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Jiandong Zhang et al.
American journal of physiology. Renal physiology, 301(4), F723-F732 (2011-07-29)
The limited antifibrotic effect of therapeutic angiotensin blockade, the fact that angiotensin blockade dramatically elevates renin levels, and recent evidence that renin has an angiotensin-independent, receptor-mediated profibrotic action led us to hypothesize that combining renin receptor inhibition and ANG II
Salih Pay et al.
Joint, bone, spine : revue du rhumatisme, 73(6), 691-696 (2006-09-22)
To analyze the CXCR-1 and CXCR-2 chemokine receptor expression on peripheral blood neutrophils (PBN) and synovial fluid neutrophils (SFN) of patients with rheumatoid arthritis (RA) and Behçet's disease (BD) (characterized by erosive and non-erosive arthritis, respectively), and to compare them
Giuseppe M Raffa et al.
The Journal of heart valve disease, 19(6), 724-730 (2011-01-11)
Endothelin-1 (ET-1) and B-type natriuretic peptide (BNP) have been reported to be involved in numerous cardiovascular diseases. The study aim was to monitor the circulating plasma levels of these peptides in patients affected by aortic disease, and to identify any
Y Wang et al.
British journal of pharmacology, 172(11), 2905-2917 (2015-01-30)
Medical therapy of lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) targets smooth muscle contraction in the prostate, or prostate growth. However, current therapeutic options are insufficient. Here, we investigated the role of Rac in the control
Makoto Daimon et al.
Diabetes research and clinical practice, 56(2), 147-152 (2002-03-14)
A G-to-A (UCSNP-43) polymorphism of the calpain-10 gene was significantly associated with type 2 diabetes (DM) in Mexican-American, and was postulated, together with a T-to-C (UCSNP-44) polymorphism, as a risk factor for DM. We examined the association of these genotypes
Vicente Ferreira et al.
Journal of chromatography. A, 1010(1), 95-103 (2003-09-25)
A method for the analytical determination of sotolon [4,5-dimethyl-3-hydroxy-2(5H)-furanone], maltol [3-hydroxy-2-methyl-4H-pyran-4-one] and free furaneol [2,5-dimethyl-4-hydroxy-3(2H)-furanone] in wine has been developed. The analytes are extracted from 50 ml of wine in a solid-phase extraction cartridge filled with 800 mg of LiChrolut
Abdelwahab E Saeed et al.
BMC cell biology, 5(1), 47-47 (2004-12-18)
Fibroblasts, as connective tissue cells, are able to transform into another cell type including smooth muscle cells. alpha1A-adrenergic receptor (alpha1A-AR) stimulation in rat-1 fibroblasts is coupled to cAMP production. However, the significance of an increase in cAMP produced by alpha1A-AR
Akira Funada et al.
Circulation journal : official journal of the Japanese Circulation Society, 74(12), 2674-2680 (2010-10-27)
Although the renin-angiotensin system (RAS) can affect the development of left ventricular (LV) hypertrophy, few data exist regarding the relationships between RAS polymorphisms and alteration of LV function. The effect of RAS polymorphisms on LV function in genotyped hypertrophic cardiomyopathy
Wen-Hui Zhang et al.
Ecotoxicology and environmental safety, 120, 369-376 (2015-06-27)
Three hundred Mn-resistant endophytic bacteria were isolated from the Mn-hyperaccumulator, Phytolacca americana, grown at different levels of Mn (0, 1, and 10mM) stress. Under no Mn stress, 90%, 92%, and 11% of the bacteria produced indole acetic acid (IAA), siderophore
V M Guillem et al.
Leukemia, 21(7), 1413-1422 (2007-05-04)
Therapy-related myelodysplasia and acute myeloid leukemia (t-MDS/AML) is a malignancy occurring after exposure to chemotherapy and/or radiotherapy. Polymorphisms involved in chemotherapy/radiotherapy response genes could be related to an increased risk of developing this neoplasia. We have studied 11 polymorphisms in
Takumi Kurabayashi et al.
Journal of bone and mineral metabolism, 22(3), 241-247 (2004-04-27)
We longitudinally studied whether vitamin D receptor (VDR) and estrogen receptor (ER) gene polymorphisms in Japanese women influenced the effect of longterm hormone replacement therapy (HRT) on bone mineral density (BMD) in the lumbar spine. The 81 subjects were aged
Francesc Vidal et al.
Journal of hepatology, 41(5), 744-750 (2004-11-03)
The relationship between polymorphisms at the alcohol dehydrogenase 2 (ADH(2)), ADH(3), CYP(450)2E1 and aldehyde dehydrogenase 2 (ALDH(2)) loci and the individual predisposition to alcoholism and alcoholic liver disease in Caucasians is controversial. We determined the genotypes of ADH(2), ADH(3), CYP(450)2E1
Eric Druyts et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 56(7), 961-967 (2012-12-18)
A systematic review and meta-analysis were conducted to examine the efficacy and safety of pegylated interferon (peg-IFN) alfa-2a and peg-IFN alfa-2b plus ribavirin (RBV) in children and adolescents with chronic hepatitis C virus (HCV). Medline, Embase, and Cochrane Central Register
Ling Li et al.
Transfusion, 60(8), 1773-1777 (2020-06-04)
A novel coronavirus has caused an international outbreak. Currently, there are no specific therapeutic agents for coronavirus infections. Convalescent plasma (CP) therapy is a potentially effective treatment option. Patients who had recovered from COVID-19 and had been discharged from the
Amit Kundu et al.
Toxicology and applied pharmacology, 390, 114899-114899 (2020-01-26)
High-fat diet (HFD)-induced obesity is implicated in diabetic nephropathy (DN). EX-527, a selective Sirtuin 1 (SIRT1) inhibitor, has multiple biological functions; however, its protective effect against DN is yet to be properly understood. This study was aimed to explore the
Rudi Beschorner et al.
Acta neuropathologica, 117(6), 667-675 (2009-03-14)
Microscopic distinction of normal choroid plexus (CP) from choroid plexus tumors (CPT) may be difficult, especially in small samples of well-differentiated CP papillomas. So far, there are no established markers that reliably distinguish normal and neoplastic CP epithelium. Recently, a
Janet Pan et al.
Cancer chemotherapy and pharmacology, 70(6), 791-799 (2012-09-18)
HIV protease inhibitors are associated with HIV protease inhibitor-related lipodystrophy syndrome. We hypothesized that liposarcomas would be similarly susceptible to the apoptotic effects of an HIV protease inhibitor, nelfinavir. We conducted a phase I trial of nelfinavir for liposarcomas. There
Kiyoshi Misawa et al.
PloS one, 10(3), e0118588-e0118588 (2015-03-04)
The aim of this study was to define somatostatin (SST) and somatostatin receptor type 1 (SSTR1) methylation profiles for head and neck squamous cell carcinoma (HNSCC) tumors at diagnosis and follow up and to evaluate their prognostic significance and value
Francesco Ferrini et al.
Pain, 129(1-2), 195-209 (2007-02-24)
Inhibitory neurotransmission in spinal cord dorsal horn is mainly mediated by gamma-amino butyric acid (GABA) and glycine. By patch clamp recordings and correlative immunocytochemistry, we studied here the effect of 2 microM capsaicin-induced vanilloid receptor-1 (TRPV1) activation on IPSCs in
Rimma Kalina et al.
Peptides, 104, 41-49 (2018-04-24)
Sea anemones are an abundant source of various biologically active peptides. The hydrophobic 20% ethanol fraction of tropical sea anemone Heteractis crispa was shown to contain at least 159 peptide compounds including neurotoxins, proteinase and α-amylase inhibitors, as well as
Olof Rask et al.
Acta paediatrica (Oslo, Norway : 1992), 94(6), 717-722 (2005-09-29)
To identify prothrombotic risk profiles in children and adolescents referred to a regional coagulation centre in southern Sweden for a first thrombotic event. One hundred and twenty-eight consecutive children and adolescents (newborn to 20 y) referred for evaluations of a
Adeline Ruyssen-Witrand et al.
Rheumatology (Oxford, England), 52(4), 636-641 (2012-12-25)
To determine whether a functional single-nucleotide polymorphism in the B-cell activating factor (BAFF) gene correlates with the response to treatment with rituximab (RTX) in RA. SMART is a randomized open trial (NCT01126541) assessing two strategies of re-treatment in patients responding
Javier A Bustos et al.
Clinical and vaccine immunology : CVI, 19(4), 570-573 (2012-02-18)
Taenia solium causes taeniasis and cysticercosis, a zoonotic complex associated with a significant burden of epilepsy in most countries. Reliable diagnosis and efficacious treatment of taeniasis are needed for disease control. Currently, cure can be confirmed only after a period
Piotr Kubler et al.
International journal of cardiology, 129(3), 373-378 (2007-12-07)
Optimal risk stratification in heart failure patients surviving an episode of acute decompensation has not yet been established. We investigated whether a lack of significant decrease in plasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) during hospital stay can identify
Niikee C Schoendorfer et al.
European journal of clinical investigation, 42(7), 768-776 (2012-02-04)
Methylation cycle and folate-mediated one-carbon metabolism maintenance is important for many physiological processes including neurotransmitter regulation, nerve myelination and DNA synthesis. These processes play an indispensible role in growth and development, as well as in cognitive function and neuromuscular stability
Jason L Hornick et al.
The American journal of surgical pathology, 29(7), 845-858 (2005-06-17)
Perineuriomas are uncommon benign peripheral nerve sheath tumors that include soft tissue, sclerosing, and intraneural variants. Fewer than 50 soft tissue perineuriomas have been reported to date, and the clinical significance of atypical histologic features is unknown. To characterize these
E Sekerina et al.
Journal of molecular biology, 301(4), 1003-1017 (2000-09-01)
The 131-amino acid residue parvulin-like human peptidyl-prolyl cis/trans isomerase (PPIase) hPar14 was shown to exhibit sequence similarity to the regulator enzyme for cell cycle transitions human hPin1, but specificity for catalyzing pSer(Thr)-Pro cis/trans isomerizations was lacking. To determine the solution
Nils Kucher et al.
Circulation, 107(20), 2545-2547 (2003-05-14)
Rapid, noninvasive, and accurate prognostic assessment with an inexpensive cardiac biomarker is an appealing approach for patients with acute pulmonary embolism (PE). We measured at the time of admission the plasma level of plasma brain natriuretic peptide (BNP) to determine
Erdal Alkan et al.
Urolithiasis, 43(3), 243-248 (2015-01-13)
The objective of the study was to ascertain whether flexible ureteroscopy with holmium laser lithotripsy and/or extraction of stone fragments is as effective in obese patients as in non-obese patients. The patients were divided into four groups (group 1: normal
Christophe Corpechot et al.
Hepatology (Baltimore, Md.), 48(3), 871-877 (2008-08-30)
Biochemical response to ursodeoxycholic acid (UDCA) in patients with primary biliary cirrhosis (PBC) is variable. It has been recently proposed that an alkaline phosphatase (ALP) decline of more than 40% in baseline value or a normal level after 1 year
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