by cleavage after dibasic residues by prohormone convertase 1. Phosphorylation of Ser(75) has previously been suggested, on the basis of indirect evidence, to inhibit cleavage of progastrin
Sarbjit S Saini et al.
The Journal of investigative dermatology, 135(1), 67-75 (2014-07-22)
ASTERIA I was a 40-week, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of subcutaneous omalizumab as add-on therapy for 24 weeks in patients with chronic idiopathic urticaria/spontaneous urticaria (CIU/CSU) who remained symptomatic despite H1 antihistamine treatment at
Chang-Su Park et al.
Applied microbiology and biotechnology, 92(6), 1187-1196 (2011-06-22)
A putative N-acyl-D-glucosamine 2-epimerase from Caldicellulosiruptor saccharolyticus was cloned and expressed in Escherichia coli. The recombinant enzyme was identified as a cellobiose 2-epimerase by the analysis of the activity for substrates, acid-hydrolyzed products, and amino acid sequence. The cellobiose 2-epimerase
Niwat Chawachart et al.
Extremophiles : life under extreme conditions, 18(6), 1023-1034 (2014-07-31)
GH10 xylanase from Thermoascus aurantiacus strain SL16W (TasXyn10A) showed high stability and activity up to 70-75 °C. The enzyme's half-lives were 101 h, 65 h, 63 min and 6 min at 60, 70, 75 and 80 °C, respectively. The melting
Mine G Gulluoglu et al.
Pathology, 40(1), 35-41 (2007-11-27)
Histological subtyping of periampullary carcinomas is considered as a criterion for prognosis and therapeutic implications of these tumours. We assessed the immunoexpression rates of HepPar-1, CDX2 and MUC2 antibodies in different subtypes of periampullary adenocarcinomas (PAC), intestinal and pancreatobiliary, in
O Petrenko et al.
Gene, 160(2), 305-306 (1995-07-28)
A cDNA encoding a novel chicken chemokine homologous to mammalian chemokine macrophage inflammatory protein 1 beta (MIP-1 beta) was isolated and characterised. The cDNA encodes a protein which is 75-80% homologous to human and mouse MIP-1 beta. All conserved amino
Ljilja Torović
Food additives & contaminants. Part B, Surveillance, 8(4), 235-244 (2015-07-01)
Aflatoxin M1 (AFM1) occurrence was analysed in 80 samples of milk and 21 samples of infant formulae on the Serbian market, using high-performance liquid chromatography with fluorescence detection. All milk samples collected in 2013 showed AFM1 contamination in the range
Yuanyuan Han et al.
Macromolecular bioscience, 12(10), 1436-1442 (2012-09-12)
Annealing of PDADMAC/PSS multilayer microcapsules assembled on PSS-doped CaCO(3) particles at 80 °C for 30 min reduces their size dramatically from 6.9 ± 0.3 to 3.1 ± 0.5 µm. Methylene blue molecules are encapsulated by spontaneous deposition and post-annealing with
Pieter-Jan De Kam et al.
Platelets, 25(7), 480-487 (2013-11-12)
Laropiprant is an antagonist of the prostaglandin PGD2 receptor DP1. Laropiprant has a weak affinity for the thromboxane A2 receptor TP. Two double-blinded, randomized, placebo-controlled, crossover studies evaluated the effects of multiple-dose laropiprant at steady state on the antiplatelet effects
Samantha Y A Terry et al.
European journal of nuclear medicine and molecular imaging, 42(9), 1430-1438 (2015-05-28)
Here, the expression of F4/80 on the cell surface of murine macrophages was exploited to develop a novel imaging tracer that could visualize macrophages in vivo. The immunoreactive fraction and IC50 of anti-F4/80-A3-1, conjugated with diethylenetriaminepentaacetic acid (DTPA) and radiolabelled
Syed A Sattar et al.
PloS one, 6(2), e17340-e17340 (2011-03-11)
Human noroviruses (HuNoV), a major cause of acute gastroenteritis worldwide, cannot be readily cultured in the lab. Therefore, a feline calicivirus (FCV) is often used as its surrogate to, among other things, test alcohol-based handrubs (ABHR). The more recent laboratory
Akihiro Michihara et al.
Biological & pharmaceutical bulletin, 33(9), 1471-1476 (2010-09-09)
In the present study, we investigated the dose-dependent effect of delta-tocotrienol long term (48, 72 h) on the melanin content of cells treated with delta-tocotrienol, and whether cells treated with delta-tocotrienol for long a time show cytotoxicity. We also examined
Mario Dell'Agli et al.
Journal of natural products, 71(9), 1513-1517 (2008-09-10)
Plant extracts traditionally used for male impotence (Tribulus terrestris, Ferula hermonis, Epimedium brevicornum, Cinnamomum cassia), and the individual compounds cinnamaldehyde, ferutinin, and icariin, were screened against phosphodiesterase-5A1 (PDE5A1) activity. Human recombinant PDE5A1 was used as the enzyme source. Only E.
A E Ahmed et al.
Journal of biochemical toxicology, 6(2), 115-121 (1991-01-01)
The haloacetonitrile, dibromoacetonitrile (DBAN), is a direct-acting genotoxic agent that has been detected in drinking water. In a time course study, male Sprague-Dawley rats were treated with DBAN (75 mg/kg PO), and killed at 0.5, 1, 2, and 4 hr
N Erdil et al.
European review for medical and pharmacological sciences, 20(1), 180-187 (2016-01-28)
To investigate the effects of N-acetylcysteine (NAC) on pulmonary function tests and arterial blood gases in patients undergoing on-pump coronary artery surgery. The effect of NAC was assessed within the scope of a prospective, single center, double-blind, placebo-controlled, parallel group
Michal Fornalczyk et al.
Organic & biomolecular chemistry, 10(16), 3332-3342 (2012-03-17)
Two approaches have been developed for the enantioselective Reformatsky reaction of ethyl iododifluoroacetate with ketones to form a quaternary carbon centre using (1R,2S)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol as the chiral ligand. Good yields and high enantioselectivities (80-91% ee) were achieved with a range of
Freddy R Escobar-Ledesma et al.
Molecules (Basel, Switzerland), 25(21) (2020-11-04)
Inulin is a polysaccharide of fructose widely used in the food and pharmaceutical industry due to its physicochemical properties and technological applications. Inulin from jicama (Smallanthus sonchifolius) and cabuya (Agave americana) was obtained. The steps for inulin obtention were: raw
Ho-Jun Jang et al.
Drugs & aging, 34(6), 467-477 (2017-05-01)
Compared with dual antiplatelet therapy including aspirin and clopidogrel, triple antiplatelet therapy including cilostazol has a mortality benefit in patients with ST-segment elevation myocardial infarction. However, whether the mortality benefit persists in elderly patients is not clear. From 2007 to
J D Edwards
Critical care medicine, 19(5), 658-663 (1991-05-01)
To review clinical studies of oxygen transport in cardiogenic and septic shock. Descriptive and prospective studies. University hospital multi disciplinary ICU. Critically ill cardiogenic and septic shock patients greater than 18 and less than 80 yrs of age. The responses
Qiu-Ping Wu et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 33(4), 363-365 (2008-06-07)
To establish a method for determining the content of primary chemical constituents in the leaves of Cassia angustifolia. The HPLC with Diamonsil C18 (4.6 mm x 250 mm, 5 microm) column was used , acetonitrile-1% acetic acid (10:90-15: 85-18: 82-20:
F R Bakunzi
Journal of the South African Veterinary Association, 79(1), 54-55 (2008-08-06)
A survey was conducted on the occurrence of anthelmintic resistance of nematodes in communally grazed sheep in a semi-arid area near Mafikeng, South Africa, from January to March 2006. In the herds belonging to twelve smallholder sheep farmers, the efficacies
Yun Zhang et al.
Food chemistry, 241, 397-402 (2017-09-30)
The objective of this work was to study solid/oil/water (S/O/W) emulsions as delivery systems with retained lactase in milk and controlled release during in vitro digestion. Spray-dried lactase powder was suspended in anhydrous milk fat/Span® 80 emulsified by sodium caseinate
Lixin Xia et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 844(2), 213-216 (2006-09-02)
A 67-kDa hemagglutinin composed of two identical subunits was purified from Phaseolus vulgaris cv. 'Dark Red Kidney Bean'. It was unadsorbed on DEAE-cellulose but adsorbed on Affi-gel blue gel. The hemagglutinin was highly purified after the two aforementioned chromatographic steps
Lang-Song Hao et al.
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 40(1), 44-47 (2009-03-19)
To investigate the expression of glucose transporter 1 (Glut1) in human breast cancer and its relationship to proliferating cell nuclear antigen (PCNA) protein, other tumor biomarkers and clinical pathologic factors. Imunohistochemical staining (SP) was applied to measure the expression of
Koichi Mitsukura et al.
Biotechnology letters, 27(17), 1305-1310 (2005-10-11)
Mucor circinelloides and Mortierella isabellina hydroxylated dehydroabietic acid (DehA). DehA was converted regio- and stereo-selectively by whole cells of Mr. circinelloides to give 2alpha-hydroxydehydroabietic acid in a 75% molar conversion yield (11 mM from 14.7 mM DehA) after 72 h
C L Vishwanathan et al.
Indian journal of pharmaceutical sciences, 70(2), 245-249 (2008-03-01)
Four N-(benzenesulfonyl)-L-glutamic acid bis(p-substituted phenylhydrazides) were synthesized and evaluated for anticancer activity in vitro in DU-145 and PC-3 prostate cancer and in COLO-205 colon cancer cell lines by MTT assay. The analog with the nitro group substitution exhibited potent activity
Reinhard B Raggam et al.
Mycoses, 58(7), 394-398 (2015-05-12)
Serum 1,3-beta-d-glucan (BDG) testing is an established diagnostic marker for invasive fungal infections (IFI) among patients with haematological malignancies. In contrast limited data exist regarding the application of urine BDG testing. Same-day midstream urine and serum screening samples were collected
V Kuokkanen et al.
Water research, 79, 79-87 (2015-05-15)
Electrocoagulation (EC) treatment of 100 mg/L synthetic wastewater (SWW) containing humic acids was optimized (achieving 90% CODMn and 80% DOC removal efficiencies), after which real peat bog drainage waters (PBDWs) from three northern Finnish peat bogs were also treated. High pollutant
Hiroshi Kanazawa et al.
Chest, 125(4), 1368-1371 (2004-04-14)
The interaction between chronic hepatitis C virus (HCV) infection and bronchial asthma is of considerable interest. This study was designed to examine whether differences in airway responses to an inhaled anticholinergic agent exist between asthmatic patients with and without active
Donna M Dambach et al.
Hepatology (Baltimore, Md.), 35(5), 1093-1103 (2002-05-01)
The biological effects of monocyte chemoattractant protein (MCP) 1 are mediated by binding to C-C chemokine receptor (CCR) 2. In the present studies, we used CCR2 knockout (CCR2-/-) mice to examine the role of MCP-1 in acetaminophen-induced macrophage accumulation in
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