80100

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Rapid screening and identification of multi-class substances of very high concern in textiles using liquid chromatography-hybrid linear ion trap orbitrap mass spectrometry.

Li Zhang et al.

Journal of chromatography. A, 1386, 22-30 (2015-02-24)

A new analytical method was established and validated for the analysis of 19 substances of very high concern (SVHCs) in textiles, including phthalic acid esters (PAEs), organotins (OTs), perfluorochemicals (PFCs) and flame retardants (FRs). After ultrasonic extraction in methanol, the

A dose response study to assess effects after dietary administration of diisononyl phthalate (DINP) in gestation and lactation on male rat sexual development.

Rebecca A Clewell et al.

Reproductive toxicology (Elmsford, N.Y.), 35, 70-80 (2012-09-05)

Male rat sexual development was evaluated after dietary administration of 0, 760, 3800, 11,400 ppm diisononyl phthalate (DiNP) and 7600 ppm dibutyl phthalate (DBP) from gestation day (GD) 12 to postnatal day (PND) 14. Maternal weight was reduced on GD

Di-n-butyl phthalate disrupts the expression of genes involved in cell cycle and apoptotic pathways in mouse ovarian antral follicles.

Zelieann R Craig et al.

Biology of reproduction, 88(1), 23-23 (2012-12-18)

Di-n-butyl phthalate (DBP) is present in many consumer products, such as infant, beauty, and medical products. Several studies have shown that DBP causes reproductive toxicity in rodents, but no studies have evaluated its effects on ovarian follicles. Therefore, we used

Exuberant sprouting of sensory and sympathetic nerve fibers in nonhealed bone fractures and the generation and maintenance of chronic skeletal pain.

Stephane R Chartier et al.

Pain, 155(11), 2323-2336 (2014-09-10)

Skeletal injury is a leading cause of chronic pain and long-term disability worldwide. While most acute skeletal pain can be effectively managed with nonsteroidal anti-inflammatory drugs and opiates, chronic skeletal pain is more difficult to control using these same therapy

Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring.

Richard Ivell et al.

Asian journal of andrology, 15(2), 261-268 (2013-01-15)

Maternal exposure to estrogenic xenobiotics or phthalates has been implicated in the distortion of early male reproductive development, referred to in humans as the testicular dysgenesis syndrome. It is not known, however, whether such early gestational and/or lactational exposure can

Urine phthalate concentrations are higher in people with stroke: United States National Health and Nutrition Examination Surveys (NHANES), 2001-2004.

I Shiue

European journal of neurology, 20(4), 728-731 (2012-09-13)

Associations between plastic-associated chemicals, such as bisphenol A, and cardiovascular disease have begun to emerge in the current century. However, the relationship between urine phthalates and risk of stroke is unclear. It was aimed to study the relationship between urine

Association between PGC-1alpha gene polymorphisms and type 2 diabetes risk: a case-control study of an Iranian population.

Shabnam Shokouhi et al.

Canadian journal of diabetes, 39(1), 65-72 (2014-10-06)

The peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) gene could play a role in the onset of type 2 diabetes mellitus. The aim of this study was to explore the possible associations among polymorphisms Gly482Ser, Thr394Thr and Thr528Thr of the PGC-1alpha

Migration of myeloid cells during inflammation is differentially regulated by the cell surface receptors Slamf1 and Slamf8.

Guoxing Wang et al.

PloS one, 10(3), e0121968-e0121968 (2015-03-24)

Previous studies have demonstrated that the cell surface receptor Slamf1 (CD150) is requisite for optimal NADPH-oxidase (Nox2) dependent reactive oxygen species (ROS) production by phagocytes in response to Gram- bacteria. By contrast, Slamf8 (CD353) is a negative regulator of ROS

Identification of transcription factors and coactivators affected by dibutylphthalate interactions in fetal rat testes.

Simon M Plummer et al.

Toxicological sciences : an official journal of the Society of Toxicology, 132(2), 443-457 (2013-01-30)

Previous analysis of in utero dibutylphthalate (DBP)-exposed fetal rat testes indicated that DBP's antiandrogenic effects were mediated, in part, by indirect inhibition of steroidogenic factor 1 (SF1), suggesting that peroxisome proliferator-activated receptor alpha (PPARα) might be involved through coactivator (CREB-binding

An approach for integrating toxicogenomic data in risk assessment: the dibutyl phthalate case study.

Susan Y Euling et al.

Toxicology and applied pharmacology, 271(3), 324-335 (2013-03-30)

An approach for evaluating and integrating genomic data in chemical risk assessment was developed based on the lessons learned from performing a case study for the chemical dibutyl phthalate. A case study prototype approach was first developed in accordance with

Genetic contribution to the variance of blood pressure and heart rate: a systematic review and meta-regression of twin studies.

Biqi Wang et al.

Twin research and human genetics : the official journal of the International Society for Twin Studies, 18(2), 158-170 (2015-03-07)

The genetic contribution of blood pressure and heart rate (HR) varied widely between studies. Demographic factors such as ethnicity, age and/or sex might explain some of the heterogeneity. We performed a systematic review focusing on four phenotypes: systolic blood pressure

[Study on chemical constituents of the ethyl acetate extract from Blumea aromatica].

Ming-sheng Lan et al.

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(2), 229-231 (2012-07-25)

To study the chemical constituents of the ethyl acetate extract from Blumea aromatica. Column chromatographic techniques were used for the isolation and purification. Spectroscopic techniques were used for the identification of structures. Seven compounds were isolated from the ethyl acetate

Ovarian development in Wistar rat treated prenatally with single dose diisobutyl phthalate.

B Ray et al.

Bratislavske lekarske listy, 113(10), 577-582 (2012-10-26)

Phthalates are a class of industrial compounds with an array of toxicological properties used in day to day life. Diisobutyl phthalate on (DIBP) is used as an additive to keep the plastics soft or flexible (plasticizer) in nitrocellulose plastic, nail

Occurrence of phthalic acid esters in source waters: a nationwide survey in China during the period of 2009-2012.

Xiaowei Liu et al.

Environmental pollution (Barking, Essex : 1987), 184, 262-270 (2013-10-01)

The first nationwide survey of six phthalic acid esters (PAEs) (diethyl phthalate (DEP); dimethyl phthalate (DMP); di-n-butyl phthalate (DBP); butyl benzyl phthalate (BBP); bis(2-ethylhexyl) phthalate (DEHP); di-n-octyl phthalate (DnOP)) in source waters was conducted in China. The results showed these

Acetylsalicylic acid mitigates erythropoietin-associated blood pressure increase in nonuremic rats.

Maristela Böhlke et al.

Clinical and experimental hypertension (New York, N.Y. : 1993), 37(3), 235-240 (2014-10-15)

Approximately 30% of the chronic kidney disease patients using recombinant human erythropoietin (rhuEPO) have an increase in blood pressure (BP). Its mechanism and whether it depends on renal function remain unclear. There is early evidence that acetylsalicylic acid (ASA) prevents

Hot-melts in buccoadhesive patches: an approach for bioavailability enhancement of highly-metabolized drugs with short elimination half-life.

Galal M El Mahrouk et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 1005-1011 (2014-12-03)

The present study deals with the inclusion or incorporation of hot-melts into buccoadhesive patches. Our aim is to develop a patient-friendly dosage form that is capable of extending release of short elimination half-life drugs so to decrease dosing frequency and

A novel quantitative body shape score for detecting association between obesity and hypertension in China.

Shukang Wang et al.

BMC public health, 15, 7-7 (2015-01-18)

Obesity is a major independent risk factor for chronic diseases such as hypertension and coronary diseases, it might not be only related to the amount of body fat but its distribution. The single body mass index (BMI), waist circumference (WC)

Biodegradation of di-n-butyl phthalate by a stable bacterial consortium, HD-1, enriched from activated sludge.

Zhixing He et al.

Bioresource technology, 128, 526-532 (2012-12-04)

HD-1, a stable microbial consortium capable of mineralizing di-n-butyl phthalate (DBP), was developed from activated sludge. The dominant microorganisms in the consortium, Gordonia sp., Burkholderia sp. and Achromobacter sp., were identified by denaturing gradient gel electrophoresis (DGGE). The consortium could

Orthostatic hypotension in Parkinson disease: how much you fall or how low you go?

Jose-Alberto Palma et al.

Movement disorders : official journal of the Movement Disorder Society, 30(5), 639-645 (2015-02-14)

Orthostatic hypotension (OH) is frequent in patients with Parkinson's disease (PD) and can occur with or without symptoms. Pharmacological treatments are effective, but often exacerbate supine hypertension. Guidelines exist for the diagnosis, but not for the treatment of OH. We

Association of single nucleotide polymorphisms in VDR and DBP genes with HBV-related hepatocellular carcinoma risk in a Chinese population.

Qiliu Peng et al.

PloS one, 9(12), e116026-e116026 (2014-12-30)

Polymorphisms of genes encoding components of the vitamin D pathway including vitamin D receptor (VDR) and vitamin D binding protein (DBP) have been widely investigated because of the complex role played by vitamin D in cancer tumorogenesis. In this study

Characterizations of plasticized polymeric film coatings for preparing multiple-unit floating drug delivery systems (muFDDSs) with controlled-release characteristics.

Sheng-Feng Hung et al.

PloS one, 9(6), e100321-e100321 (2014-06-27)

Effervescent multiple-unit floating drug delivery systems (muFDDSs) consisting of drug (lorsartan)- and effervescent (sodium bicarbonate)-containing pellets were characterized in this study. The mechanical properties (stress and strain at rupture, Young's modulus, and toughness) of these plasticized polymeric films of acrylic

Phthalate and di-(2-ethylhexyl) adipate (DEHA) intake by German infants based on the results of a duplicate diet study and biomonitoring data (INES 2).

Hermann Fromme et al.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 53, 272-280 (2012-12-19)

Phthalates as well as di-(2-ethylhexyl) adipate (DEHA) are used as plasticizers in diverse applications and are of toxicological concern. The study was conducted with a study population of 25 German subjects aged between 15 and 21 months. Overall, 16 phthalates

Serum vitamin D, vitamin D binding protein, and lung cancer survival.

Gabriella M Anic et al.

Lung cancer (Amsterdam, Netherlands), 86(3), 297-303 (2014-12-03)

Vitamin D may prolong cancer survival by inhibiting tumor progression and metastasis, however, there are limited epidemiologic studies regarding the association between circulating 25-hydroxyvitamin D (25(OH)D) and lung cancer survival. The aim of this study was to examine the relationship

Antiandrogenic effects of dibutyl phthalate and its metabolite, monobutyl phthalate, in rats.

Makoto Ema

Congenital anomalies, 42(4), 297-308 (2003-03-14)

Developmental toxicity following administration of dibutyl phthalate (DBP) and its major metabolite, monobutyl phthalate (MBuP), by gavage was determined in Wistar rats. DBP on days 0-8 of pregnancy induced an increase in the incidence of preimplantation loss at 1250 mg/kg

Direct sample introduction gas chromatography and mass spectrometry for the determination of phthalate esters in cleaning products.

J I Cacho et al.

Journal of chromatography. A, 1380, 156-161 (2015-01-15)

A method using direct sample introduction (DSI) coupled to gas chromatography-mass spectrometry (GC-MS) is developed for the determination of six phthalate esters (dimethyl, diethyl, dibutyl, butylbenzyl, diethylhexyl and dioctyl phthalate) in cleaning products. The different variables involved in the DSI

Evening versus morning dosing of antihypertensive drugs in hypertensive patients with sleep apnoea: a cross-over study.

Alexandros Kasiakogias et al.

Journal of hypertension, 33(2), 393-400 (2014-10-17)

Beneficial effects of continuous positive airway pressure (CPAP) on both blood pressure (BP) levels and variability have been documented in patients with obstructive sleep apnoea (OSA). We investigated the relevant impact of different dosing times of antihypertensive drugs beyond CPAP

Association between low education and higher global cardiovascular risk.

Tiziana Di Chiara et al.

Journal of clinical hypertension (Greenwich, Conn.), 17(5), 332-337 (2015-02-24)

This study was designed to evaluate the impact of educational status on global cardiovascular risk in a southern Italian urban population. The study population consisted of 488 consecutive outpatients aged 18 years and older. Educational status was categorized according to the

Attributing population-scale human exposure to various source categories: merging exposure models and biomonitoring data.

Hyeong-Moo Shin et al.

Environment international, 70, 183-191 (2014-06-18)

Information about the distribution of chemical-production mass with respect to use and release is a major and unavailable input for calculating population-scale exposure estimates. Based on exposure models and biomonitoring data, this study evaluates the distribution of total production volumes

Evaluation of a brachial cuff and suprasystolic waveform algorithm method to noninvasively derive central blood pressure.

Benedict T Costello et al.

American journal of hypertension, 28(4), 480-486 (2014-09-07)

Central blood pressure (BP) can be estimated noninvasively by analyzing brachial artery waveforms. In this study, our aim was to assess the validity of a brachial cuff-based (suprasystolic) technique for estimating central BP (CBPestimated) by comparison with invasive aortic BP

Cloning of a dibutyl phthalate hydrolase gene from Acinetobacter sp. strain M673 and functional analysis of its expression product in Escherichia coli.

Jun Wu et al.

Applied microbiology and biotechnology, 97(6), 2483-2491 (2012-06-26)

A dibutyl phthalate (DBP) transforming bacterium, strain M673, was isolated and identified as Acinetobacter sp. This strain could not grow on dialkyl phthalates, including dimethyl, diethyl, dipropyl, dibutyl, dipentyl, dihexyl, di(2-ethylhexyl), di-n-octyl, and dinonyl phthalate, but suspensions of cells could

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