800811O

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Comprehensive and Reproducible Untargeted Lipidomic Workflow Using LC-QTOF Validated for Human Plasma Analysis.

Anik Forest et al.

Journal of proteome research, 17(11), 3657-3670 (2018-09-27)

The goal of this work was to develop a label-free, comprehensive, and reproducible high-resolution liquid chromatography-mass spectrometry (LC-MS)-based untargeted lipidomic workflow using a single instrument, which could be applied to biomarker discovery in both basic and clinical studies. For this

Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols.

B R Ganong et al.

Proceedings of the National Academy of Sciences of the United States of America, 83(5), 1184-1188 (1986-03-01)

The specificity of protein kinase C activation by sn-1,2-diacylglycerols and analogues was investigated by using a Triton X-100 mixed micellar assay [Hannun, Y. A., Loomis, C. R. & Bell, R. M. (1985) J. Biol. Chem. 260, 10039-10043]. Analogues containing acyl

Specificity and Mechanism of Protein Kinase C Activation by sn-1,2-diacylglycerols.

Ganong BR, et al.

Proceedings of the National Academy of Sciences of the USA, 83, 1184-1188 (1986)

Mechanism of activation of plant monogalactosyldiacylglycerol synthase 1 (MGD1) by phosphatidylglycerol.

Milène Nitenberg et al.

Glycobiology, 30(6), 396-406 (2020-02-27)

Mono- and digalactosyldiacylglycerol are essential galactolipids for the biogenesis of plastids and functioning of the photosynthetic machinery. In Arabidopsis, the first step of galactolipid synthesis is catalyzed by monogalactosyldiacylglycerol synthase 1 (MGD1), a monotopic protein located in the inner envelope

Identification of Inhibitors of triacylglyceride accumulation in muscle cells: comparing HTS results from 1536-well plate-based and high-content platforms.

Eliot Sugarman et al.

Journal of biomolecular screening, 19(1), 77-87 (2013-08-31)

Excess caloric consumption leads to triacylglyceride (TAG) accumulation in tissues that do not typically store fat, such as skeletal muscle. This ectopic accumulation alters cells, contributing to the pathogenesis of metabolic syndrome, a major health problem worldwide. We developed a

Conical lipids in flat bilayers induce packing defects similar to that induced by positive curvature.

Lydie Vamparys et al.

Biophysical journal, 104(3), 585-593 (2013-02-28)

In biological membranes, changes in lipid composition or mechanical deformations produce defects in the geometrical arrangement of lipids, thus allowing the adsorption of certain peripheral proteins. Here, we perform molecular dynamics simulations on bilayers containing a cylindrical lipid (PC) and

Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets.

E G Lapetina et al.

The Journal of biological chemistry, 260(3), 1358-1361 (1985-02-10)

The ability of exogenous sn-1,2-diacylglycerols and analogs to function as bioregulators of protein kinase C in human platelets was investigated. The activation of protein kinase C in platelets is indicated by specific phosphorylation of a 40,000-dalton protein. Dihexanoylglycerol, dioctanoylglycerol (diC8)

Identification of Inhibitors of triacylglyceride accumulation in muscle cells: comparing HTS results from 1536-well plate-based and high-content platforms

Sugarman E, et al.

Journal of Biomolecular Screening, 19(1), 77- 87 (2014)

Conical Lipids in Flat Bilayers Induce Packing Defects Similar to that Induced by Positive Curvature

Vamparys, L

Biophysical Journal, 104, 585-593 (2013)

Probing the global cellular responses to lipotoxicity caused by saturated fatty acids

Piccolis M, et al.

Molecular Cell, 9, 347-347 (2019)

sn-1,2-Dioctanoylglycerol. A cell-permeable diacylglycerol that mimics phorbol diester action on the epidermal growth factor receptor and mitogenesis.

R J Davis et al.

The Journal of biological chemistry, 260(3), 1562-1566 (1985-02-10)

The cell-permeable diacylglycerol, sn-1,2-dioctanoylglycerol (DiC8), is shown to mimic the effect of tumor promoting phorbol diesters on epidermal growth factor (EGF) binding and action in intact cells. DiC8 inhibited the binding of [3H]phorbol dibutyrate to A431 cell monolayers indicating that

Quantification of Signaling Lipids by Nano-Electrospray Ionization Tandem Mass Spectrometry (Nano-ESI MS/MS).

Mathias Haag et al.

Metabolites, 2(1), 57-76 (2012-01-01)

Lipids, such as phosphoinositides (PIPs) and diacylglycerol (DAG), are important signaling intermediates involved in cellular processes such as T cell receptor (TCR)-mediated signal transduction. Here we report identification and quantification of PIP, PIP2 and DAG from crude lipid extracts. Capitalizing

Diacylglycerols mimic phorbol diester induction of leukemic cell differentiation.

J G Ebeling et al.

Proceedings of the National Academy of Sciences of the United States of America, 82(3), 815-819 (1985-02-01)

Activation of cellular protein kinase C appears to be involved in the mechanism by which phorbol diesters induce differentiation of human myeloid leukemia cells (HL-60). Protein kinase C is thought to be physiologically activated by diacylglycerol derived from receptor-mediated phosphatidylinositol

Control of plasma membrane lipid homeostasis by the extended synaptotagmins.

Yasunori Saheki et al.

Nature cell biology, 18(5), 504-515 (2016-04-12)

Acute metabolic changes in plasma membrane (PM) lipids, such as those mediating signalling reactions, are rapidly compensated by homeostatic responses whose molecular basis is poorly understood. Here we show that the extended synaptotagmins (E-Syts), endoplasmic reticulum (ER) proteins that function

Liposome-based carrier systems and devices used for pulmonary drug delivery

Biomaterials and Medical Tribology, 19(1), 395- 443 (2013)

Activation of ROP6 GTPase by phosphatidylglycerol in Arabidopsis

Han X, et al.

Frontiers in Plant Science, 9, 347-347 (2018)

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