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JeongWoo Kang et al.
Applied biochemistry and biotechnology, 174(1), 1-5 (2014-07-30)
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the group of drugs having the therapeutic efficacy of analgesic and antipyretic. To detect health-threatening residues of NSAIDs, a fast and easy multiresidue method based on liquid chromatography tandem mass spectrometry (LC-MS/MS) was described. Ten
Małgorzata Maciążek-Jurczyk
Pharmacological reports : PR, 66(5), 727-731 (2014-08-26)
A combination of phenylbutazone (PBZ) and ketoprofen (KP) is popular in therapy of rheumatoid arthritis (RA) but could be unsafe due to the uncontrolled growth of toxicity. Quenching fluorescence of serum albumin in the presence of the both drugs has
Xiangge Tian et al.
The AAPS journal, 17(1), 156-166 (2014-09-11)
Andrographolide (AND) and two of its derivatives, deoxyandrographolide (DEO) and dehydroandrographolide (DEH), are widely used in clinical practice as anti-inflammatory agents. However, UDP-glucuronosyltransferase (UGT)-mediated phase II metabolism of these compounds is not fully understood. In this study, glucuronidation of AND
Else Jacobson et al.
PloS one, 10(4), e0122220-e0122220 (2015-04-04)
It is not known how extensively a localised flexor tendon injury affects the entire tendon. This study examined the extent of and relationship between histopathologic and gene expression changes in equine superficial digital flexor tendon after a surgical injury. One
Peter Lees et al.
Veterinary journal (London, England : 1997), 196(3), 294-303 (2013-06-01)
The presence of horse meat in food products destined for human consumption and labelled as beef has raised several concerns of public interest. This review deals solely with one aspect of these concerns; samples of equine tissue from horses destined
Bone marrow depression due to mianserin, phenylbutazone, oxyphenbutazone, and chloramphenicol--Part I.
S Chaplin
Adverse drug reactions and acute poisoning reviews, 5(2), 97-136 (1986-01-01)
M Kopcha et al.
Journal of the American Veterinary Medical Association, 194(1), 45-49 (1989-01-01)
Presently, in the United States, there are no nonsteroidal anti-inflammatory drugs, except aspirin, that are approved for use in animals intended for food production. Use of phenylbutazone, flunixin meglumine, and dipyrone for treatment of food animals may be considered in
L B Jeffcott et al.
Equine veterinary journal, 9(3), 105-110 (1977-07-01)
The clinical uses and side-effects of phenylbutazone in man, horses, and other animals are reviewed. The blood dyscrasias commonly described in man have not been reported in the horse, although several of the more minor side-effects have occasionally been seen
Sharanne L Raidal et al.
American journal of veterinary research, 75(7), 668-679 (2014-06-25)
To compare the effects of 2 NSAIDs (phenylbutazone and meloxicam) on renal function in horses. 9 Thoroughbred or Standardbred mares (mean ± SD age, 5.22 ± 1.09 years [range, 2 to 12 years]; mean body weight, 470 ± 25 kg
Marco Pistolozzi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 968, 69-78 (2014-01-30)
A series of novel tocainide analogues were characterized for their HSA and RSA binding, by using high-performance liquid affinity chromatography (HPLAC) and circular dichroism (CD). In this HPLAC study, HSA and RSA were covalently immobilized to the silica matrix of
Matthew Di Rago et al.
Forensic science international, 243, 35-43 (2014-05-06)
The aim of this study was to develop an LC-MS/MS based screening technique that covers a broad range of acidic and neutral drugs and poisons by combining a small sample volume and efficient extraction technique with simple automated data processing.
[Phenylbutazone and chromosome injuries].
K Berg
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 93(31), 2330-2332 (1973-11-10)
[Multiple manifestations of intolerance in association with anti-inflammatory agents. Role of phenylbutazone].
F Tolot et al.
Semaine des hopitaux. Therapeutique, 52(3), 185-190 (1976-03-01)
Kohei Matsushita et al.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 67(1), 31-39 (2014-12-03)
The kidney is a major target site of chemical carcinogenesis. However, a reliable in vivo assay for rapid identification of renal carcinogens has not been established. The purpose of this study was to develop a new medium-term gpt delta rat
M Maciazek-Jurczyk et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 74(1), 1-9 (2009-07-21)
The monitoring of drug concentration in blood serum is necessary in multi-drug therapy. Mechanism of drug binding with serum albumin (SA) is one of the most important factors which determine drug concentration and its transport to the destination tissues. In
Mike De Vrieze et al.
Analytical and bioanalytical chemistry, 406(25), 6179-6188 (2014-08-16)
Over the past decades, several in vitro methods have been tested for their ability to predict drug penetration across the blood-brain barrier. So far, in high-performance liquid chromatography, most attention has been paid to micellar liquid chromatography and immobilized artificial
[Biological availability and solubility of phenylbutazone].
L Krówczyński et al.
Folia medica Cracoviensia, 21(1), 141-147 (1979-01-01)
J Aarbakke
Clinical pharmacokinetics, 3(5), 369-380 (1978-09-01)
More than 25 years after phenylbutazone was introduced as a non-steroidal anti-inflammatory agent, basic knowledge is still accumulating on its pharmacokinetics in man. Phenylbutazone is almost completely absorbed after oral administration. A large fraction of the drug in plasma is
T Tobin et al.
Journal of veterinary pharmacology and therapeutics, 9(1), 1-25 (1986-03-01)
Phenylbutazone is an acidic, lipophilic, non-steroidal anti-inflammatory drug (NSAID). It is extensively metabolized in the horse. The metabolites so far identified, oxyphenbutazone, gamma-hydroxyoxyphenbutazone, account for some 25-30% of administered dose over 24 h. The plasma half-life of phenylbutazone and termination
Robert D Combes
Alternatives to laboratory animals : ATLA, 41(3), 235-248 (2013-08-27)
Published in silico, in vitro, in vivo laboratory animal and human data, together with information on biotransformation and data from structure-activity analyses with two decision-tree systems (ACToR and Toxtree), have been used in a weight-of-evidence (WoE) assessment to determine whether
Bone marrow depression due to mianserin, phenylbutazone, oxyphenbutazone, and chloramphenicol--Part II.
S Chaplin
Adverse drug reactions and acute poisoning reviews, 5(3), 181-196 (1986-01-01)
Abdelmonaim Azzouz et al.
Food chemistry, 178, 63-69 (2015-02-24)
A sensitive, selective, efficient gas chromatography-mass spectrometry method for the simultaneous determination of 22 pharmacologically active substances (antibacterials, nonsteroidal antiinflammatories, antiseptics, antiepileptics, lipid regulators, β-blockers and hormones) in eggs and honey was developed. The sample pretreatment includes precipitation of proteins
[Phenylbutazone and its analogs. Synthesis, chemical and pharmaceutical properties].
M I Santoro et al.
Revista de farmacia e bioquimica da Universidade de Sao Paulo, 11(2), 117-141 (1973-07-01)
L R Soma et al.
Journal of veterinary pharmacology and therapeutics, 35(1), 1-12 (2011-06-15)
This review presents a brief historical prospective of the genesis of regulated medication in the US racing industry of which the nonsteroidal anti-inflammatory drug (NSAID) phenylbutazone (PBZ) is the focus. It presents some historical guideposts in the development of the
[Mechanism of the ulcerogenic effects of phenylbutazone and indomethacin].
M Valentík et al.
Ceskoslovenska gastroenterologie a vyziva, 32(8), 494-500 (1978-12-01)
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