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Oliver Teuffel et al.
British journal of haematology, 161(2), 192-203 (2013-02-13)
This systematic review and meta-analysis compared the efficacy of different anthracyclines and anthracycline dosing schedules for induction therapy in acute myeloid leukaemia in children and adults younger than 60 years of age. Twenty-nine randomized controlled trials were eligible for inclusion in
Santiago Palacio et al.
International journal of stroke : official journal of the International Stroke Society, 10(5), 686-691 (2013-05-23)
It remains controversial whether dual antiplatelet therapy reduces stroke more than aspirin alone. We aimed to assess the effects of adding clopidogrel to aspirin on the occurrence of stroke and major haemorrhage in patients with vascular disease. Meta-analysis of published
J Sun et al.
British poultry science, 53(3), 374-378 (2012-09-18)
1. A pharmacokinetic study of valnemulin was conducted in healthy Muscovy ducks after intravenous (IV), intramuscular (IM) and oral administrations at a dose rate of 15 mg/kg body weight. 2. Drug concentrations in plasma were determined by high performance liquid
Sara Marinelli et al.
BMC cancer, 14, 403-403 (2014-06-07)
Development of escape pathways from antiangiogenic treatments was reported to be associated with enhanced tumor aggressiveness and rebound effect was suggested after treatment stop. Aim of the study was to evaluate tumor response simulating different conditions of administration of antiangiogenic
Berit A Payer et al.
European journal of clinical investigation, 42(6), 599-606 (2011-11-29)
A polymorphism near the IL28B gene has been shown to be associated with virologic response to antiviral treatment in HCV-infected patients. The predictive value of interferon-gamma inducible protein 10 (IP10) on treatment outcome has been described in HCV patients. Data
Dengfeng Cao et al.
Human pathology, 42(5), 710-718 (2011-02-04)
LIN28 is an RNA-binding protein involved in maintaining the pluripotency of embryonic stem cells. Using formalin-fixed, paraffin-embedded tissue blocks, we performed immunohistochemical staining of LIN28 in 103 primary and 81 metastatic testicular germ cell tumors (54 intratubular germ cell neoplasias
Angelo Di Leo et al.
The Lancet. Oncology, 12(12), 1134-1142 (2011-09-16)
Prediction of response to anthracycline-based therapy for breast cancer is challenging. We aimed to assess the value of HER2 and TOP2A as predictive markers of response to anthracycline-based adjuvant therapy in patients with early breast cancer. We did a meta-analysis
Maiko Kusano et al.
Forensic science international, 300, 125-135 (2019-05-20)
Trends in forensic toxicology show the advancement of rapid and sensitive analytical methods for qualitative and quantitative analysis of drugs of abuse. However, forensic toxicologists are continuously faced with the challenges of identifying and quantifying drug blood concentration while simultaneously
Alice T Shaw et al.
The Lancet. Oncology, 12(11), 1004-1012 (2011-09-22)
ALK gene rearrangement defines a new molecular subtype of non-small-cell lung cancer (NSCLC). In a recent phase 1 clinical trial, the ALK tyrosine-kinase inhibitor (TKI) crizotinib showed marked antitumour activity in patients with advanced, ALK-positive NSCLC. To assess whether crizotinib
Julie E Bines et al.
The Lancet. Infectious diseases, 15(12), 1389-1397 (2015-09-01)
Despite the success of rotavirus vaccines, suboptimal vaccine efficacy in regions with a high burden of disease continues to present a challenge to worldwide implementation. A birth dose strategy with a vaccine developed from an asymptomatic neonatal rotavirus strain has
Svjetlana Radović et al.
Bosnian journal of basic medical sciences, 13(2), 72-77 (2013-06-04)
NM 23 protein was originally identified as a metastasis suppressor protein. The expression of NM23 has been correlated with tumour metastatic potential in various human carcinoma, mostly in ductal breast and colorectal carcinomas. Evidence for their expression in gastric cancer
Lesly A Pearce et al.
The Lancet. Neurology, 13(12), 1177-1185 (2014-12-03)
The primary outcome results for the SPS3 trial suggested that a lower systolic target blood pressure (<130 mm Hg) might be beneficial for reducing the risk of recurrent stroke compared with a higher target (130-149 mm Hg), but that the
G Lefèvre et al.
Journal of clinical laboratory analysis, 15(1), 40-42 (2001-02-15)
Influence of protein composition on total urinary protein assays was evaluated for pyrogallol red-molybdate both with and without sodium dodecyl sulfate (SDS) and pyrocatechol violet-molybdate complex (UPRO) techniques. Using mixtures of albumin and gamma-globulins (n = 8; albumin/globulin ratio, 0
Jean-Jacques Wyndaele et al.
Neurourology and urodynamics, 35(2), 252-259 (2015-01-20)
Evaluate the efficacy, safety, and tolerability of a novel pressure-attenuation balloon for the treatment of female stress urinary incontinence (SUI) using a prospective, randomized, single-blind, multi-center design, evaluated at 3 months. Sixty-three females with SUI were randomized 2:1 to treatment
Nancy J Hong et al.
American journal of physiology. Renal physiology, 303(8), F1151-F1156 (2012-08-17)
We previously showed that luminal flow stimulates thick ascending limb (TAL) superoxide (O(2)(-)) production by stretching epithelial cells and increasing NaCl transport, and reported that the major source of flow-induced O(2)(-) is NADPH oxidase (Nox). However, the specific Nox isoform
Li Fu et al.
Fertility and sterility, 92(1), 47-53 (2008-08-08)
To determine possible involvement of splice variant 1 (SV1), a variant of the pituitary growth hormone-releasing hormone (GHRH) receptor, in the development of endometriosis. Comparative and laboratory study. University teaching hospital reproductive endocrinology and infertility practice. Eutopic and ectopic endometrial
J F Gregory et al.
The Journal of nutrition, 130(12), 2949-2952 (2000-12-09)
Folate turnover involves urinary excretion, fecal excretion, and catabolism that involves cleavage of the C9-N10 bond to yield pterins and para-aminobenzoylglutamate (pABG). Little is known about the relationship between the function of folate pools and their rates of catabolism. We
V R G Mercadante et al.
Journal of animal science, 93(2), 776-785 (2015-05-29)
To determine whether supplementation of anti-phospholipase A antibody (aPLA) would alter voluntary DMI, feed efficiency (FE), acute-phase protein concentration, and blood differentials (BD) due to a change in diet from a forage-based to a grain-based diet, individual daily DMI was
Rebecca B Lipton et al.
Pediatric diabetes, 12(4 Pt 2), 388-395 (2011-03-23)
To understand the etiology of childhood-onset diabetes, we examined genetic risk markers, autoantibodies, and β-cell function in a mixed race group of young patients. One hundred and forty-five patients aged 0-17 at diagnosis (54% African American, 22% Caucasian, 16% Latino
A A A Jacobs et al.
Animal : an international journal of animal bioscience, 7(9), 1508-1516 (2013-04-20)
Stearoyl-CoA desaturase (SCD) in the bovine mammary gland introduces a cis-double bond at the Δ9 position in a wide range of fatty acids (FA). Several long-chain polyunsaturated fatty acids (PUFA) inhibit expression of SCD, but information on the effect of
M C Perdomo et al.
Journal of dairy science, 103(1), 325-339 (2019-11-05)
The objectives were to evaluate the effects of feeding different amounts of supplemental live yeast (LY) on performance and digestion of cows under heat stress. Sixty Holstein cows, 27 multiparous and 33 primiparous, were blocked by parity and milk yield
A J A Meershoek et al.
The British journal of surgery, 106(6), 665-671 (2019-04-12)
Guidelines recommend treating patients with an internal carotid artery near occlusion (ICANO) with best medical therapy (BMT) based on weak evidence. Consequently, patients with ICANO were excluded from randomized trials. The aim of this individual-patient data (IPD) meta-analysis was to
Pharmacodynamics and pharmacokinetics of fluticasone furoate/vilanterol in healthy Chinese subjects.
Xia Chen et al.
Pharmacotherapy, 35(6), 586-599 (2015-06-11)
To investigate the pharmacodynamic and pharmacokinetic profiles of fluticasone furoate (FF)/vilanterol (VI) - a fixed-dose combination of an inhaled corticosteroid (ICS) and a long-acting β2 -agonist for the treatment of asthma and chronic obstructive pulmonary disease - after single and
R V Knox et al.
Theriogenology, 82(3), 379-386 (2014-06-04)
Previous studies have shown that triptorelin gel (TG) given intravaginally in gel form is effective for advancing the time of ovulation in weaned sows. Three experiments were performed to determine the effects of altering the dose and timing of administration
Diamant Thaçi et al.
Lancet (London, England), 387(10013), 40-52 (2015-10-12)
Data from early-stage studies suggested that interleukin (IL)-4 and IL-13 are requisite drivers of atopic dermatitis, evidenced by marked improvement after treatment with dupilumab, a fully-human monoclonal antibody that blocks both pathways. We aimed to assess the efficacy and safety
Richard S Craig et al.
The Cochrane database of systematic reviews, 4, CD012879-CD012879 (2020-04-22)
Shoulder replacement surgery is an established treatment for patients with end-stage glenohumeral osteoarthritis or rotator cuff tear arthropathy who have not improved with non-operative treatment. Different types of shoulder replacement are commonly used, but their relative benefits and risks compared
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