806552

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L-Cysteine-mediated modulation of copper trafficking in prostate cancer cells: an in vitro and in vivo investigation with 64Cu and 64Cu-PET.

Joanna J Bartnicka et al.

Metallomics : integrated biometal science, 12(10), 1508-1520 (2020-09-23)

Copper imbalance is implicated in many diseases, including cancer. Copper in blood is mainly transported by carrier proteins but a small fraction is bound to low molecular weight species, possibly amino acids. Their roles in cellular copper delivery are unknown.

Human sperm acrosomal status, acrosomal responsiveness, and acrosin are predictive of the outcomes of in vitro fertilization: A prospective cohort study.

Fang Xu et al.

Reproductive biology, 18(4), 344-354 (2018-11-14)

The sperm acrosome reaction (AR) is a physiological secretory course of membrane fusion and hydrolytic enzymes, as well as matrix protein release, enabling spermatozoa to penetrate the egg surroundings. An instable acrosomal status before a specific stimulus, insufficient acrosomal responsiveness

Partial leptin deficiency confers resistance to diet-induced obesity in mice.

Shangang Zhao et al.

Molecular metabolism, 37, 100995-100995 (2020-04-15)

Hyperleptinemia per se is sufficient to promote leptin resistance in the obese state. Leptin sensitivity can be restored by reducing circulating leptin levels within a physiologically healthy range and is a viable antiobesity and antidiabetic strategy. However, a previous study

Capacity of the medullary cavity of tibia and femur for intra-bone marrow transplantation in mice.

Dieter Fink et al.

PloS one, 14(11), e0224576-e0224576 (2019-11-08)

Intra-bone marrow transplantation (IBMT) has been adapted for mouse models to improve the seeding efficiency of transplanted hematopoietic stem and progenitor cells. Commonly used injection volumes for IBMT into the tibia differ between 10 and 40 μL even though considerable

Human Endometrial Stem Cell Isolation from Endometrium and Menstrual Blood

Tavakol S, et al.

Molecular Neurobiology (2016)

Cancer Stem Cell-Inducing Media Activates Senescence Reprogramming in Fibroblasts.

Patrick M Perrigue et al.

Cancers, 12(7) (2020-07-08)

Cellular senescence is a tumor-suppressive mechanism blocking cell proliferation in response to stress. However, recent evidence suggests that senescent tumor cells can re-enter the cell cycle to become cancer stem cells, leading to relapse after cancer chemotherapy treatment. Understanding how

A biosensing system employing nanowell microelectrode arrays to record the intracellular potential of a single cardiomyocyte.

Yuting Xiang et al.

Microsystems & nanoengineering, 8, 70-70 (2022-07-02)

Electrophysiological recording is a widely used method to investigate cardiovascular pathology, pharmacology and developmental biology. Microelectrode arrays record the electrical potential of cells in a minimally invasive and high-throughput way. However, commonly used microelectrode arrays primarily employ planar microelectrodes and

The small molecule PSSM0332 disassociates the CRL4ADCAF8 E3 ligase complex to decrease the ubiquitination of NcoR1 and inhibit the inflammatory response in a mouse sepsis-induced myocardial dysfunction model.

Qingyun Peng et al.

International journal of biological sciences, 16(15), 2974-2988 (2020-10-17)

Sepsis-induced myocardial dysfunction (SIMD) is a life-threatening complication caused by inflammation, but how it is initiated is still unclear. Several studies have shown that extracellular high mobility group box 1 (HMGB1), an important cytokine triggering inflammation, is overexpressed during the

Recovery and chemical disinfection of foot-and-mouth disease and African swine fever viruses from porous concrete surfaces.

L R Gabbert et al.

Journal of applied microbiology, 129(5), 1092-1101 (2020-05-08)

Develop an effective laboratory method to consistently recover viral loads from porous concrete coupons sufficient for disinfectant efficacy testing. Investigate the role of concrete matrix pH on the recovery of foot-and-mouth disease virus (FMDV) and African Swine Fever virus (ASFV)

Improvement of Remyelination in Demyelinated Corpus Callosum Using Human Adipose-Derived Stem Cells (hADSCs) and Pregnenolone in the Cuprizone Rat Model of Multiple Sclerosis.

Rasoul Ganji et al.

Journal of molecular neuroscience : MN, 70(7), 1088-1099 (2020-04-22)

Adipose-derived stem cells (ASCs) have neuroprotective effects, and their repair ability has been approved in neurodegenerative studies. Pregnenolone as a neurosteroid plays significant roles in neurogenesis. We aimed to consider the effect of ADSCs and pregnenolone injection on the multiple

Intramuscular accumulation of pentadecanoic acid activates AKT1 to phosphorylate NCOR1 and triggers FOXM1-mediated apoptosis in the pathogenesis of sarcopenia.

Fa-Xiu Chen et al.

American journal of translational research, 12(9), 5064-5079 (2020-10-13)

Sarcopenia is an age-associated disorder that results in skeletal muscle loss. Apoptosis and inflammation are the two major contributors to sarcopenia. Emerging evidence has shown that long-chain fatty acids (LCFAs) are implicated in the muscles of sarcopenic animal models. However

Technical brief: Direct, real-time electrochemical measurement of nitric oxide in ex vivo cultured human corneoscleral segments.

Pinkal D Patel et al.

Molecular vision, 26, 434-444 (2020-06-23)

Chronic elevation of intraocular pressure (IOP) is a major risk factor associated with primary open angle glaucoma (POAG), a common form of progressive optic neuropathy that can lead to debilitating loss of vision. Recent studies have identified the role of

Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death.

Daniel Fisch et al.

Cell reports, 32(6), 108008-108008 (2020-08-14)

Interferon-inducible guanylate-binding proteins (GBPs) promote cell-intrinsic defense through host cell death. GBPs target pathogens and pathogen-containing vacuoles and promote membrane disruption for release of microbial molecules that activate inflammasomes. GBP1 mediates pyroptosis or atypical apoptosis of Salmonella Typhimurium (STm)- or

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